It is said that in the 17th century, a Spanish count brought his beloved wife to Lima, the capital of Peru. His wife contracted malaria and was cared for by an Indian girl. Seeing that her condition was getting worse, the Indian girl decided to quietly treat her. The Count quietly watched the Indian girl's actions, and the Count believed that the Indian girl was going to murder his wife and punish her, and she had no choice but to tell the secret of the "cinchona tree". After his wife recovered, the Spanish count returned to Europe with the bark.

Later, the Swedish scientist Linayus carefully studied the bark of this plant and extracted the active ingredient in it, which was named "quinine". "Quinine" means bark in Peruvian words.

Artemisinin is extracted from Artemisia annua, for which Tu Youyou also won the Nobel Prize in Medicine. The ancients had known about the use of Artemisia annua to treat malaria for a long time, and as for which dynasty it started, Li Zhiyun did not know.

Li Zhiyun walked up to Doctor Jia and said in a slow tone: "Doctor Jia, this king shouldn't be angry at you, please forgive me." Doctor Jia hurriedly waved his hand and said, "No, no, Jia is incompetent and deserves to be scolded, don't blame His Highness." Li Zhiyun paused for a moment and said, "Doctor Jia, why don't you use Artemisia annua to treat my second brother?" ”

"Artemisia annua?" Doctor Jia looked at him in surprise, "Your Highness also understands medical skills?" ”

"You don't care about this. I just ask you, did you know that Artemisia annua can treat malaria? ”

Doctor Jia shook his head blankly and said, "Jia doesn't know. Li Zhiyun didn't know if it was not recorded in the medical books at this time, or if this Doctor Jia was lonely and unheard. He was just about to say something more, but Dr. Jia suddenly slapped his head and shouted, "By the way, Jia remembered." Your Highness, wait a moment. ”

Dr. Jia walked out, and after a while he came back with a book in his hand. He lived next door, apparently going back to get the medical book. Doctor Jia handed the book to Li Zhiyun and said, "Your Highness, the recipe for treating malaria with Artemisia annua you just mentioned is in this book. ”

Li Zhiyun took it and took a look, it was the "Elbow Reserve Emergency Prescription" written by Ge Hong of the Eastern Jin Dynasty. The so-called post-elbow means that it can be hung on the elbow of the arm for easy carrying, similar to the clinical practical manuals of later generations. The book looked brand new, not like the one in the medicine box, which was rolled up in the corners. It seems that Dr. Jia is not very interested in this "Elbow Reserve Emergency Prescription" on weekdays.

The book is as thick as a brick, and Li Zhiyun doesn't have the time to dig through it page by page. He handed the book back to the other party and said, "Where?" You find it and I'll take a look. Dr. Jia took the book back, flipped through it for a while, and then handed it to him, "Here it is." Li Zhiyun took it and took a look, and sure enough, it read "Cure cold and fever malaria": hold Artemisia annua, stain it with two liters of water, wring the juice, and take it.

Li Zhiyun looked at it and said, "Doctor Jia, since you know that there is such a formula, why don't you use it?" Doctor Jia hesitated for a moment and said, "Your Highness doesn't know that this Ge Hong is a Taoist priest who alchemizes, not a doctor. Moreover, there are a lot of fallacies in his formula, and Jia generally does not use it. If your Highness doesn't believe me, read on. He listed more than a dozen prescriptions for malaria, most of which were absurd. ”

Li Zhiyun listened, and then looked down, only to see that the book read: Another party, bow down towards the sunrise and pour ink into both ears. On the other hand, grab a spider and swallow it with rice. On the other hand, find a soybean and cut it in half, write the sun and the moon, and eat it facing the sun. And so on, and there are many bizarre recipes behind it.

After Li Zhiyun finished reading it, Zhang Zheng took the book over and looked at it, and said, "Lord Wang, what Doctor Jia said is right, is the recipe written by the surname Ge reliable?" King Qin is a precious woman, but don't use the wrong recipe. If Li Zhiyun wasn't a traverser, then he would definitely be the same as Zhang Zheng, thinking that the recipe recorded in Ge Hong's book was not reliable at all. But he knew that no matter how absurd Ge Hong's other prescriptions were, it was true that Artemisia annua could cure malaria!

Li Zhiyun estimated that Ge Hong must have written all the recipes he collected from the people into the book, which was inevitably mixed. However, Artemisia annua is definitely a good cure for malaria. It is said that artemisinin has saved millions of lives in Africa, and that is still in the presence of quinine, which shows how effective artemisinin is in treating malaria.

Since Li Zhiyun repeatedly patted his chest and guaranteed that there was no problem, Dr. Jia finally relented and said, "Since His Highness insists on using this method, let's try it." Artemisia annua can be eaten originally, and it has the effect of clearing heat and detoxifying, which can neither cure malaria miasma, nor is it harmful. ”

"Can Dr. Jia recognize Artemisia annua?" Li Zhiyun asked worriedly.

