Zhao Chunlin looked up at the people who came in suspiciously.

"Oh, is it? Then you can send me the information to see, if you can really make this animal model, it would be great. ”

said so, but Zhao Chunlin didn't take his words seriously at all.

He thought to himself, with my current connections all over the country, I haven't been able to find a suitable company to do laboratory animal models.

Now that you can find the right company after reading a new guideline, haven't I been a fool for the past 20 years?

"Zhao Bo, the information has been sent to your mailbox, you can take a look at it later, I'll tell you directly now."

"This version of the latest guidelines was updated only a few days ago, and I found out today that this new version of the guidelines has recommendations for sequencing and laboratory animals, and both technologies are from the same company. ”

Zhao Chunlin became interested and said, "Which company?" ”

"You've probably heard of this company, it's the Morning Moon creature that caught fire recently."

Zhao Chunlin nodded, he did know the Morning Moon Creature.

Moreover, the second-generation sequencing of his own company is done in Chenyue Biology.

He was very impressed with the company because he had seen the sequencing results returned by their company for himself.

At the time, he was amazed at the results of this sequencing that far exceeded that of other platforms.

After reading it, he immediately made a decision that all the sequencing of the company in the future would be sent to Chenyue Biology for do.

It was his decision that brought the company's project forward for more than two months.

Otherwise, they wouldn't be able to do the security evaluation step at all.

And it also saves the company a lot of money.

But when did Chenyue start modeling experimental animals again?

"It's Chenyue Biology, isn't our sequencing done in their company? But when did they start making laboratory animals, and is this reliable news? ”

"Can't be wrong, even the new guidelines issued by the state recommend their company's experimental animal models, or let's try it."

Zhao Chunlin didn't think about it anymore, there is no other company to do now, so he can only call and ask.

So he said, "Then you can call and consult, and let me know as soon as possible when the results are available." ”

The director of the quality inspection department answered and immediately walked out of the office to make a call.

Less than half an hour later, he was back in the president's office.

"The result was determined so quickly?" Zhao Chunlin asked.

"Yes, there are already results, and I made detailed requests to them. They told me that they could do it very definitely, and that it would only take 12 days to get the first wave of mouse models, and for rabbit and monkey models, they had to estimate the delivery time. ”

The director of the quality inspection department said excitedly.

Zhao Chunlin immediately stood up, if there is a humanized disease model, then this project is really hopeful.

He hurriedly said: "Now let's do the mouse experiment first, and the rabbit and monkey experiment will be talked about later, but you can also let them prepare first, if the mouse experiment results are good, the rabbit and monkey experiment will be carried out immediately." ”

After Zhao Chunlin finished speaking, he saw that the face of the director of the quality inspection department was a little unnatural.

So he asked, "What's wrong?" Is there something else wrong? ”

"There's nothing else wrong with that, but, that's it, they're a bit expensive."

The director of the quality inspection department said hesitantly.

Zhao Chunlin smiled.

In his opinion, how expensive is the modeling of an experimental animal?

Mice plus rabbits and monkeys, the three experimental animals together, only 2 million died.

The director of the quality inspection department said: "Zhao Bo, I don't know if our budget is enough, they quoted 2 million for mouse modeling alone, and the follow-up rabbit and monkey modeling have not yet quoted us, but the price must be above the mouse." ”

Zhao Chunlin's face suddenly stiffened, what kind of experimental animal is this, and the price is so expensive?

He still has some understanding of the price of experimental animals.

Even if it is a fully humanized mouse modeling, plus gene knockout or knock-in, it even helps to establish relevant patents.

This whole set of processes only needs about 1 million at most.

But now Chenyue Biotech has no intention of helping to apply for a patent, but offers 2 million, which makes him a little unexpected.

Such a terrifying price that Zhao Chunlin directly ignored the 12-day delivery of the first wave of mice said by the director of the quality inspection department.

"Their price is a little more expensive, but their advantages are also very obvious, first of all, the mice they used to engineer are themselves genome-wide humanized, and then build disease models on this basis."

The director of the quality inspection department continued: "And according to them, their company's mice are specially modified, and their growth rate is three times that of ordinary mice, I took a look at the relevant technical parameters they sent me, and all the validation experimental data are very stable, if we can really use such mice, I think we can definitely rule out the problems of the experimental animals themselves, and speed up the project." ”

After Zhao Chunlin heard this, he was shocked.

Three times the growth rate of ordinary mice, such a powerful technology, it is indeed worth the price.

He muttered for a moment.

Now the company's economic situation is very bad.

If you spend at least seven or eight million on experimental animals, then the number of subjects may have to be reduced in the subsequent clinical trials.

But after thinking about it, if the safety evaluation of the drug can't pass now, let alone any clinical trials, even the IND application will not pass.

I hope that after using this mouse model, I can bring them some miracles.

After making a decision in his heart, Zhao Chunlin took a deep breath.

He said slowly: "There is no way, only they in the country can do this mouse modeling, you go and sign a contract, let them produce for us as soon as possible." ”

After the director of the quality inspection department should make this matter, he hurriedly went to the finance department to go through the relevant process.

Similar plots are being played out all over the country.

Now in the whole of China, there are indeed many companies that make gene therapy drugs related to rare diseases.

Some people are holding that they must improve the state of rare diseases without cure, and do drug research and development.

And now the technical bottleneck of gene therapy drugs cannot be broken, and they don't have a system as powerful as Zhang Chen.

As far as the current modification technology is concerned, it has not reached the level where the virus capsid can be modified at will.

So it leads to a situation that happens.

Although there are very good therapeutic genes, there is a lack of effective delivery vectors.

If the virus is not modified in place, the therapeutic gene cannot be delivered to the designated location in the human body, and the expected therapeutic effect cannot be achieved.

However, the site of action of some rare diseases is exactly where the virus that is now modified and perfected can reach the position.

So far, it has only stayed at the level of developing gene therapy drugs for rare diseases.

Even all gene therapy drug R&D companies in the world are basically focusing on rare diseases as their primary target.

Even if foreign technology is slightly ahead, it has not been able to break through this technological limitation.