May Day was connected with the weekend, and it was supposed to be a three-day holiday, because he was worried about the generic drug synthesis test being carried out by the research team of the Technology Center, and after breakfast on the third day, Fang Hanmin had to go to work.

After knowing his thoughts, Song Yuping teased: "As the factory director, you are busy with work, you can give up the marriage leave given to you by the policy, but the May Day holiday must also be dedicated. ”

The resentment of the newlywed wife was obvious, but Fang Hanmin wanted to know the progress of the experiment in the past two days, even if he would come back after understanding the situation, so he said with a hippie smile: "Yuping, in broad daylight, you don't need me to accompany you, right?" You read a book at home, and I'll go back when I go. ”

"Hey, it seems that anyone is rare for you to accompany you, you can go if you want, no one will stop you, it's your business when you come back, it has nothing to do with me." Knowing that Fang Hanmin had made up her mind, Song Yuping simply came to have nothing to do with herself, but her resentment was not eliminated.

"You can't say that, why doesn't my business have anything to do with you? But I'll be back in a minute. Dissipate your anger and smile for ten years, and you will look better when you smile. ”

In Song Yuping's impression, Fang Hanmin never coaxed people to be happy, but the last sentence amused her, "Go, I don't care when you want to come back." ”

With Song Yuping's permission of half-truths, Fang Hanmin suddenly kissed her on the face, "Thank you, madam!" I won't keep you waiting too long. ”

......

Because Fang Hanmin was not seen for two consecutive days, the colleagues in the research group thought that he was on vacation at home, and when he appeared in the laboratory of the technology center, the colleagues were surprised, "Director Fang, why are you here?" ”

"Oh, I have a bit of a personal matter, these two days have been dealt with, I'll take a look at the results of the test the day before yesterday and yesterday."

Guo Peng handed the two-day test records and test results to Fang Hanmin, "The results are similar to what you expected, and the sample content has also risen, but my colleagues from the testing agency reported to me that on the spectrum, the main peak of the sample seems to be the overlap of two peaks, and when the melting point is determined, it is found that the melting point of the sample is two degrees wider than the melting point range given in the literature." ”

Fang Hanmin casually looked at the test records and carefully analyzed the sample test data, "Judging from the test data alone, the results are not bad." If the main peaks on the map overlap and the melting point range does not match the literature value, what happens to that? ”

"The people at the test center can't tell, and I don't know why." Guo Peng said frankly.

"You guys get on with the work, I'll go to the test center and look at the spectrum."

Out of the laboratory, Fang Hanmin turned around and came to the analysis and testing center, he asked the staff to call up the sample test spectrum yesterday and the day before yesterday, and after careful identification, he found that the main peak of the sample was indeed not smooth enough, he asked the person in charge of the analysis center next to him: "Wang Gong, do you think this small piece of drum is the main peak of another component?" ”

"The main peak of the sample should be very smooth, and in this case, I don't think it can be ruled out that it is the main peak of another component."

"That is, the two peaks are too close together and overlap on the spectrum? Have you changed the detection conditions in an attempt to separate them? ”

"I think it's just that the main peaks of the two components overlap, and we changed several detection conditions and failed to separate them. In addition, it is not normal for the sample to have a wider melting point range than the literature value. ”

"How can there be two ingredients? And the boiling point is still so close, what impact will this have on the efficacy of generic drugs? ”

The test results were in front of him, and Fang Hanmin had to admit this fact, but he couldn't figure out for a while what went wrong.

Leaving the analysis and testing center with great doubts, Fang Hanmin rode a bicycle to go around the main positions and departments of the whole factory to see if the operation was normal.

May Day holiday for three days, if it is not for a marriage, as the leader of the whole factory, Fang Hanmin must be on duty in the factory, yesterday and the day before yesterday he did not enter the factory, in addition to remembering the test results of the technology center, he is also concerned about the operation of all departments of the plant.

Seeing that the administrative institutions were safe and sound, and the production units were operating normally, Fang Hanmin was also relieved. He returned to the research group of the technology center again and talked to Guo Peng and others about his views on the test results of these batches of test samples, "The sample spectrum is indeed abnormal, and I suspect that the main peaks of the two components overlap. ”

"How is that possible? Where do the two ingredients come from? Guo Peng and others found it difficult to understand.

"Nothing is impossible, according to the analysis of the spectrum, it is two components, and as for where the second main component comes from, I can't say for a while."

After discussing with Guo Peng and other technicians for a while, no one said why, Fang Hanmin gave an explanation to Guo Peng, and left the research group.

When Fang Hanmin returned home, it was already half past one in the afternoon, and after entering the house, he found Song Yuping sitting on the edge of the bed reading a book, the food on the table was motionless, and there was no heat, as if it had been on the table for a long time.

Knowing that he was coming back late, Fang Hanmin took the initiative to speak: "Yuping, the food is cold, why don't you eat?" ”

"If you don't come back, can I eat?"

Knowing that he was at a loss, Fang Hanmin hurriedly compensated, "I went around the main departments of the whole factory, delayed a little time, and came back late, I'm sorry!" ”

"Okay, I still know that it's good to go home, I'm afraid that you will take the factory as your home and forget this home one day." Song Yuping said coldly.

