"Acquire us?"

In April, the weather on Hong Kong Island was in the twenties, which was relatively comfortable, and Li Yuan met with Michael Kadoorie and An Wenchao, the general manager of the pharmaceutical factory, at the gate of the pharmaceutical factory's laboratory, and said speechlessly: "What kind of, call me out of the laboratory for this?" ”

An Wenchao said busily: "Doctor Li, it was Roche who wanted to buy it, and said that the price given would definitely satisfy you." ”

Michael shrugged and said, "My father and I came to visit Lid Hoffman, the Hoffman family is one of the ten richest families in the world, and the Roche company has controlled the vitamin dynasty for half a century. And stability, which is simply crazy in the West. In addition, Roche is also unique in the field of viruses. After learning that Datang Pharmaceutical had developed a drug to carry the influenza virus and cooperated with Glaxo, he was very interested. ”

Li Yuan said: "What does his interest have to do with me?" If you can't cooperate, the pharmaceutical company is not for sale. I'm very busy experimenting here, don't bother me if there's nothing serious. ”

Of course he knew who Roche was, how could a medical student not have heard of Roche?

The crown of global medicine is not on the head of the United States, but on the head of Switzerland.

In less than half the size of Sichuan and Chongqing, it has two of the world's top pharmaceutical giants, Novartis and Roche.

The key is that oseltamivir, which is also a flu-specific drug Tamiflu, should have been born in Roche......

"By the way, Awen, has the FDA done it?"

Before entering the laboratory, Li Yuan asked.

An Wenchao shook his head and said: "It's much more difficult over there, Glaxo's opinion is to either increase investment again, or wait for the European side to open up the situation before entering the United States, otherwise the price will be too high." ”

Li Yuan frowned and said: "Glaxo is a little ignorant, they want to increase the share ratio again, and it is really the stinky problem of the Big Mac." You tell them that if they're really struggling, Roche will be happy to help me solve it. Glaxo is only responsible for sales in Europe, and North America is handed over to Roche. ”

An Wenchao's eyes lit up and he smiled: "Doctor Li, this is a good idea, why don't you just do it?" ”

Li Yuan shook his head and said: "Our drugs can pass the European drug supervision, which not only has the credit of Glaxo, but also the face of the Lancaster family and the Commolly family." The good things that have been said can't flash them. ”

Michael reminded: "Li, a favor is a favor, and a business is a business. Both families have a stake in Glaxo, and if you come forward, they will benefit as well. ”

Li Yuan shook his head and said, "It's not good, don't make it difficult for Margaret and Catherine." ”

An Wenchao tried to persuade: "Doctor Li, I know that you are very affectionate, but Glaxo may not be like this, otherwise, they will not put pressure on us in this way and stick our necks in order to increase the share." It's not the first time! Their people, very arrogant! ”

Michael also said again: "The reason why the Hoffman family can prosper for a long time, is rigid, but sincere, is their family's winning weapon. Lee, you really should try to communicate with their family. Roche is not in a very good situation right now, and the current president, Adolf Jenn, is a ...... Shrewd and arrogant guy. He once made great achievements, but with his continuous success, he became more and more rude and offended many people.

Now the United Kingdom, Germany, Sweden, Australia, South Africa and other countries are investigating Roche's excess profits, believing that the price of Valium is too high, and there is a monopoly trade in vitamins.

So the Hoffmans had to come forward in person, and it was a good opportunity to make an offer, and it was also a good opportunity to hand over friendship. Lee, I won't lie to you.

You've been very interesting enough with Glaxo, and you've ceded huge profits, but they're not satisfied, and no one will say it's your fault. ”

Li Yuan thought for a while and said, "Needless to say, oseltamivir...... In this way, I have developed the next drug, which is also an antiviral drug, which has a special effect on the herpes simplex virus, and I can work with Roche. Glaxo ...... Alas, I would have set my heart on the bright moon. ”

Michael didn't know much about medicine, so he didn't react much.

