For doctors, it is very sad that patients are incurable. But it's only "sad". But for the families...... The news was a bolt from the blue.

The description of a thunderbolt on a sunny day is a bit ...... Not appropriate enough. Sun Lien looked at Cao Zhiquan's son, and his feelings were a little complicated.

For a young man in his early twenties, the world should have been full of hope and color. Parents are not very old, and they can not only take care of their own lives, but also help themselves who are just starting to become independent.

That's how it should have been.

Xiao Cao sat in his seat, his hands clenched tightly into fists by his side, trembling all over, and his face was pale. He was stunned for a moment before he opened his mouth and asked in a trembling voice, "Really...... There's no way around it?"

"If it's really Creutzfeldt-Jakob disease, there's no way. Although he wanted to comfort the little brother in front of him, Sun Lien couldn't think of how he could comfort the other party - if he didn't have a positive 14-3-3 protein in cerebrospinal fluid, he could only confirm Creutzfeldt-Jakob disease through a brain biopsy. In other words, even if there is a positive report of CSF 14-3-3 protein, a brain biopsy is still required in a thoroughly confirmed patient. The presence or absence of a report of cerebrospinal fluid (CSF) will only affect the doctor's confidence when recommending a brain biopsy.

But in reality, it is not a simple task to detect 14-3-3 protein. Even though the testing equipment in the comprehensive diagnostic center is new, there is still no corresponding reagent that can be used to detect this one protein.

Taking 10,000 steps back, assuming that the Creutzfeldt-Jakob disease (Creutzfeldt-Jakob disease) that Cao Zhiquan suffered from is a hereditary Creutzfeldt-Jakob disease (PID) that is relatively easy to detect, the diagnosis needs to be confirmed by a PCR test of the patient's cerebrospinal fluid or peripheral blood samples to detect the PRNP gene coding sequence that causes the lesion.

But PCR isn't a one-size-fits-all machine – just throw a sample into the machine and wait for the high-tech-looking PCR machine to rumble and get the results. If it were that simple, there wouldn't be countless creature dogs wailing in schools.

To detect a specific gene sequence using PCR, the specific gene in the sample is first amplified. The specific detection fragment in the sample can be detected by the machine after 30 rounds of multiplication, that is, a billion-fold increase in replication. In addition to the long wait during the amplification process, it is more important to find the right primer that can amplify the specific gene structure.

PCR detection of PRNP gene coding is a relatively mature technology, but practical difficulties still exist. The most straightforward difficulty lies in the primer design.

The most important primers are not readily available in the complete process of amplifying the PRNP gene. At least not in the Fourth Courtyard or even in Ningyuan or even in the entire Song'an Province. If you want to do this kind of examination, you can only send the sample to the relevant company in the capital or Shanghai, and entrust it to someone else for testing. Once this goes, according to the speed of progress of Cao Zhiquan's symptoms, I am afraid that he has already died in front of the results.

"At the moment...... We don't have a good idea. However, according to the advice of a specialist, we can also try hormone pulse therapy. After thinking about it, Sun Lien decided to work hard for Cao Zhiquan's life again. "If the hormone pulse therapy is effective, then he may have a disease with similar symptoms, but there is still a ...... for life"

Doctors rarely say this to their families. The word "give it a try" itself implies uncertainty. And the patient's family is averse to uncertainty. But in the current situation, apart from fighting on this uncertainty, Sun Lien has no more options.

The vast majority of patients with CJD die of bedsores or lung infections shortly after falling into inactive silence. Not to mention curing the disease, modern medicine does not even have any effective treatment that can improve their quality of life. Frequent turn-overs and aerosol inhalation with vibration vests may be able to prevent pressure sores and lung infections to some extent, but they still do not substantially improve the patient's condition.

More than 50 years after the landing of man on the moon, there are still a large number of diseases in the world that doctors cannot handle. Even if satellites can locate almost all users on Earth in space, we can't even see a possible way to solve problems in the face of many diseases.

Sun Lien felt very frustrated.

Doctors' frustration is actually a common occurrence. From not going well at work to patients not cooperating and families not understanding, there are many ways to frustrate a doctor who works every day until he dies of overwork. Thanks to the status bar and Sun Lien's own "good luck", the feeling of frustration is actually a bit ...... for Sun Lien Fresh.

Freshness meant he didn't have much experience dealing with that feeling. In the past, I felt "frustrated", and almost all of it was because of exams and study problems. When he was a student, like everyone else, for Sun Lien, exams and studies were the biggest difficulties in the world. But it was only after he went to the clinic and began to treat patients that he realized that he was frustrated before...... It's not worth mentioning.

It's not a strong feeling, but it's so presence. Looking at Xiao Cao's back slowly leaving, Sun Lien felt like a stone was pressed on his chest. The throat is also not very comfortable, as if there is still a small piece that is stuck near the Adam's apple, and even the speech is a little unsharp.

For a moment, Sun Lien even wanted to stop Xiao Cao, and then persuade him to go through the discharge procedures for Cao Zhiquan.

Although he said that he could also use hormone pulse therapy to give it a hope, Sun Lien himself knew very well that such a classic and standard symptom was unlikely to be VGKC. Cao Zhiquan's athleticism has always been normal, and he does not have the characteristic movement difficulties of VGKC.

In this case, is it necessary to continue hospitalization? Although the Comprehensive Diagnostic Center itself has the support of Takeda Pharmaceutical, it is able to reduce a large part of the cost of examination and treatment...... However, it is still inevitable that it will take up the family's time and energy. The cost of nursing care and hospitalization still need to be paid as usual......

Isn't that really good? If you give up treatment and go home, the financial pressure on the family will be a little less, right?

But looking at Xiao Cao's back, Sun Lien still couldn't say this. He knew very well that if he made such a suggestion, it would basically be equivalent to signing Cao Zhiquan's death sentence. As a family member, Xiao Cao accepts the proposal or refuses...... I'm afraid I'll have a pimple in my heart.

A life cannot be measured in a few simple words.