Chairman's Office.

"Whew...... It's finally done. ”

After signing the last agreement in his hand, Lin Yu threw it on the table casually, breathed a long sigh of relief, lay down on the sofa, and said with a sigh: "It's really troublesome to acquire the company, I would have let Li Xuan deal with it if I knew it." ”

The market valuation of Baiji formula is currently around 5 billion, and the amount required for the acquisition is relatively large, so she handed over to the finance department of Baiji.

Otherwise, how could Lin Yu be doing those tedious things here.

Hearing Lin Yu's complaint, Ouyang Lei, who was dealing with the agreement on the side, said with a smile: "You just felt troublesome when you took office, what should you do in the future." ”

"Isn't there still you dedicated employees?"

Lin Yu waved his hand and said indifferently.

Hearing this, Ouyang Lei was also a little helpless, as soon as others became the chairman, they were all kinds of dismounts, looking for opportunities to improve their prestige.

As a result, his own family is good, and as soon as he takes office, he wants to be the shopkeeper......

Leaning softly on the sofa with his eyes closed, Lin Yu checked his page in his mind.

[Host]: Lin Yu

[Skills]: speed reading shorthand, integration, cooking skills...... (Expand)

[Number of check-ins today]: 1

[Today's rebate times]: 3

After finding out that he still had one sign-in and three rebates today, Lin Yu didn't think much about it and planned to use it up directly.

As the system's prompt sounded, a familiar voice came.

【Ding, you have successfully signed in Baiji Biotechnology Co., Ltd., and you will be rewarded with CAR-T cell therapy technology!】 】

[Ding, the host can sign in at the moment: 0]

Before Lin Yu could react, in a trance, the familiar white space reappeared.

A second later, Lin Yu opened his eyes violently, and a huge surprise flashed in his eyes.

Just now, he has almost completely mastered the CAR-T cell therapy technology!

The appearance of this technology, even Lin Yu was excited, because it was simply too powerful!

What is CAR-T cell therapy?

In simple terms, it is a personalized immunotherapy method that can specifically eliminate specific cells in the body.

In other words, it is a huge lethal weapon that specializes in fighting tumor cells, and it belongs to anti-cancer drugs, and it is a very powerful one.

This method is mainly to genetically engineer the patient's T cells, add a chimeric protein to their surface, and then expand and activate them in vitro before delivering them back to the body.

Through the single-chain antibody of the chimeric protein on the surface, the strengthened T cells can obtain the ability to recognize tumor cells, and the co-excitation part of the chimeric protein can be intensified, triggering a cellular immune response, thereby destroying the tumor target cells!

From the perspective of weapons, then this CAR-T cell therapy technology is equivalent to transplanting the T cell shell from the body, and then artificially upgrading it into a strategic missile.

By the way, it also opened a precision strike and precise navigation system for the strengthened T cells (missiles), which can directly hit the tumor target cells from the root, a strong batch.

As for why Lin Yu said that this cell therapy technology is powerful, it is because it can prolong the survival period of about 3 years after one use, even for people with advanced cancer.

In game terms, that's to add three years to your lifespan when you're waiting to die! It is not an exaggeration to say that this is an "anti-cancer elixir"!

According to the information that Lin Yu learned from reading the book, the current number of new cancers in China is 4.57 million, accounting for 23.7% of the global number of new cancers

Because of its high population base, China is the country with the largest number of new cancers in the world, and last year alone, 3 million patients died of cancer in China.

Combined with the number of new cancers and the number of people surviving with tumors, the number of cancer patients in China is at least more than 20 million.

In other words, nearly 20 million patients are waiting for cancer drugs every day. Some are unaffordable, while others are cured by myrrh......

Thinking of this, Lin Yu felt a little anxious in his heart.

It is necessary to get BTK inhibitors and CAR-T cell therapy technology out as soon as possible, and then apply for marketing, so that more Chinese people can enjoy low-cost anti-cancer drugs!

Controlling the mobile phone and using up all the three rebate opportunities today, Lin Yu handed over all the 39.2 billion he got to Li Xuan, and then left 22.4 billion in the account to be swiped tomorrow.

After doing all this, Lin Yu looked directly at Ouyang Lei, who had finished sorting out the agreement, and asked, "Old Lei, how far is our company's R&D center for researching anticancer drugs from here?" ”

After the previous acquisition agreement, he has learned that Baiji is focused on developing and innovating affordable medicines.

Moreover, Baiji is at the forefront of discovery, development and innovation of targeted immuno-oncology drugs, as well as the treatment of cancer.

This is also the reason why they are short of capital chains.

