The superior of Yunhe Children's Hospital is the Institute of Children's Medicine, Chinese Academy of Sciences. As the top pediatric medical research center in China, their pathology testing is definitely the best in the first echelon.

But the samples sent to the capital ...... No meaningful content was detected. After receiving the sample, the pediatric research institute gave a pathological diagnosis that "a little white matter structure was seen under the microscope, glial cells were mildly proliferated, the nuclear anisotropy was not obvious, and the interstitium was slightly edema." In view of the high proliferation index of multiple repeats and multiple clonal immunohistochemical markers, and the current histomorphology cannot explain this phenomenon, it is recommended to follow up closely and send samples for testing if necessary. ”

In simple terms, "Something is wrong with the sample you sent, but we don't know what's wrong." To translate it in a more understandable way, it is, "Check the loneliness." ”

Sun Lien frowned. The pathology tests of the pediatric research institute did not understand what was wrong, and this seems to be a big trouble.

"Then we were discharged...... Because I always feel that the pediatric hospital can't figure out what's going on. Nannan's mother said in a low voice, "Later, we took our children to many hospitals, both inside and outside the province...... The last one in the province is the infectious disease hospital where Professor Zhang is located. ”

Because the onset of the disease is acute-subacute, it is not nonsense to consider infectious diseases when hormones are ineffective. It's just obvious that this road doesn't work.

"In the end, we listened to Professor Zhang and went to Tongxie Hospital in the capital. Sure enough, after being transferred to the hospital one after another to seek medical treatment, Nannan's parents regarded the Capital Tongxie Hospital as the last straw. However, the association did not find out what kind of disease she had.

After living in Tongxie for a month, Nannan's eyes have ...... It's out of sight. Nannan's father covered his eyes, and he choked up a little, "We did a second biopsy at Tongxie, but we still didn't find out what the problem was." ”

If the pathology test of the Institute of Pediatrics is the first echelon, then the pathology test of Tongxie is the top three level in the country without dispute. According to some evaluation criteria within the industry, Tongxie Pathology is ranked second only to Hudan Cancer Hospital and Southwest Hospital. Moreover, judging from the experience and level of Tongxie in dealing with incurable diseases, the cases that they cannot solve must be extremely uncertain.

Sun even suspects that this may be a completely new disease that has never been detected before.

The medical history was basically collected, and according to these medical histories, Sun Lien was able to gradually have a general understanding of Nannan's condition.

Intuitively, Sun Lien's first suspicion was a tumor. There were extensive and obvious lesions in the brain, but no obvious traces of spinal cord lesions were found from the first examination at Yunhe Hospital or at Tongxie Hospital.

The presence of both myelitis and optic neuritis is necessary for the diagnosis of neuromyelitis optica spectrum disease. Neuromyelitis optica spectrum disease (NMO) can only be diagnosed if both of these symptoms are present, and two of the three conditions are "three or more abnormal lesions on spinal cord MRI, brain MRI does not meet the diagnostic criteria for MS, and serum AQP4-IgG is positive".

From this point of view, it is no wonder that the doctors at Yunhe Children's Hospital wonder if there is a problem with the diagnosis of neuromyelitis optica spectrum disease. At least from the information that Sun Lien has in his possession, Nan Nan has no symptoms of myelitis, and there are no indications for abnormal lesions on spinal cord MRI and positive serum AQP4-IgG.

But if it's a tumor...... There's no reason why two biopsies can't detect mutated cells. According to the results of brain MRI, there are very obvious intracranial multiple mass lesions. She has distinct T1 hypointensity areas in both her optic nerve and brain. But two biopsies of the brain did not detect any valuable information.

There is nothing of value other than "histomorphology cannot be explained".

Starting from the direction of pathology is definitely a dead end.

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After leaving the conference room, Sun Lien and Professor Zhang Zhifu walked to the office in silence.

"This child's condition has worsened. Professor Zhang skimmed his steps, walking much slower than usual. As he walked, he suddenly said to Sun Lien, "What about this child's condition...... Are you sure?"

The word "grasp" sounds a bit harsh to doctors. No one can be 100% sure of something, especially when it comes to disease health.

We know so little about how the body works and how diseases work, and there are so many ways in which diseases can affect people.

Sun Lien did not have any psychological fluctuations because of Professor Zhang's words, he admitted very calmly, "I am not sure, I am not even sure." ”

If you are sure, you can call it a ghost. Together with the cases that the association could not handle, they were put into the fourth hospital and handed over to Sun Lien...... If this is certain, Sun Lien should be immediately suspended and sent to a local mental health center for a mental examination.

Overconfidence can be a very serious psychological problem.

"It's because I'm not sure that I'm going to let you come. Professor Zhang seemed to be very satisfied with Sun Lien's answer, he nodded and said, "I'll do the work on the family's side...... They've basically given up on treatment. But I always feel that even if the child is gone, at least we must understand what killed her. ”

It's a heavy topic. Sun Lien did not reply.

In terms of medical development, such a combination of family and patient is simply the most ideal. The disease is rare, but families are hopeless about follow-up treatment. They just want to find out what the hell is going on...... For this purpose, they are willing to put almost everything on the countertop.

But Sun Lien didn't feel relaxed or optimistic at all, he felt that there was a mountain on his shoulders. He hasn't been a doctor long enough to "treat patients as cases rather than people."

"Anyway, I'll do my best. Sun Lien wanted to change the subject, he shook his head, and after making a concluding statement, he walked into the office with Professor Zhang Zhifu.

"Today's patient is in trouble. "When communicating with Professor Zhang Zhifu, Sun Lien was a self-positioning of a backward student. But when communicating with the other doctors in the group, Sun Lien has become accustomed to himself as the backbone of the final decision. He summed up to the doctors in his group, "She has a special situation, and it is likely that she will need many hospital-wide consultations or even out-of-hospital consultations...... Speaking of this, Sun Lien paused, and decided to tell everyone the real difficulty in advance, so that they can have a number in their hearts, "The patient has been transferred to the hospital many times, and even the Tongxie Hospital in the capital has been there." A total of two biopsies were performed, but neither the Capital Institute of Pediatrics nor the pathology department of Tongxiel Hospital found valuable content in the pathological samples. ”

Sun Lien stood in the office and said in a deep voice to his colleagues, "Although it sounds a little heavy, we are her last hope." ”