Office of the Institute of Cryptococcal Diseases.

"Hello Zhou, God has been friends for a long time, and today I finally saw the real person. ”

"Haha, it's the same! I have admired you for a long time, Director Zhang, and I have always wanted to visit you, but unfortunately I have never been able to make the trip. ”

Zhang Wen held Zhou Wen's hand and said with a smile: "If I had known that you would go to Zhonghai last time, I would have said that I would not go on a business trip." ”

Zhou Wen laughed, "That's not good, it's a sin to delay your work." ”

Although the age difference between the two is more than 20 years, they both hit it off at first sight, sympathize with each other, and talk quite speculatively!

In addition to the well-known identity titles, Zhang Wen is also the director of the Department of Infectious Diseases of Huashan Hospital, the director of the Department of Internal Medicine of the School of Medicine of Fuzheng University, and the doctoral supervisor, and he also has an identity - a biomedical researcher of Fuzheng University.

Don't underestimate the identity of this biomedical researcher, Zhang Wen's main direction is microbiology.

All of his achievements can be said to have come from microbiology.

"Okay Zhou Wen, don't patronize Zhang Wen, let me introduce you, this is Pan Renfeng, director of the Department of Infectious Diseases of Harmony Hospital. ”

"Hello Pan Lao......"

In the laboratory in the morning, when these bigwigs came over, Zhou Wen didn't have time to get to know them one by one.

Unlike those scholars in China who are busy with political life, those who are here today are some academic bigwigs who are really working on the front line.

Everyone has a very subsequent, approachable personality.

After a brief greeting, everyone's conversation naturally quickly focused on the neutralization effect test.

Everyone had a lively discussion.

……

……

The Cryptococcosis Research Institute of Jiangzhou Hospital, the news of the successful isolation of antigenic B cells has spread.

As soon as the news came out, it immediately attracted the attention of the domestic medical community.

Before the domestic medical community reacted, the latest news revealed that it was not only as simple as successful isolation, but that it had been successfully amplified and expressed antibodies.

Now it's not just as simple as paying attention, but they have begun to inquire about the truth of the matter.

However, at this time, Jiangzhou Hospital announced that the antibacterial cells had passed the neutralization effect test.

One stone stirs up a thousand waves!

Now everyone couldn't sit still.

Through the neutralization effect test, in other words, the next step can be to start clinical testing, as long as there is no rejection, or large side effects, it can be officially launched to the market as a new cryptococcal vaccine.

That's big news.

According to the latest research in the Proceedings of the National Academy of Sciences, infections caused by cryptococcosis neoformans kill about 1 million people worldwide every year, of which about 600,000 are in sub-Saharan Africa.

Cryptococcus neoformans enters the body mainly through the lungs and can spread throughout the body, including the brain.

The result of the infection is cryptococcosis, which causes chest pain, dry cough, bloating, headache, blurred vision or confusion. This infection can be fatal, especially if there is no antifungal infection treatment.

And even with treatment, the mortality rate is as high as more than 30%.

It's terrible!

Soon, calls came from health organizations in several countries, and even from the World Health Organization.

In addition, some large pharmaceutical groups and research institutes have also called to inquire about the technology of isolating antigenic B cells......

The successful replication of antimicrobial cells is of great significance.

……

At a time when the global medical community is paying attention to this matter, the School of Medicine of Jiangzhou University and the School of Medicine of Tanzhou University are also discussing with Zhou Wen on the issue of patent ownership of some technologies.

At the beginning, Jiangzhou Medical College did not expect Zhou Wen to successfully replicate antibacterial cells, and the main purpose was to increase the influence of Jiangzhou University Medical College with the help of Zhou Wen's influence in prions.

Tanzhou Medical College is the same, in fact, the purpose is similar, it is best to succeed, and to earn an academic reputation if it is not successful.

But I never expected that Zhou Wen would succeed.

There's really no place to make sense of this.

Now that it's been successful, it goes without saying much about halo honor, but it's all superficial.

But the issue of core interests is also very important.

That's the issue of patent ownership.

The anti-cryptococcal vaccine involves at least 5~10 patented technologies, each of which can bring long-term and huge benefits, which must be made clear as soon as possible to avoid unnecessary disputes in the future.

And although Zhou Wen didn't want to talk about such a naked thing as soon as the results came out, there was no way, the leaders of the two universities were in a hurry, so he could only come.

Jiangzhou University Medical Center, Conference Room.

Chen Tongguang, director of the medical department, said: "Professor Zhou, you are the main person in charge of the project, tell me your opinion!"

Zhou Wen said straight to the point: "Okay, then I'll tell you my opinion."

The Institute of Cryptococcosis was established with the support of the leaders, and there was an agreement between the two sides before, so I think it is enough to distribute it according to the agreement.

After the follow-up vaccine clinical trials and marketing sales, 90% of the expenses and revenues generated will be equally distributed by Jiangzhou University and Tanzhou University, and the remaining 10% of the revenue (excluding clinical trial costs) will be distributed by all our experimenters. ”

Lu Yongfeng, director of the School of Medicine of Tanzhou University, asked: "Of course we know this, but what about other patents?"

