"Wu, I don't want to listen to the final conclusion, can you tell me the most critical theory?" Rodriguez asked.

"My research, the final step – found that deep in the brain may be able to reset the unstable patterns of neuronal oscillations in Alzheimer's patients, and in particular, the theta rhythm of the hippocampus may play an important role in learning and memory. ”

“......”

"Veterans don't die, they just slowly wither. "In fact, the cerebral cortex cells are not dead, but the neuronal oscillation appears in an unstable pattern." ”

"You're going to solve ...... with quantum theory," Rodriguez muttered.

"No, just inspired. Wu Mian said, "After reading the final results, you will know that the treatment is not as difficult as imagined, and the key lies in positioning." Positioning, on the other hand, is based on your genius idea – the DST Surround Matrix Gradient System. ”

Rodriguez was silent.

Neurons oscillate, unstable patterns appear, and this kind of statement and narrative is often seen in quantum physics.

However, the SIGNA Pioneer 3.0T magnetic resonance is a product of classical physics and has nothing to do with uncertain quantum physics.

"Rhodes, in the past, our study showed a significant increase in selective feeding in rats by performing bilateral basal nucleus macrocellular low-frequency electrical stimulation, and neuronal activation in the prefrontal cortex, hippocampus CA1CA2 CA3, and ventral dentate gyrus after electrical stimulation. ”

Chu Zhixi went to pick up the patient, and Wu Mian took advantage of this time to say to Rodriguez, "Bilateral basal nuclear cells are associated with the process of memory formation, and this process is mainly realized through the projection of large basal nuclear cells to cholinergic neurons in extensive cortical regions, and this view has been confirmed by a number of later studies." ”

"Cholinergic neurons, what a wonderful word. ”

"Wu, and then?"

"Then there's the trade secrets. Wu Mian said with a smile.

"......" Rodriguez really wanted to rush forward and beat Wu Mian hard with his fist.

If it weren't for the fact that he couldn't beat him, he would have rushed up early in the morning to do so.

Either he didn't say it, or he said it, but he actually got to the most critical point, and then stopped abruptly! Rodriguez almost didn't spurt out a mouthful of old blood.

"Look at you, my old friend, don't look like that. Wu Mian said, "Then I will say a little more, as a sincerity to invite you." ”

"It's not an invitation, it's coercion! If I come to you, I'll get a lawyer's letter from General Medical the next day!" Rodriguez said angrily.

"Neuronal proliferation-entorhinal region: After electrical stimulation of the entorhinal region in rats, it was found that the proliferation of neurons in the dentate gyrus of the hippocampus could be induced, and at the same time, the spatial memory function of mice was improved, and the ......"

"And what?"

"And I found that the improvement of spatial memory function can be antagonized by temozolomide. ”

Memory, this is a forbidden area in neurology!

Now Wu's research has begun to touch the forbidden area? And it is not a touch, but further research has been carried out, and antagonistic drugs have even been discovered.

"Prethalamic nuclear stimulation also induces neuronal proliferation in the hippocampal dentate gyrus in rats, which occurs 24 hours after short-term electrical stimulation, peaks on day 3, and can last for 4 weeks, and the intensity of proliferation correlates with the frequency of stimulation. ”

"Rod, do you know what that means?"

"I don't know if we can treat Alzheimer's disease, damn it, your habits have infected me, it's Alzheimer's disease!" Rodriguez grumbled and continued, "but Alzheimer's disease can already be prevented, Wu, can I understand that?"

"Yes. "The Tang team in California first administered electrical stimulation to the fornix in a disease model of Rett syndrome, which can significantly improve spatial cognitive memory function and restore it to the level of normal animal cognitive function." ”

"When?"

"Thirteen months ago, published in the journal Nature. ”

Rodriguez shrugged his shoulders, he was only an engineer and did not delve too far into the basic theory.

In other words, deep brain electrical stimulation can promote the release of nerve growth factor, promote neuronal proliferation in the subgranular region of the dentate gyrus, alter the electrical activity of hippocampal neurons, and promote acetylcholine release. A theoretical pathway has formed a closed loop, and as long as it can be located, we can try to treat Alzheimer's disease. ”

"It's Alzheimer's disease!" Rodriguez stressed.

"It's all the same, you know what I'm talking about. "However, the research on brain networks is still in a relatively backward stage, but that was in the past, and from now on, none of this exists." ”

"Are you really sure?"

"Of course, Rod. Wu Mian said, "What I want to show you is the miracle of breaking the cocoon and turning into a butterfly." ”

"Breaking the cocoon and turning into a butterfly?"

Obviously, Rodriguez couldn't understand the beauty of the Chinese language. Wu Mian's words translated into English are not so smart and expressive.

Wu Mian did not continue to explain, but played the previous magnetic resonance image of the little patient in a vegetative state.

This time it's the full version, not the processed version that Jack Jones saw 36 hours ago.

Brain tissue below the hypothalamus is highly active, but the further out you go, the worse the activity. It's like a tree, a tree that stands in the cold Siberian winter, with only a trunk and a few branches.

It seems to have withered and has no life.

The three-dimensional image is slowly rotating, and the gray outer layer is like a silkworm cocoon, and the inside is empty.

"Wu, why did you make it so beautifully? at least 30% of the system's speed was wasted!" Rodriguez complained.

"That's business value, Rhodes. Not only can you and I understand it, but at least Jack can understand it before it can be considered a success. Wu Mian looked at Jack Jones and said.

"Since 1985, Professor Turnbull has been using basal nuclear stimulation to treat dementia, which is not a new procedure. It's just that all research has stopped at positioning, and there has been no breakthrough. ”

"Wu, why?"

"Because...... Their surgical techniques and positioning are very rudimentary. Wu Mian said calmly.

"I regret your statement. ”

"The target of the hypothalamus and the nucleus of the fornix is located below the lateral ventricle, anterior to the third ventricle, and the implanted electrode must pass through the lateral ventricle. Since the tip of the implanted electrode is coarser and blunt than the microelectrode, the tip of the implanted electrode is prone to slide along the lateral ventricular wall when passing through the lateral ventricular wall after the microelectrode is recorded, which affects the accuracy of the target. ”

"There is no accuracy in itself, and it is affected by surgical errors, so the results can only be unsatisfactory. It's all about luck, and that's how I sum up the past. ”