But An Wenchao's eyes were straight, and he said excitedly: "Doctor Li, are you kidding me?!" Is it really a special drug for herpes simplex virus?! Do you know how many people in the West suffer from the herpes virus!! ”

Michael Gao heard something, his eyes were round, and he looked at Li Yuan and said, "Could it be ......" He pointed to his dick and shook his finger.

Li Yuan was speechless, but he nodded and said, "It is indeed the first choice for the second herpes virus, and in addition, not only the second child, but also the mouth, face, hands and other parts of the person will grow." It is very unlikely that people will want to avoid this virus in their lifetime, but most people have no symptoms and their own immunity is enough to suppress the virus attack. However, there are still a considerable number of people who will develop symptoms, and once they have symptoms, they will have an immune reaction, which is carried for life. Although the medicine I invented is a special medicine, it can only eliminate the symptoms, not cure it. That is, there will be recurrent attacks. ”

This means that the market is incomparably large!

An Wenchao's eyes were a little straight, and he said: "In the United States, there are more HSV patients than sardines, and countless people suffer from this virus, as long as it is really effective, it will definitely be very popular!" Dr. Lee, I'm going to Mr. Hoffman now! ”

After he ran away, Li Yuan saw Michael looking at Li Yuan with strange eyes.

Li Yuan knew at a glance that this grandson didn't hold back any good fart, and scolded: "Get out, it's not because I got it!" I have always lived a simple life and guarded like a jade, how can I be infected with this disease? ”

Michael let out a strange laugh, and when he saw Li Yuan raise his foot to kick, he turned around and ran away, shouting as he ran: "Li, Jesus' teeth are going to be laughed off by you!" ”

Li Yuan gestured his middle finger and returned to the laboratory.

There is a reason why he is so tolerant of Glaxo, the second type of drug he "invented", he chose acyclovir, a special drug for the treatment of herpes virus.

This miracle drug was originally invented by Glaxo and brought huge benefits to Glaxo......

When these two drugs were launched one after another, it caused a sensation, and Datang Pharmaceutical on Hong Kong Island would almost become famous in the world's pharmaceutical industry.

It will take at least six years for acyclovir to go public, which is just right to ensure that Datang's cash flow continues to ......

……

In the afternoon of the same day, Li Yuan met Lide Hoffmann from the Hoffmann family in Sweden at the Peninsula Hotel.

A middle-aged man who looks clean and refreshing, not at all as greasy as Michael......

Wearing gold-rimmed glasses, shirts, slacks, and a well-groomed beard.

"I spent an afternoon gathering all kinds of amazing news about you, but I didn't expect, Dr. Lee, that you would be so young and so handsome. Wow, no wonder Catherine and Margaret like you so much. If I were a woman, I don't think I would be able to say no to such a good man. ”

Leader shook hands and smiled.

Li Yuan blamed Michael: "Didn't you say that the people in the Hoffman family are very stereotypical? Why is Mr. Reid so funny and humorous? ”

Michael: "......"

After the four of them sat down, An Wenchao said to Li Yuan: "Mr. Lide is very interested in the kind of antiviral medicine you said!" ”

"Actually, as far as I know, there are more than 100 pharmaceutical companies developing this drug, including Roche, Glaxo, Pfizer and other pharmaceutical companies. Lee, I don't doubt you, but can you be sure that you really succeeded? ”

Li Yuan said: "I don't have enough time, and I don't have such a good sense of humor as Mr. Lead, so I won't joke about this kind of thing." The pharmaceutical compound has been designed and synthesized enough for you to test in the lab. If Roche is willing to cooperate, then you can send a team of researchers over and you will test it. After the success, together with my team, we completed the development of the industrial process on Hong Kong Island. After that, a series of operations, including marketing, promotion and so on, can all be operated by Roche.

