The sun was high and the mist was lifting.

[Tang Guo's positive sentiment has reached 5000/5000, congratulations on getting a green card for product listing......]

Came to invest in the company, in the boss's office.

Yuan Ze drank the Tieguanyin soaked by his secretary Qiao Shuang, while checking the harvest that was picked from Tang Guo's head last night.

[A product listing green card]: This card is a kind of treasure that can make any product go on the market quickly. After using any qualified product, the supreme rules will automatically review whether the product meets the market regulations, and can skip all kinds of cumbersome review stages. Once the product passes the review, the production license will be issued directly by the Supreme Rule. If the product does not pass the review, the baby will not be able to be used. (Details)

"Sure enough, it's exactly what I imagined!"

According to the details introduced by the baby, Yuan Ze found that the green card for the listing of a product can indeed greatly reduce the time for a product to be listed.

For example, as long as Lipolyxin can pass the review of the supreme rules and meet the listing standards of the pharmaceutical industry, then Lipolyxin will be able to directly bypass the cumbersome phase III clinical trials, directly obtain the drug production approval, start manufacturing and market sales.

In short, as long as the product is fine, then it can be quickly inspected and approved by the highest rules, skipping all kinds of unnecessary links, compared with manual review, the efficiency is not much higher, and the time cost is greatly saved.

"With this green card for the listing of the product, as long as there is no problem with the Liporein sample from Wang Jingshan, then the listing of Liporetic is a sure thing! Moreover, even if Fat Reduction Ling is not good, you can also let Zhuyan Ling go on the market first! ”

For a while, Yuan Ze felt a little excited.

Two days ago, he was still in the phase III clinical trial and marketing approval of anxiety drugs for too long, but now the problem has been basically solved.

Then, the next problem is much simpler, which is to open a pharmaceutical factory, build a corresponding production line for mass production, and then start to sell it.

"Let's go, let's go to the laboratory first and see if the sample of Fat Loss Ling can pass the review!"

Without hesitation, after Yuan Ze poured the tea into his stomach, he got up and left the company quickly.

……

The second floor of the Harmony Road Laboratory.

In an office, Wang Jingshan was looking at a huge string of drug formulas with a sad face.

"It's difficult, it's too difficult, the basic steps of this string of molecular formulas can't be reversed in a conventional way, and even if a supercomputer with exabyte-level computing power comes, it has to be blind......ed."

Wang Jingshan shook his head and sighed.

At this moment, there was a sudden knock on the door, and a researcher told Wang Jingshan that Mr. Yuan was here.

"Mr. Yuan is here? Okay, I got it! Wang Jingshan immediately cleaned up his mood and went downstairs to greet Yuan Ze.

After meeting, knowing that this boss needed to see a sample of fat loss ling, Wang Jingshan first took him to change into a dust suit, and then quickly came to the experimental area.

After instructing Fei Bai to take out several samples of Fat Reduction Ling from the medicine storage cabinet in the laboratory, Wang Jingshan personally showed and introduced them to Yuan Ze.

"Mr. Yuan, this is the No. 1-1 sample of Lipolyxin made in our laboratory, which is a kind of Liporexin suitable for males, and the molecular content of the FL1 type drug specifically for fat burning in the sample is about 20%.

At present, sample No. 1 has been tested on male experimental mice for five days, and according to experimental data, an average of 80g-120g of white fat in male mice can be effectively burned and metabolized within 2 hours by this sample, and there is basically no additional impact on the physical function of mice.

In other words, FL1 drug molecules can burn and metabolize fat cells as efficiently as 400-600 times. ”

Wang Jingshan said excitedly: "The main reason why it is so powerful is that the FL1 drug molecule, once it enters the fat cells, will carry out indiscriminate chain catabolism on the lipid droplets in the center of the cell, just like dominoes, until the triglycerides in the lipid droplets, and some free fatty acids, phospholipids and cholesterol in the cells are eliminated." ”

Wang Jingshan picked up another medicine and said: "This is the No. 1-2 sample of Liporelentine, which is a kind of Liporelentine specifically for females, and the content of FL1 drug molecules in the sample is also 20%.

