The same question, Guan Yuntian once asked Dr. Tong, but Tong Wei's major is materials science, after all, he is not a person majoring in medicine, Guan Yuntian felt that his answer at that time was not professional enough, and today I saw Deputy Director Huang, Guan Yuntian wanted to hear the views of this industry insider.

As the leader of the industry department, he has some friendship with Guan Yuntian, and he is happy from the bottom of his heart to see that his subordinate units are willing to make a difference in the research and development of new drugs, so he attaches great importance to Guan Yuntian's problem.

Seeing Lao Huang's serious look, Guan Yuntian hurriedly complimented: "Huang Ju, you are not only the leader in charge of the pharmaceutical industry in the province, but also an expert in this field, and the answer you know from here must be the most accurate." ”

Of course, Lao Huang likes to listen to this, and his expression became relaxed, "First of all, I declare that the topics we are talking about here only include chemically synthesized drugs and biological products, and have nothing to do with Chinese patent medicines. In short, as far as chemical synthetic drugs are concerned, the most cutting-edge research field is mainly to screen the components that are curative for human diseases from the molecular structure of nature, and then dissect the molecular structure, and then use synthetic or semi-synthetic methods combined with biological fermentation to develop this ingredient until it is brought to the market. Of course, this is accompanied by a variety of safety tests. ”

"It sounds like a few words, but it should be a long process to do. ”

"Yes, this is where the development of new drugs is difficult. ”

"Comparatively speaking, what stage is the country at in this regard?" Guan Yuntian said.

"To tell you the truth, basically no one in China does this work, because everyone is imitating those drugs whose patents have expired. Didn't you just ask about the gap in drug development? This is the real gap. ”

"Huang Ju, you are not only an expert in the industry, but also an industry leader, standing at your height, what do you think is the reason for this gap?"

Lao Huang didn't answer immediately, he thought about it, and then said: "In the final analysis, the first is funding, and the second is technology. It is said that in the 90s of the last century, when foreign countries developed a new drug, the investment in scientific research and development alone amounted to more than $1 billion! It can be imagined how much money is burned in the research and development of new drugs! However, those large multinational pharmaceutical companies can get this money, and they have been conducting research in this area all year round. On the other hand, even if the so-called major pharmaceutical groups have a net profit of several major pharmaceutical companies every year, even if they have such an idea, they will not be able to come up with that amount of money, and the gap will naturally form. ”

"In addition to financial constraints, is there a gap in technology?"

"In my opinion, the technical constraints are greater, in fact, there must be good signs, funding is not too big a problem, because domestic venture capital is gradually rising, and it is not difficult for good projects to be financed in financial institutions or other channels, the key is the lack of technology, especially basic research, and new drug research is not even a problem. ”

"It seems that basic research is too important in the development of new drugs!" Guan Yuntian said.

"Yes, as mentioned earlier, there is no wrong direction in the direction of screening molecular structures that are curative of human diseases from the natural world, but you must first figure out what kind of molecular structures are curative of which types of diseases? And then you must know roughly which plants or animals can find compounds with this structure, otherwise it is a needle in a haystack, and the result is that a lot of manpower, material and financial resources are spent, and in the end nothing is found. The above process cannot be carried out without the support of strong basic research in related disciplines. "Old Zodiac.

"Director Huang, it is said that basic research results cannot be patented, and generally have to be published publicly, now that the Internet is so developed, domestic researchers can also learn about the latest research progress in related fields from the Internet, why can't we use the results of others in basic research to serve our new drug research and development?" Guan Yuntian's science background helps him understand this information.

(This chapter is not finished, please turn the page)

"The hero sees the same thing, your idea, some domestic scientific and technological personnel engaged in pharmaceutical research and development have also thought of it, this idea is a shortcut, on this basis, a very small number of domestic research and development institutions and scientific researchers have also made some achievements in the research and development of new drugs. However, there are two factors that seriously hinder the implementation of this idea: on the one hand, many scientific and technological personnel either do not understand foreign literature in the field of basic research at all, or they do not know much about how to use the results for their own use, and there are very few scientific and technological personnel who can understand the true significance of those basic research results; on the other hand, the research and development of new drugs requires a large amount of capital investment, which is also the biggest obstacle. ”

"Yes, if you can't read foreign literature, you can find someone to translate it, the basic theory is esoteric and difficult to understand, and you can gradually understand its meaning through learning, these should not be very difficult, the key is that the research and development of new drugs requires a large amount of investment, and this problem is not easy to solve. Guan Yuntian paused, "Well, doesn't it mean that domestic venture capital is also very hot?

Lao Huang shook his head when he heard this, "Ouch, how can you see things so simply as a big boss? Institutions engaged in venture capital are all extremely shrewd, so they don't want to take any risks with you." ”

"What is venture capital without taking risks?"

Only when your research and development reaches a certain level and achieves certain results, and the value of the results is recognized by the authoritative department, will the venture capital institutions look at you squarely, otherwise, you will not even have the opportunity to talk to them!" It seems that Lao Huang has some understanding of venture capital.

"Then we will first carry out the R&D work, show them it, and then invite venture capital institutions to join after achieving certain results. "Guan Yuntian said.