Sitting down next to Song Yuping, Fang Hanmin put his hand on her shoulder, and pretended to be affectionate: "There is such a beautiful daughter-in-law waiting at home, no matter how busy I am, I can't forget my home." ”

"Let's go! What time is it, aren't you hungry yet? Song Yuping pushed him.

"Don't say it, I'm really hungry."

"The food is already cold, I'll go warm it up and get ready to eat."

After a while, Song Yuping put the hot meal back on the table, Fang Hanmin set up the dishes and chopsticks, and during the meal, Song Yuping talked about the marriage leave, "The education department stipulates that older young people have ten days of marriage leave, unlike you, I will not waste a day, and I will take all ten days of marriage leave." ”

"That's the benefit you should enjoy, some time ago when you were preparing for a wedding, you were tired, and you just had a good rest at home for a few days."

"I mean, we have officially married and started a family, and I want to use the marriage leave to go back to my hometown to meet with our parents and families, and by the way, I will inform them about our marriage, so as not to worry about them."

"Back home?" Fang Hanmin thought for a while, "We are newlyweds, I won't accompany you when you go back to your parents' house, or if you don't pick you up in a few days, what will your parents and family think?" ”

"You don't have time, don't worry what they think."

"Ouch, we haven't gone back to our hometown for the wedding, and we've already made them unhappy, if you don't take into account their feelings, do you think it's appropriate?"

"What do you say? A son marries a daughter-in-law and a daughter marries, and the parents of both sides can't be kept in the dark, right? ”

Fang Hanmin nodded in agreement, "I should let the parents of both sides know, but it is obviously not appropriate for you to go back by yourself, and I don't have time to go back with you, or ......, Yuping, let's not go back for the time being, write a letter to the parents of both sides, and inform them?" ”

Song Yuping smiled, "This is something you planned a long time ago, right?" I remember you once said that if you don't want to go back to your hometown for a marriage, you just need to inform your parents and family after marriage. ”

"You see, I'm so busy all day, how can I have time to go back to my hometown to deal with those scenes? Also, I really don't like the customs of my hometown. Let me tell you, let's get married in the city, it's cheap for you, if you go back to your hometown to get married, on the wedding night, those people in the village who make trouble in the cave house will have to toss you enough. Such a beautiful daughter-in-law, I am reluctant to let the people in the village tease me, what, are you willing to be tossed by those guys? After speaking, Fang Hanmin showed a wicked smile.

Song Yuping gave him a blank look, "Nonsense!" Who wants to? I'm just reminding you not to forget the proper procedure. ”

"Then it's decided, let's not go back for the time being, you write a letter to both parents and explain the situation."

"It's no problem for me to write a letter for you, but have you ever thought that before we went back to our hometown to get married, we have already made your parents very angry, and I will inform them of the situation after marriage, if I ghostwrite it, they won't even see your handwritten letter, what do you think they will think?"

"This ...... I didn't think about it," Fang Hanmin felt that the idea just now was indeed inappropriate, "Yuping, you reminded me right, I should write the letter to my parents myself." ”

......

Since the first test of the second workshop, more than ten years have passed, Fang Hanmin has made more than 20 process transformations and innovations for Hongxing Pharmaceutical Factory, and has basically not encountered much difficulty in technology, and even solved all technical problems only with the common-sense pharmaceutical science and technology knowledge mastered by the traverser in his previous life. However, in the imitation test of the patented drug, two almost overlapping main peaks were found on the detection spectrum of the obtained sample, which caused a problem for Fang Hanmin.

The cause of this phenomenon must be identified as soon as possible, otherwise the goal of continuing the experiment will not be clear. Fortunately, the traverser has a very deep academic background, combined with the basic theory of pharmaceutical science and technology mastered by the traverser, Fang Hanmin carefully analyzed the sample spectrum, and he believes that the two main peaks overlapping on the spectrum may be the target product and its enantiomer.

"Enantiomers?" The scientific and technological personnel of the research group, including Guo Peng, are relatively unfamiliar with this, some have never heard of it, and some people have only heard the term mentioned by teachers in relevant majors during their college years, but they have little impression of it.

"Yes, it's also called mirror isomers, or chiral molecules." Fang Hanmin tried to put it in layman's terms.

Fang Hanmin believes that this is not a big problem, after all, the most important work at present is to find the reason for the formation of enantiomers as soon as possible, and how to separate and purify the enantiomers from the target products.

Through analysis, Fang Hanmin believes that the product generated by this drug in the synthesis process is a mixture of enantiomers, but I don't know if the original patent was not found, or deliberately concealed, and this situation was not mentioned in the corresponding patent specification, so Fang Hanmin did not think about this aspect before.

Enantiomers are divided into levorotators and dextrotators, the same amount of levorotators and dextators are mixed, called the so-called racemates, although most of the physical and chemical properties of the two isomers are exactly the same, but their biological activities are essentially different, whether levorotators or dextators are the active ingredients of drugs? Or are both isomers active ingredients in the drug? To answer these questions, Fang believes that there is still a lot of work to be done.

I thought that it would be relatively easy to imitate patented drugs, but now it seems that this matter is not as simple as imagined.