Chapter 42 Publication of Papers, Application for Patents (Ask for Support!) )
If the improved carrot wants to be marketed, it must be certified by a professional testing agency, otherwise others will worry that it is a genetically modified plant.
The difference between transgenic and gene editing technology is that transgenic is to embed the genes of other species into the original plant, while gene editing is to alter the original genes of the species.
If the latter detects the gene, it will be found that the gene is still a carrot gene, without any changes, which is equivalent to another carrot variety.
In the end, Lu Yuyao decided to take the carrots to a professional institution for inspection, and after obtaining some certificates, she sold them online.
Yang Zhou doesn't have to worry about sales, and can focus on scientific research.
Before the new paper is published, it is still necessary to review it for Bai Shulong.
Yang Zhou returned to the campus to find Bai Shulong.
When Bai Shulong saw Yang Zhou's paper, he was taken aback, he didn't expect Yang Zhou's speed to be so fast, he thought that even if there was a nutrient solution, the carrot growth rate would be doubled at most, it would have taken more than 100 days, but now it takes more than 50 days.
But it has only been about a month since Yang Zhou planted the seed.
That's 3 times faster!
It seems that the nutrient solution technology is far more powerful than he imagined.
Looking at the colorful giant carrots in the paper, Bai Shulong was also proud.
In Yang Zhou's paper, there are two technologies that are not explained, one of which is gene lock technology, even if others get seeds, they cannot plant the second generation.
The other is the nutrient solution.
In publications, this is common.
Published papers basically only have basic theories, but they will conceal or obscure some things, such as the paper on building the atomic bomb, which will roughly write about how the atomic bomb was made, but will not tell you how the specific equipment is made and how to extract radioactive elements.
What's more, in Yang Zhou's paper, there is a final product, which means that the gene editing has been successful.
After reading the paper, Bai Shulong said: "The paper is generally fine, but some English grammar and format are still a little flawed, I will help you change it today." ”
Although Yang Zhou has obtained the system, he has not published in international journals before, and some minor problems must exist.
Hearing that the tutor was willing to help, he hurriedly thanked him and asked Bai Shulong if he wanted to add his name to the author.
"My name will be the corresponding author." Bai Shulong said very calmly.
He didn't have a technical guide for the whole project, and he didn't have the cheekiness to be a co-author.
On Yang Zhou's paper, one is him, the other is Tang Yue, the mailing address is Qingbei University, and the corresponding author is Professor Bai Shulong.
"Have you decided which journal to submit?" Bai Shulong asked again.
"Are the three major journals okay?" Yang Zhou asked with some expectation.
Bai Shulong shook his head without hesitation and said: "It's not enough, the technology you use is the technology that has been published by others, unless the technology is breakthrough, but looking at the content, you haven't written it." ”
"The three major journals, unless you disclose all the functions of the carrot gene, or the level of nutrient solution, you should be on the three major sub-journals at present."
Yang Zhou was a little disappointed, but he also knew that Bai Shulong had a point.
Cas9 technology was invented by someone else, and he also cited other people's papers in his paper.
Equivalent to a gun made by someone else, he shot new prey.
Unless you build a more powerful gun or a new one, this situation will definitely make it to the top three journals.
"The sub-journal is not bad, I will help you choose a publication with a good impact factor, but the economic value of your research is greater than the actual value, others have read your paper, and I am afraid it is a little difficult to repeat the experiment, there are too many coincidences." Bai Shulong comforted Yang Zhoudao.
Bai Shulong even suspected that Yang Zhou himself could not find the same gene repeatedly for editing.
One of the difficulties in gene editing is to find the relevant genes, and the second difficulty is to edit the corresponding genes after the Cas9 virus gene is created, but there is a high probability that it will lead to gene breakage, which has an uncontrollable self-repair process.
Completely dependent on carrot cell's own protein repair within cells.
Bai Shulong previously asserted that 1,000 seeds would not germinate, but he felt that all of them would be genetically broken.
Yang Zhou's success rate is outrageously high, Bai Shulong actually suspects that Yang Zhou also uses new technology, but he did not choose to disclose it in the paper, which is not easy to ask, after all, this kind of technology has great commercial prospects.
Anyway, Yang Zhou is considered a success, even if others can't repeat the experiment, but Yang Zhou has grown something new, this is Niu X, and others only have envy.
On the same day, Bai Shulong helped Yang Zhou revise his paper in the office, and finally decided to submit it to Chemistry-Biology.
The impact factor is only about five or six points, while the three major journals all start at 40 points.
In fact, the impact factor is the annual average number of citations when everyone writes a paper, for example, Yang Zhou used Cas9 technology, and he should cite the paper that published Cas9 technology.
Similarly, there are several places in Yang Zhou's paper that may be cited by others.
That is, Yang Zhou discovered the color gene of carrots, and the genes that control size.
This may also find a corresponding gene in other plants, and it may be cited at that time, because Yang Zhou's paper is an inspiration to others.
But there is a key point, that is, the genetic description in Yang Zhou's paper is relatively vague, and he himself uses mysterious space to operate.
There is a high probability that others will not be able to find the genes mentioned in Yang Zhou's paper.
At first, Yang Zhou wanted to publish papers, and he also wanted to get a school bonus, but now it seems that it is not possible, and many people in the school have published papers with an impact factor of about 5.
This level is slightly higher than that of doctors, but lower than that of professors.
If Yang Zhou summed up his experience, studied another plant of the same family, or other vegetables, and found common ground by generalizing the genes that control the fruit size of plants in the two papers, this paper is likely to appear in the three top journals.
Because the economic value is too great, with the guidance of this paper, countless fruits and vegetables in the world may become larger and more colorful.
Bai Shulong suggested that Yang Zhou study this next.
"This project is very promising, you already have experience, see if you can repeat the experiment to find the carrot size, color experiment, and then find other fruits and vegetables size gene switch, if you can send a few more papers like this, you are an expert in the field, and it is no problem to come to Qingbei University as a teacher and professor." Bai Shulong encouraged Yang Zhoudao.
"Can I stay in school now?"
Yang Zhou is still very obsessed with the temporary post in Qingbei, and he has been working hard for this goal back then.
"It's still almost, I know your strength, others don't know, you don't disclose the technology of the nutrient solution, and then accumulate it, in addition, your carrot becomes bigger and the color change technology has to apply for a patent, otherwise you will suffer." Bai Shulong reminded.
The publication of the paper is basically equivalent to the open technology, and it is not excluded that others can also get inspiration based on Yang Zhou's paper, and if they are lucky, they can also transform carrots.
Then you have to register a patent to protect your interests.
The patent law stipulates that any technology used for profit infringes a patent subject to royalties, but there is no restriction on the use of experimental research.
"I have already arranged for someone to apply, and now I can find someone to apply for a global patent in China, I will pay attention." Yang Zhou nodded and said.
Don't worry about others reading papers and preemptively registering patents, because the ownership is confirmed according to the application time, so the technology to change the size and color of carrots, in the case of Cas9 technology, must belong to Yang Zhou.
If others bypass Cas9 technology, there is no way, there is no other technology in this world that directly edits genes, and Yang Zhou's technical route has become the only one.
Even if foreign laboratories replicate Yang Zhou's experiments, they will not be able to be commercialized in the end.