Chapter 183: Neural Stem Cell Transplantation
Next.
Eight forty in the morning.
After the morning meeting, Gao Jun called Zhao Heng to the office.
"Xiao Zhao, Sun Xinxin is about to be sent in the evening, how are you preparing?"
Sitting on the sofa, Gao Jun asked Zhao Heng with great concern.
For the nascent anesthesia and perioperative medicine center, receiving Sun Xinxin can now be said to be the top priority.
From the other side of the ocean to Beishi, due to some reasons, there is only a flight that arrives at 7 o'clock in the evening, so Sun Xinxin's reception will also be carried out in the evening.
"All the preparations are in place, and now we are waiting for someone to send them."
Zhao Heng said.
Speaking of which, although Sun Xinxin is a very important patient, the ICU is relatively complete with various instruments and equipment, so Zhao Heng did not need to spend too much effort to complete the preparations.
"This is all the medical records and information about Sun Xinxin from the Mayo Clinic, you can take a look at it first."
Gao Jun opened the laptop on the coffee table, handed it to Zhao Heng and said.
"Hmm."
Zhao Heng took the laptop from Gao Jun's hand and began to look at it carefully.
After just looking at it for a while, Zhao Heng's expression became solemn.
"Teacher, the situation is even more serious than we estimated before, judging from the information from Mayo, Sun Xinxin is now in a continuous vegetative state."
Zhao Heng said very solemnly.
Vegetative state is clinically defined as periodical wakefulness and sleep in the body, but without any evidence of cognition or the ability to express behavior or brain metabolism in response to external events or stimuli.
And when this cognitive loss lasts for more than three months, it is called a persistent vegetative state.
In this state, the patient is completely "living dead", not only completely losing knowledge of himself and his surroundings, but also losing the ability to understand and express language, incontinence, a sleep-wake cycle, and complete or partial preservation of autonomic function in the hypothalamus and brainstem.
"Yes, in Sun Xinxin's case, the Mayo Clinic has determined that it is a neuroaxon injury to the ascending reticular activation system of the brainstem caused by a severe head injury. During Sun Xinxin's hospitalization at Mayo, all the treatments that could be done over there were done, but Sun Xinxin still did not show any signs of sobriety. ”
Gao Jun said very solemnly.
As the world's top hospital, the Mayo Clinic has the most cutting-edge treatment methods, and these methods have been used, but the patient still has not woken up, so to speak, to some extent, Sun Xinxin was sentenced to "death".
"What do you think about Sun Xinxin's treatment?"
After a pause, Gao Jun asked again.
He was looking forward to hearing different ideas from Zhao Heng's mouth.
In the past, several times Zhao Heng put forward ideas and solved problems when everyone was helpless.
This is also the reason why Gao Jun attaches so much importance to Zhao Heng.
"I look at the treatment records of the Mayo Clinic, and Sun Xinxin has been given medication to awaken her, as well as some music therapy and family therapy, but basically the effect is very small. Because Sun Xinxin still has a brainstem aneurysm in her brain, the means of electrical stimulation cannot be used. ”
"Therefore, I think that Sun Xinxin's brain cells have been seriously damaged, and it may be difficult to use ordinary methods to awaken her."
Zhao Heng said very methodically.
"Xiao Zhao, what do you mean?"
Hearing Zhao Heng say this, Gao Jun couldn't wait to know if Zhao Heng had other ideas.
"I think we can try some unconventional treatments in terms of arousal, such as neural stem cell transplantation, gene therapy, and embryonic brain transplantation."
Zhao Heng said what he thought, since he learned from Gao Jun that Sun Xinxin was sent, he had been thinking about what kind of treatment he could use for Sun Xinxin after she was sent.
The treatments that have already been done at the Mayo Clinic have had little effect, and there is obviously no need to repeat them again.
"Gene therapy and embryonic brain tissue transplantation are still far from practical, but this neural stem cell transplantation is a new idea."
When Gao Jun heard Zhao Heng say this, his eyes suddenly lit up and said.
Neural stem cell transplantation is a technology that transplants neural stem cells into the host, so that the neural stem cells tend to the lesion site of the nervous system, aggregate, survive, proliferate, and differentiate into neurons and glial cells, thereby promoting the partial recovery of the host's lost function.
"In fact, there are many treatments for long-term coma at home and abroad, but at present, there is no specific treatment that can accelerate the recovery of patients' perception ability. There are various causes of long-term coma, but for Sun Xinxin, I think the biggest cause of her long-term coma is most likely severe head injury, which damaged brain cells. ”
"Therefore, through the means of neural stem cell transplantation, the damaged brain cells can be replenished to the greatest extent, so that the brain function can be restored, so as to awaken the sleeping consciousness."
Zhao Heng said very seriously.
Obviously, he was prepared, and he was well prepared.
"Well, and neural stem cells can also be transplanted by arteriovenous injection, so that there is no damage to brain tissue at all, and there is no effect on brainstem aneurysms in the patient's body, which is very worth a try."
Gao Jun nodded again and again, it was obvious that Zhao Heng's idea was a big breakthrough for Sun Xinxin's treatment, which had been stagnant at present.
Young people, just dare to think and dare to do!
Thinking of this, Gao Jun couldn't help but glance at Zhao Heng with great satisfaction.
The best thing about this plan that Zhao Heng thinks of is that there is no need to make a big move, as long as the cerebral crest fluid is extracted through spinal puncture, and neural stem cells can be extracted from it, which can be differentiated and cultivated, and then injected into the patient's body again, which is fine.
"The Mayo Clinic has actually proposed the latest treatment plan, that is, deep brain stimulation, which is a wake-up treatment that Mayo has been enthusiastically researching."
After a pause, Gao Jun said again.
"Sun Xinxin's family didn't agree?"
Zhao Heng asked with some confusion.
"Of course I don't agree, according to our doctors over there, Mayo internally believes that the success rate of deep EEG stimulation is less than 30 percent, but it bears the risk of permanent damage to brain function due to EEG stimulation."
Gao Jun said slowly.
"This is really the thinking of Lao Mei, simple and rude."
Zhao Heng said noncommittally.
To put it bluntly, deep EEG stimulation for patients in long-term coma and electrical defibrillation for patients with cardiac arrest are a mechanism.
If your heart doesn't beat, I'll call you, and if your brain is inactive, I'll give you a call.
For patients who are functioning normally and do not have serious brain damage, this treatment may be a try.
But Sun Xinxin's situation is obviously different, she not only has a very serious head injury, but also has an aneurysm in the brain stem, this "electricity", the effect is unknown, but the complications and sequelae are serious.
This is the difference in the clinical thinking of doctors on both sides.