Zhou Wen said strangely: "What other patents are there?"

Lu Yongfeng smoked a cigarette and said, "Cell separation technology, expansion technology, assay technology, and primer design data, etc., these should all be counted, right?"

Zhou Wen glanced at Chen Tongguang and asked, "Director Chen, is this the result of your discussion?"

Chen Tongguang said with a helpless expression: "This is not the meaning of the medical department, it was proposed by the school." ”

Zhou Wen nodded and said: "Okay! Then I'll say it directly, except for the vaccine, the rest of the patented technology is all owned by me, which I have made clear when I first served as the deputy director of the institute, and it is written in black and white in the contract." ”

Lu Yongfeng smoked a cigarette and said slowly: "You can't say that! A contract is a contract, but you can't ignore the facts."

The vaccine was indeed researched under the leadership of Professor Zhou, but in this process, other researchers also paid hard work and sweat, so you can't take all the benefits by yourself and others have nothing, right?"

Zhou Wen frowned, "What do you mean that I take all the benefits by myself?"

Without me, does Director Lu think antigenic B cells can be isolated?

Without me, does Director Lu think the sequence amplification can be successful?

Without me, does Director Lu think a vaccine can be developed?

We must not only respect the facts, but also act according to our conscience, let alone ignore the facts!"

Seeing that the atmosphere in the conference room was a little stiff, Secretary Liu, who came to preside over the negotiation work from Tanzhou University, said with a smile: "Professor Zhou, don't be angry and listen to me.

It's a good thing that the vaccine research is out, and there is still a lot of work that needs to be presided over by Professor Zhou, so let's talk about it calmly. ”

After a pause, he said: "You see if this will work, let's take a step back, Professor Zhou can just take out the separation technology and amplification technology, and the rest will be owned by you personally." ”

Zhou Wen smiled and said, "Secretary Liu, do you think it's possible?"

After a pause, Zhou Wen said: "At the beginning, your Director Cheng asked me to mutate the cryptococcal serum, and I gave it without saying a word, and later your Xiangya Hospital successfully cured the new type of cryptococcosis and won countless honors and applause.

And I was criticized for this, and I was deducted from the bonus!

Later, when you Xiangya Hospital wanted to set up a cryptococcal disease research institute, you specially asked me to be the first person in charge of the project, but I was unwilling, and it was also your leaders who repeatedly invited me to agree.

It was also agreed to give 90 percent of the proceeds to the medical schools of both companies.

Now let me take a step back.

I'm sorry Secretary Liu, I can't take this step back today. ”

Saying that, Zhou Wen stood up, "Either you come according to the contract, or you go and sue me!"

After speaking, Zhou Wen turned around and left, leaving a room of people looking at each other.

……

Jiangzhou Hospital Testing Center, PCR Group.

In the office, Zhang Shuguang, Yang Liqun and Wang Huiyao were chatting.

Because Zhou Wen is gone, Zhang Shuguang can't find a successor, so he has been serving as the leader of the PCR team.

As for Wang Huiyao, he is good friends with Yang Liqun, and he came to see him today.

"It's a shame that the kid is gone. Zhang Shuguang said smoking a cigarette.

Yang Liqun smiled: "I don't think it's a pity! If he is still in the PCR group, how can he grow to this point?"

Wang Huiyao also smoked a cigarette and sighed: "Yes! His talent in biology is something I have only seen in so many years, and it can be called unprecedented. ”

Yang Liqun said: "I think it's normal! The vast majority of geniuses become famous as teenagers.

For example, Newton was only 24 years old when he discovered the three laws, the law of universal gravitation, and calculus, Einstein was 28 years old when he discovered the theory of relativity, and Schrödinger was only 26 years old when he proposed glass dynamics. Who else?"

Zhang Shuguang continued: "Heisenberg discovered the uncertain relationship at the age of 26, Bohr proposed the hydrogen atomic model at the age of 28, and Josephson predicted the Josephson junction at the age of 24. ”

Wang Huiyao nodded, and then added: "Anderson seems to have discovered positron at the age of 22, and the youngest of the Nobel laureates is Little Prague, who seems to be only 21 years old." ”

After Wang Huiyao finished speaking, Yang Liqun followed: "And Maxwell was 24 years old when he discovered the law of electromagnetism. ”

Zhang Shuguang said: "Why do you say?"

As soon as his words fell, Zhou Wen's laughter came from the open office door, "Because when a person receives a large amount of cutting-edge knowledge in the shortest possible time, it is most likely to make a discovery."

At this time, they are less constrained, their thinking is quick, and they can find the most critical and useful information from a large number of intricate materials.

If you use a step-by-step approach, you may gain a lot, all knowledge points are well-founded and logically rigorous, but at the same time, there is inertia in thinking, and it is difficult to make breakthrough discoveries!

As you get older and have more experience, you think less and less.

Because in many cases, experience can replace thinking, so that there will be fewer and fewer problems, and solving problems always depends on experience first, and in the end, there will be basically no new questions, and there will be no new discoveries......"