Of course, I know that this is the best way for pharmaceutical companies to make a name for themselves, and it also has a huge boost to the company's stock price. But I'm willing to give in, just one request, don't let me come forward, because I still have to move forward in the laboratory. ”

Lied Hoffman was surprised: "Lee, what if...... I'm not suspicious of you, but I'm just saying that if the medicine you invented really works, then you will reap countless glories, why would you refuse? ”

Li Yuan sighed, looked out the window with a sad face, and said, "Lide, you are lucky, Sweden is such a developed and rich country. Your compatriots are free to soak up the spring afternoon sunshine and enjoy afternoon tea. But my compatriots, hundreds of millions of them, are still in extreme poverty and suffering, and they are taking very poor medicines, and even then, the vast majority of people cannot afford to take them. Therefore, I have to work hard to develop more useful drugs in order to accumulate wealth, and I don't have time to enjoy personal glory by exchanging their mature drug production processes with developed pharmaceutical companies. ”

Lied Hoffman was moved: "So, that's why you want Roche's process R&D team to come to Hong Kong Island, right?" ”

Li Yuan nodded and said, "That's right." ”

Leader stood up, shook Li Yuan's hand, and said, "Li, you are a great doctor, and your benevolence has made this world a better place!" ”

Li Yuan said humbly: "You are too famous, I just did something I had to do, and it was so insignificant." ”

Lid Hoffman thought for a moment and said, "Li, if the drug you developed can really treat herpes simplex virus, then in addition to this cooperation, Roche is willing to form a partnership with your Datang Pharmaceutical." ”

This also means that Datang Pharma can win the generic right of Roche's patented drugs after expiration, and share some patented drugs after the expiration of the drug, although it has not obtained the generic right, but Roche spontaneously conquers the drugs manufactured by the production process, such as a generation of cephalosporin.

These are the most attractive to Li Yuan.

Even though Glaxo had determined the effect of oseltamivir, it did not give him such a right.

Li Yuan clasped Lied Hoffman's hand and said, "Thank you." ”

Leader suddenly felt that this "thank you" was particularly sincere.

Of course, sincerely, if the first-generation cephalosporin of the original drug, such as cephalexin, itself has a lot of nephrotoxicity, far inferior to the second-generation cephalosporin, not to mention the third-generation cephalosporin, which has almost no nephrotoxicity, then the cephalosporin currently produced in China is ...... If you think too much, you can't produce cephalosporin in China at all.

It would be another ten years before it could, but at that time, the side effects of the imitation cephalosporin were beyond imagination.

Not to mention liver toxicity and nephrotoxicity, tens of thousands of children are deaf every year.

A few years later, 18 of the 21 deaf-mute performers of "Guanyin with a Thousand Hands" were caused by drug toxicity.

What Li Yuan did couldn't change the general trend of history, because most of the drugs used by real bigwigs at home were imported special drugs.

However, he can still change the fate of countless ordinary people.

That's enough......

Roche moved quickly, and just a week later, a team of experts was sent to Longhu Pharmaceutical Factory.

It took a month to repeatedly confirm that in addition to recruiting herpes virus patients on Hong Kong Island, he also brought a batch of drugs to the R&D base in the United States for laboratory tests.

In the sixties and seventies in the United States, the prevalence of hippies caused a flood of sexual diseases.

Herpes simplex virus is one of the main pathogens.

Two months later, the team of Roche pharmaceutical process researchers came to Hong Kong Island with Catherine, Margaret and her mother, Ms. Lorina.

……

"Mr. Gobert, welcome!"

At Kai Tak Airport, Li Yuan shook hands with a middle-aged foreigner who was still meticulous in a suit in the summer.

Fritz Goebel, one of the vice presidents of Roche.

The current president, Adolf Jenn, is almost dead, and Fritz Gobert is one of the board's most favored successors.

Fritz Goebel exclaimed: "Lee, you are so young and incredible, and you are such a genius. ”

Li Yuan smiled: "I also thank Roche for his generosity. ”

This time, Roche also brought the production process of the penicillin drug ampicillin and the cephalosporin drug cephalexin.

Although the drug is similarly effective, cephalexin is much more potent.

When ampicillin is resistant or allergic to penicillin, cephalexin may be the choice.