"Your idea is not bad, but the problem is that to carry out research and development work, and to achieve certain results in the development of new drugs, it also requires a lot of investment, where does this money come from?

"It seems that things are not as simple as imagined, and there are many difficulties in drug innovation, and it is not easy to make a difference in this area. However, the difficulty of our Changda Group lies in the first aspect, as for the funding, it is not too much of a problem. ”

"What you lack is talent, what's this...... , you can recruit!"

"Recruitment is one of the ways to solve the talent problem, but what we need is academic leaders, and it is difficult to select the talents we need through general recruitment channels. "Guan Yuntian said.

"Academic leaders, almost expert-level talents, are really not easy to recruit, what are you going to do?"

"I don't want to ask you for help. ”

"You know that we are only in charge of the industry, and we don't have the power to transfer personnel, so I'm afraid this favor won't help you. Lao Huang spread his hands.

"Huang Bureau, now is not the era of planned economy, even if you are the leader of the personnel department, it is estimated that you will not be able to help this favor, because the current employment mechanism is a two-way choice, who do you want to work in Changda Group, people may not be willing to go. "Guan Yuntian said.

"Yes, you know I can't help you, so what's the use of you looking for me?"

"We don't have the power to deploy personnel, but you have the information resources! We need the relevant information you have, and then we can find people based on the information. Guan Yuntian told the truth.

"Oh, that's what you mean!, so what kind of information do you need?" Lao Huang thought that Guan Yuntian's recruitment plan was unique.

"Huang Ju, you are not only an administrative leader, but also an expert in the industry, you must have an understanding of the province's and even domestic drug research and development institutions, which universities and scientific research institutions do you think are stronger in drug research and development?"

"Well...... Lao Huang stopped, he felt that this was a need to recognize

(This chapter is not finished, please turn the page)

When dealing with real problems, the information given should at least be accurate and reliable, so as not to mislead old friends, so it took him several minutes to tell him everything he knew about scientific research institutes and colleges and universities.

Guan Yuntian listened very carefully, interjected from time to time and made notes.

"That's all I know about the industry, in fact, most of this information can be found on the Internet, but the content is not necessarily so specific. Lao Huang finally said.

Guan Yuntian felt quite rewarded, "Huang Bureau, thank you for the information! That's right, a lot of the information I found on the Internet is not very accurate, a lot of information is outdated, and the information of some units has not been updated for several years. ”

"The information I provide is not necessarily comprehensive, but what I have learned is basically accurate, because every year at the national industry conference, we have to meet with the leaders of these units. ”

"That's why I'm going to consult you personally, otherwise, where would we get such accurate information! Huang Ju, it's almost noon time to get off work, you find a place, let's have lunch." "Guan Yuntian said.

"You can't drink at noon, let's get together later. ”

"After you were promoted, this is the first time we have met, you have to give me a chance to congratulate you, in addition, I still have some questions to ask you, and I hope that Huang Ju will not hesitate to give advice. ”

Lao Huang had no choice but to ask for leave from the bureau office, falsely claiming that there were guests at home and he needed to go home at noon.

In a small private room in a high-end hotel, Guan Yuntian sat down with Lao Huang, and after arranging the dishes, he asked the waiter to serve a bottle of Moutai, "It's free, we can't drink at noon!" Lao Huang excused himself.

"Drink less, the two of us have a bottle of wine, and we won't delay anything. ”

"That's not okay, the unit has rules, this is discipline, and no one can violate it. ”

"I've heard you ask for leave from the office, this is your first meeting since you were promoted, and you have to have a drink. ”

Lao Huang couldn't refuse, so he had to agree, "Okay, never drink too much." ”

After the wine and food were served, the two chatted while drinking, "Mr. Guan, why did you suddenly think of doing new drug research and development? I have never heard you say it before." ”

"It's not a whim, it's something we've wanted to do for years, but I haven't had the opportunity to mention to you that our technology center is not only about new drug development, but also in the field of new materials, we also want to do some pioneering research. ”

"Your ambition is not small! You must know that scientific research investment is not like production, the risk is very high, many times the input-output ratio is very low, and it is even possible to only see input, no output, as an enterprise, do you have no worries?"

"The risk issue has been considered for a long time, but we know that a company without scientific and technological innovation capabilities, even if it does well at that time, the enterprise is not viable, and in the fierce competition, it may be eliminated that day. No matter what kind of product is made, if the enterprise itself does not have the ability to develop new products and new technologies, it is not only impossible to achieve continuous technological progress by introducing technology from the outside, it is difficult to achieve a complete product chain, and it is impossible to achieve the sustainable development of the enterprise. This risk is nothing compared to the life and death of the enterprise. "Guan Yuntian said.

"That's true, you can calculate this account very clearly, according to so many companies I have contacted, almost no one in other units has thought of such a stake. ”

"Yes, people are very realistic, and many people are really reluctant to invest their hard-earned money in scientific research and development with huge risks, which is also one of the main reasons why it is difficult for us to produce a century-old enterprise in the manufacturing field, right?" Guan Yuntian said.

It is not difficult to understand that you are not flattering in person, you are the real entrepreneur, not only seeing the essence of the problem, but also taking practical actions to pursue the advantages and avoid the disadvantages, and your business has been developing very well. ”

(End of chapter)