Because the research and development of every anti-cancer drug is very expensive, and even 50 million can be burned in a day, which is very exaggerated.

"Huh?"

Hearing Lin Yu's leapfrog question, Ouyang Lei paused slightly, as if he was not very accustomed to the title of "Lao Lei", and said after coming back to his senses: "It's not far, it's only a dozen kilometers away from the company, and it will take about half an hour to reach ......."

"Okay, let's go, let's go there."

Lin Yu nodded, got up and said, "Regarding the research and development of anti-cancer drugs, I have some ideas that I want to put into practice recently to see if they can help the company's research team." ”

Listening to the meaning contained in Lin Yu's words, Ouyang Lei was almost stunned.

R&D of anti-cancer drugs? Idea in practice??

The new chairman of his own board of directors is still a researcher of anti-cancer drugs?!

This world is inevitably too crazy, and such outrageous things can still happen in front of you.

And you're always a billion-dollar veteran, and I'm afraid no one will believe it at all.

However, when he thought that Lin Yu had just appeared in a taxi, Ouyang Lei suddenly understood something.

He, the chairman, may be different from other CEOs, and in terms of behavior patterns, he may be more... Well... Personality is distinctive.

Keeping these thoughts in his heart, Ouyang Lei soon began to arrange, and by the way, he also asked people to say hello to the R&D center in advance.

At present, the layout of Baiji Company is mainly composed of four parts in terms of disease fields, namely solid tumors, hematological tumors, tumor immunity and autoimmune diseases.

Each of these accounts for about 25% of the total, and each has a dedicated R&D center.

After all, Baiji Company also has to make money from drugs, although it is now a situation where it is unable to make ends meet, but it can still make less money.

Soon, under the leadership of Ouyang Lei, the two drove to one of the four major R&D centers under the name of Baiji Company.

Along the way, Lin Yu also learned about the situation of this R&D center from Ouyang Lei's mouth.

It turns out that their current research direction is the antigen receptor of B cells, Bruton's tyrosine kinase (BTK).

In other words, they're working on BTK inhibitors right now, but they're not successful yet, but they're already looking at the eyebrows and getting a glimpse of the way.

The reason for the tight capital chain before was because this R&D project was in a stage of rapid development and needed to burn money like crazy.

At present, BTK inhibitors have become a popular target for the treatment of hematological malignancies and autoimmune disorders.

As long as it can be successfully developed, the situation that the entire Chinese anti-cancer market can only enter but not exit will be completely broken, and the R&D company can also obtain huge benefits.

It can be said that it is a good thing for both fame and fortune, so those pharmaceutical companies feel that even if it is worth paying a big price.

This is also the direction of the joint efforts of all pharmaceutical companies, whoever can come out on top will be able to occupy the Chinese anti-cancer market and expand foreign markets!

Because cancer is not only found in China, but in almost every country in the world.

And all cancer patients, they are eager for new anti-cancer drugs to appear as soon as possible.

When the two arrived at the R&D center, Amy, the head of the R&D center in hematology and oncology, had been waiting at the door with the management staff for a long time.

Looking at the person in charge, Lin Yu recognized at a glance that this was one of the foreigners who had dinner together at noon.

Well, that's right, it's the same middle-aged foreign man who sees him as a pervert sees a peerless beauty.

"Oh, look who this is, my dear chairman, it's our honor for you to visit the R&D center." Amy looked at Lin Yu with fiery eyes and said very enthusiastically.

Lin Yu was helpless, this damn translation tone was really uncomfortable to listen to.

Ouyang Lei introduced with a smile on the side: "Chairman, this is the chief medical officer of hematology-oncology of our Baiji Company, Amy Peterpat, and he is also the person in charge here. ”

"Well, hello, Amy."

Lin Yu replied lightly and said straight to the point: "Please take me directly to the research laboratory, I have some research ideas on anti-cancer drugs that need to be certified." ”

Lin Yu's words shocked De Amy: "Oh my God! How incredible it is that our chairman is still a great researcher! ”

Lin Yu: "......"

If it weren't for the fact that he was a foreigner, Lin Yu seriously suspected that this was forcing him to confine himself.

After a short greeting, Lin Yu followed Amy for more than ten minutes, and finally came to the outside of the BTK inhibitor research room in the R&D center.

Through the glass, Lin Yu could clearly see the situation inside.

Here, hundreds of professional team members wear white masks and white overalls, sitting at their posts, staring at the glass test tubes, liquid tubes and other experimental devices in their hands with serious expressions, and constantly repeating the work at hand

"What stage has the research of BTK inhibitors developed now?"

Lin Yu asked while watching the operation of the researchers inside.

