Can't keep it a secret?

Qing Yun didn't care about this question at all.

All he wants is no secrecy.

Patting them on the shoulder, he smiled wryly, "You just have to do it." If others see it, you are not to blame. ”

Liu Shiheng was dumbfounded when he heard this, he felt that his brain CPU was going to burn.

Bai Le over there figured out a little bit of taste.

But he wasn't sure if it was a business or a private matter.

Qingyun, who saw Liu Shiheng's small expression, smiled but didn't say a word, and glanced at Bai Le, who had a slight understanding over there, "What do you think?" ”

Bai Le pondered for a moment when he heard this, "Mr. Xiaoqing, you must have said this on purpose, and you wanted to leak the news through the mouths of this group of people." ”

Qingyun nodded, "Smart, how do you think it should be arranged?" ”

Bai Le didn't rush to answer, he thought about it carefully, and then said, "Mr. Xiaoqing, it is better to say that it is the internal audit of the group, which can not only arrange the office justifiably, but also allow you to have a certain amount of exposure." ”

Qingyun bowed slightly in satisfaction, "Okay!" Then you go and arrange it, I'll go upstairs in 20 minutes. ”

Bai Le's arrangement, while conforming to convention, is not in line with common sense.

But, this ...... That's exactly what he wanted to achieve.

……

Yanhuang Group's Yanjing Branch on Saturday morning was actually very leisurely.

The branch is naturally not as functional as the subsidiary, and it is newly built, mainly for sales.

In fact, if there is no business, it is okay not to go to work on weekends.

But there are no holidays, and employees can't find fault with it, doing sales, and also doing sales in the consumer goods market, where will there be the concept of weekends?

The branch has just been established, and it is the stage of erecting rules, and they are not newcomers in the workplace, and they will not find uncomfortable bumping into the muzzle.

Paid fishing, this kind of thing is actually very pleasant.

Everyone is tacitly 'busy'.

It's not that it's completely nothing, there are not a lot of things that a company should organize, file, and post invoices, and it's okay to do it on weekends to pass the time.

And there are interns here, and weekends are the best time to command these college students.

However, today, the quiet years of the Yanjing branch were suddenly broken.

After Liu Shiheng, the company's boss, came back from a trip downstairs, he hurriedly announced in the office that the internal audit department of the group company would enter the venue in 20 minutes, so that everyone could move.

Inspection, this is a big deal in all companies.

Whether it is an agency or an enterprise, a state-owned enterprise or a private enterprise, even foreign enterprises cannot run away.

This is the most important thing for foreign subsidiaries throughout the year, and there is no one.

No matter how well you do it, except for the mistakes, it is equivalent to a year of waste.

The group of new employees in the Yanjing branch, although they were strange in their hearts, did not check the fart business with a hammer, but they also knew that this kind of inspection was very random, maybe others took advantage of the new establishment to check what start-up expenses, expense reimbursement, and daily style.

Everyone in the office suddenly became busy, which made Zhang Li look a little confused.

Frankly speaking, the office atmosphere in the company just now is very similar to the appearance of her parents in the government unit when she was a child.

She just had a little bit of that kind of daily office experience, and this sudden change caught her off guard.

Liu Shiheng, who was standing in the middle of the big office, saw this, patted his head, and quickly explained loudly, "Xiao Zhang, you are responsible for receiving the internal audit with the General Department, your brain is smart, and your mouth is dessert, you have nothing to buy drinks and fruits these days and send them over, look for your Sister Liu to report, remember to issue an invoice." ”

After that, Liu Shiheng instructed the other people how to place the green plants, collect the sundries in the aisle to the warehouse, and beckon people to buy cigarettes, set ashtrays, make tea, etc., making a mess busy.

Everyone had no doubts about arranging for Zhang Li to receive the internal audit.

The beautiful little girl is engaged in reception, which is pleasing to the eye.

It's not that there's anything unsightly in it, it's an image engineering, a cabin crew major, and the most beautiful graduates with the best temperament, who have never been in airlines, but in large companies, this is still the atmosphere brought up by Hua Wei.

But Zhang Li herself has doubts.

Let her do the reception?

Is this appropriate?

