Zhang Chen handed over the matter of buying a house and a car to Zhang Yue.

He plans to complete the houses and cars for the old employees, Xu Zimo, Qian Sibo, and Wang Lele.

Let them devote themselves more distractions to the cause of making money for themselves, which is the right thing to do.

Everything that can be solved with money is not called a thing.

Today is August 2nd.

Jiang Wu called yesterday and said that the desalination plant in Haicheng had been completed.

Zhang Chen asked him to build another reservoir to store fresh water.

He also asked him to contact Zhang Yue and start the construction and renovation of the reservoir, and then the large-scale cultivation of seedlings of sargassum green algae will be placed in Haicheng.

Today, several other plants have been renovated, and Chenyue Biotech has its own GMP workshop.

Several bioreactors for the pilot were also in place, and all media and reagent consumables were prepared.

And a week has passed since the launch of the "Lanyue 001" project.

It is estimated that the plasmid has been constructed and the virus packaging is ready.

The principle of this gene therapy is actually quite simple.

Insect cell expression system, only two plasmids need to be constructed.

One plasmid carries the gene of interest for the treatment of cardiovascular disease, and the other plasmid carries the gene fragments needed to produce the viral shell.

The two plasmids are transfected into insect cells, and after a series of complex reactions, the insect cells produce two secretory baculoviruses.

The baculovirus produced by the two different plasmids is not the same.

The two baculoviruses are then transfected into new insect cells at the same time, and after a series of reactions, the two baculoviruses will assemble the adeno-associated viruses we need in the cells.

At this time, adeno-associated virus is packaged and preserved by the preparation process, and the finished drug is generally packaged in vials, which can be made into dry powder or liquid.

The adeno-associated virus produced is actually designed to be no longer virulent, but it can still be accurately located to the location to be treated.

In this way, a large number of viruses carrying therapeutic genes begin to play a role in delivering therapeutic genes to normal cells in the human body.

At this time, the therapeutic gene is transcribed and translated into a specific protein in the cell, which is the core of the treatment of cardiovascular disease.

It will continue to work in cells, and can always regulate the body's blood oxygen level and prevent intracellular catabolic disorders, so that it can effectively treat and prevent the occurrence of cardiovascular diseases.

According to the plan discussed by Zhang Chen and Tian Wenbin before.

After the launch of the "Lanyue 001" project, plasmid construction was completed in the first week, adeno-associated virus assembly and preparation were completed in the second week, mouse experiments were carried out in the third week, and monkey experiments were carried out in the fourth week.

This is a step to supplement the R&D data.

After the plasmid is completed in the first week, the process scale-up culture needs to be carried out at the same time in the second week, and the virus yield is increased directly on the fermenter to produce the adeno-associated virus required for clinical trials.

In the second week, the preparation packaging work needs to be completed, and in other companies, even the preparation process needs to be explored for a while.

But Zhang Chen has a system, and he can get the perfect preparation process by directly spending some points.

Then, a part of the finished preparation was separated, and the mouse experiment was carried out on the third week and the monkey experiment on the fourth week.

After all the data are perfectly presented, it is submitted to the CDE for clinical trial application.

The most important thing here is the data, and all the data needs to meet expectations.

But this is not a problem for Zhang Chen, there is a system in hand, if you can't even control the data, then what is there to say, just buy a piece of tofu and die.

Zhang Chen came to Tian Wenbin's office, and Jiang Lu and Tian Wenbin were chatting excitedly at this time.

"Tian Bo, Jiang Bo, what are you discussing?"

Tian Wenbin couldn't hide the smile on his face and said, "Zhang Chen, everyone worked overtime and took turns to build plasmids. ”

"I even completed the expected task two days ahead of schedule, and I was able to purify the baculovirus this afternoon, so that all the experiments were ahead of schedule, and maybe the next experiments could be completed ahead of schedule." Jiang Lu also said with a smile.

"That's great, Tian Bo, you are in charge of the experimental progress in the company, and Jiang Bo, you are responsible for supervising the experimental progress of the CDMO company."

Zhang Chen smiled slightly and said, "Just use the money to smash them, and find a few more companies to do it at the same time, so that they can all spin together."

If everything goes well, we will be able to submit a clinical trial application in early September.

When the time comes, I will think of a way to see if I can pass the application as soon as possible, and it will be easy to do it on the clinical trial. ”

Today is such a good day, it is completely possible to organize a wave of team building and go to Bangsheng to celebrate.

Zhang Chen returned to the office and asked Zhang Yue to inform everyone that the team building would start tonight.

........

Capital.

It's still in that simple courtyard.

This time, in addition to the old man in cloth, there was also a middle-aged man with a big beard sitting opposite the stone table.

"Old Wei, there is news from above, a plant called Horsetail Green Algae has recently come out, which can desalinate seawater, and the above asked us to find a way to get this technology to our disposal." The middle-aged man frowned and said.

"This advertisement is flying all over the sky, how did you do the information, and you only learned about it after the import and export meeting was held on it."

The old man in cloth showed no mercy, he didn't care about intelligence, he only cared about business matters.

The bearded man said helplessly: "I didn't pay attention to the new product release of a start-up, who would have thought that such a small company could come up with a high-tech that would make everyone above do it." ”

"So what is our mission goal, what small company, what startup, what are your brains?" The old man almost laughed angrily.

"In our opinion, it is great for this company to come up with a high-end sequencing, I really didn't expect to make such a big move, let alone know in advance What's the use?"

The middle-aged man explained with a smile.

The old man in cloth clothes brushed his clothes and said, "I don't care about your intelligence, now that the pressure from above is on everyone, what do you say?" ”

"If this thing is not done well, everyone will be uncomfortable, this time we will help you."

"You're going to meddle too?"

"Solve it early, rest assured." The middle-aged man also stood up, "I told someone to leave for Shaocheng tomorrow, and you can find a way to get Zhang Chen out of the company, his company is too evil." ”

After finishing speaking, the middle-aged man turned around and walked out of the small courtyard.

"I really didn't expect that this Zhang Chen has come up with a new high-tech, the sequencer hasn't come out yet, and now he wants to steal the core technology of sargassum green algae, how can it be so easy?"

The old man in cloth slowly sat back on the rattan chair, and his heart began to worry.

"This time, there are intelligence people interfering, I really don't know what will happen."

He took out his phone and made a call to his grandson.

"You find a way to invite Zhang Chen to the manor, someone will be sent over, let's just cooperate, remember to pick yourself up."

The young man wondered, it's only been a few days, and he's going to start working again?

"Grandpa, it's not good to do it again so quickly."

"Hey, that sargassum green algae that Zhang Chen made is more important than the sequencer, remember to pick yourself out, you must be careful."

"Okay, I'll be careful."

After the young man hung up the phone, Mosuo lowered his chin, and began to wonder in his heart, how to invite Zhang Chen over.