Chapter Seventy-Nine: High-dose atropine

Xu Yourong "appropriately" exaggerated the degree of poisoning of some pilots. In fact, Zhao Bo fell into a coma about 20 minutes after he was admitted to the hospital. But considering that he had been thoroughly cleaned and kept away from the toxin environment when he was admitted to the hospital, in fact, the judgment of ten minutes was not necessarily wrong.

Xu Yourong's face did not change, she really did not lie - at most, she did not make it clear that the time of the coma was her own speculation.

Secretary Chen put down the pen, covered his eyes with both hands, slowly rubbed his somewhat sour eyes, and sighed, "Fortunately...... Lucky. ”

In adverse weather conditions, there was a serious series of car accidents on the highway, resulting in many injuries and seven poisonings. This is already a very serious security incident. If a rescue helicopter had an accident during the transfer, the consequences would have been unimaginable. It may be that what punishment to carry is not even within the scope of Secretary Chen's consideration - the plane fell from the sky, and now the time is close to the noon meal rush hour, who knows how many innocent people will be killed and injured!

Secretary Chen opened his eyes, looked at Sun Lien in front of him and said in a deep voice, "Good job!"

Sun Lien was stunned.

"Although I don't understand medicine, I also know that doctors should be more capable the longer they work. Secretary Chen seemed to be a little relieved from his fantasies, and he began to ask about Xu Yourong's situation with interest. "You are a medical doctor who has returned from studying abroad, and you are a student of Dean Liu. Why did you learn from Dr. Sun, who was trained in the rules?"

Xu Yourong's expression remained unchanged, "Because I think it's necessary." ”

"Xiao Sun has two brushes. Secretary Chen nodded, then pondered for a while, and said to Sun Lien, "Prevention is better than prevention, you are the first credit." But I'm also concerned about the four firefighters — how are they doing?"

"Dr. Sun went to the pharmaceutical factory to help coordinate the rescue drugs. Xu Yourong continued, "I have been staying in the emergency room, and I know more about the situation of the four firefighters, so let's talk about it." ”

"The two firefighters brought in by the helicopter had severe hypothermia in addition to obvious symptoms of organophosphate poisoning. We estimate that it may have been caused by the damage to the firefighting uniforms of the two when they were being urgently disinfected at the scene. Xu Yourong said, "The other two are in better condition, and they are only showing symptoms of organophosphate inhalation poisoning." But vital signs were stable — one person developed generalized muscle rigidity and respiratory failure. We gave symptomatic treatment. ”

Secretary Chen shook his head, "I don't understand this kind of words, I just want to know if the lives of these four people have been saved, and if not, when will they be saved." ”

This kind of remark is actually quite unreasonable, but Sun Lien can fully understand Secretary Chen's worries and concerns. He groaned for a moment and said, "The main problem we are facing now is that there is no large dose of atropine injection. The new replacement, Changtoning, is not in stock at all. Mr. Shen from the No. 2 Pharmaceutical Factory has given us great support, and more than 50 boxes of atropine have been moved to the pharmacy. As long as the ampoule is knocked fast enough, the lives of these four firefighters can be said to have been saved by about eighty percent. ”

Saving eighty percent of his life is not Sun Lien's nonsense. There are two main causes of death from organophosphate poisoning, one is muscarinic symptoms – spasms of smooth muscle and increased glandular secretion due to parasympathetic nervous system excitation, which may lead to pulmonary edema and respiratory obstruction. Nicotinic symptoms, on the other hand, can cause respiratory paralysis and arrhythmias. Symptomatic treatment given by the emergency department and the "atropineization" caused by a large number of atropine injections can effectively organize the onset and further spread of these two symptoms. Even if the condition cannot be completely curtailed, doctors can still combat it by opening advanced airways, ventilator support, and more than 50 arrhythmia medications.

The reason for the 20% deduction is that four firefighters may have been present, but have not yet shown nerve damage and multi-organ failure.

Although relatively rare, organophosphate poisoning can cause neurological damage. When the injury occurs in the terminal nerves, the condition manifests as paralysis of part of the limb. However, if it manifests in the parasympathetic or sympathetic nervous system, it can lead to irreversible respiratory failure – the system that is supposed to control breathing is unable to transmit signals effectively, and the patient will not be able to breathe effectively unless they rely on a ventilator.

The parasympathetic nervous system also controls the body's internal organs, gastrointestinal motility, liver work, and even heartbeat. If there is damage here, eventually the main organs of the human body will strike completely.

It can be said that there is only one ultimate goal in the rescue process of organophosphate poisoning, which is to prevent damage to various organs and nervous system by supporting the body's system and preventing cholinergic nerve damage.

After listening to Sun Lien's explanation, Secretary Chen was silent for a moment, and suddenly asked, "Have you seen Mr. Shen from the No. 2 Pharmaceutical Factory?"

"Yes. Sun Lien nodded, and after a moment's hesitation, continued, "Her daughter was admitted to the hospital yesterday due to a sudden illness, and I was responsible for the treatment. Dr. Xu performed her first exploratory surgery. ”

"Why can't you immediately produce a batch of large doses of ......," Secretary Chen hesitated, and the district magistrate Ouyang Hua next to him reminded in a low voice, "Atropine." ”

"Yes, what about atropine?" Secretary Chen asked, "I majored in automation in college, although it is not compatible with pharmacy, but if I just adjust the production dose, it should be completed quickly, right?"

The middle-aged man who had been silent next to him said in a low voice, "Changing the production line may cause very serious impact and losses to the enterprise. ”

"You can't just put your life aside for the sake of making money, right?" Secretary Chen was a little angry, but he also understood that what he said was a bit nonsense. Waving his hand, he sighed, "Anyway, it's hard work for you." ”

"Actually......" Sun Lien said suddenly, "maybe I can talk to Mr. Shen." Maybe they can provide a batch of APIs. ”

Atropine itself is a white or colorless crystalline substance that is highly soluble in water. Although there are many important processes in the production of pharmaceutical factories, the bottom line is only to dissolve the raw materials and then aseptically fill them.

Sun Lien's suggestion is tantamount to planning to move the production workshop of atropine to the hospital. Dissolve atropine APIs directly in the hospital to make much-needed high-dose drugs to relieve urgent needs.

Xu Yourong suddenly became anxious. She tugged at Sun Lien's clothes, her eyebrows upside down, "Are you crazy?"