In the hometown of otherworldly souls, it generally takes many steps for new drugs to be launched.

Experimenters need to identify a drug target from a wide range of options and then look for compounds that can act on that target, either from long-term research and development or from an otherwise unrelated experiment.

After the development of the difficult or European emperor, the experimenter proves that the drug can indeed solve the disease at the cellular level and in animal experiments, and does not solve the patient at the same time, and after a lot of lengthy but necessary ethical approvals, it may be able to enter clinical trials, from experimental animals to humans.

In the early days of brutal development, when security awareness and conditions were not so sufficient, developers would occasionally replace themselves. Of course, this is not recommended.

After approval, the drug enters the well-known phase III clinical stage. The pharmacokinetics of the first phase of the test drug in the human body, and the clear safe dose; In the second stage, the efficacy and safety of the drug were preliminarily evaluated, which provided a reference for subsequent trials.

In the third phase, the trial will be expanded to further validate efficacy and safety through large, double-blind randomized controlled trials. It needs to be carried out by multiple medical centers under the strict supervision of doctors.

Only a lucky few will be able to complete these steps in the past few years, and finally be approved for production and marketing, either as a savior for the benefit of the patient, or as a disaster for the fish that slips through the net.

Although there will always be fish that slip through the net in various senses on longer time scales, it is still an important line of defense to ensure the safety of life.

And in the current North, the situation is much simpler.

As long as a person who claims to be a doctor comes up with a new drug through research and development methods including but not limited to personal reflection, literature research, pharmacological derivation, what to eat and what to supplement, and dreams of gods, then he can announce the good news to his colleagues in the industry, relatives and friends, and ignorant patients on the same day.

The drug then enters markets of different sizes and is applied to different groups of people, depending on its personal impact.

The effects and consequences of drugs, as well as the social problems that come with them, are up to doctors and patients.

Digitalis is a drug whose toxic dose is close to the effective dose, and it is a drug that needs to be used with diagnostic ability, and it is different from ether, which is pure and natural, and almost no threshold is required to prepare.

At present, most doctors who are similar to David's level will only see edema and prescribe medicine, but in addition to heart failure, which can show edema, there are also nephrogenic edema, nutritional edema, allergies and inflammation can also cause edema.

In the case of thinking that the drug should be effective, but in fact it is ineffective, taking David as an example, his first reaction will definitely not be a misdiagnosis, but will increase the dosage.

If they dare to announce the ingredients today, they will be able to create a large number of digitalis poisoning cases the next day. At that time, instead of thinking about how to treat it, it is better to go directly to the priest to study medieval hospice, which is more cost-effective and has fewer doctor-patient conflicts.

For the sake of others, Kraft thinks that it should be tried on a small scale first, and then launched in conjunction with the diagnostic criteria for heart failure.

As a result, only a few cases of gossip came out of the small number of patients that there was some kind of special drug for edema in that particular clinic, which was nothing compared to the "treatment of tuberculosis" and did not attract much attention.

Green lifted his forehead, which had been pressed red by the folds of his sleeves, and found that the light of the candles on the candlestick was already faint, and the flames were falling along the serpentine-twisted black line, about to sink into the clumps of molten wax.

There are a few paperwork on the table, which have just been delivered today. An account of the month's expenses, bereavements for the martyrs, daily reports, and official letters from the bishopric.

He didn't seem to have all of it before he fell asleep.

He had already read the last one, which had been given to him by his immediate supervisor himself, and his attitude had changed subtly from before, saying that the matter was over, and suggesting that he take a few days off before committing to other matters.

A few days have passed, and the bishopric has unexpectedly but justifiably failed to impose substantial punishment for the casualties, merely giving written reprimands, forbidding participants from talking about relevant topics, limiting their range of action for two weeks, and going to the small prayer hall at regular intervals every day to reflect under the watchful eye of the Father.

It's not so much punishment as appeasement.

Looking at this trend, things are really ready to pass like this, undisturbed in the tributaries of time, far behind, just like those that happened in the past.

From a personal point of view, it is inevitable to feel a little unwilling, but rationally speaking, Kraft's attitude is very right, and it is the best way to deal with it by letting those things continue to be buried deep in the ground and never touched again.

And he himself now needs to clean up the matter, arrange the bereavement work, explain to the family of the deceased that they have dedicated themselves to the Father, and go to the United States first.

Every time he said this, he felt very awkward, and his thoughts repeatedly reflected on those who believed in the path of "ending all suffering", and the smile that melted on his face.

"The paranoid pursuit of metaphysical concepts, and the expectation of a supreme external force to intervene to achieve it" This experience generated a deeper feeling in his mind, which he felt should be recorded, "There is never something that does not end in tragedy." ”

Except for a few documents on the table, there was no extra paper for a while, and I couldn't even find a bookmark.

"Vardy, can you get me some more paper?" Green shouted out the door, continuing to open the monk's report. It had just been delivered by Wadin, who was still outside helping to sort out the rest of the paperwork.

Since the clinic attack, the heretics have not organized any activity that can be noticed, and presumably their main members, as Craft judged, will never return after entering the other world, and will naturally lead to self-destruction without much attention.

However, the guards around the clinic have not all been removed, and some of this report was sent by them, and there are no new discoveries, and the main content is only one thing.

[A professor recently started using a new drug, which is said to have a significant effect]

Green put his cold hands on his face, trying to wake up his mind, which was not yet fully awake. How could it be such a coincidence that a new drug was developed just a few days after returning with the sample?

No, you have to check it out.

"Vardy, can you come over for a moment?" The priest read two sentences, all anecdotes and invalid information collected from the patient, and someone had to go and see them.

"Vadine.?"

Green pushed his chair away and looked at the half-open door, calling for Vardin for the second time. A strange sensation rose, as if a stone had been thrown into the pool, failing to set off normal ripples, not even the sound of falling water.

Maybe he didn't want to bother and left early?

“.” A voice, a muffled voice.

Before I could tell where it was, it vanished, evaporating like a mist, as if it had never existed. It's not Wattin, the timbre is very young, like a child who has not yet reached the stage of voice change.

"Who? Still out there so late? "There were children in the church, but they were all in the choir, they had a fixed quarter, they were strictly disciplined, and they rarely wandered anywhere else.

If he gets lost, then he'd better send someone back as soon as possible, otherwise this little guy will be lightly reprimanded.

Taking a step towards the door, the strangeness became more obvious, and transformed into a sense of disobedience that could not be ignored, and Vardine should not leave without taking it with him.

“.” Breath-like air seeped out of the cracks in the tiles, old, shriveled, and whipped into the pinna.

Fear makes the heart tighten, the spirit tenses, and the subconscious exerts force. However, the floor was empty, the floor shattered and pulled away, and everything around it was speeding away, galloping into the endless thick darkness, and the weightlessness made the body tremble instinctively.

The fall lasted only a moment, and a feeling of support appeared under the overlapping arms.

Green looked up, the stinging pain of the folds of his sleeves remaining on his forehead, and the candle flame flickered in front of his sleepy eyes. The dripping drips blew into the room with the night breeze, wetting the papers on the table and falling on the face.

It's raining outside.

(End of chapter)

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