Vaccines are mainly divided into five categories: inactivated vaccines (such as rabies vaccines, influenza vaccines, etc.), live attenuated vaccines (such as BCG, polio vaccines, etc.), recombinant protein vaccines, recombinant virus vector vaccines, and nucleic acid vaccines.

Inactivated vaccines and live attenuated vaccines belong to traditional vaccines; Recombinant virus vaccines, recombinant protein vaccines, and nucleic acid vaccines are new vaccines developed by human beings using genetic engineering technology, so they are also called second-generation vaccine technologies.

Among them, inactivated vaccine is a classic technical route in traditional vaccines.

The advantages are obvious, the preparation method is simple and fast, the safety is relatively high, and inactivated vaccines are usually used in response to the spread of acute diseases. Commonly used hepatitis B vaccine, inactivated polio vaccine, inactivated Japanese encephalitis vaccine, diphtheria-pertussis vaccine, etc. are all inactivated vaccines.

The main way of working is that they are cultured in vitro and then inactivated to make them non-toxic, but these "corpses" can still stimulate the body to produce antibodies that make immune cells remember what the virus looks like.

As for the disadvantages, of course, there are also periods of time for which the immune response lasts, multiple vaccinations are required, and the immune route is single.

As for mRNA vaccines, they belong to nucleic acid vaccines, which are a new type of vaccine, and no vaccine based on mRNA technology has been approved for marketing in the world.

His advantages are obvious, compared with the other 4 categories of vaccines, the development speed is faster, easy to mass production, from the perspective of production capacity and production time, so theoretically, it is the best candidate vaccine route to deal with the strong mutation virus of masks.

The principle of mRNA vaccine is simply to directly introduce the mRNA (messenger RNA, that is, a place of communication) encoding the viral antigen protein into the human body, without going through in vitro culture or vector, and directly introduce this mRNA into the human body, and the whole process is very hardcore. After the mRNA of this virus is introduced into the human body, it uses human cells to synthesize antigen proteins in the human body, stimulates the human body to produce antibodies, and directly activates immune protection when the virus is encountered again.

Of course, the hardcore results, as the host of vaccination, will inevitably be a little more uncomfortable.

Compared with inactivated vaccines, the risk of toxicity of mRNA is greater.

This is mainly due to the toxicity of nucleic acid analogues in synthetic raw materials, as well as the toxicity of the encapsulating material used in mRNA.

Of course, none of this really matters.

In fact, the most important thing is security.

In the past, it took at least 5-7 years to evaluate the efficacy and safety of a vaccine, after all, it is a technology applied to the human body.

No matter how good the security is, it's just a theory after all.

Therefore, Liu Gong was so surprised when he heard Wu Zhou say that Mi Guo was already researching mRNA vaccines.

In terms of biomedicine, the most important thing is actually safety.

Therefore, if the difference between the effectiveness of inactivated vaccines and mRNA vaccines is not too large, inactivated vaccines should actually be used preferentially.

Although this technology is backward, it is safer.

Although mRNA vaccines are theoretically more effective, the immune response time is longer. But it is still uncertain.

As the saying goes, if you are not afraid of 10,000, you are afraid of just in case.

It's just that Liu Gong is not Wu Zhou after all, and he doesn't know the future harmfulness of masks. Superior immune evasion, combined with constant mutation and soaring transmissibility, has caused round after round of widespread repeated infections.

And repeated infections again and again can bring deeper health problems.

In the end, Liu Gong was persuaded by Wu Zhou and left Wu Zhou's chairman's office worriedly.

As soon as I returned to the R&D center, the division of labor began.

"I went to Mr. Wu just now, and Mr. Wu said that after the vaccine is successfully developed, I will give you another reward." Liu Gong looked around and held up a finger.

"One hundred thousand?" When someone says this, be careful.

In fact, before Wu Zhou came, the monthly salary of Sinovac researchers actually started at 1w.

Then after Wu Zhou came, it was directly doubled to 2w. It can be regarded as catching up with the salary level of the head of the domestic industry.

Now that I have entered this inactivated vaccine team, my salary has doubled again, becoming 4w.

Such a simple and crude way to raise salaries, who is not impressed.