Luo Lina, the director of Glaxo, said in a strange manner: "Fritz, Roche is really looking for opportunities, Datang is Glaxo's partner!" ”

Fritz nodded happily and said, "It's ours now." ”

Luo Lina was angry, looked at Li Yuan and said, "Li, why do you want to do this to us?" ”

Li Yuan shook his head and said, "It's not for you, it's for Glaxo." Glaxo was my first chosen partner, and I thought it would be a pleasure to work with. However, Glaxo has repeatedly coerced to increase its share for various reasons, and now Glaxo's share has exceeded 60%, and it is still pressuring. Lorina, if Glaxo continues to lose its trust like this, Datang will change partners. Therefore, any lawsuit, I think Roche is interested in helping me solve this problem. ”

Fritz laughed and said, "Two elephants fighting is the best marketing pitch in itself." Rolena, would you like to give it a try? ”

Lorence angrily scolded: "Swiss guys, fuck off!" ”

Li Yuan said to An Wenchao: "Take Mr. Fritz to the hotel." ”

Fritz hurriedly said: "Let's visit the pharmaceutical factory first, is it okay?" ”

Li Yuan smiled: "Of course you can." With that, shake hands with each of the process engineers.

After Luo's people left, Li Yuancai hugged Catherine and Margaret respectively.

Catherine looked at Li Yuan with a gratifying gaze, and said, "Li, really congratulations, oseltamivir is not on the market yet, you already have new achievements, you are too hardworking, have you been living in the laboratory?" ”

Li Yuan was surprised: "Catherine, how do you know?" Is there anyone close to me who is telling you? ”

Catherine couldn't keep her mouth shut, and Margaret might have been more shrewd, and asked more trickyly: "Lee, how many children do you have now?" ”

Li Yuan squinted: "Nine, what's wrong?" ”

Margaret laughed and said, "Are you in love with your wife in the laboratory?" ”

Catherine laughed and reproached: "Mary~"

Li Yuan said thoughtfully: "Look down on you Mary, or you can play." ”

Margaret was "furious": "It's not me! ”

Luo Lina said disgustedly: "Get in the car, get in the car, go to the hotel first!" ”

In the eyes of all kinds of people, Li Yuan took his foreign wife to his RV.

"Lee, you're really too uninteresting. Why don't you tell me if there's a new drug? None of the problems you are talking about are problems! ”

After getting in the car, Lorena couldn't wait to get out of the way.

Li Yuan smiled faintly and said, "Lorina, Datang wants to cooperate with Glaxo, not become a vassal of Glaxo." He glanced back at Lorena and added, "Me too." ”

Feeling the faint sense of oppression, Lorina held on for a few seconds, then she was discouraged and said, "Damn, if only I were a few years younger." ”

Li Yuan was curious: "Why?" ”

Rollena said confidently: "When I spread my legs, no man can walk out straight. Why is Fritz arguing with me? ”

After Catherine and Margaret accused, Lorena said, "Okay, okay, let's not talk about that." But Lee, your actions really made the company's top brass angry. ”

Li Yuan said with a smile: "Glaxo's high-level executives, angry with me? ”

Lorina sighed, "You know what? Glaxo's R&D team is only half a step slower than yours. Three weeks after Roche helped you patent the compound, Glaxo also produced the compound. Do you know how much the company has invested in this? Tens of millions of dollars! The reason why it is half a step slower is because the company has increased its resource investment in oseltamivir. I don't even know if it's a good thing or a bad thing. ”

Li Yuan said: "Of course it's a good thing. The need for oseltamivir is by no means less than that of acyclovir. ”

Luo Lina frowned and said: "But the production line of oseltamivir is not in the UK, but on Hong Kong Island, and we don't even have the initiative." ”

Li Yuan said with a smile: "That's because some raw materials are produced in China and on Hong Kong Island, which can greatly reduce costs." "The production capacity is on Hong Kong Island, which can ensure that Glaxo does not dare to go too far in financial settlement.

