In the blink of an eye, it was the fifth year of Xiyuan, Liu Zhi's worries did not come true, although the country also had many small problems this year, but in general it was thriving.

With the advent of spring, merchants from all walks of life gathered in Luoyang, bringing infinite vitality to this bustling metropolis.

On the street now, you can casually meet a few blonde and blue-eyed people from the Western Regions, and everyone is used to it, and they are not surprised to see it.

Merchants from all over the country also flocked to Luoyang, setting up shops in Dongshi and Li Lane, making these places more lively than ever.

Especially in the lanes, they used to be some destitute families, and later when Zhao Jie rebelled, due to the critical situation at that time, he used the poor people and gangsters there to make up the numbers and scare off the mutinous Henan Yin.

Later, Liu Zhi fulfilled his promise and recruited them all into the official establishment of the forbidden army and the city gate guards, and with their salaries, many families began to be well-off.

The snowstorm the year before last, the alley was almost reduced to ruins, and Liu Zhi simply carried out planning and construction, making it gradually prosperous.

In the past two years, various industries in the capital have flourished unprecedentedly, and there is a shortage of people everywhere, and the residents of the alleys have basically found jobs as long as they have labor.

Liu Zhi has two considerations for setting up a trade zone in Lixiang, because it is a newly renovated community, with spacious places and complete supporting facilities, which is more convenient.

Moreover, it is to develop the economy of the alley and make this former slum completely rid of poverty.

As the land trade became more and more frequent, Liu Zhi instructed the Da Yue clan and Da Wan to buy a large amount of grain from Tianzhu and Shen Poison to solve the problem of military rations on the border.

Due to the mild climate and high grain production, Tianzhu and Shenfu have a large amount of grain backlogged in the warehouse.

In addition, the trade between the two sides is very unequal, and the goods of the Han are very popular here, but there are very few things that need to be purchased except for jewelry.

With the grain trade, the trade deficit was immediately resolved, and everyone was happy.

This move has also greatly eased the pressure on the grain-producing areas of the Central Plains, which can calmly develop domestic agricultural production.

It's just that due to transportation troubles, the trafficking of bulk goods is very difficult, and Liu Zhizhi plans to wait for the opening of the Maritime Silk Road to solve this problem.

Deng Yan has been in the South Seas for a year, and according to the news he came back, he encountered a hurricane on the way, and after losing a building ship, he finally arrived at his destination, the Strait of Malacca.

During the Eastern Han Dynasty, Myanmar was still within the sphere of influence of the Dian Kingdom, while Thailand had not yet formed a unified country, among which the Shan State in the north was the most powerful, and during the period of Emperor Shun of the Han Dynasty, envoys were sent to meet the emperor three times.

As for Malaysia, it was called the Golden Peninsula by the ancient Indians who first came here to do business, and the Eastern Han Dynasty also upheld this name.

There are many small countries on the Golden Peninsula, such as Langya Xiu, Jiecha, Dandan, etc., and the Strait of Malacca, which Liu Zhi has in mind, is called Ivory Bay because of its abundance of ivory.

Even if only two ships arrived on the coast, it still shocked the local aborigines, who had also heard of the wealth and power of the land of heaven and Han, but what Deng Yan brought was still unexpected.

Because he came with a mission, Deng Yan simply stopped at the beach, first figured out the local situation, and then slowly figured it out.

The three ships combined had more than five hundred people, and although one ship was lost, people were saved.

Except for some professional guides and sailors, most of the rest were recruited from the navy, and they themselves had strong combat capabilities.

Coupled with the fact that the weapons are many times more advanced than the natives, there should be no problem if you take the strategy of attacking them one by one.

But Deng Yan did not want to adopt such a bloody model, nor did he want to forcibly conquer with wanton killing, and there was no colonial consciousness in the cultural thinking of the Han people.

Therefore, Deng Yan's intention was to turn them into vassal states of the Han Dynasty.

After learning about the Golden Peninsula, Deng Yan set his sights on Indonesia on the other side of the strait, where most of the place was still a tribal society.

There was only one slave country called Ye Tiao, and they were closely related to the ancient Indians who came to do business, and even the social system was copied.

So Deng Yan decided to change his strategy, conquer the other side first, first he circled some no-man's land in Indonesia and reclaimed it as his base.

Then, by hiring and buying off neighboring tribesmen, the territory was gradually and quietly expanded.

Of course, when encountering a particularly disobedient tribe, he will still teach a lesson by force, so in less than half a year, when Ye Tiaoguo came to his senses, Deng Yan's territory was already on par with him.

