"Alas!"

In the office, Mo Kai sighed.

He never imagined that after waiting for five days, he would wait for such a result.

There is no cure for Marburg virus.

How does this make him talk to the patient's family?

glanced at Li Xiyang and found that the latter looked sluggish.

It's too sad to think about it, and I can't accept it for a while.

Alas!

"Lao Xu, I have to talk to the inner courtyard, and I'll leave first!"

"Xiyang, you don't have to go!"

Mo Kai just turned around to leave,

"Wait a minute!"

Li Xiyang suddenly asked, "Team Leader Xu, could this be a mistake?" ”

Xu Bing frowned, and his face was a little displeased.

Mo Kai hurriedly said, "Xiyang, don't make trouble!" ”

If you are questioned about your professionalism, you will be unhappy with anyone.

But Li Xiyang continued, "But I don't think the shape of the virus is like the Marburg virus!" ”

"There's nothing strange about that!" Xu Bing said lightly, "It is normal for the virus to change with the outside temperature when it leaves the human body. ”

Li Xiyang shook his head, "The high-speed operation of the centrifuge may also deform the virus, right?" ”

Xu Bing was stunned, "That's right, but judging from the structure of the virus, it is undoubtedly the Marburg virus." ”

Li Xiyang did not continue to dwell on this issue, but asked rhetorically, "Team Leader Xu, what is the pathogenic mechanism of the Marburg virus?" ”

Xu Bing didn't know what this kid was going to do, but he still replied, "After the Marburg virus enters the human body, it first invades the dendritic cell and mononuclear phagocyte system, spreads in the lymphatic system, and infects the liver, spleen and other organs and tissues through the bloodstream.

Studies have shown that Marburg attacks a variety of cells, especially macrophils and hepatocytes of the immune system.

It has been suggested that damage to these cells causes blood from within the capillaries to flow backwards into peripheral organs, causing a breakdown of the circulatory system and causing a person to die quickly.

In Marburg virus damage, increased endothelial permeability, as well as damage to capillaries, are key to pathological damage. ”

After Xu Bing finished speaking, he found that Mo Kai's face had changed.

"What's wrong, Old Mo?"

"Am I not right?"

Mo Kai said quickly, "Old Xu, the patient has liver failure, which affects the kidneys and brain function, and there is no bloodstream infection." ”

Xu Bing was stunned, "How is it possible?" ”

Bloodstream infection is the most prominent feature of Marburg virus pathogenesis.

Looking at Mo Kai's expression again, it doesn't look like he's joking with himself.

Is it really wrong?

Xu Bing's face changed, "You come with me!" ”

Following Xu Bing, the two entered the laboratory of the inspection department.

The laboratory is full of petri dishes, and through the sterilization window, you can see various colors and different regular shapes of bacteria.

Continuing to walk inside, Xu Bing opened a door near the right, and a cold cold air instantly hit his face.

Li Xiyang couldn't help but shudder.

"Inside is a culture room of minus 20 degrees, and there are cotton clothes in the cupboard over there, let's change them first!"

"Thank you, Team Leader Xu!"

Li Xiyang quickly changed into cotton clothes, and then followed.

Inside is a large laboratory with a table full of equipment.

Xu Bing walked to a disinfection window, took out a flat glassware from it and said, "This is the virus I isolated from the patient's pathological section." ”

Through the petri dish, Li Xiyang saw some transparent liquid.

It was a cell culture medium, and the virus was too small to be visible to the naked eye.

Then Xu Bing opened the petri dish and placed it on the electron microscope next to him.

"Look, this is what the virus looks like at minus 20 degrees."

Li Xiyang stood over and put his eyes on the microscope.

Under the camera, creatures that look like mites are wriggling rapidly.

Energetic!

Xu Bing explained, "The virus is moderately resistant to heat, even if it is placed at 60 or 70 degrees, it cannot be completely inactivated, and its infectivity is basically unchanged when stored at room temperature for 35 days.

The lower the temperature, the more active it is.

It can be inactivated unless a certain dose of ultraviolet rays, γ rays, lipid solvents, phenols, etc. ”

As he spoke, he put the virus dish into a high-speed centrifuge and purified it.

Through fluorescence rustic, it can be found that the virus is a negative-strand linear RNA molecule encoding 7 viruloid structural proteins.

Everything is exactly the same as the Marburg virus.

"There is also a specific diagnostic method based on the specificity of the Marburg virus."

"Viral antigens can be isolated and detected by indirect immunofluorescence assays, and if the N-protein antigen is found to be positive, the diagnosis of Marburg hemorrhagic fever can be confirmed."

Previously, Xu Bing basically concluded that the virus was Marburg virus, so he did not carry out this step.

Well?

However, the test had just begun, and Xu Bing noticed that something was wrong.

Under the fluorescent labeling, the N protein antigen actually did not react.

"I see, it's pseudoprotein!"

"Damn, this virus can be disguised."

Xu Bing's already bloodshot eyes looked even redder.

Mo Kai looked shocked, "So that means this is not the Marburg virus?" ”

Xu Bing glanced at Li Xiyang and felt a little embarrassed, but he still nodded, "I made a mistake!" ”

Mo Kai hurriedly said, "Now is not the time to say right or wrong, we have to quickly figure out what kind of virus this is?" ”

Xu Bing sighed, "It's the first time I've seen a disguised virus, and I'm afraid it will take a lot of time!" ”

Hearing this, Mo Kai was anxious.

Where can the patient's current physical condition be delayed?

Even in the past few days, the patient has also relied on Li Xiyang's traditional Chinese medicine prescription to forcibly continue his life.

Xu Bing is also helpless, the detection methods of general molecular biology rely on sequence conservatism to a large extent, and when applied to new variants, strains or viruses may fail.

Therefore, real-time information sharing, especially sequence data, is important for virus identification.

However, there is no data on the same sequence in the domestic virus database.

This shows that the virus has never appeared in China, at least not in the public health system.

In the face of a virus that has never been seen before, it is a very complicated and time-consuming task to detect its structure and characteristics.

And the detection of the virus is not the same as a cure.

You must know that the emergence of the first influenza vaccine in China, from research and development to production, took 9 months.

Can patients afford to wait?

Just when the two of them felt powerless, the door to the laboratory was suddenly opened.

The two looked over and saw that Li Xiyang had already walked outside.

Without waiting to ask more, I listened to Li Xiyang say, "Let's go, I already know what the virus is." ”