Among the liposcopic samples, there was a B1 molecule that could protect the breast fat of female animals from the marker of FMM1 type drug molecules, so as to avoid the indiscriminate fat decomposition of FL1 drug molecules and cause the fat loss of female breast ......"

Wang Jingshan is introducing the drug content and experimental effects of various samples of Liporetic for Yuan Ze one by one.

While listening, Yuan Ze silently called out his personal interface and selected the green card for the product listing in the treasure warehouse.

Then, according to the prompts of the card, the test of the sample of Liposulfate began.

[The review function of the green card has been launched, please select the product ...... that needs to be reviewed]

[Samples of Lipolyxin No. 1-1 have been selected, under review, please wait...... 59，58…… After the review, the product meets the listing standards of the Food and Drug Administration, and the production license can be obtained for marketing and sale......]

[Samples of Liporein No. 1-2 have been selected, under review, please wait...... Obtain a production license for market sale......]

【……】

[Samples of Lipolyxin No. 3-2 have been selected, under review, please wait...... Obtain a production license for market sale......]

Yuan Ze tested the samples of three categories and a total of six kinds of fat loss spirit one by one, and found that all of them were qualified.

This made him happy in his heart, and he couldn't help but say to Wang Jingshan: "Are there any other samples?" ”

After introducing the three categories of six samples, Wang Jingshan was stunned when he heard this, and said: "Yes, but they are all samples with high molecular concentration content of FL1 drugs, and they have not been tested experimentally......

Yuan Ze said: "It's okay, take it out quickly, I'll take a look." ”

"Okay." Wang Jingshan nodded and said to Fei Bai, "Take out all the fat loss samples." ”

Fei Bai hurriedly did so, and quickly took out more than a dozen sealed test tubes containing liporetic from the medicine storage cabinet.

Seeing this, Yuan Ze directly tested these samples of different concentrations of liporexin one by one.

As a result, most of them were not qualified.

The main reason is that the effect of FL1 drug molecules is to decompose triglycerides indiscriminately, and after the concentration is too high, there will always be mistakes, resulting in the decomposition of other beneficial fat cells, which will have an adverse effect on the human body.

Therefore, those samples containing a high concentration of FL1 drug molecules are all unqualified.

In the end, it seems that the three samples prepared by Wang Jingshan are the best, and the concentrations of FL1 drug molecules are between 20% and 30%.

After making up their minds, Yuan Ze and Wang Jingshan walked around the experimental area, and then went to his office to chat.

"Director Wang, the progress on your side is very good, I see, those three samples, you can already find some volunteers to test." Yuan Ze said.

Wang Jingshan smiled bitterly: "We want to find someone directly to conduct the test, but isn't the current application for clinical testing not yet down?" ”

Yuan Ze smiled and said, "Don't worry about this, you just go to someone to test it." ”

Wang Jingshan looked slightly stunned: "Mr. Yuan, this is not a joke, if you don't declare or approve it, you will find someone to do it, this is illegal, once you catch our company, you will suffer......"

Yuan Ze smiled mysteriously: "Illegal or not, what others say doesn't count, I have the final say......"

After thinking about it, Yuan Ze still decided to make up a white lie, so he added: "Just tell Director Wang, let's just tell Director Wang, I have opened up the road to market through personal relationships, and even the production license is in hand, and it can be marketed at any time, do you think the problem of phase III clinical trial is still a problem?" ”

"This ...... Mr. Yuan, are you serious? Didn't joke with me? ”

"Of course, such an important thing, how can I laugh." Yuan Ze patted Wang Jingshan's shoulder, and said lightly: "So, Director Wang, you can let go of your hands and feet to do it, our goal is to strive to go public and sell before the National Day, and the time is very tight, there is only one month."

On your side, you need to come up with an experimental data on humans in the next half a month. ”

Wang Jingshan frowned and said, "Is the time so rushed?" But Mr. Yuan, there is no way to recruit volunteers in the laboratory, and it is estimated that it will take several days just to do this......"

