Professor Huang is in his fifties, gentle and elegant, graduated from the Department of Chemistry of Peking University in the late fifties, and is now the director of the Department of Chemistry of a key university in China.

As a well-known expert in the industry, Professor Huang was invited to attend the Pharmaceutical Science and Technology Seminar, Professor Huang did not expect to meet a young scientific and technological talent like Fang Hanmin, the first day of the paper, Fang Hanmin gave Professor Huang a very deep impression, and the report on the development trend of pharmaceutical science and technology made yesterday afternoon made Professor Huang even more impressed with him.

Although they had eaten at the same table for the past two nights, Professor Huang and Fang had little to no communication, and he thought that the table was full of people and it was not suitable to discuss technical issues.

Just now, Professor Huang saw Fang Hanmin sitting alone on the side leisurely, and he immediately walked over, wanting to take this opportunity to have an in-depth exchange with Fang Hanmin.

Lao Huang was so solemn, of course Fang Hanmin had to take it seriously, he was sitting upright, "Professor Huang, you are a well-known expert in the industry, I am very honored and a little flattered to be able to chat with you." ”

"Section Chief Fang, there are only you and me here, don't be polite to me. We don't have any well-known experts in the industry, and you don't need to be flattered, let's sit together and discuss technical issues at will, isn't that good? "Professor Huang wanted to make the atmosphere more casual.

"I was very touched by Professor Huang's approachability, but I wonder what Professor Huang wants to talk about."

"Let's start with the paper you read." Lao Huang took a sip of the teacup.

"Oh, my thesis ......, what is there to talk about?" Fang Hanmin was puzzled.

"In fact, the four papers you published in the journal "Pharmaceutical Science and Technology", I have carefully studied, the writing level of the paper is of course very high, but this is not the topic we want to talk about, the technical level involved in the paper has reached an unprecedented height of pharmaceutical science and technology, which is not only my evaluation, but also affirmed by Professor Fei, and won the first prize of provincial scientific and technological progress as evidence."

"But what does that have to do with the paper I'm reading?"

Professor Huang nodded slightly, "Section Chief Fang, if I guessed correctly, the paper you read yesterday is not the core of your technology, and the focus of your technology should be in the second of the four papers, that is, the preparation of palladium-carbon catalysts?" ”

Fang Hanmin smiled, "Professor Huang is worthy of being a well-known expert in the industry, and he can see the essence of the matter at a glance. It is no wonder that catalysts are becoming more and more important in the field of organic synthesis, and the application of catalyst technology in the pharmaceutical industry has great potential. ”

Lao Huang agrees with Fang Hanmin's statement, "A high-efficiency catalyst can not only improve the selectivity of organic reactions, shorten the reaction time, reduce production costs, but also minimize the generation of by-products, for the pharmaceutical industry, this is conducive to improving the purity of APIs, thereby reducing the toxic side effects of drugs, which is of great significance!" ”

"Professor Huang is an expert in this area, and you have the most say in this area."

"However, the paper you read at the seminar did not choose the one related to the preparation method of palladium-carbon catalyst, and the preparation method of palladium-carbon catalyst is the core of hydrogenation reduction technology.

"This ......," Fang Hanmin thought for a moment, "Professor Huang, if you are interested in the preparation method of palladium-carbon catalysts, you can read that paper in the journal Pharmaceutical Science and Technology, so we don't have any concerns." ”

Lao Huang smiled and waved his hand, "Section Chief Fang, that's completely different!" After all, there are only a handful of people who can read that paper in a magazine, and even fewer people who can read it. If you read that paper in person at the seminar, not only will more people know about it, but through your explanation, more people will know about the preparation method of palladium-carbon catalyst, and the meaning is completely different. So I think you still have some concerns. ”

Although Fang Hanmin did not admit that he had concerns, Lao Huang guessed correctly, the preparation of palladium carbon catalyst is a fairly cutting-edge technology, even if it does not involve the interests of the Red Star Pharmaceutical Factory, from Fang Hanmin's own point of view, he will not unreservedly make all the technical details completely public, after all, the traveler has experienced the 21st century and has long been aware of intellectual property protection.

When he received the invitation to participate in the conference, the conference organizer asked Fang Han to select a paper to be read at the seminar, and he thought twice that any other content could be selected, except for the paper on the preparation method of palladium-carbon catalyst.

Although Lao Huang guessed his thoughts, Fang Hanmin didn't feel embarrassed, he prevaricated: "Professor Huang, what you said may be reasonable, but we also have hardships, and some things are not up to me to decide." ”

"Section Chief Fang, I understand your difficulties, a middle-level cadre, who is restricted by factory-level leaders everywhere, lacks freedom in his work. Okay, let's not talk about that, would you mind talking to me about palladium-carbon catalysts? ”

"Talking about palladium carbon catalysts? Of course not, are you going to talk about its application prospects? Speaking of a wide range, such as petroleum processing, fine chemicals, pharmaceutical synthesis,"

Fang Hanmin deliberately deviated from the topic, and Lao Huang interrupted him, "Section Chief Fang, I also know that the application prospects of palladium carbon catalysts are very broad, let's not talk about this." ”

"And what do you want to talk about?"