When Dr. Jia heard this, he smiled and said, "Jia is the one who eats this bowl of rice." But there are no plants and trees that can be used in medicine, Jia does not know. This Artemisia annua is not a rare thing, it is not difficult to find, there may be one on the mountain in this area, and Jia immediately took someone up the mountain to collect it. ”

Dr. Jia took a soldier with bamboo on his back to collect Artemisia annua in a nearby mountain. In less than half an hour, they picked the Artemisia annua.

Li Zhiyun glanced at it, Artemisia annua is a very common blue-green plant, about a foot tall, with long and narrow leaves. According to the recipe in Ge Hong's book, Dr. Jia soaked it in twice as much water, squeezed it to extract the juice, and then gave it to the second brother to take it all at once.

However, after taking a few pairs of medicines, the second brother's condition still did not improve, and he was still unconscious.

What's going on? Li Zhiyun felt puzzled, and his heart suddenly became suspicious. He looked at Dr. Jia with suspicious eyes and said, "Are you picking up Artemisia annua?" Dr. Jia patted his chest and assured that it was absolutely right. He was afraid that Li Zhiyun would not believe it, so he specially found a few villagers. When the villagers were not working, they often went up to the mountains to collect medicinal herbs and sell them to the pharmacies in the city to subsidize their families. So, they know a lot of herbs. After the villagers saw the plant, they all said that it was Artemisia annua.

Li Zhiyun hung his head and had nothing to say for a while. Although Dr. Jia didn't say anything, his face was clearly written: How is it? I said it a long time ago, right? However, as Langzhong, if he can't cure the patient, it is not a glorious thing for him after all. So, Dr. Jia returned to his house and took out a large pile of medical books and flipped through them, hoping to find a special prescription for malaria.

In the first battle of Qianshuiyuan, due to the incompetence of Liu Wenjing and Yin Kaishan, the Tang army was defeated unprecedentedly, losing 780,000 horses and horses, and the generals Murong Luo, Li Anyuan, and Liu Hongji were all killed. Xue Ju then waved his troops to conquer Gaoqi City, and then collected the corpses of Tang soldiers and built a high platform to promote martial arts. After Liu Wenjing and Yin Kaishan led the remnants of the defeated army to flee back to Chang'an, they were all dismissed by Li Yuan.

High Jaw City. Xue Ju sat upright in the lobby, and many civil and military ministers were neatly arranged in the hall. Xue Ju's gaze roamed majestically over everyone's faces, and he said loudly, "Where is the prince?" Xue Rengao stood up, hugged his fists and said, "Abba, Erchen is here!" ”

"Did Li Shimin catch it?"

"Not yet. Abba, Erchen searched the entire Gaojaw City, but Li Shimin was not caught. Erchen estimated that he had fled. ”

"What?" When Xue Ju heard this, he glared and said, "Where did he flee to?" ”

"It's not clear." Xue Rengao said, "However, Abba, please rest assured, Erchen has already blocked all roads to Chang'an, and he will not want to escape back to Chang'an even if he puts on his wings." Erchen guessed that he might be hiding somewhere nearby. ”

"That's good." Xue Ju ordered, "Prince, you immediately send a large team of men to search for Li Shimin, and you must catch him." To live to see people, to die to see corpses! ”

"The retainers obey!"

At night, Li Zhiyun sat in front of his second brother's sickbed and refused to go back to his room to sleep. The second brother has been unconscious, and the water and rice have not been eaten for a few days, and his originally handsome face has been tortured by the disease.

Li Zhiyun felt like he was in a dream. He couldn't believe that the dying patient in front of him was Li Shimin, the powerful generation of heroes in history. It seems that human life is really too fragile, whether it is a cloth cloth or a heroic hero, in the face of the forces of nature, it is the same small and insignificant.

The second brother's illness is getting worse and worse, and his life is losing little by little, but Dr. Jia is helpless, and Li Zhiyun doesn't know how to deal with this situation. He only knew that he must not watch his second brother die of illness. The Tang Dynasty has to rely on the second brother to unify the country, and the prosperous era of the Tang Dynasty created by the second brother must not disappear from history.

According to the news from the scouts, Xue Ju had sent troops to block the roads leading to Chang'an, and they could not return to Chang'an for the time being, so they could only hide in this small mountain village. However, there is neither a famous doctor nor a good medicine here, and the second brother's illness cannot be delayed. Li Zhiyun felt that he had been pushed to the edge of the cliff.

Li Zhiyun thought of Artemisia annua again. There is no doubt that artemisinin is a special drug for the treatment of malaria, otherwise, Tu Youyou would not have won the Nobel Prize in Medicine. However, Artemisia annua is used on the second brother's body, why does it have no effect at all? Li Zhiyun even began to wonder if the second brother had malaria? However, as soon as this idea came to him, he quickly dismissed it.

Although Li Zhiyun does not understand medical skills, judging from the symptoms of the second brother's illness, there is no doubt that he has malaria. Besides, no matter how bad Dr. Jia's medical skills are, he won't even be able to figure out what illness the second brother has, right?

Li Zhiyun seems to have heard before that malaria is the most important infectious disease in human history, causing far more deaths than smallpox, plague and even the Black Death, and can be ranked as one of the three major diseases faced by human beings along with cardiovascular disease and cancer. He heard Dr. Jia say that malaria can be divided into many types. Which kind of second brother did he get, and there was no cure?