The Tianzhu businessman, who had controlled Ye Tiaoguo for a long time, was naturally unwilling to give up his interests, and Deng Yan sent a local spy who was bribed to instigate him repeatedly.

As a result, Ye Tiaoren, who couldn't hold back, actually launched an attack brazenly without his strength, which was exactly in Deng Yan's arms.

So a grand battle of defense began, and he deliberately hid the true force value, which finally made King Ye Tiao regret his mistake.

And those wealthy merchants in Tianzhu, whom he regarded as his backers, turned their heads and became good people, and actually took the lead in selling him in exchange for the qualification to continue to do business with them.

Businessmen are very profitable, especially these Tianzhu people who have no faith in themselves, and they have no affection at all.

King Ye Tiao suffered a great loss and regretted it too late, but Deng Yan did not kill him, but appointed him as the governor of the entire island, officially becoming the jurisdiction of the Han Dynasty overseas.

The residents of the Golden Peninsula saw a series of changes on the other side, and they were shocked by Deng Yan's strength and began to want to have a good relationship with him.

Surprisingly, Deng Yan did not take the opportunity to cross the sea and destroy these three countries, but began to seriously manage Ye Diaoguo.

The former king Star was the governor, and Deng Yan appointed himself as the local general to protect the sea, firmly grasped the military power, and appointed his subordinates Li He, Zhong De and others as administrative officials.

A group of former tribal leaders were selected and brought to power, balancing the power of all parties, and reforming the local system.

Most of the slaves were freed as commoners, and the official system was changed to the Han system, because there was no unified local language, Deng Yan took the opportunity to open a school and implement the official dialect, that is, Luoyang dialect.

This is his old profession, very good at it, and there is no official writing and language in the local area, which also gives him an opportunity.

A place, as long as they change their thinking culturally and have the same ancestry, they will completely identify with the suzerainty of the Han Dynasty.

So he was not in a hurry at all, and stayed for a long time to work steadily, while developing the economy of Ye Diao, while imparting cultural thoughts.

As for the Yellow Turban Peninsula on the other side, it also began to infiltrate economically and culturally, so that they were shocked by the majesty and majesty of the Han Dynasty, and they were also envious of the wealth and benevolence of the Han Dynasty.

In his letter to Liu Zhi, he described his plans in detail, and in the port of Guangzhou, the construction of new ships is being intensified, and it will be built into an ocean-going fleet in the future.

With Ivory Bay as a transit port, it sails to the world.

The time came to the summer of the fifth year of the Xiyuan Dynasty, and the five states of the Central Plains suddenly began a large-scale drought, but due to the construction of many water conservancy projects in recent years, a number of water trucks were prepared.

Therefore, although the drought is very serious, it can barely be maintained under the unified deployment of all localities.

However, the high temperature caused by drought has caused the temperature to continue to rise, and in ancient times, there was neither air conditioning nor electric fans, and water became precious in drought conditions.

The drought began in mid-June, and by mid-July, there were many acute deaths caused by heat stroke in various places.

At the beginning, the people who died were mainly old, weak, sick and disabled, and this was normal under such a heat wave, so it did not attract much attention.

As soon as the weather improves, the situation will improve as soon as the temperature drops.

At the end of August, the weather suddenly began to change, not only rain, but also hail, sometimes accompanied by tornadoes, and the weather was very strange.

In many places, the temperature dropped from 44 or 5 degrees Celsius to a few degrees, and the temperature difference was appalling.

Such extreme weather seems to have returned to a few years ago, and it was recorded during the reign of Emperor Chong: when it is warm and cold, when it is cold and hot, when it is warm in summer and hail in winter, yin and yang are out of balance, and heaven and earth are out of harmony.

After a long period of drought, devastated by such a harsh climate, agricultural products in many places have failed.

And because of the sudden cold and hot weather, a large number of people were unable to adapt, and then fell ill and died.

Liu Zhi was worried about this, and while asking the national teacher Zhang Daoling to open the altar and pray for the blessings of the Han people, he fasted and apologized.

At the same time, the uneasiness in his heart became more and more serious, so he specially asked the imperial doctor to make Dou Yun talk in detail.

It is no wonder that he is so worried, according to records, since the "Xia and April Huiji Great Plague" in the sixth year of Emperor Han An, almost every few years, there will be a large or small plague.

There were three major plagues during the Andi period, and two major plagues also broke out during the Shun period, the most recent of which was after he ascended the throne, that is, in the winter of the third year of Jianhe.

