Chapter 193: A Great Repercussion from the Biology Community
Hearing this sudden call, Li Mu couldn't help but be stunned.
Cold Spring Harbor Laboratory?
He had heard the name of this laboratory because his sister Li Ruyu had told him a few times.
This is one of the most famous biological laboratories in the world, which studies the world's most difficult biological problems, such as nerves, and genes, and of course, the study of cancer is also the focus of this laboratory.
According to Li Ruyu, this laboratory is a place where the vast majority of biomedical researchers want to work, after all, the world's top experimental equipment alone can make countless researchers covetous, especially with financial support.
Of course, having said that, Li Mu is not a researcher in biomedicine, so the Cold Spring Harbor Laboratory is really not attractive to him.
But the question is - a Wolf Prize winner in medicine, a researcher at Cold Spring Harbor Laboratory, actually called him out of the blue and invited him to join Cold Spring Harbor Laboratory?
Li Mu was a little caught off guard.
"Uh...... Professor Kleiner, if you can call me, you should know that I'm a mathematician, and of course a physicist, or maybe a chemist, but I'm not a biologist or a medical scientist...... So, why did you invite me all of a sudden? ”
"Your papers have all been accepted by Cell, and the mathematical analysis in that paper is definitely the best of all the biomedical papers I have read, even if you are not a biomedical scientist, I am willing to call you a biomathematician." Adrian Kleiner said: "With your analytical skills, please believe that the cancer that has plagued mankind for so many years may indeed be solved in our hands!" When the time comes, we will easily win the Nobel Prize in Physiology and Medicine! ”
Of course – this is not just the Nobel Prize, it is an achievement that will go down in history! You ......"
Listening to Adrian's string of accolades that he would receive in the future, it was as if the problem of cancer could be solved immediately.
Li Mu couldn't help but think, this must be a skilled painter.
Especially very good at painting flatbread.
Listen to the other party's skillful pie painting skills, if you really change someone, maybe you will really be deceived.
But in fact, this kind of pie is really not a big pie for him.
At least for now, his name is indispensable in various new mathematics textbooks on number theory, as well as in quantum mechanics and physics.
Speaking of the new fundamental force of dimensional force, editors of physics textbooks all over the world have revised their textbooks overnight to add dimensional force.
As for the Nobel Prize or something......
One thing to say, as the chairman of the Save the String Theory organization, a large number of Nobel physicists in this organization have said that they will nominate him to the Nobel Prize Committee as a candidate for the Physics Prize.
Of course, not to mention the rescue of the String Theory Organization, the realization of which is now considered by the entire physics community to be worthy of the physics prize.
If it is found that the results of a fundamental force are not enough to win the Nobel Prize, then there is probably no achievement that can win the Nobel Prize.
Therefore, he has already become a candidate for the award, and he really doesn't care about the fact that he "maybe" become a Nobel Prize candidate.
What's more—if mathematical analysis is the key to solving cancer, then what do biologists do?
所以他打断了对方对画饼的激情:“好了,好了,克莱纳教授,你说得对,但癌症是由人体细胞变异而来,有着相当多不确定的因素在其中,数学上的分析只能提供一定的辅助作用,最终还是需要依靠生物医学家在临床试验上尝试解决。 ”
"No, no, no, trust me, we can make it!"
"I'm sorry, Professor Kleiner, but I don't have the idea of going in the direction of biology yet." Li Mu bluntly refused.
"If you think about it, it's a really cool direction!"
"I'm sorry, I have something else to do, so I'll say goodbye first."
Li Mu hung up the phone directly.
However, not long after hanging up, the other party called again.
"Mr. Li, this is cancer! It's really cool......"
Li Mu hung up again, and by the way, he blocked this phone number directly.
However, just after the operation, another phone call came in, and after connecting: "Hello Mr. Li Mu, this is the Institute of Immunology of the Max Planck Society, we invite ......"
"Sorry, you made the wrong call."
Without waiting for the other party to finish speaking, Li Mu replied directly, and then hung up the phone.
However, for the next period of time, his phone kept ringing, all of which were calls from the world's most famous biomedical research institutes, including the Max Planck Institute alone.
The Max Planck Society has 80 institutes, many of which are related to biomedicine.
Until the end, Li Mu had no choice but to skillfully turn off his mobile phone.
"Damn, these guys are crazy, aren't they?"
He complained, and then he wondered, what could make these biological research institutes all over the world call him so crazy?
Soon he had one thing in mind.
This is the only thing that can cause such a situation.
He immediately pulled out his phone - oh, it was turned off.
Then change to a mobile phone, and he also has a completely private number anyway.
Then he called Li Ruyu directly.
The call was quickly connected.
"Hey, stinky brother, do you still know how to call your sister, do you miss your sister?"
李如雨的声音从电话之中响起,李牧说道:“对对对,是想你了。 ”
"Yo? Is your mouth so sweet today? ”
“…… Let me ask, have you already solved that problem? The paper was also accepted by Cell? ”
"What 'yours' should be 'ours', you are still a co-author of this paper." Li Ruyu corrected it, and then asked suspiciously, "However, how do you know?" ”
Li Mu finally decided now, it is really Academician Chen Shanping's topic about immune cells and cancer cells!
He immediately cried and laughed and told Li Ruyu about so many calls to him just now.
"What? Professor Kleiner from Cold Spring Harbor Laboratory called you? He's the winner of this year's Wolf Prize in Medicine! He actually invited you to join Cold Spring Harbor Labs? ”
Li Ruyu exclaimed.
