On the first day of the first month of the second year of Hongwu, it was a busy and orderly day.

Zhengdan Pilgrimage.

His Majesty the Emperor was congratulated by hundreds of officials in the Fengtian Palace, and feasted the ministers, and at the same time, the Empress Niangniang and the Kunning Palace entertained the women.

After the banquet, I felt that the advance and retreat of the ministers on this day were well-founded, and Lao Zhu specially issued an edict to exhort: "Between the court, the etiquette is the mainstay, the people are polite, such as the clothes are orderly, and the advance and retreat of the Qing and others are not rude, I am happy for it, and the Qing and others can always be like this, why do you have no praise in the future?" ”

Zhu Yuan got up before dawn every day, participated in the court meeting on time, and insisted until the end of the banquet before returning home.

For Lao Zhu's edict, Zhu Yuan didn't know what other people thought, and whether he would forget it after hearing about it, but he himself was very touched, and in connection with the previous history, he began to feel Lao Zhu's bitter heart.

Once read this period of history, one of the common feelings is Lao Zhu's bitter heart.

It's even a bit like an old man with a broken mouth.

Repeatedly, chanting and chattering, constantly exhorting the courtiers to be cautious, to learn etiquette, and not to act arbitrarily, so that they can always be together and prosperous. This point is vividly expressed in the book "Yu'en Lu" by Liu Jing, the second son of Liu Ji.

Obviously, Lao Zhu knows what the people below look like.

The Ming Dynasty succeeded, and a group of people who started in Huaixi became a rebel army. But, actually...... If you want a reference, the group of people in "Water Margin", which was written during the same period, may be realistic.

And the people gathered together, ate large pieces of meat, drank large bowls, and divided the gold and silver, and saw which one was not in order, and rushed over and slashed them.

That's it.

After all, Shi Nai'an was a person from the late Yuan Dynasty and the early Ming Dynasty, although he borrowed the narrative of the Song Dynasty, but the rules of officialdom were still the rules of his era after all.

Later, when people read "Water Margin", if they are people with more positive views, they often have an illusion when they look at the various roles in it: Is there still a royal law, is there still a law?

It's a mess!

However, in this day and age, this is actually the case.

Wang Fa or something, many times, even the patriarchal law within the ethnic group is not as good, and it can't even compare to the righteousness of the rivers and lakes between the green forests.

In such an environment, Lao Zhu's success shows that he must be a very righteous person, otherwise it would be impossible to gather so many people around him to fight the world together in just over ten years.

However, when you become an emperor, your status is different, and your position is different, then, in Lao Zhu's eyes, whether it is the royal law or the etiquette law, it is more important.

The problem is that Lao Zhu is a person with a strong will, and he can reverse it himself, but it is not easy to turn the old brothers who have been with him to fight the country together.

Isn't it natural for everyone to put their heads on the waistband and accompany you to lay down the country, enjoy some wealth and enjoy some privileges?

Of course.

Lao Zhu recognized it in his heart.

Therefore, until the twenty-third year of Hongwu, Lao Zhu's attitude towards Xungui was actually similar to that towards his children, with a stern appearance and actual connivance. It is said that in the thirteenth year of Hongwu, Lu Zhongheng and Fei Ju were involved in the Hu Weiyong case for the first time, and after Hu Weiyong and others were disposed of, Lao Zhu directly said that he would not be held accountable for the merits of Lu, Fei and others.

If you look at it more, you will find that the mistakes of Lu, Fei and others are not only conspiring with Hu Weiyong, but also not wanting to make progress militarily, extravagant and decadent in life, in short, there are all kinds of bad things.

However, Lao Zhu still let it go.

Because it's almost the same attitude towards children.

For example, Lu Zhongheng.

An interesting passage in history.

Lao Zhu led the soldiers out and found a young man who had been killed by the rebels hiding in the grass on the side of the road. ”

Lu Zhongheng: "Okay. ”

The boy who was only 15 years old at the time entered the old Zhu army in this way, fought in the south and north for more than ten years, and was finally named the Marquis of Ji'an.

With Lao Zhu's character of liking to take in his godson, this is almost a godson.

Can a godson be killed?

No, I can't.

is still the same sentence, in this world, there is a cause for effect, at the end of the Hongwu period, after Zhu Biao gradually grasped power, why did he set off the Hu Weiyong case again and eliminate so many nobles?

No matter how hypocritical and ruthless Xiao Zhu is, the whole thing will not be for no reason.

