Shao Cheng, Beihe Gene Technology Co., Ltd.

Since the problem of sequencing was solved by Chenyue Biology, the project in charge of Huang Ruifang has progressed rapidly.

Recently, however, new problems have begun to emerge.

The new drug they made was injected into mice, but it only played a weak role, and the growth of the tumor was not effectively inhibited.

Even, after a period of time, the tumor grows back to its original size.

This shows that this oncolytic virus drug is basically ineffective.

Huang Ruifang was alone in the office, consulting various documents at home and abroad, hoping to find some solutions.

This project was brought out of scratch by her.

She really didn't want to see such a good idea, so she just put it on hold.

But if you want to achieve complete independent research and development from scratch, the difficulty of this project is self-evident.

While Huang Ruifang was seriously looking at the literature, Liu Qiang knocked on the door and walked in.

"Boss Huang, this is the data you want."

Everyone in the company is used to calling Huang Ruifang Boss Huang, and she is also very easy-going and does not correct anything.

Liu Qiang put a stack of materials on Huang Ruifang's desk.

He continued: "The experimental results of this batch of nude mice are still not satisfactory. ”

Huang Ruifang nodded, picked up the experiment report and read it.

After a few minutes, she frowned and said: "The tumor formation effect is good, but there are still problems encountered before, the tumor removal effect after administration is not obvious, and after a few days, the tumor size has recovered again." ”

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Liu Qiang said with a bitter face: "Yes, this shows that the drug is not working well, it is completely not in line with expectations, I really don't know which link went wrong, could it be that the people in our group made other mistakes when raising the raisers?" Not really. ”

When Huang Ruifang heard Liu Qiang's words, he seemed to suddenly remember something, and hurriedly said: "The method of administration is intratumoral injection, there should be no problem, can't it?" ”

Liu Qiang didn't know why, "It has always been intratumoral injection." ”

Huang Ruifang nodded, opened a document on his laptop, and then pushed the computer in front of Liu Qiang.

"If you look at this literature, it just talks about some conjectures about the efficacy verification of mice, and the author has done a lot of experiments, and finally came to the conclusion that the humanized mouse model has the least effect on the efficacy."

The so-called humanized animal model is to create animals with certain characteristics of human tissues, organs, and cells through advanced gene editing and other methods.

These animals are then used to construct disease models, which can be used to study the pathogenic mechanism of various human diseases, or to test the effects of drugs.

The advantages of humanized mouse models are obvious, and it is more suitable for pharmacodynamic experiments.

And there is only one disadvantage, that is, the price is very expensive.

If you need to knock out or knock in a specific gene, the price is even more impressive.

"You mean, maybe the problem is with the mice?" Liu Qiang wondered.

Huang Ruifang nodded, "It may have an impact, our drug has been done now, you can't give up halfway, you go to a company that can do humanized mice, let's directly customize fully humanized point mutant mice, we must eliminate all influencing factors as much as possible." ”

She said for a while, but finally hesitated: "It's just time, I'm afraid it's too late." ”

Liu Qiang's eyes suddenly lit up, "Boss Huang, why don't we try it with Chenyue Creature?" ”

"Morning Moon Creature? Can their company also customize experimental mouse models? ”

Huang Ruifang usually doesn't do idle things.

In addition to her work, she reads literature, and basically hasn't brushed Douyin or Weibo, so she hasn't seen the advertisement of Chenyue Biotech's experimental animals until now.

"Well, you're really ......"

Liu Qiang was only halfway through his words, and finally shook his head and said: "Their company has already started to publicize, and the categories of experimental animals they can do are very complete, and the cycle is fast." ”

"As far as I know, other companies, as long as they involve humanized gene knockout or knock-in, it will take at least a month and a half to get the first generation of humanized mice."

He paused for a moment, and then said: "But Chenyue Biology is different, they claim that it only takes fifteen days to complete any desired target humanized mouse, but the price is ......."

"It's already this time, don't think about the price anymore, you go and contact immediately, no, I'll contact Chenyue Creature, this time thanks to your reminder, let's get busy first."

After listening to Liu Qiang's words, Huang Ruifang's eyes lit up.

Can you get the first generation of humanized mice in fifteen days?

She can also choose the location of gene knockout or insertion at will, which makes her a little unbelievable and a little beyond her knowledge.

But after thinking about it, people can even take out the sequencing quality far beyond the third-generation sequencing, and now they can mass-produce this kind of sequencer.

In this way, the project seems to have hope again.

However, Huang Ruifang fell into deep thought again, and he was a little uncertain about paying attention.

Custom-made targeting humanized mice, even in other companies, the price is ridiculously high.

If you go to Chenyue Biology to customize, with their company's urine properties, the products they come up with will definitely crush other companies with their technological content.

Therefore, this price is estimated to be far higher than that of other companies.

In fact, Huang Ruifang gradually discovered that there are still some design flaws in this drug.

But she's also not sure whether it's the mouse model or a flaw in the drug design itself that makes the mouse data poor.

If it's really the problem of the drug itself, then after fixing the defect, everything needs to start all over again.

Now we can only choose to spend money to solve the problem of mouse models, eliminate the interference problem in this regard, and finally determine whether the drug design is reasonable.

This is the difficulty of new drug development.

In the process of developing a new drug, there are various problems encountered.

But I can only try my best and spend a lot of money to eliminate the interfering factors one by one, and finally develop the most suitable and effective drugs.

Huang Ruifang took out her mobile phone and called her little friend and best friend.

"Yueyue, are you busy?"

"Xiaofang? I'm okay, why are you free to call me? ”

Zhang Yue was a little surprised that it turned out to be the phone call of Huang Ruifang, a scientific research maniac.

Usually, whether it is a weekday or a Saturday or Sunday, it is even more difficult to make an appointment with Huang Ruifang once than to meet some big-name stars.

In Zhang Yue's impression, Huang Ruifang is either busy or on the way to be busy, as if there are endless things to do every day.

Compared with her, Zhang Yue's previous rent-collecting life was simply not too idle.

"That's right, the project I brought is going to use laboratory animals recently, and I heard that your company is doing this, so I want to call and ask you."

Huang Ruifang said as concisely as possible.

She is usually such a person, she can explain it in one sentence, and she resolutely does not break it down into two sentences.

When Zhang Yue heard this, she was immediately interested, until now, the experimental animals of Chenyue Biology have not been opened.

If you can win Huang Ruifang's order and lay a solid foundation for word of mouth, then there is hope that the market for laboratory animals will slowly open up.