Chapter 18: The Terrible Rebound Phenomenon
Seeing that gastric lavage has begun, and now it is necessary to use antidote drugs immediately, Ye Nan said in a low voice: "The rescue doctor's order began to record: atropine 10mg intravenous push, 10% glucose 20ml plus pralidoxime 1.0 intravenous push, and at the same time, blood was drawn to urgently test cholinesterase live surname!"
Atropine is an anticholinergic drug, which can effectively inhibit the combination of organophosphorus and other poisons with cholinesterase in the human body to relieve the inhibition of cholinesterase by toxins, so that the human body can avoid further deepening of poisoning, and has the effect of detoxification.
Pralidoxime is a special antidote for organophosphate poisoning, which can revive the inhibited cholinesterase and increase the live life of cholinesterase in the human body to play a role in detoxification.
Hospitals can usually estimate the patient's poisoning by drawing blood to measure the live surname of cholinesterase and use it to guide the treatment of drugs!
Listening to Ye Nan's instructions, the nurses neatly dispensed medicines, pushed medicines, and drew blood, and completed them within one minute! Ye Nan looked at it and nodded secretly, only a hospital of the level of the Second Affiliated Hospital would have such efficiency, if it was a suburban hospital before, it would take at least two minutes or more to complete!
Seeing that the two drugs have been slowly injected into the patient's body, I am now waiting for the drugs to take effect, hoping to make the patient achieve atropine as soon as possible.
Atropineization is an important medication rescue index, which is mainly reflected in the following aspects: dilated pupils, dry mouth, dry skin, facial flushing, decreased or absent pulmonary rales, and increased heart rate. And only when atropine is achieved, the treatment can work, otherwise it will be difficult for the patient to be rescued!
Ye Nan looked at it, and the other bucket was full of liquid that had been flushed out of the patient's stomach. The bucket was now all that faint brownish-black, and a strong smell of garlic wafted from it.
Looking at the bucket full of brown and black, Ye Nan shook his head and sighed, looking at this, the patient drank at least half a bottle of methamidophos, maybe a whole bottle of methamidophos, I really admired her courage, such a bad thing, she can drink it!
After waiting for a few minutes, the patient's sweating subsided slightly, but the whole body was still wet, it seemed that it was still far from atropine, and he had to continue to add drugs, Ye Nan then ordered: "Atropine 5mg intravenous push, 10% glucose 20ml plus pralimidine 1.0 intravenous push again!"
After waiting for the medicine to advance, after waiting for about ten minutes, the patient no longer sweated obviously, Ye Nan took a small flashlight to shine on the patient's pupils, and now the pupils are much larger than before, and they have changed from the size of the needle tip to about 1.5mm!
After listening to the lungs again, there are still a lot of rales in the lungs, but they are a little less than before! The heart rate is about 86 beats per minute!
It seems that you have to continue to use the drug in order to achieve atropine, Ye Nan explained in a deep voice: "Continue to push 5mg of atropine intravenously, and add 1.0 intravenous drip of pralidoxime with 250ml of 10% glucose!"
After that, he looked at the liquid that had been washed out of the patient's stomach, and now the water in the bucket had begun to show a light gray, no longer the brownish-black, and it seemed that a lot had finally been washed out, so he asked the nurse who was washing the stomach on the side, "How much water have you washed?"
The nurse glanced at the bucket next to her and replied, "It's already a bucket and a half!"
"Hmm...... Continue until the water is completely clear!" "The patient's stomach has been washed with nearly two large buckets of water, and it is still this faint gray, this woman is really ruthless, I am really afraid that I will swallow a bottle and go in!"
After pushing atropine three times, the patient's skin finally began to become dry, the face gradually appeared flushed, and the pupil also recovered to about 2mm!
In this case, the patient has successfully achieved atropine, and the next drug can be reduced! Moreover, within half an hour, the patient can successfully achieve atropine, and the chance of the patient being rescued is greatly increased!
At this time, the nurse who lavaged the stomach also reported: "The liquid has been completely cleared!
Ye Nan looked at the liquid that had been washed out of the bucket and had obviously cleared up, so he nodded and said with a smile: "Pull out the gastric tube! Push 2mg of atropine every half an hour to observe the changes in vital signs! Notify me immediately if there is anything!"