One of the very important reasons is that in the impression of later generations, all kinds of old Comrade Zhu who 'cunning rabbits die and lackeys cook', in fact, on the contrary, not only did not cook rabbits and dead dogs, but they were too protective of their old subordinates who followed him to fight the country.

So much so, just like parents who spoil their children unprincipledly, they spoil their children, and they are too bad!

If you don't clean it up, you can't do it.

Well.

Subverted again.

The second day of the first month.

Zhu Yuan still got up very early, and it was the first moment to eat breakfast.

Today, I want to accompany Lao Zhu Weifu for a private visit.

About a pre-arranged creative talk event.

However, according to Zhu Yuan's arrangement, a certain couplet can only be regarded as a small activity in today's schedule, and it is not the main thing, the key is to accompany Lao Zhu to take a walk north of Xuanwu Lake and look around.

For example, the various universities, such as the placement of craftsmen who came to the capital, and so on, also have a more intuitive impression of the many things to be done next.

Leaving the mansion on Xuanwu Lake and coming to the North Shore Road, a carriage was already waiting.

Take a ride today.

Zhu Yuan has been sitting in a sedan chair, because he can't stand the bumps of riding in this era, but that was before, and now it can be better, because today's carriage is specially arranged, and the seats inside, from the cushion to the backrest, are all springed.

Speaking of which, the carriage itself can also be modified, plus a suspension system.

It will take time, though.

I'll make do with it this time.

After getting into the car, I felt the carriage start to move forward, and the sack next to me was more nervous than Zhu Yuan, and I sat carefully on the side for a moment to confirm that my adults did not have a tendency to be upside down, and then I was a little relieved. This reaction made Zhu Yuan a little funny, so he grabbed Nizi and kissed her a few times.

The first stop, Houhu Medical University, is still the courtyard where the laboratory is located.

Zhu Yuan got out of the car and entered the courtyard guarded by the guards, Lao Zhu had already arrived, and this time he was with him...... Not counting the guards, there are only two people, Li Shanchang and Chang Yuchun.

Well.

plus Zhu Yuan, a total of four people.

It was supposed to be a day of rest, Lao Zhu was going to come over, Sun Shouzhen and Dai Sanchun naturally appeared, everyone was checking a new penicillin concentrate air-drying equipment that had just been built in the Westinghouse, the main change was the multi-layer glass shelf that Zhu Yuan mentioned before, which directly increased the air-drying efficiency many times.

After Lao Zhu and the twenty-third grandson of his own treasure gave him a salute and greeted Li Shanchang and Chang Yuchun, he said very excitedly: "Yuan'er, you have a good method, I just heard them say, this year is dedicated to building a penicillin workshop, if it goes well, I am afraid that I will be able to get several catties of penicillin in one day in the future, how many people will be saved?" ”

Zhu Yuan listened and subconsciously calculated, even if it was about three catties a day, it would only produce 1,000 catties of penicillin a year. Comparative...... Although I don't know the specific value, the penicillin production in later generations should definitely be calculated in 'tons'.

Therefore, even if there is really 1,000 catties, it is still far from reaching the level of popularity.

Thinking so, Zhu Yuan nodded on the surface, looked at Dai Sanchun, and asked another question: "What is the effect ......of solid penicillin after placement?" How is everything? ”

At present, the most critical penicillin obtained by this original production method is still whether it can be effectively stored for a long time.

Not to mention a few years, even if there can be a few months, this era is enough.

Zhu Yuan's problem is the key point, Dai Sanchun put away his expression, and said seriously: "Last month, the twenty-second made solid penicillin, and the lower officials have kept samples and continued to test them, so far for 10 days, the first batch has not been inactivated, and how long it can be stored depends on how long it can be kept." ”

"Ten days," Zhu Yuan said, "If there is an emergency, it is already very meaningful." ”

Chang Yuchun took a plate of penicillin that had just been scraped from the hands of the craftsman who demonstrated the operation on the side, and said: "Ten days is enough, if there are injured people in urgent need, it will only take as much time as possible to get from Beijing to that side of Xinjiang." ”

Someone said, grinning and directly plucking some powder, sending it to his mouth, and while quickly tensing his face, he nodded and sighed: "Okay...... Good stuff. ”

Lao Zhu smiled and saw that love was going to be like this, so he didn't stop it, but nodded his head, and said very agreeably: "Good medicine is bitter!" ”

Zhu Yuan: "......"

How do you tell it's a good thing?

And also......

Ancestor, how do you know that this is bitter?

Thinking so, I saw that Chang Yuchun picked up some more.

What about you as a snack?