However, in order to avoid someone deliberately fishing and wanting to delay the progress of the work, of course, there are constraints, such as the elimination of the last position, the slow completion of the task, the poor completion of the task, and so on.

"1 million?" Some people have also boldly said the number of millions.

Once he said this, the eyes of many people around him were about to glow.

Liu Gong nodded with a smile and shook his head again.

"Not only that, one million is a daily project bonus, and the other is that everyone's daily salary will be raised by another level."

"Wow."

After Liu Gongcai finished speaking, in an instant, everyone in the entire research room instantly became lively, and their faces were full of smiles. No one is going to have trouble with money.

How many geniuses have had to give up their favorite scientific research because of life.

Life is not a fairy tale after all, it needs firewood, rice, oil and salt.

Scientists want to make money, shabby?

"Mr. Wu's atmosphere is bright."

"He deserves to be the richest man in China."

"Mr. Wu would have been here a few years earlier, and I guess I could buy a house."

"yes, come earlier, at least I should be able to pay the bride price, alas"

After all, many of the trivialities in life are related to money.

"Come on, boys, this is just the beginning, come on, get the results done as soon as possible." Liu Gong looked at the young people around him, his eyes reminisced, and he remembered some very potential students he had brought with him.

In the end, I had to bow my head in the face of reality and go to the easy-to-make industries such as IT or finance.

"Maybe the domestic pharmaceutical industry needs a layman like Mr. Wu."

Aiying Biotech is stepping up research and development and inactivation.

On the other hand, there are three medical device companies, and now only the last one is still not fully negotiated.

But these two medical devices cost Wu Zhou 11.8 billion.

However, when it came to the third medical device company, it encountered some twists and turns.

The market's valuation of him is only 2.8 billion, Wu Zhou is willing to buy it at a premium of 50%, and the negotiation is almost over, Wu Zhou is also over and is ready to sign the contract, but this person suddenly changed his mind and sat on the ground to start the price.

"Mr. Wu is the richest man in China, a top rich man who can donate 14 billion at a time, although the scale of my medical company is not as good as Mr. Wu's company, but some products are still very recognized by consumers, if Mr. Wu acquires our company, coupled with your company's operational capabilities, Mr. Wu will definitely make a lot of money at that time. Now the market underestimates our company, and we can't buy it at this price. ”

"Mr. Zhao, we talked about it before, and you have already agreed."

"This is the case in the business field, it is changing rapidly, Liu is always old, it should be clear." After Zhao Deqing finished speaking, he looked at Wu Zhou.

It's just that Wu Zhou didn't get used to him and left directly.

Zhao Deqing didn't expect that Wu Zhou, a young man, would have such a personality.

"Mr. Wu, you are not satisfied with this price, we can talk about it again."

It's just that when Zhao Deqing finished saying this, Wu Zhou had already left the conference room quickly.

"Young man, still frizzy, not the slightest patience, I really don't know how to do it." Zhao Deqing saw Wu Zhoutou leave without looking back, and said with a slightly ugly face at the end.

There will be only Mr. Liu, the broker, left, and finally glanced at Zhao Deqing. "Mr. Zhao, we can't do this business, the price given by Mr. Wu is not low, it is already the highest price in the industry, if you do this, it will be passed out in the future, alas." Mr. Liu left quickly without finishing speaking.

Wu Zhou left angrily, the reason was not that Zhao Deqing sat on the ground and raised the price, mainly because he went back on his word, which was a waste of his time.

I was originally in Cloud City, and I came to Shenzhen City thousands of miles away, in order to have a result.

looked at the list of shares of Zhao Deqing's medical devices in his hand.

Although Zhao Deqing's medical device company is not large, its products are rich, covering health monitoring, rehabilitation aids, respiratory support, medical care and so on.

But the main products are actually the four products of oximeter, ventilator, oxygen concentrator, and electric wheelchair.

These 4 products, although the market share is average, but according to the meaning of the system, the technical strength can reach the domestic leading level, although Zhao Deqing is not very good, but the company still has a certain R & D ability.

As for other products, they are actually made for the sake of doing them, and most of them are at the level of the second and even third lines in China.

"These small shareholders, if contacted, can be taken first at a premium of up to 100%."

"In addition, help me investigate Zhao Deqing's detailed information, by the way, as well as his wife's information."

(End of chapter)