Chapter 270: Marriage of close relatives
Neurological diseases?
Zheng Xiaoyu asked, "You mean mentally retarded?" β
Dong Lin shook her head, "Not necessarily, maybe it's facial nerve paralysis, or meningitis, but these are just speculations." β
The worst part is that he is still young and many tests cannot be done.
The crowd was worried.
At this time, Li Xiyang's focus was on the cause of neurological diseases.
"Dr. Dong, based on your years of experience in obstetrics, what are the general causes of these diseases?"
Dong Lin thought for a while and said, "There are many specific triggers, but more than half of the reasons are at the original level of parents. β
"For example, the mother itself carries a disease, or... Marriage of close relatives! β
Zheng Xiaoyu was stunned, this can't be.
What kind of society is now, and the harm of consanguineous marriage has long been known to everyone.
A consanguineous marriage is a marriage in which there are three or fewer generations of common ancestors. If they intermarry, it is called a consanguineous marriage. Consanguineous couples may have acquired the same genes from their common ancestors and passed them on to their children. If this one gene is inherited in an autosomal recessive manner, the child may develop the disease because it is homozygous for the mutation.
As a result, consanguineous marriages increase the risk of certain autosomal recessive disorders. For example, albinism, dementia, congenital heart disease, etc., many congenital diseases are mostly caused by the marriage of close relatives. The probability of getting such a pair of homozygous genes, or the same genes, among the children of consanguineous marriage, is called the proximity coefficient.
According to expert estimates, each normal person may carry several, or even up to a dozen harmful recessive alleles, and inbreeding will make these recessive alleles have more chance of collision, and may produce genetic abnormalities.
The risk of first-degree consanguineous relatives is increased by 31 times; The risk rate of intermarriage between brothers and sisters is 125 times higher than that of normal marriage!
Of course, except for those in the big ravines, there may still be such bad habits.
But in the imperial capital, no one should be so stupid.
Dong Lin shrugged her shoulders, she said that there was a possibility.
Li Xiyang thought for a while and said, "Since the child can't be examined now, he can only be observed in the hospital first, if more specific symptoms can be found, he can prescribe the right medicine in time!" β
Dong Lin nodded, and wiped the child's saliva with a wet tissue.
Li Xiyang glanced at the child and said, "Since the child is not born prematurely, then don't send it to the incubator." β
Otherwise, the child will be protected by the incubator after birth, and his physical fitness will deteriorate, and he will be more likely to get sick when he grows up.
Dong Lin nodded, "Then let's send it to the feeding room first!" β
The little nurse on the side said, "Doctor Dong, this baby doesn't cry until it's in the incubator, if you take it to the feeding room, other babies will probably cry with it, it's not easy to bring!" β
Dong Lin nodded, this is a problem.
This little guy has a loud voice and keeps crying.
At this time, Li Xiyang said, "That's it, just when we are going to see a patient, let's take the child with us, maybe I won't cry when I get to my mother!" β
Dong Lin nodded, the pregnant woman has been in a coma and has not seen her child, I am afraid that the first thing she will do after waking up is to find the child.
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So they took the baby to the ward.
At the same time, the pregnant woman in the ward was lying on the bed in the ward, and the nurse stood aside to change the nutrient solution hanging bottle for her that was about to be empty.
Suddenly, the woman's eyelids moved, and she slowly opened her eyes.
"You... Who are you? Where am I? β
The woman's voice was weak, and she squinted and looked around.
Suddenly, the woman noticed that her belly was small, her eyes widened, and she said with a panicked face, "My child, what about my child?" β
The little nurse in the ward hurriedly said, "Don't get excited, patient, there are still knife cuts on your body, be careful to break away." β
"Don't worry, the child is fine, it's okay, congratulations on the little girl you have left."
"Girls? You say I gave birth to a girl? β
The woman looked at the little nurse with excitement on her face.
The little nurse nodded, "Yes, it's a very cute girl, and the child is now being taken care of by special medical staff in the warming room, and she will take good care of him."
Later, I'll bring her over and let you breastfeed, you lie down now, don't move! β
"Okay, good, I don't move, I don't move, girl, it's really good!"
The woman lay down again, tears of happiness sliding down the corners of her eyes.
"By the way, what about my husband? And my son, where are they? β
Only then did the woman notice that there was no family member in the ward.