The nurses all nodded in agreement, Ye Nan pushed open the door and walked out, a large number of people surrounded the door, seeing Ye Nan coming out, the man rushed over and asked nervously, "Doctor, how is my wife?"
Ye Nan nodded: "I have stabilized for the time being, but I haven't woken up yet, so I am still in danger, and I need to continue to observe!"
After that, he took the man back to the office and signed a critical illness notice, and then asked the man to accompany him to the emergency room.
After the critical illness notice was signed, Ye Nan was relieved, it was really uncertain whether this patient could be saved, but looking at the current situation, the hope was still very big!
Write down your verbal medical instructions on the medical record just now, write the rescue record just now, and then improve the first course of illness record, finally done it temporarily!
It had been half an hour since he looked at his watch, and Ye Nan went to the emergency room to see the patient again, at this time, the patient still hadn't woken up, and his face was flushed with pieces of atropine, but his hands were unconsciously groping around!
Ye Nan sighed, at this time, the laboratory had already sent over the results of the emergency cholinesterase test, and the cholinesterase was only thirty percent of the normal value!
Finding that the patient's cholinesterase was so low, Ye Nan reluctantly explained to the nurse on the side: "Hemodialysis immediately! Dialyze the toxins out of the blood!"
Hearing Ye Nan's instructions, the nurse hurriedly prepared a cart and instructed the patient's family to carry the patient onto the cart and send him to the hemodialysis room as soon as possible.
Hemodialysis is a treatment method that uses a machine to extract human blood and then cleanse and filter the impurities and poisons in the blood, and then infuse it back into the human body, which has a good effect on some early poisoning diseases!
Ye Nan saw that the patient's poisoning was extremely serious, but under the control of the drug, the effect was still not obvious, so he had to use this method to assist in treatment, hoping to help the patient get rid of the poison in the blood as soon as possible and recover as soon as possible! This is the last resort, if the patient still does not have enough effect, then it will be really difficult to rescue!
Fortunately, after an hour passed, after hemodialysis, when the patient was pushed back, he had recovered a little bit of sanity, and the person was much more awake, which made Ye Nan very relieved.
Since the patient has become much more conscious, there is no need to continue to stay in the emergency room, and Ye Nan transferred him to the general intensive care unit.
However, the nurse continued to ask the patient to give the patient a 10mg intravenous push of atropine, because under the strong effect of hemodialysis, although the patient's blood was eliminated a lot, the drug in the body was also excreted from the body, so after all, the drug should be replenished as soon as possible to maintain the efficacy.
After pushing this drug, Ye Nan changed the amount of atropine injection every half an hour to once an hour, and now the patient's condition has improved a lot, and the drug requirements for maintaining atropine are much lower.
In this way, under Ye Nan's careful medication treatment, two hours later, the patient was finally fully awake, Ye Nan carefully did the lower physical examination again, the breath sounds of both lungs were rough, but no longer heard obvious rales, the heart rate was maintained at 100-120 beats per minute, the diameter of the double pupils was about 2.5mm, the skin was dry, the complexion was slightly red, and the person was slightly irritable!
I am very satisfied, now the atropine maintenance is good, there is no overdose, as long as this situation can be maintained for 24 hours, then the patient is basically out of danger! Because the risk of rebound within 24 hours is the highest, so now can not be careless, after 24 hours, the risk of rebound is greatly reduced!
At this time, the patient's husband was already a lot relieved, and he couldn't stop thanking Ye Nan by the hand, but Ye Nan didn't dare to be careless, and hurriedly reminded him: "Your wife is temporarily stable now, but you still have to take care of it, because serious poisoning like this may cause the disease to rebound at any time!
The man hurriedly nodded and agreed: "The doctor has worked hard, I will definitely watch carefully, and I will notify the doctor immediately if there is a situation!"
Hearing that the other party wrote down his words, Ye Nan returned to the office with confidence, for the sake of this patient, he tried his best today, but it was really hard!
Ye Nan returned to the office, he hadn't drunk much water after a busy day today, so he poured a cup of hot tea, sat down on the chair, and breathed a sigh of relief, if it was like this every day, it would be really hard!
However, Ye Nan, there is no easy time today, just sat for less than an hour, and the call bell rang again: "Doctor Ye Nan, please go to the intensive care ward immediately, Doctor Ye Nan, please go to the intensive care ward immediately!"
Ye Nan was taken aback, could it be ....... "rebound?"
(To be continued)