In the past 100 years, the average life expectancy of human beings has been greatly extended, in addition to the improvement of living conditions, another major reason is the continuous improvement of medical standards, and the continuous advent of various therapeutic drugs is a prerequisite for the improvement of medical standards.

Medicine is a special product, closely related to human life, is the patron saint of life, its development process ups and downs, the miraculous preparation process and production technology is the crystallization of human wisdom.

In ancient times, people knew that willow bark had certain antipyretic and analgesic effects, but they did not know what the active ingredient was, and it was not until 1800 that someone extracted an active ingredient called salicylic acid from willow bark that has antipyretic and analgesic effects.

In the following decades, in order to overcome the side effects of the drug in clinical application and expand its therapeutic range, technical experts in the industry made several improvements to the extraction and synthesis process of aspirin, the active ingredient changed from salicylic acid to acetylsalicylic acid, and the dosage form was developed to enteric-coated sustained-release tablets.

Since its clinical application, this drug has saved tens of millions of lives, eliminated or alleviated the suffering of countless people, and created the legend of immortality of the century-old drug aspirin.

Before penicillin officially became a clinical drug, human beings were at a loss to treat bacterial infections, and tuberculosis alone was a disease that claimed tens of millions of lives in history.

In fact, the scientist Alexander ▪ Fleming discovered penicillin by chance in an experiment in 1928, but at that time, the biological culture technology was backward, and the key was the lack of efficient and practical separation and purification process, and the inability to obtain high-quality products with practical value, resulting in the failure of human society to realize the importance of penicillin for a long time.

Ten years later, through unremitting efforts, many scientists finally found a method to isolate and purify penicillin, but these process technologies are limited to laboratory applications and are still far from the requirements of large-scale production.

It was not until 1941 that scientists not only discovered a method for cultivating penicillin efficiently, but also successfully used corn syrup as a culture medium, laying the foundation for the industrial production of penicillin.

In 1942, scientists at the University of Oxford invented the freeze-drying process for isolating and purifying penicillin, and they used this technology to obtain high-quality penicillin crystals, which was a landmark technological breakthrough and removed the biggest obstacle to the clinical application of penicillin.

Using the existing process technology, with the cooperation of scientists and entrepreneurs, the large-scale production of penicillin was finally realized in 1943.

Since it has been widely used in clinical treatment, in the seventy or eighty years of history, including war years and peacetime, penicillin has not only saved hundreds of millions of lives, but also provided a broad perspective and ideas for the development of new antibiotic drugs later.

The success of Professor Tu Youyou, the first Nobel Prize in Science (Physiology and Medicine) in Chinese mainland, is due to her discovery of the ether extraction process for isolating artemisinin from Artemisia annua.

Artemisia annua is a plant that is naturally widely distributed, and its efficacy has long been recorded in ancient Chinese medicine, but modern medicine has higher requirements for its use.

Although everyone knows that the active ingredient of Artemisia annua is artemisinin, how to extract the active ingredient and make it convenient for clinical use, people have made a lot of attempts, either the active ingredient is destroyed, or the high-purity crystals cannot be obtained. Professor Tu took a different approach, starting with solvent extraction, and found that ether extraction was the most effective. The innovation of the extraction process has solved the problem that has plagued scientists for many years.

......

Eating grains and giving birth to all kinds of diseases is an objective reality faced by human beings. Minor diseases such as common colds and fevers can be cured by the body's own immune system, while some diseases, such as the great plagues that have occurred many times in history, will fall into a situation from which mankind will be in a state of no recovery if there is no vaccine and effective drug treatment.

In the face of the new coronavirus, which is raging all over the world and is said to coexist with humans, it will ultimately be possible to get social life back on track with effective treatment drugs. Some diseases, even if drugs cannot completely cure them, can help people to alleviate their condition.

There is neither an elixir for life, nor a cure for all diseases, although the medicine itself also has the defect of "three parts of poison", but in addition to air and water, as well as clothing, food, shelter and transportation and other necessities, medicine is also indispensable for human beings, which is a fact that no one can deny.

It is the common desire of human beings to look forward to the emergence of drugs with higher efficacy, fewer toxic side effects, or even no toxic side effects.

Fang Hanmin is a top student of 985 University, not only obtained a doctorate in pharmacy and pharmaceutical science from Oxford University, but also became the project director of the new drug creation center of RGP in Europe after graduation, but during an official performance, due to a plane crash, he traveled back to the end of the 70s of the 20th century from the 21st century, and was attached to a temporary worker with the same name and surname in the Red Star Pharmaceutical Factory.

As an overseas child, although he was in Europe, Fang Hanmin would return to China sooner or later, but he didn't expect to come back in such a way.

Crossing is a one-way ticket, aware of the real situation, Fang Hanmin is relieved, he is a doctor of pharmaceutical science from Oxford University, and is the project director of the new drug creation center of RGP company......