Li Yuan reminded again: "Lorina, Roche is already a partner company of Datang. We've started to share some of Roche's generic manufacturing rights, and Glaxo doesn't show your sincerity in that. ”

Lorena smiled bitterly: "There is really no way about this. Glaxo is different from Roche, although the Hoffman family's shareholding in Roche is not high, but Roche is a dual-class share structure, which ensures that the Hoffman family has the right to speak in Roche, and their family can make decisions on many things. And the Commolly family is far from such a position in Glaxo, sorry. ”

Li Yuan shrugged and said, "Of course I don't blame you, the Hoffman family gave a surprise, and Glaxo is the normal logic of the company." How can I get angry with normal business logic? But, in that case, Glaxo has no reason to accuse me of any immorality, right? ”

Lorina looked at the young man beside her again and said, "Li, you are really getting stronger and stronger. ”

Li Yuan smiled: "I'm just protecting my own reasonable interests...... Let's go, I'll take you to the hotel, and I'll take Catherine and Margaret home." ”

Lorina: "......"

Catherine was very happy and said, "Betty said, your youngest daughter Xiao Jiu is an angel who landed in the world, I really can't wait." ”

Margaret reminded: "Betty also said that the mother of the ninth sister is the battle angel Ak'anger, a very powerful woman. ”

Catherine didn't care: "I'm here to see the ninth sister, and I'm not here to fight." By the way, I'm going to see Xiao Qi. ”

Luo Lina looked at Li Yuan meaningfully and said, "Li, you really have a hand." ”

Li Yuan: "......"

After sending Rollena to the Peninsula Hotel, witnessing her summoning Glaxo's people for a meeting, Li Yuan really took Catherine and Margaret back to Tsing Yi Island Manor......

……

Forty-nine cities, flower halls.

Seeing Qin Daxue and the two staff members come in with a basket of watermelons, Cao Lao got up and looked at it and smiled: "Is this a result?" Oops, look at your skinny! ”

Qin Daxue has lost a lot of weight, but her eyes seem to be brighter than before, and she smiled brightly: "It's good to be thinner, and to be thinner!" Cao Lao, this is a watermelon grown in the greenhouse, and I will send it to you to taste. ”

Cao Lao was not very happy and said: "It's not the season to eat watermelon, it's so expensive, what to send me?" I thought it was a basket of vegetables. ”

Qin Daxue said with a smile: "It's really not the first batch, the first batch has been sold, sold to foreigners in Sijiu City, they have money, and they are willing to spend money." Cao Lao, I didn't expect that this batch of watermelons helped a lot. Half of the famine owed by the greenhouses was repaid, and the remaining half was almost gone as the fennel was harvested. In autumn, half of it is planted with fennel and half with vegetables. You can have a big profit this year! Isn't this a happy event, send a few watermelons to you to report the good news. ”

Cao Lao said happily: "Wow, good! I knew you could do it, and I really got results. Sit back and relax. ”

After Qin Daxue helped Cao Lao sit down, he said, "Cao Lao, my movements are too big, so you have to worry about it." ”

At present, it is far from being fully opened up, and she has opened up and cooperated in the suburbs of Beijing to develop the economy, and all kinds of means are amazing, which has really aroused a lot of criticism.

If it weren't for Cao Lao's protection by Prime Minister Yu Wei, even if Qin Daxue didn't go in to drink tea at this time, he would have been appointed to dismiss the official again.

Struggle is still the theme of the moment......

Cao Lao patted her hand and said with a smile: "Don't be afraid, don't worry about anything, as long as you do the right thing and serve the people wholeheartedly, it doesn't matter." Your district is still based on the production brigade as the basic unit, and it is still a collective system. Some people criticized you as a female doll, and your methods are too ruthless. He instructed the public case unit to crack down too the offenders in the area and to strike too hard. What is this called? You can't do whatever you want just because you're against those people, so what's the difference between that and some people in the last decade? Heavy snow, don't worry, let go of the dry. When Gu Gu came to see me yesterday, he also specifically mentioned you, and he spoke highly of you, saying that you are a woman who does not let you shave your eyebrows, and you are heroic! ”

……

(End of chapter)