This Mr. Liu is not afraid of being gagged by the big bad guy?

In last night's exchange, she already knew very well how perverted the possessiveness of that bad guy was, so her clothes and dresses today were very conservative, and she could even be said to be old-fashioned.

After thinking about it, Zhang Li could only shrug her shoulders helplessly, turn her head and do what Liu Shiheng instructed.

After all, in the eyes of others, she is just a sales intern, which is also what Qingyun and her have clearly said.

Although he didn't know what he would do to him, Zhang Li knew very well that Qingyun couldn't treat her harshly.

The kiss of skin in the car last night, Qingyun's brake at the last moment, although it was a pity in Zhang Li's opinion, also represented his respect for her.

If she was just playing with her, she wouldn't have to go back to her bedroom last night.

So, she still has confidence in this, he wants to last a long time, and she is the same.

At this moment, the grievance point is the grievance point, anyway, don't let people take advantage of it, and finally he knew that it was Liu Shiheng who died, what does it have to do with her?

20 minutes is not short, but it is not long, and soon the time is up, the office has a new look, the windows in the small conference room are relatively clear, and the drinks and fruit plates urgently purchased on the conference table are also in place.

Qingyun, who had sunglasses on the bridge of his nose, went upstairs with someone pinching it, and Liu Shiheng took someone to pick up at the elevator door.

Zhang Li, who was standing in the crowd, rolled her eyes, but the corners of her mouth involuntarily curled.

I see.

He must be thinking of me too, right?

Zhang Li, who was slightly blushing, held back a smile and listened to the greetings in front of her.

Qingyun ...... Oh no, at this time his name is Qin Yan, the senior project manager of the internal audit department of Yanhuang Group.

Zhang Li took a bite of a little liar in her heart, but her heart was sweet.

Husband and wife means husband and wife.

Dead scumbag!

It's really flirtatious!

After giving him a vague look of 'sister likes it very much', Zhang Li obeyed Liu Shiheng's instructions, like a lady of etiquette, and guided Qingyun and his party to the small conference room in a generous manner.

Subsequently, there was a closed-door meeting, and in the Yanjing branch, only Liu Shiheng, the vice president who presided over the daily work, and Bai Le, the sales supervisor, participated, and even Zhang Li was invited out by Yang Bingnan.

Knowing that men have something serious to talk about, Zhang Li is not hypocritical, but when the door is closed, the peach blossom eyes are gently Wink.

Emperor Yun, who was wearing sunglasses, suddenly shook his heart.

I have to say that Zhang Li is professional in expression and demeanor, and the appearance of this emperor makes his heart scratch like a cat scratching a dog.

The widow has a disease and needs medicine, mainly because he is too ......

Itchy!

Why don't you copy this song out another day, form a girl group with your own women, and sing it to yourself?

Shaking his head, Qingyun drove out the thoughts in his head, and hurried to get down to business.

Since Jiryu thinks that he himself is a whetstone, then he is not welcome.

Although I still can't do anything with Zhiliu now, Qingyun feels that it is the obligation of our generation of young people to let the elderly move their brains more and avoid Alzheimer's disease.

Liu Shiheng on the opposite side was making a formal work report, and Qingyun interrupted him after listening to it for a while, and began to ask and answer.

There is no business, just established is a matter of establishing rules and regulations, these Dongdong, the group company has a template, it is nothing more than to catch the medicine according to the order, many things need to be run up, and the problem will come out.

At this moment, the main problem of Yanjing Branch, in addition to business, is personnel.

The team is unstable, seeing that there is no business to do, and within a month of joining, the staff has lost 20%, which is actually very scary.

In ancient times, a casualty rate of more than 10% would cause the army to collapse, and the same is true in modern companies, and a turnover rate of more than 10% will cause the company to be demoralized.

This situation made the hair on Liu Shiheng's head visibly decrease during this time, and he naturally complained bitterly in front of the chairman at this time.

Children who can make trouble have milk to eat, and it is the same wherever they are placed.

Qingyun listened, his fingers tapped rhythmically on the table, and after half a ring, he made a phone call.

Liu Shiheng and Bai Le over there were smiling happily as they listened.