When a plague broke out in Hedong County, Sili Prefecture, it was reported that the situation was very miserable, and it was said that more than half of the villages had died.

The dead are pillowing each other, and the counties and counties are strange, and there are them everywhere.

Due to the proximity to the Beijing Division, it also caused a collective panic, but fortunately, after the isolation, it did not spread and was suppressed.

Since then, Liu Zhi has been very worried, and deliberately asked Dou Yun to strengthen his research in this area, and be sure to find a set of effective treatment options.

Now that three years have passed, he is worried that history will repeat itself, so he urgently summoned Dou Yun to ask about the treatment plan for the plague, what happened.

"Back to Your Majesty, the minister has made some progress, but the effect still needs to be tested to know."

It is impossible to figure out the source of the great plague that has been going on since the end of the Han Dynasty, and some suspect that it is due to the epidemic caused by the changing climate.

But there is also a theory that when the Xiongnu were defeated, in order to retaliate and curse the Han army, they dispatched a shaman archmage.

According to the record, a Xiongnu captive once said: "When the Han army came, the Xiongnu made the witch bury the sheep and cattle out of the road and water to curse the army." ”

That is to say, bury the cattle and sheep that died of the plague in the water source where the Han army passed.

In the eyes of the Huns, this is a curse launched by a sorcerer with filth and evil things such as sick and dead cattle and sheep, but the real lethality of this behavior is obviously a virus.

At that time, people called it "typhoid fever", so the famous doctor of the Three Kingdoms, the medical saint Zhang Zhongjing, wrote a special explanation of this disease.

The main symptom of this disease is that patients often have high fever and wheezing, and death from exhaustion, and some patients also have blood spots and bruises, which is acute and violent, and the mortality rate is very high.

Obviously, this is not what we call "typhoid fever" today, so modern medical experts believe that it is most likely epidemic hemorrhagic fever, a virulent infectious disease with a mortality rate of more than 50%.

For more than 100 years from the end of the Han Dynasty to the Three Kingdoms, this plague has been lurking in the Central Plains and has never been extinct, breaking out every few years.

Historically, there were also three major outbreaks during the reign of Emperor Huan of the Han Dynasty, and more frequent during the reign of Emperor Ling, with incidents occurring once in about two or three years.

The interweaving of plague, famine, and war, coupled with the weakening of imperial power at the end of the Han Dynasty, the interference of foreign relatives, the dictatorship of eunuchs, and the expansion of local military and political officials, caused the collapse of the ruling order of the Han Empire and the paralysis of the state apparalyz.

In his poems, Cao Cao once described the tragic situation after the plague: the white bones were exposed in the wild, and there was no rooster crowing for thousands of miles. The people are one in a hundred, and the thoughts are overwhelming.

During the reign of Emperor Ling of the Han Dynasty, there were four consecutive outbreaks of large-scale plagues in 171, 173, 179, and 182.

The three brothers Zhang Jiao, Zhang Liang, and Zhang Bao were the monks who used Fu Shui to treat the people, and the Great Plague also directly gave birth to the Yellow Turban Uprising.

Therefore, the collapse of the regime at the end of the Han Dynasty, in addition to the reasons of the empire itself, the pandemic of plague is also one of the main reasons.

It has directly led to a sharp decline in the population and the lack of livelihood for the people.

Thinking of this, Liu Zhi shuddered, although his arrival has changed a lot, making the country become rich and powerful step by step.

But in the face of natural and man-made disasters, his strength is still so small, and in the face of the menacing plague, there is nothing he can do.

"I'm worried that the weather is abnormal, and the plague from before will rear-head again, Doctor Dou Ling thinks it's okay?"

Looking at the worried emperor, Dou Yun's mood was also very heavy.

"Chen has specially studied the previous epidemics, and indeed found that every epidemic is related to the weather, so this outbreak is also very likely."

Not to mention ancient times, even now, medicine is highly developed, and the plague is like a rush and a lot of losses.

Therefore, it is also important to be able to predict in time, after all, prevention is much easier than cure.

"I have read the reports in the past few days, and I feel that the number of victims in Jiujiang County, Yangzhou is too high, and the symptoms are strange, and I suspect that there is already an epidemic there."

Dou Yun frowned and stood up, "Please bring someone to Yangzhou immediately, it is bound to reduce the plague to the lowest range." ”

Liu Zhi nodded, now the only one with the most exquisite medical skills in the Manda Han is Dou Yun, although he knows that it is very dangerous, but except for him, no one can afford this heavy responsibility.

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