"Let's talk about the preparation of palladium-carbon catalysts, I believe that Section Chief Fang must be very experienced. Is the preparation process of this catalyst with precious metals as raw materials very strict? Otherwise, once there is a scrap product, the loss will be large. ”

Fang Hanmin finally knew the purpose of Professor Huang's chat with him, and it turned out that Lao Huang was very optimistic about the application prospects of palladium-carbon catalysts, so he was very interested in this catalyst. However, the preparation of palladium-carbon catalyst is an insurmountable hurdle.

When Professor Huang saw Fang Hanmin's paper in the journal Pharmaceutical Science and Technology, he was very encouraged, but after careful study, he found that the preparation of palladium-carbon catalysts in the paper was relatively general, especially the formula and manufacturing process, and the explanation in the paper was relatively vague. Because precious metal raw materials are involved, there are few opportunities for imitators to try and make mistakes, so Lao Huang failed to find what he was looking for in Fang Hanmin's paper.

Originally, he thought that Fang Hanmin, who was invited to participate in the seminar, would read a paper on the preparation of palladium-carbon catalysts, and Lao Huang planned to discuss the preparation process and formula of catalysts with him in detail in the interactive session.

If he refuses to discuss this issue with Professor Huang, Fang Hanmin feels a little rude, after all, Lao Huang is a senior in the industry, and he is highly respected, if it spreads, the outside world will think that Fang Hanmin has no respect for his superiors, and it doesn't matter if he is suppressed, the key is that he is afraid of bringing adverse effects to Red Star Pharmaceutical Factory in the industry.

Since he couldn't refuse Lao Huang's request, Fang Hanmin had no choice but to agree, "Professor Huang, palladium-carbon catalyst is a solid catalyst, and the preparation process has a great impact on the performance of the catalyst. ”

Because there are no substantive issues involved, this is equivalent to not saying it, but this is Fang Hanmin's strategy, although he agreed to exchange the preparation method of palladium carbon catalyst with Lao Huang, it does not mean that the technical secrets and process conditions must be completely disclosed to him.

It is not that Fang Hanmin is conservative, this is related to the living space of Red Star Pharmaceutical Factory, because once the outside world masters this technology, the paracetamol API produced in the second workshop of Red Star Pharmaceutical Factory will instantly lose its competitive advantage.

Lao Huang heard it very clearly, Fang Hanmin's words were completely playing Tai Chi, which made it difficult for him to find the focus point, but he couldn't find any big fault.

The preparation process of palladium carbon catalyst involves a variety of factors such as raw material formulation, mixing uniformity, metal deposition, temperature, pressure, time, particle size and strength.

In addition, every step of the preparation process requires very skilled techniques, even if Fang Hanmin said clearly, if you have not seen it with your own eyes and do not have very skilled operators, you will still not be able to make a palladium-carbon catalyst with excellent performance.

However, since this opening has been opened, even if he faces more problems, Lao Huang can't get nothing, so he chose a more complicated link and asked: "Let's talk about the metal deposition process, what do you think should be paid attention to?" ”

As a first-class expert in the industry, Fang Hanmin believes that Lao Huang's choice of entry point is very important, but he will have reservations, "There are also many factors involved in metal deposition, such as liquid phase temperature, concentration, feeding speed, stirring speed, deposition time, etc., which not only requires skilled operation, but also requires considerable experience." In short, skilled operation techniques and rich operation experience are indispensable. ”

Speaking of theory, Professor Huang is undoubtedly one of the few experts in China, but the actual operation is not necessarily, regardless of the operation techniques and experience, it needs to be practiced and accumulated for a long time.

During his PhD studies in Oxford and as the project director of RGP's Center for New Drug Discovery, Fang Hanmin benefited a lot from this, so he dared to take a group of novices who had never seen the world to prepare palladium-carbon catalysts in the humble laboratory of Red Star Pharmaceutical Factory.

Because of the limited conditions, Professor Huang is in his fifties and has worked in scientific research and teaching positions for more than 20 years, but he has many fewer opportunities to do experiments by himself than Fang Hanmin.

After chatting for nearly two hours, although there were reservations, Fang Hanmin also introduced the preparation process of palladium carbon catalyst from beginning to end, and some places were more detailed. Professor Huang listened to the general idea, but if he was allowed to do it himself, he still did not have confidence in himself. As a matter of fact, when it comes to practical issues, the core issues cannot be solved by mere rhetoric on paper.

Seeing a few participants walking around the neighborhood, Professor Huang realized something, "Today, the conference team arranged for everyone to interact, and these people may want to discuss problems with you." ”

"Professor Huang, you are an expert, they may have something to consult with you."

Lao Huang turned around and asked, "Seeing that you have been wandering around for so long a day, is there something wrong with you?" ”

"If Mr. Fang is free, we would like to ask him some questions."

"See? Find yours. Okay, let's stop here today, I hope we can keep in touch with you in the future, and I hope that Section Chief Fang will not refuse to discuss technical issues with me. After speaking, Professor Huang picked up the water glass, took the materials and left.