People are idle for a long time, but they are actually looking forward to something.

But listen, listen, they don't understand again.

What the hell is this......

Qingyun, who hung up the phone, pointed to Liu Shiheng and Bai Le's computers on the table, "Plan, Mr. Guo sent it to your mailbox, and the demonstration prototype will be in place on September 15th. ”

Bai Le swallowed a mouthful of saliva with difficulty, then licked his lips, hesitated for a long time and then opened his mouth, "Mr. Xiaoqing, I understand your intentions, but at present, our problem is that the people in our hands now, we don't know who the mole is, this kind of thing, we can't keep it a secret."

And ......"

He gritted his teeth and continued, "What's even more difficult is that today on the 11th, to the 15th, it will only take 4 days to get full, and I can't organize a new team." ”

……

"Judging from the plan discussed by Fudan and Fuhua and the health department, the consistency evaluation of generic drugs is completed through bioequivalence testing."

In the conference room of Fantasy Group, Zhao Linhuan, one of the five young marshals and responsible for the investment of the pharmaceutical sector, is reporting to Zhiliu and other members of the executive committee of the group's highest decision-making body.

"At present, the news we have received is that the specific operation method of Fudan Fuhua is to recruit a group of healthy volunteers, the number of which is initially estimated to be about 200 people, divided into two groups, and successively cross-take generic drugs and original drugs, that is, a group of volunteers take generic drugs first, and then take the original drugs after a period of time; Another group of volunteers took the original drug first, followed by a generic drug at intervals.

Whether it is bioequivalent is judged by comparing the maximum blood concentration Cmax of the drug with the AUC of the drug exposure in vivo after taking the generic drug and the original drug in healthy volunteers.

If the Cmax of the generic drug reaches 70-143% of the original drug, and the AUC of the generic drug reaches 80-120% of the original drug, it can be concluded that the generic drug is bioequivalent to the original drug and has substitutability. ”

Zhao Linhuan knew very well that a group of people at the conference table did not understand these specific terms and indicators at all, and after briefly introducing the operation methods of Fuhua, he directly talked about the points he was concerned about.

"In fact, these two indicators are not too high, and the drug concentration and exposure only meet the minimum standards of 70% and 80%, and they can pass the consistency evaluation.

So from this plan, we can see that the country is actually still open, and there is no requirement that these two indicators must reach more than 95%, which gives many manufacturers a chance to breathe and objectively reduces the difficulty. ”

Li Qin, the second master of the Fantasy Group, opened his mouth with a blank face, "Xiao Zhao, let me interject, see if I can understand it this way, the concentration of the drug is only 70% to meet the standard of the original drug, does it mean that the drug itself is ...... Impurities, inconsistent with the original drug? ”

Zhao Linhuan smiled and nodded, "Yes, Mr. Li, you understand correctly." ”

Li Qin hissed, with a puzzled expression, "Does that mean that this medicine ...... In fact, it is still ineffective, for example, it takes 80% of the volume to solve the problem, but the drug can only provide 70% of the volume, which does not meet the threshold of treatment. ”

Zhao Linhuan hurriedly explained, "No, no, no, it is completely different from the previous ineffectiveness, in the past, there may be very few active ingredients in the drug, or even none, but now the consistency, the minimum standard is to solve the problem, just to say, at the same dose, it is slower than the original drug, and the blood concentration can be solved by the intake of the drug dose." ”

He scratched his head and continued, "Let's just say that, like ...... Mycoplasma pneumonia infection, what children need is azithromycin dry suspension, a macrolide drug, a domestic generic drug, which actually doesn't work no matter how much you eat before.

Now, after passing the consistency evaluation, a total of 1000mg of azithromycin dry suspension is taken for three days with imported and standardized treatment, while 1500mg may be required for domestic treatment, which also solves the problem. ”

Zhiliu smiled and added next to him, "It's okay, as long as it can solve the problem, we have a phobia of insufficient firepower, so we like to be full." ”

In this regard, he understands a little, and he is concerned about economic accounts, and now it seems that the country does not mean to kill everything, and his heart that has been hanging is finally relaxed.

Generic drug consistency evaluation, this policy caught him off guard.