Li Mu: "You haven't explained why you haven't told me." ”
"Isn't that trying to surprise you! Our paper was only accepted by Cell today, but it will probably be published soon, and I plan to tell you about it when it does. ”
Li Ruyu smiled: "This is "Cell"! You're still a work! And you have absolutely no idea how heavyweight our results are! It is very likely that we have found the decisive key to solving lung cancer cells, and we will have to conduct clinical trials on this discovery for some time to come. ”
"The decisive key?"
"Yes! Based on the results of your last analysis, we conducted repeated observations and studies on more than 30 sets of experiments, and finally determined that the process by which immune cells recognize lung cancer cells is neither derived from a single receptor protein nor from a single tumor antigen. ”
“而是源于一个成体系的机制,这个机制是一整套下来的,不仅包含了对受体蛋白的识别,也包含了抗原的识别,同时还有免疫细胞的条件…… All in all, as long as we can help the immune cells in the body to carry out such a mechanism, lung cancer cells will be able to be easily addressed! ”
"And that's thanks to your help in the first place!"
"That's ......" Li Mu still asked, "But what does it have to do with those people looking for me?" ”
Li Ruyu thought for a while and said: "Lao Chen seems to have said that if it weren't for your mathematical analysis, we would never have discovered this key so easily, or even at all!" That's probably why. ”
"Those labs want you to work with you, presumably because you can help them analyze the differences in the experimental data."
"In the past, although we attached great importance to experimental data, if we couldn't analyze the detailed differences in these data, even if we had data, it would be useless."
"So those people probably think that with your analysis, maybe you can find some heavyweight results from the data."
"It's like us."
Li Mu nodded thoughtfully, and then said, "So that's the case, I know." ”
"Hehe, it's a pity that you're not in the country, otherwise, we would definitely have to come to you for the celebration banquet last night, and Lao Chen will definitely express his gratitude to you."
Li Mu couldn't help laughing: "There will always be a chance." ”
……
Li Mu probably still couldn't imagine that the little help he provided at the beginning would have such an important impact on the entire biomedical community.
Their topic is not only of considerable importance to cancer research in terms of results, but also innovative and pioneering in their research methods for the entire biomedical community.
Over the next few days, the paper's influence gradually fermented, until it was officially published in the journal Cell, and it reached a peak.
John Fan, editor-in-chief of the journal Cell, commented on the paper: "This paper is undoubtedly successful, and it is not only successful in conclusion, but also in process and methodology.
In conclusion, it reveals a mechanism that we have never noticed before, and perhaps if we want to use the immune cells in our body to kill cancer cells, mastering such a mechanism will be the key, and now I believe that the solution of cancer cells will no longer be a human luxury.
In terms of process and method, I never thought that our discipline could apply experimental data to such an extent, those seemingly boring data, actually hide the truth that we can't see, I used to be only good at observing experimental phenomena, but never good at analyzing experimental data, but now it seems that I should change my mind.
But the most surprising thing is that the person who did this kind of thing was actually a mathematician who had never studied biology! 】
OF COURSE, NOT ONLY THAT, BOTH SCIENCE AND NATURE HAVE ALSO CITED THIS PAPER, AND IT IS ALSO PLACED UNDER THE COLUMN OF "RESEARCH HIGHLIGHTS", WHICH MEANS THE CURRENT RESEARCH HOTSPOT.
And both journals invited Nobel laureates in physiology or medicine to comment on the results.
James Allison, an immunologist and cancer researcher and winner of the 2018 Nobel Prize in Physiology or Medicine, spoke highly of it: "The results of this paper are outstanding, not only revealing a new immune mechanism between lung cancer cells and immune cells, but also bringing great help to the fight against lung cancer." ”
"Of course, we also know that this is definitely not the most important thing, in fact, this is a paper that can change the landscape of our biomedical world, in the past, we may have valued experimental data, but we tend to focus on the experimental data that looks very prominent, not the mediocre data."
"But now, the processing of experimental data in this paper is undoubtedly worth learning from all of us."
"A petri dish is like a chaotic system, no one knows what is going on inside, and it also gives us a feeling: such a complex chaotic system, no results can be analyzed."
"And this paper proves that this is not true."
"With enough mathematical ability, any chaotic system can be analyzed."
"Of course, at this time, I have to mention how strong mathematical ability is needed to be able to do the level of analysis in this paper?"
"Oh, you need to have the mathematical ability of a hail conjecture or a twin prime conjecture provers to do this?"
"That's fine."
“……”
James Allison's evaluation made every biological researcher smile after reading it, but after laughing, he wanted to cry without tears.
Do you need such a strong mathematical ability to be able to do this?
Oh my God, this is literally killing them creatures.
If they had that kind of mathematical ability, they would have studied mathematics a long time ago, how could they study biology?
But at this very moment, the chemistry community next door also had something to say.
The chemistry community has been through the same thing for a long time.
After Li Mu's theoretical chemistry papers were released, the entire chemical community entered the era of mathematics, and all kinds of chemists embarked on the road of studying mathematics.
As a result, when they began to study mathematics, they found that it was a point of no return.
If you can't learn it, you can't learn it at all.
I don't understand a little bit at all.
As a result, now they find that the biology community also seems to be moving towards this point of no return?
The relationship between biochemistry is very close, almost like a brother's relationship.
What are brothers used for? Of course it's for pits.
So the scholars in the field of chemistry immediately persuaded the scholars in the field of biology to study mathematics with them.
The entire biological world, under Li Mu's mathematical analysis and the pull of "brothers", gradually began to fall into the pit.
It's just that Li Mu, as one of the culprits, doesn't know at all.
……
(End of chapter)