Yuan Ze chuckled: "The drug is aimed at a wide range of people, and almost every adult who is dissatisfied with his body is considered a target experimental group.

Of course, you can rest assured that the recruitment of the target experimental population does not need to be worried about by you, I will let Zhan Ping handle it.

Under our company, there happens to be a beauty hospital, and there are quite a lot of customers.

Besides, as long as you spend some money, there should still be many people who are willing to volunteer. ”

Wang Jingshan breathed a sigh of relief: "That's good, but Mr. Yuan, what standard should this test be based on, is it Phase I, Phase II or Phase III?" ”

Yuan Ze said: "Let's test it directly according to the standards of the phase III clinical trial, pull up the number of people, and see the group effect." ”

Wang Jingshan nodded: "Okay, in that case, the number of people will have to be pulled to more than 300 people, and there is a lot of demand for fat loss spirit, it seems that I have to step up to prepare more finished products of fat loss spirit." ”

Saying that, Wang Jingshan thought of something, and said with a bitter face: "By the way, Mr. Yuan, I don't have enough manpower here, when will the company transfer some more people for me." ”

Yuan Ze was a little helpless when he heard this, and said half-truthfully: "Director Wang, the company has been recruiting for manpower, but you also know how important our experimental products are, and we can't recruit people casually, otherwise there will be a mistake and a big loss."

So, this matter can't be rushed, the more urgent it is, the easier it is to go wrong, I hope you can understand. ”

Wang Jingshan sighed: "Okay, okay, what you said makes sense, Mr. Yuan, but I still hope that the company can stuff more people in me as soon as possible without making mistakes." ”

"Don't worry, Director Wang, I'll personally help you urge Mr. Zhan when I go back to this matter." Yuan Ze smiled.

He was also very helpless, there was no way.

Due to the importance of Fat Loss Ling and Zhuyan Ling, Yuan Ze did not dare to trust it, and only allowed people who had signed a confidentiality agreement to come in and work.

However, Yuan Ze doesn't have a few confidentiality agreements now, so he can only wait for more confidentiality agreements to be obtained later, so that more people can be arranged to come to the laboratory.

Now, I can only suffer Wang Jingshan and others first.

After talking about the manpower in the laboratory, Wang Jingshan asked again: "Mr. Yuan, I have asked people to check it in the past few days, and I found that there seems to be no papers and news about fat loss in all journals around the world, so the ......"

Seeing Wang Jingshan's twisted appearance, Yuan Ze knew his thoughts at a glance, and said with a smile: "Director Wang, you want to publish a paper on fat loss spirit, right?" ”

Seeing through his thoughts, Wang Jingshan was a little embarrassed, and said with a smile:

"Hehe, yes, there are currently more than 20 papers that can be published in the Fat Reduction project, and several of them should be on top journals, and when the time comes, if they are included in top journals such as Nature and Science, I think it should also have a certain positive publicity effect on the product of Fat Reduction Ling, right?"

For people like Wang Jingshan who are engaged in scientific research, let alone being listed in top journals such as Nature, even if they can publish a SCI paper in Zone 1 and Zone 2, it is already very remarkable.

Don't think that people who are engaged in scientific research don't have a sense of comparison, in fact, their comparison heart is more important than any industry, everyone wants to be famous, want to become a scientific research elder, and be admired.

And if they can publish a few SCI papers, or even appear in the sub-kan or main journal of journals such as Nature, it will be a great honor for them, and they will be happier than studying happy things with their girlfriends!

Source change app】

Anyway, for scientific research dogs, at present, no one in China can refuse the temptation to be featured in top journals such as Nature.

Wang Jingshan was originally a layman, so he was inevitably vulgar in this regard.