The little nurse in the ward shook her head, "I don't know about that!" β
The woman suddenly became a little flustered.
At this time, Li Xiyang and a few people walked in, Zheng Xiaoyu walked to the bed with the child in her arms and said to the woman, "This is the child you gave birth to, look at how cute she is, do you want to hug her?" β
"It's... This is my child? β
There was a little tremor and excitement in the woman's voice.
Dong Lin said, "I helped you do the caesarean section, this is indeed your child!" β
"Woo woo, my child!"
The woman instantly shed tears and reached out to hug her child.
"Baby, I'm a mother, I'm a mother!"
And at this moment, the child's crying really gradually stopped, and it was no longer as loud as the god who had just hugged him.
Several people glanced at each other, and it was really useful.
Sure enough, it's a mother-son connection!
"This child is so sensible, he knows that he can't cry anymore when he returns to his mother's arms." The little nurse in the ward also felt magical.
After letting the mother and daughter get along quietly for a while, Li Xiyang asked, "Ms. Zhang, you were already in a coma when you were brought here, do you remember what happened before you came to the hospital?" β
What happened before coming to the hospital?
The pregnant woman thought hard and said, "My husband is going to take me to the hospital to give birth, it seems that there has been a car accident, and I can't remember it later." β
Li Xiyang nodded, "Yes, you did have a car accident and fell into a coma at the time, so it's normal not to remember what happened later." β
"What about my husband? And my son, where are they? β
"Is there anything wrong with them?"
The woman recalled the terrible scene before the car accident and immediately panicked.
Li Xiyang hurriedly said, "Don't get excited, you and your son both have skin trauma, and you can be discharged after a few days of recuperation in the hospital, but your husband's problem may be a little more complicated, and his impact caused him the most damage, injuring his spleen." β
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"However, we have already had the operation, and the operation went well, but we will have to recuperate in the hospital later, and then have a second laparotomy."
"Huh?"
"Still need surgery?"
The woman's face was full of distress and sadness.
Li Xiyang said, "Don't worry, as long as you transplant a new spleen to him, he will live like a normal person!" β
"Really?"
"Really!"
The woman was a little less nervous.
"Thank you, thank you doctors, thank you for saving my brother and my son, and also for saving my life."
Your brother?
Li Xiyang and the others glanced at each other.
"You call your husband brother?"
The daughter wiped her tears and nodded at the same time, "My husband was originally my cousin!" β
What?!
Li Xiyang and the others were stunned, and they really got married recently!
Zheng Xiaoyu suddenly became a little angry, "Don't you know the danger of close relatives getting married? β
"Listen... I've heard that when my brother and I were together, my family didn't agree, but my brother and I really loved each other, so we eloped behind my family's back! β
The woman lowered her head and recalled the past, as if she was a little embarrassed to say it.
"I knew we couldn't get married anytime soon, but after we had our first baby, we did a serious check-up and found no problems, and my son is now healthy and healthy enough to be eight years old."
Zheng Xiaoyu frowned, and said with a serious expression, "There is no problem now, it doesn't mean that there will be no problem in the future!" β
The woman's nerves tensed instantly, "You... What do you mean? Could it be that my son..."
Li Xiyang hurriedly said, "Your son is fine, the injuries on his body have been cleaned up, and he is now asleep in the emergency ward, but,"
Li Xiyang broke off and said, "We're talking about you, the newborn daughter!" β
"My daughter?"
"She... What's wrong with her? β
"Doctor, don't scare me!"
Li Xiyang sighed, pointed at the girl and said, "Have you noticed, she has been drooling non-stop from the beginning!" β
The woman lowered her head, and sure enough, the corners of her daughter's mouth and chin were full of shiny saliva.
"Doctor, what the hell is going on? What is my daughter's illness? β
The woman asked anxiously, her tone beginning to hurry.
Li Xiyang said, "We suspect that your daughter has congenital neurological dysfunction, but don't be too excited, because it's just a preliminary speculation now, and it hasn't been confirmed yet!" β
Neuropathy?!
This, this...
The woman trembled violently.
Li Xiyang hurriedly explained, "It's not neuropathy, it's neurological dysfunction." β
The woman didn't understand, "Doctor, what the hell is that?" β
Li Xiyang waved his hand, "It's useless to talk too much now, because it's only in the suspicion stage!" β
"Then hurry up and do an examination, doctor, don't worry, I'm willing to spend as much as I want, and I must cure my child!"
