Chapter 49: Genius Yang Zhou
Yang Zhou's theme has expanded from a single carrot species to the entire genetic level, and even boldly predicts that if he is familiar with the genetic code, he can also carry out research on rice, corn, soybeans, etc. in the future.
It is also possible to double the food eventually.
At this point, almost everyone in the audience spontaneously applauded.
It's just that the doubts in many people's minds have not been eliminated, the gene code theory is not actually the first creation of Yang Zhou, some science fiction writers, and even scientists have put forward it, but no theory has been formed, and no clear evidence has been found.
After all, there are still few ways for humans to observe the microscopic world, and there is also a lack of technology to directly control the base macromolecules in genes.
Do anything to the genes and the whole gene will collapse.
After Yang Zhou finished finishing the paper, Academician Liao asked the question in everyone's mind, "Yang Zhou, we are all curious, why is your success rate so high?" Was any technical means used? ”
Yang Zhou nodded and said, "Yes, I have discovered a new type of bacteria, which can repair the sheared gene fragments by itself and will not cause gene collapse." ”
"What!"
"How is that possible, how did you find out?"
"Could it be some special archaea?"
Everyone in the audience questioned in disbelief what kind of bacteria could have such abilities and why they had never been discovered before.
This time, the people who asked questions were not limited to the examiners, and other academicians who participated in the meeting said that they would use the microphone to ask questions.
Bai Shulong didn't dare to offend these people, and handed the microphone to the nearest academician.
This academician has been engaged in microbial research for a long time, and it can be said that he has a deep knowledge of bacteria and viruses.
He wondered, "How did you find this bacteria?" Moreover, designing the Cas9 gene editor itself is a very difficult technical task, I see that in the paper, you also purchased experimental materials, can it be said that part of the paper does not use the purchased materials, but the gene editor designed by yourself? ”
Yang Zhou actually ignored this loophole, but fortunately this loophole is not serious and can be remedied.
The company that sells Cas9 materials is a company authorized or directly controlled by Zhang Feng.
Yang Zhou wants to break away from the Cas9 technology patent, and sooner or later he will disclose the matter of special bacteria, and this time he will simply disclose it together, but he needs to find a reason not to go.
Soon Yang Zhou thought about it.
"The discovery of this bacterium is quite coincidental, in fact, I don't know where this bacterium appeared, but when I studied my own feces, I accidentally discovered its existence, it has CRISPR properties, and it is one of the rare 40% species of bacteria."
The people present are all biology experts, and naturally know that CRISPR is the full name of the English abbreviation: Clustered+regularly+interspaced+short+palindromic+repeats, that is: regular clustering of short palindromic repeats.
This structure is only present in 40% bacteria and 90% archaea.
Yang Zhou said that he had extracted special bacteria from his feces, and it was obvious that he had accidentally infected this bacteria in his past food or environment, resulting in the presence of this bacteria in his stomach and intestines.
And Yang Zhou tested his feces, which made many people change their faces.
Normal people, even scientific research workers, would not casually test their feces, obviously something must have happened to Yang Zhou, which caused Yang Zhou to attack his feces.
"When I discovered this bacterium, I modified it into a gene editor, and eventually used it on both the size and color of the carrot seeds, and as for the other cases mentioned in the paper, the gene editor I still use is related to the gene fragment I extracted."
"Through the imaging analysis of the crushing and cutting genes, I came up with a complete carrot gene chain, and others are prone to failure, and a large part of the reason is that there was a mistake in the design of the gene editor, and too many or too few genes were cut, which led to gene collapse, and I did just that." Yang Zhou patiently explained.
This is indeed the real reason for the high success rate.
He looked at the real three-dimensional structure of the microscopic world of carrot genes, knew how long each piece of DNA was, and when it was cut, he accurately extracted this piece of DNA and then entered it into the Cas9 system.
The Cas9 system, in fact, is a bacterium in the end, but this bacterium has a special immune system for foreign viruses.
There is an area within the bacteria that, in the long evolution, records the genes of countless viruses, and when the bacteria detect the presence of the virus, they will actively shield the genes of the virus, thus forming autoimmunity.
Yang Zhou is equivalent to entering a certain gene of a carrot into the virus library, making the bacteria think that this gene is a virus, and then sending the bacteria into the carrot cell, and the bacteria's immune system will actively cut out the virus gene it thinks is the virus.
When others design the "viral gene", they are not sure what effect the gene will have on the species, so they can only choose randomly.
Yang Zhou has achieved accurate selection, which is the main factor for Yang Zhou's high success rate.
Those present were shocked again.
Because, according to Yang Zhou, his success does not only rely on the newly discovered virus, but also uses normal methods to get a very high success rate.
"May I ask, how do you know exactly how a certain gene is useful?" An academician asked.
"I have constructed a complete carrot gene structure in the brain, and I have come up with some rules, this is the core genetic code, through analysis, as long as the core genetic code of carrot survival is not cut, and other genetic codes are knocked out, the probability of success will be very large." Yang Zhou replied calmly.
Next, more and more people asked questions about the genetic code, and finally came to the conclusion that Yang Zhou was a genius, and his spatial perception and imagination were very powerful.
Even if the mutilated carrot gene fragment was obtained, and it was still a two-dimensional imaging map, through the analysis of multiple pictures, a three-dimensional structure map could be constructed in the mind.
Some time ago, Google's Alpha GO team came up with a new artificial intelligence, this time not Alpha GO playing Go, but using big data intelligent algorithms to derive protein structure maps.
Using countless supercomputers and analyzing hundreds of millions of trillions of data, the success rate reached more than 90%, but Yang Zhou relied on the human brain to construct the three-dimensional structure of the carrot and analyze the gene code theory by using only a few thousand microfocus microscope pictures.
This is simply a genius among geniuses!
"My team needs a genius like Yang Zhou!"
"And Yang Zhou graduated, it's time to dig people!"
Countless people have the idea of poaching people in their hearts, and after graduation, Yang Zhou is no longer a unique talent of Qingbei University, and everyone can compete.
The dissertation was naturally passed, Yang Zhou obtained a doctorate, and a certificate could be issued to Yang Zhou alone in a few days.
Now Dean Liao looked at Yang Zhou's eyes with great eagerness, he must leave Yang Zhou at Qingbei University, Dean Liao quietly looked at the others, and found that these people had similar expressions to him.
For example, the people of the Academy of Sciences, these guys must want to dig Yang Zhou to the Academy of Sciences, as well as Wuhan University and Shuimu University, Academician Liao did not wait for others to speak, and after Bai Shulong's announcement was over, he immediately stood up and walked quickly to Yang Zhou, and cordially took his hand and chatted with Yang Zhou.
When someone approached, he blew people away with a straight face, like an old hen guarding food.