Yuan Ze didn't have any g-points about this, and said with a smile:

"It doesn't matter, Director Wang, you can send it if you want to, as long as you hang the name of our laboratory. Oh yes, when it comes to the content of the patent application that hasn't come down yet, it's best not to send it, so as not to be shamelessly preemptively registered when you get it, Director Wang, you need to communicate with Mr. Zhan, anyway, you can just watch it yourself. ”

Wang Jingshan was overjoyed when he saw that Yuan Ze agreed: "Thank you, Mr. Yuan, Mr. Yuan, you are so good!" ”

"Haha, don't just send me a good person card." Yuan Ze smiled heartily, and then said: "In addition, regarding the production line of fat loss spirit, Director Wang, you also have to step up to give a plan, so that Mr. Zhan can purchase equipment as soon as possible." ”

"I understand this, I am about to sort out the corresponding information, and I can hand it over to Mr. Zhan tomorrow at the latest."

"That's good."

After the two finished chatting about Fat Loss Ling, when Yuan Ze mentioned Zhu Yan Ling, Wang Jingshan's face immediately sank.

After sighing, he said helplessly:

"Mr. Yuan, I won't tell you anything, after more than half a month of research, I have now finished analyzing the main ingredients of Zhuyan Ling.

The main components include bosonine, fullerene C60, water, collagen and collagen mediator molecules.

Among them, bosonine, water and collagen are easy to say, but fullerene C60, the production cost of this thing is quite high.

In addition, the kind of collagen medium molecule that can seamlessly link collagen, the molecular formula is a bit like K, I call it K-type molecule, the chemical formula of this K-type molecule is quite complex, I have never seen it before, and in a short period of time, I can't find an effective synthesis step for it. ”

Through the experiments of Jiang Hao and Lai Xuewen, coupled with Wang Jingshan's personal participation from time to time, the basic structure and constituent elements of k-type molecules have been determined.

But the problem is that now they don't know how to synthesize this molecule effectively and quickly!

Yuan Ze was surprised: "Even if you know the molecular formula, will it still be combined?" ”

Wang Jingshan said dryly: "Theoretically, as long as you know the molecular formula of the drug, you can synthesize the drug, but in practice it is not.

Because there are many complex drug molecules, there are many steps in synthesis, the side reactions are complex, the yield is very low, and a large number of raw materials and a lot of labor are required to make them, which is not cost-effective at all.

For example, in the 60s of the last century, China's artificial synthesis of bovine insulin was made by hundreds of people, which was time-consuming and laborious, and there was no economy at all, but now after changing the synthetic thinking, insulin has been changed to use more convenient transgenic E. coli to produce. ”

Yuan Ze nodded slightly, thoughtfully.

Wang Jingshan went on to say: "Regarding the synthesis of k-type molecules, in fact, it is the same as having a decomposable large number of hundreds of digits in front of us.

When encountering this kind of problem, it is no longer possible for human beings and ordinary classical computers to calculate, and even if a supercomputer comes, it is not easy to use.

This belongs to the special field of quantum computer + Xiuer algorithm, I don't know if I say this, can you understand Mr. Yuan? ”

Yuan Ze smiled: "I see, I probably understand something." ”

Wang Jingshan's statement just now is very vivid, and even the problem of the synthesis step of k-type molecules is actually the problem of large number decomposition.

This kind of computing problem that would take hundreds of millions of years for classical computers to solve can be answered in minutes or even seconds with a quantum computer and the right algorithms.

Therefore, it can also be seen from this aspect that once multi-qubit quantum computers can be commercialized, it will definitely have a huge boost effect on the pharmaceutical field and life science field.

Yuan Ze said: "It's okay, the matter of Zhu Yan Ling is not in a hurry, you can continue to try, if it really doesn't work, put it on hold for the time being, and when the technology of quantum computers matures in the future, it's not too late to pick it up and study it, the main task at present is still to be placed on Fat Loss Ling!" ”

Zhu Yan Ling's synthesis steps can't be figured out, and it's fine, Yuan Ze is not very worried about this matter.

Because as soon as I was lucky, I got a complete information about Yan Ling, and I had everything.

If the technology in reality doesn't work, then hand it over to luck, hand it over to the plug-in, and hand it over to the protagonist's aura, anyway, Yuan Ze has been like this all the way.

……