Hurriedly stopped: "General, this is a medicine after all, don't try it if it's okay, eating too much may make the body resistant." ”

Chang Yuchun obviously didn't listen to persuasion, paused when he heard the words, but still put the twisted powder into his mouth, pursed his lips and tasted it like drinking, and said, "It's okay, this is a good thing...... We don't eat it often. ”

Dai Sanchun accurately grasped another key in Zhu Yuan's words: "Pingzhang, what is it...... Resistance? ”

When others heard this, they were also curious.

Zhu Yuan explained: "Penicillin can kill bacteria, but it is not absolute, there are always some bacteria that can survive under penicillin. Well...... It's probably like no matter how fierce an epidemic is, there will always be people who can survive. Moreover, some epidemics, once they get it, people have resistance, and they will not get it again. Shrinking down to this bacterial world, it is the same, some bacteria carry penicillin, survive, and then encounter penicillin, it is ineffective, and the offspring of this bacterial reproduction can also resist penicillin. This kind of thing is put on the human body, if a person eats too much penicillin, the bacteria in his body develop resistance, and then because of this bacterium, it will be difficult to treat. ”

After Zhu Yuan finished speaking, Chang Yuchun, who had already picked up the third handful, suddenly stopped.

Li Shanchang, who had not spoken just now, said at this time: "If this is the case, this penicillin ...... I'm afraid that it's not magical, huh? ”

Zhu Yuan looked at Lao Li: "Zuo Xiang's statement is not right, what I said about drug resistance is just a theoretical state." Actually...... A person, under normal circumstances, who occasionally gets sick and uses penicillin for the rest of his life, does not necessarily develop resistance. This is because our human body itself is also protected against bacteria, called the immune system. Penicillin kills most of the bacteria that can be killed, and in small amounts, it can also be killed by our body's immune system. On the other hand, even if you develop resistance to penicillin, there are many antibiotics such as erythromycin and chloramphenicol in nature, so there is no need to worry too much. ”

Lao Li: "......"

I shouldn't have spoken.

Thinking in his heart, Lao Li instantly thought of the meeting a year ago, and the meeting ...... That often meets spring has 'Wusha', and that Kang Mao is ...... Anyway, there is a solution.

What about yourself?

Lao Li hadn't slept well for several days, and he always felt that he might have something 'evil', but a certain annoying teenager Pingzhang didn't tell him. And also...... The lord does not tell himself.

I Li Shanchang is conscientious and conscientious for the Ming Dynasty!

When Lao Li's thoughts drifted away, Lao Chang relaxed and continued to put the pinch of penicillin powder into his mouth.

Well......

Drinking is the same.

Bitter!

Comfortable!

Lao Zhu saw Dai Sanchun take a pen and paper from the side and quickly remember Zhu Yuan's words just now, while snatching the porcelain plate in Chang Yuchun's hand: "Yuchun, or listen to Yuan'er, don't eat it, if you love this bitter taste, go back and weigh a few catties of Coptis chinensis." ”

Dai Sanchun carefully wrote down Zhu Yuan's statement about drug resistance, and then said another thing: "Your Majesty happens to be here, and the minister and Lord Shangshu are discussing, there is one thing, and the sooner you do it, the better, just ask Your Majesty to issue a document and let the prefectures and counties of the world cooperate." ”

Lao Zhu handed the porcelain plate that he had snatched from Chang Yuchun's hand to the craftsman on the side, and gestured, "Just say it." ”

"It's about the selection of Penicillium," Dai Sanchun said: "Your Majesty also knows that the minister was fortunate to get the 'Melon Green' strain last year, and only then did he know that different Penicillium produced different Penicillium produced by Penicillium is also different. Compared to other strains, this 'melon green' is rich in penicillin, but if you can collect a variety of bacteria from all over the world and screen them, you may be able to get a better strain than 'melon green'. If there is a better strain, the penicillin production can also be more effective with half the effort. ”

After hearing this, Lao Zhu immediately nodded and said: "This is also a matter of urgency, you first draft a submission explaining what to do, send it to the palace, and then let them join together to make an edict to spread the world, and let the provinces, states and counties screen the strains and send them to the Jingshi." ”

His Majesty the Emperor agreed to this matter, and Dai Sanchun had no other problems.

Sun Shouzhen asked again: "Your Majesty, is this penicillin...... When the workshop was built, the output increased...... How should I deal with it, and there should be a charter? ”

Of course, the royal and noble take precedence.