In the past, the investment in the fantasy medical sector was all small pharmaceutical companies, and the concept was the favorite 'small and fine' company in the capital market, and there was huge room for imagination after listing.

The consistency evaluation of generic drugs is hit by this kind of enterprise.

At first, what he was most worried about was that the state imposed a high standard of consistency evaluation, and after they counted the families of the invested companies one by one, they found that if they followed the 95% floor standard, none of the companies they invested in could survive.

Then, not only will the billions of dollars invested by Fantasy Group be wasted, but even the tens of billions of leveraged funds formed through the fund will be liquidated.

This is a matter of life and death for Zhiliu.

The comprador not only didn't make any money, but also lost the principal, and it was strange that the master behind him didn't want his life.

In the case that Yanhuang Group's merger and acquisition of TOP has become a fact, Zhiliu spent a lot of energy and contacts on dredging up relationships during this time, and now he is finally relieved, so he also started a joke.

There was a lot of laughter in the conference room.

The main thing is that everyone laughed when they saw Zhiliu, and they laughed too.

The air pressure of fantasy during this time is too low, and some laughter is needed, otherwise everyone will be out of breath.

The knowledgeable Zhao Linhuan laughed the most on the field.

There's no way, he's knowledgeable, if he doesn't laugh, then he's openly slapping Zhiliu in the face.

Zhao Linhuan felt that his head was not so hard.

So he didn't bother to explain more.

After the laughter was much quieter, Zhao Linhuan continued, "So back to the perspective of investment, the original intention of the state to do this is that through this action, it can enhance the public's confidence in domestic generic drugs, reduce the cost of public drugs, and promote the development of the pharmaceutical industry."

Therefore, the consistency evaluation of generic drugs, which aims to improve the quality of generic drugs in China, will definitely have a subversive impact on the pharmaceutical industry.

For domestic generic drug manufacturers, the consistency evaluation of generic drugs referred to as GCE is a matter of life and death.

According to statistics, the GCE cost of a single generic drug, including the cost of drug research and bioequivalence testing, ranges from 5 million yuan to 10 million yuan, regardless of the outcome. Once a generic fails GCE, the company will have nothing to gain. Some small businesses have had to quit the game because of this concern.

For economic reasons, even big pharma has chosen to abandon generic drugs that are not competitive in the market. It is foreseeable that the next few years will witness the disappearance of countless generic drugs.

For those who come out on top in this big game, they will be given better gear to compete with their branded rivals.

This is a long-term impact on the business of multinational pharmaceutical companies both domestically and abroad.

Theoretically, when the patent of a branded drug expires, any generic drug can enter the market at a more competitive price, thereby lowering the price of the original drug, leading to the so-called 'patent cliff' phenomenon.

In the Chinese market, the branded drugs produced by multinational pharmaceutical companies have hardly really experienced the patent cliff.

This is because the Chinese government has been giving preferential treatment to branded drugs that have been patented, with the aim of encouraging multinational pharmaceutical manufacturers to introduce more innovative drugs into China.

Nevertheless, it is believed that the rise of generic drugs in China will inevitably reduce the necessity of this historic policy and eventually make it history.

The country's ultimate goal is to maintain the affordability and effectiveness of medicines while maintaining innovation. In order to achieve this, it is essential to have both brand-name drugs and trustworthy generics.

In essence, the GCE is a step towards the future patent cliff in our country.

So I personally have a conclusion on this matter, the final result of the consistency evaluation is a major reshuffle of the industry, the concentration of the entire industry will be significantly gathered, and the players on the track will be greatly reduced.

The pharmaceutical industry is an industrialization process, and the increase in shipments will drive the production of all raw materials, packaging materials and upstream fine chemical products, and the process can be continuously optimized. For example, the excipient process, the API process, the quality and process of upstream fine chemical products, layer by layer, a product has passed the consistency evaluation, in fact, all products in the industrial chain can only be achieved if they meet the standards!

Eventually, the entire industrial chain will be upgraded.

Therefore, I strongly recommend that we need to increase our investment in the pharmaceutical sector to protect the ...... of our previous investments."

Guo Wei, who was sitting on the side, touched his chin and looked pained.

……

(End of chapter)