Ten o'clock in the morning.

Zhao Heng was sitting in the office, the anesthesia assistant project had been officially signed, and Zhao Heng had to come up with the first phase of clinical data and related drugs and disease digital models within a month, so the time was still quite tight.

Therefore, Zhao Heng must seize every free minute of his free time to complete the digital model of drugs and related diseases, although every day is very busy, and there is almost no time to rest, but Zhao Heng still prefers this feeling of fulfillment.

This feeling of striving to achieve one's own goals is quite addictive, to be honest.

At this time, Tian Zhen walked in and said to Zhao Heng: "Doctor Zhao, there is a patient transferred from the hospital below, and the emergency department said that they can't handle it there, so they have to be sent here." ”

"Can't handle it? What kind of patient is it? ”

Hearing Tian Zhen say this, Zhao Heng was a little puzzled, the patients sent to the emergency department before were all sent over there because they were too busy, and it was the first time that a patient who could not be handled was sent over.

"It's like a skin disease."

Tian Zhen said.

"Skin disease? If you have a skin disease, don't you receive treatment from the dermatology department? ”

Zhao Heng felt even more puzzled, what did this skin disease patient do when he was sent to him?

Although Zhao Heng is now known for being good at dealing with incurable diseases in the current East Hospital, and has been recognized by almost all medical staff, it is indeed the first time that the emergency department and dermatology department like this cannot be handled, and he is sent directly.

"The dermatologists said they couldn't handle it either."

Tian Zhen said again.

"Well, let's go check it out."

Zhao Heng stood up and walked out of the office with Tian Zhen.

When he came to the ward, Zhao Heng saw a middle-aged man in a wheelchair, and a middle-aged woman standing behind him.

It doesn't matter if you send it?

Zhao Heng was even more puzzled in his heart.

Getting a little closer, Zhao Heng saw the middle-aged man's legs at a glance, and immediately gasped.

Hiss~

It can be said that Zhao Heng has never seen such a terrifying scene.

Because Zhao Heng saw that the middle-aged man's legs and feet were covered by bark-like "branches", the skin was obviously cracked, and gray-black pus flowed out between the cracks.

This kind of scene, Zhao Heng can say that he has never seen it before, although Zhao Heng has also seen the legs of patients with elephantiasis swelling before, but it is definitely not what this middle-aged man looks like now.

No wonder the emergency department and dermatology department don't admit it, it's already this terrifying-looking look, no matter what the doctor is, he will basically conclude that there is no cure.

"Doctor."

Seeing Zhao Heng coming, the middle-aged man said hello in a very vicissitudes of life, and then looked at his appearance, his face was also full of sorrow and despair.

However, there was still a glimmer of hope in his expression, and this glimmer of hope was probably to hope that Zhao Heng would be able to treat him. He had been to many hospitals before, but none of them had admitted him, even if he came to the rumored Oriental Hospital, the doctors in the two departments all politely refused to admit him, and told him that the last hope was in this ward.

If the doctors in this ward don't accept him, then he will hardly have the East to go to the doctor.

"How long have you been in this situation?"

Zhao Heng froze and asked first.

Even if it looks like a terrifying patient, Zhao Heng must be admitted, in terms of treating incurable diseases, after picking up and fusing the experience of almost all the most powerful doctors in the Oriental Hospital, Zhao Heng said second, no one will dare to call it first.

So he knew that if he didn't admit this patient, then the patient might indeed have nowhere to go to the doctor.

In fact, it is not uncommon for patients like this to be treated by doctors, the human body is too complex, and many diseases, whether it is the pathogenesis or the treatment method, almost have no clue.

"Doctor, it's been thirty years."

The middle-aged man's sad face wrinkled into a ball and said slowly.

"Have you been to any other hospital? Have you been treated? ”

Zhao Heng asked again.

"Doctor, I've had seven surgeries, and this time it's relapsed, but I can't find a hospital or doctor to do the surgery."

The middle-aged man spoke very calmly, as if he was not talking about himself, which showed that there was almost no hope in his heart.

"Seven surgeries? What did the previous doctor say? ”

Zhao Heng frowned and asked.

Some diseases are relatively easy to complicate, but at most they are only the second or third surgery, and more than four surgeries are required, which is extremely painful for the patient.

Every operation, no matter how big or small, is very damaging and depleting to the human body, let alone seven surgeries.

However, looking at the situation of this middle-aged man, perhaps because the seven surgeries were performed on both legs, this middle-aged man does not look like he has run out of oil.

"They all say that I have epidermal dysplasia."

The middle-aged man said.

"It's verrucous epidermal dysplasia, right?"

Zhao Heng thought for a while and said.

Verrucous epidermal dysplasia, (EV/Epidermodyspsia Verruis), also known as tree-man disease.

It is an extremely rare inherited skin condition that causes a high prevalence of skin cancer and is extremely prone to recurrence.

For this rare hereditary skin disease, according to the available examination data, there is a common denominator in the patient, that is, human papillomavirus (HPV) infection, and studies have shown that the incidence of EV is usually associated with HPV virus types 5 and 8.

And, most importantly, genes play a more important role in the pathogenesis of EVs than viral infections.

Studies have shown that the EVER1/EVER2 gene complex on human chromosome 17 can limit the entry of viral proteins into zinc storage areas in cells, thereby limiting the growth of the virus.

However, one of the genes of EVER1 or EVER2 on chromosome 17 of patients with EV will be mutated in PH, causing it to be inactivated, so it cannot inhibit the HPV virus accordingly, resulting in dominant infection.

It is the superposition of viral infection and genetic mutation that ultimately leads to the onset of EV.

Having said all this, I think the intelligent reader can already conclude that in order to completely cure EV, that is, verrucous epidermal dysplasia, it is necessary to start at the genetic level.

In other words, repeated surgeries to remove dendritic growths in the patient's epidermis like weeding and branch reduction are completely palliative, not curative.

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