Lao Zhu subconsciously thought, but did not speak, but turned to Zhu Yuan: "Yuan'er, what do you say?" ”

Zhu Yuan said with a smile: "What Shangshu asked should be about business operations." Ancestor, this is the one I often tell you about. Even if the imperial department can produce itself and achieve self-sufficiency, this department will be more solid and long-lasting. On the medical department's side, whether it is running a school or research, the expenses are very large. Because of the free clinic a year ago, I thought of one, opening a hospital affiliated to Houhu Medical University and charging for diagnosis, which can bring some input to the medical department. And then there is this penicillin, if the production is large enough to have an extra surplus, it can also be sold, which can also bring some expenses to the medical department. ”

Sun Shouzhen really wanted penicillin for sale...... Well, the matter of commercial operations, but when I heard Zhu Yuan's idea of the 'affiliated hospital', my eyes lit up even more.

That's a good idea.

So he looked at Lao Zhu.

Lao Zhu has been repeatedly nagged by his own baby twenty-third grandson to cultivate some thinking, and at the moment, after a little consideration, he quickly nodded and said: "This is also the method, the affiliated hospital, and this penicillin, the medical department can do it." There is only one, you are a doctor after all, you must have a benevolent heart, and you can't just drill into the eyes of money. ”

When Sun Shouzhen, Dai Sanchun and others heard this, they hurriedly bowed down and said yes.

After talking about this matter, and then talked about some things related to the construction of a penicillin workshop and the teaching of the medical university, Lao Zhu planned to leave.

When I came to the courtyard, I also asked about the filial son a few years ago.

Father and son have returned home.

After all, the New Year's Festival, and besides, the old man is almost fine, and no one wants to stay in the hospital for the New Year.

Lao Zhu just asked one more question, and when he learned that the person was safe, he didn't say anything more. However, the people around me also remember it. Obviously, His Majesty the Emperor is still very concerned about this little thing that has left a good name, in this case, if there is a chance, it is better to arrange a follow-up chance encounter and the like.

Sun Shouzhen even had a plan.

The old man's son, perhaps, could arrange a ministry for the other party at the medical university.

After leaving the Medical University, Zhu Yuan took a car, and the other three were all on horseback, coming out of the south gate and merging into the street in front of the Medical University, which is still very lively today. When we reached the end of the street at the northwest end, there were a lot fewer people, and a few people stopped and stopped to look at the roadside.

The main reason is that after Lao Zhu saw it on the spot, he wanted to ask about the commercial street again.

Zhu Yuan also described his own plan on the spot: "The initial idea is to take the south gate of the Medical University as the boundary, the northwest side, facing the people around the Shogunate Mountain, and the southeast direction, all kinds of shops and restaurants will be more high-end, facing students from various universities and the wealthy people who come out to consume in the city." Well...... This is just the beginning, and in the future, if this area can be further developed, it is also possible to divide it into several streets. ”

Lao Zhu was puzzled, and he also disagreed: "Why do you want to separate, this is the ...... How lively is it? ”

Lao Zhu doesn't understand the truth that people have high and low after all, but he thinks that this street is so popular now, which is actually good.

"This is a business-related science," Zhu Yuan said patiently: "It's called 'market positioning', to put it simply, when a businessman does business, he must first determine who he wants to sell his goods to." While everyone wants to sell their stuff to everyone, the reality is that you can't have it both ways, and you have to make a trade-off. Just like 'Shangshanju', it is positioned as a high-end consumer group, so it should be opened in the most prosperous area of the city. Otherwise, if the shop is opened in the artisan community at the foot of the shogunate mountain, it will only be left out in the cold and ruined. ”

Lao Zhu felt that he had learned again: "This ...... And so it is. ”

Lao Li didn't want to talk, but he also wanted to show his sense of existence, so he said: "This is in response to the sentence in "Dream of Red Mansions", the world is full of knowledge. ”

It was only when he said that he reacted, and "Dream of Red Mansions" ...... Well, some teenager tossed it out.

Spit!

The old lord and Lao Li, who listened with interest, both spoke, and also cheered: "That elite soldier is the right pawn." ”

Lao Zhu held his hands in the shape of an old farmer, looked at the crowded street, and said with a smile: "Yuan'er said that this commercial street should be built with everyone's money, which is considered to be an industry for the family, and after it is built, whether it is to open a store by himself or rent it out, it is a long-term livelihood. ”

Chang Yuchun rubbed his hands and agreed: "Haha, I definitely won't." ”

Of course, Lao Li would not object, and then responded: "The lord's decree." ”

(End of chapter)