At this time, Dong Lin stepped forward to comfort and explained, "The child has just been born, and his body is not sound in all aspects, so he can't accept all inspections with radiation for the time being, so..."
"Is there really no other way?" The woman's expression was pained.
Dong Lin sighed and said, "The current way is to wait for the child to grow up a little more, and then arrange a full-body examination for him, and what I can do now is to take good care of and accompany her!" β
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Zheng Xiaoyu on the side became more and more angry the more he thought about it, "Ms. Zhang, with all due respect, your choice is very irresponsible, and you are completely betting on the life and health of your child.
You don't have much to lose, but the child is a life. β
Close relatives can't get married, this is an unethical thing, the couple got married, not to mention, but also had children.
Zheng Xiaoyu really doesn't understand why such a selfish parent.
"Dr. Zheng, don't say it!"
Li Xiyang noticed that the patient's mood was very low and could no longer be stimulated.
Zheng Xiaoyu snorted coldly, "I'm just angry, how can you say that their parents can joke with their children's lives." β
Li Xiyang shook his head, "Not all people are as aware of the consequences of marriage as close relatives as we do. β
Many times in life, it is very general to say that close relatives cannot get married, and the children born are prone to get sick.
But why do you get sick, what kind of disease do you get, and do you have to get sick?
Most people still don't know.
As the patient said earlier, when they gave birth to their first child, they also had various careful examinations, and they took over the son very healthy and not sick.
Probably this made the couple have a fluke in their hearts.
The woman wiped her tears and said, "Actually, I don't think we should be close relatives, because he is not my aunt's son, but my aunt's distant nephew." β
Li Xiyang understood, this is probably the reason why the two couples were lucky.
What exactly is considered a consanguineous marriage?
In fact, starting from the generation with a common ancestor, it is counted as the first generation.
And so on, if a cousin or sister marries, the maternal grandmother of both parties belongs to the first generation, the mother of both parties belongs to the second generation, and the cousin union is the third generation.
Within three generations, it is considered a consanguineous marriage.
As for the adverse effects of consanguineous marriage on offspring?
This issue has been debated.
In ancient times, when human civilization was not yet civilized, intermarriage between close relatives was very chaotic, not only between collateral blood relatives, but even between direct blood relatives.
The rulers of ancient Egypt believed that only the intermarriage of the royal family could maintain the purity and nobility of the royal blood, so they mostly married brothers and sisters.
However, it has been concluded from numerous facts that men and women who are closely related by blood have low fertility rates in marriage, high mortality rates in offspring, and often develop congenital malformations and hereditary diseases.
In modern times, there is a large amount of data to prove that the incidence of dementia is 150 times higher than that of non-consanguineous marriage, and the neonatal mortality rate and malformation rate are also more than 3 times higher than that of non-consanguineous marriage.
It was also reported that 13.9 per cent of the children of consanguineous marriages died before the age of 20, compared with 1.7 per cent of non-consanguineous marriages.
From a genetic point of view, each of us has about 50,000 genes, half of which come from our father and the other half from our mother.
In other words, there is a 1/2 chance that the genes are the same between each child and the parents, and therefore 1/2 likely that the genes are the same between siblings.
Grandchildren, uncles, nephews, uncles, nephews, etc., are 1/4 likely to be the same.
In the same way, there is a 1/8 possibility that cousins, cousins, etc. will be the same.
The causative gene of some hereditary diseases is recessive, and if one parent has this gene and the other parent does not, the causative gene can be masked so that the offspring do not develop the disease.
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It is only when both spouses carry this recessive gene that the offspring develop the disease.
Albinism, for example, is characterized by the albino of the skin and hair all over the body.
The frequency of carrying this disease-causing gene in the population is 1/50, and if the non-inbred is married, the chance of developing the disease in the offspring is 1//,
In the case of consanguineous marriages between cousins, the chance of developing the disease in the offspring is 1 in 1600, which is more than 6 times higher than that of non-consanguineous marriages.
At present, 1232 autosomal recessive genetic diseases have been discovered.
In addition to albinism, congenital deafness, microcephaly, phenylketonuria, galactosemia, etc., are more common.