Chapter 133: AIDS and Gene Editing

At present, the treatment of AIDS is only aimed at rebuilding the immune function of the patient and preventing the disease from worsening.

The greatest danger of AIDS is not in itself, but in its complications.

Because HIV destroys the body's immune system, a body without immune system protection is a breeding ground for various other diseases.

Human beings have lost their immune system, so without taking medicine, a cold can cause death, accidentally break the skin and need to be amputated directly, and even breathe every day can get sick and die at any time.

You must know that in ordinary air, every liter of air contains more than 44,000 bacteria, and the green zone is slightly better than half of it, while in the densely populated areas of large cities, the air content is at least three times that of the usual.

If you include the presence of viruses and fungi, then the level of danger increases dramatically.

If everyone loses their immune system, then going out and wearing a gas mask is a must for everyone.

This is not alarmist, but the immune system is so important to the human body that if there is a virus that the immune system cannot do harm, then the virus will spread and become a "plague".

At present, there is an understanding of the mechanism by which HIV attacks the immune system, and the HIV virus is the main target of the most important immune cells in the human immune system, CD4+ T cells.

And a few years ago, it was discovered that B cells in the body's immune cells can effectively kill the HIV virus. It is even said that a team has long discovered an antibody that can produce broad neutralization, 3BNC117.

However, this antibody against HIV cannot be made into a vaccine using the vaccine method currently commonly used in humans, and various vaccine clinical trials have failed.

This led to a new method, gene editing, in which the research team attempted to produce a neutralizing antibody against the HIV virus by using a gene editing tool to program the body's immunocoglobulin.

Moreover, many medical teams around the world have been conducting experiments on gene editing methods, and even achieved results, but one of their problems is that the treatment drugs produced by this method are likely to have other adverse effects on the human body, and even cause cancer.

If this cannot be resolved, then this drug will certainly not pass.

However, Lin Yu knew that this method was actually very correct, but they ignored one point, which was to inject patients with this gene-edited drug, and also use oral drugs for multiple treatments.

Oral drugs should play a protective role in the human body, be able to guide the integration of the genome, and ensure that the antibodies produced will not indiscriminately attack human cells.

Therefore, compared with the treatment drugs for Alzheimer's disease, the treatment of AIDS is more cumbersome, and it is necessary to develop a variety of drugs to fully protect it.

Every time he thinks of the occurrence of AIDS, Lin Yu is troubled, AIDS is transmitted through bodily fluids, and AIDS patients will be infected if they have a relationship, and AIDS patients have been found in the United States as early as 60 years ago.

So what did the first AIDS patient do?

It is said that the virus was first carried in African monkeys, which means that the first human AIDS patient was bitten by a monkey, or at worst, he/she actually had a relationship with a monkey......

It's hard to believe what kind of mentality monkeys have.

Centrifuge, lymphocyte separation, electroporator, Cas9 protein and g-site transcription RNA, incubator, protein activation reagent, infusion set.

Lin Yu nodded to confirm that the equipment for his first gene editing experiment was ready.

"System, can this enable assist mode?"

"Yes, but I don't know what the host wants to do?"

"You sent me the information, what do you ask me to do?"

"Host, please confirm whether the AIDS vaccine development is being carried out."

"Confirm."

The system has enabled assist mode.

Lin Yu began to watch the experiment from a first-person perspective.

In auxiliary mode, Lin Yu took out some other equipment and replaced it.

"It turns out that I got the wrong device, no wonder the system is asking me what I want to do."

Different gene editing experiments require different experiments, and a simple gene editing experiment can even complete a gene editing experiment with a good microscope, a new syringe, an RNase-free bench, and a clean glass wire drawer.

However, depending on the object that needs to be genetically edited, the experimental equipment required is different.

Lin Yu was immersed in the experiment and couldn't extricate himself, it turned out that gene editing was so fun, and there was a feeling of creating new creatures.

It seems that he sensed the thoughts of the host Lin Yudu, and the system reminded him for the first time.

"Hosts, please note that gene editing is actually a very serious and dangerous experiment, and you can't have any ideas about making trouble."

"Just like gene editing of humans, any uncertain gene-editing of humans is not allowed, if such a situation is allowed, then genetic weapons can be allowed, and once a large-scale war breaks out, then the crazy side will use this weapon, which will have an impact on the entire human race."

The system paused, "This is also a painful lesson for future generations of mankind today." ”

"This effect remained uncorrected until the Age of Miracles."

"Is it so serious?"

"Yes, can you imagine a halfling human with a maggot tail?"

"Can you imagine a tiger with bat wings?"

"And horses with octopus brachiopods."

Lin Yu tried to imagine it, his mental power was too poor, and he really couldn't get what kind of situation this was, Cthulhu?

"Wait, the myths and legends of Fuxi and Nuwa, who have the body of a snake with human heads, and the Queen Mother of the West who are like leopards, and many mountain gods and monsters who look like people and animals in the "Classic of Mountains and Seas".

"The host is right, human beings in the Age of Miracles have tried to figure out whether aliens have genetically edited humans a long time ago, or that humans with gene-edited genes have returned to the ancient period, forming a closed loop of time."

"But this was not possible with the technology of the Miracle Age, so the humans of that era were also very distressed, and they did not find obvious traces of gene editing on human beings, and they could not send the gene-edited human beings back to the past."

"They couldn't even find any information about the aliens' arrival in the Blue Star, which was left in the cone of light."

"So ......"

"It is still to carry out the inferences that have been made all along, and to temporarily define it as the product of fantasy - myths and legends."

"Is that so?"

"There is no way to prove or falsify things, and human beings can only choose to be suspicious."