"In terms of the study of new drugs, we have now found targets, identified models, and are currently looking for lead compounds."

Referring to her professional field, Amy said with a serious expression: "As long as there is a large amount of capital injection, we will definitely be able to find an adapted lead compound in a short time, and then optimize it, and soon we can conduct in vitro experiments, animal experiments, and human experiments, and then we can go to market." ”

Hearing this, Lin Yu withdrew his gaze from the researcher and glanced at him lightly, a little speechless.

Do you look like a good fool yourself?

Why did he think about letting him invest money as soon as he came, and he really thought he was wronged.

Moreover, at this point in the current research progress, we have not even found the lead compound, let alone the optimization of the lead compound, and the subsequent in vitro experiments.

If I don't make it myself, I'm afraid I won't be able to make a breakthrough in a few years, because the progress is too slow.

But this is also normal, after all, the research of new drugs is troublesome.

It's like giving you the process and drawings for making a pistol, but you have to find out the raw materials of gunpowder one by one from countless materials.

However, you still need to match it once you find it, so you have to optimize the original material until it becomes real gunpowder.

Just one of the gunpowder production links take such a long time,

As you can imagine, the whole is a long and complicated job.

"You go and get some work clothes and research tools, and I'll go in and test my research ideas."

After thinking about it, Lin Yu said very seriously: "If it is successful, then the lead compound of BTK inhibitor can be found and optimized today, and then you can directly conduct in vitro experiments and animal experiments." ”

As soon as these words came out, Ouyang Lei and Amy were stunned for a moment.

Is your research idea successful to find a lead compound and be able to optimize it?

I'm afraid this is not a joke, how could such a thing happen.

However, looking at Lin Yu's serious appearance that didn't look like a joke, Ouyang Lei and Amy looked at each other, glanced at each other, and didn't know what to say for a while.

If the lead compound is really so easy to find and optimize, then they still need to analyze, screen, and study here day and night?

If the chairman of the company can really find and optimize the lead compound, then hundreds of them can pack up and go home to raise pigs.

Just kidding, how could the efforts of their professional team of hundreds of people be no match for Lin Yu's idea alone?

It can't be, absolutely impossible!

Unless he hangs up!

However, even if they didn't think that Lin Yu could succeed, they still followed the instructions of their own chairman.

Soon, under the arrangement of the two, Lin Yu put on a mask, a white scientific research coat and blue rubber gloves, and walked into the research room.

Standing at his own job, looking at these glass tools and bottles and cans in front of him, as well as all kinds of electronic instruments, Lin Yu felt a sense of comfort in his heart.

It was as if he was going home, and he knew and was proficient in all kinds of tools and instruments.

It's an amazing feeling.

Soon, as time passed, Lin Yu began to gradually enter the state, manipulating the tools in his hands with a focused and serious expression.

The research of a new drug is not easy, it requires rigorous and complex steps, a long process and a lot of money.

First, it is necessary to define and classify the new drug, and then to clarify where the drug works.

To put it simply, in the human body, where the virus wants to go, the role of the drug is to prevent it from going.

Normally, viruses go through the process of adsorption, penetration, uncoating, biosynthesis, assembly and release in the human body.

Each of these stages may be the place where the drug works, which is called the target.

Once the target is identified and the model is established, the second step is to find the "weapon" that can act on it, that is, the lead compound.

A lead compound is a molecule, and there are many ways to find it, such as screening from drugs, screening from natural substances, gene synthesis, chemical extraction, and so on.

After a series of experiments found it useful, it was made into a medicine.

The third step is through in vitro experiments, that is, experiments on non-living organisms such as proteins, cells, and tissues.

After the initial verification of efficacy, continue to optimize the lead compound to make it safer, more effective, and more desirable.

The time taken at this stage is uncertain because it is full of unknowns.

But generally speaking, it takes a long time, and it can't be done in a few years.

Then it's as simple as conducting animal experiments, and then collecting data in animal blood, urine, and feces until the data of this new drug is at a stable, normal threshold.

Finally, there are human experiments, which are the same as animal experiments, but more rigorous and safety-oriented.

If there is a slight sign of badness, the dose of the drug will be recalculated until it is safe to do so.

Like the development of a new drug, it takes at least ten years, or even a little longer.

But now it's different, because Lin Yu already has the finished product in his mind.

He can quickly find the lead compound, and he can quickly optimize it to the ideal shape in his memory.

To put it bluntly, Lin Yu now seems to be looking down on everything from the perspective of God.

When others were still struggling with the complex topic of lead compounds, he had already found the answer at the first glance of this topic!

That's right, it's such an exaggeration!