"Lao Yan, if you continue to double nitrorate C01A, what do you say will be the next product?" asked Shen Qi.

Lao Yan said: "Theoretically, the core structure of benzozoazine [3.2.1]-double bridge ring contains two functional groups of amine and aryl in close proximity, so I speculate that under the reaction condition of electrophilic substitution, the electrophilic attack on the aromatic ring is protected by carbamate and amino group, and it is difficult to nitrate the aromatic ring even if it is a strong nitrifying reagent." In other words, the next product doesn't make much sense. ”

"Simulate it. Shen Qi operated the computer and used Sybyl software to simulate.

The latest version of SybylPro is a computer-aided drug design software, based on the existing database, to assist in drug design, chemical combination protocols and other operations.

The simulated target product is a derivative of benzoaziz, and the most compatible commercial drug in the database is carbamazepine tablets.

Carbamazepine tablets are mainly used for analgesia, epilepsy, mania, psychosis, diabetes insipidus and other symptoms, and belong to the central nervous system drugs.

Lao Yan looked at the computer screen and said, "Is the next product of C01A meaningful? This thing is for mental illness?"

"It really doesn't make sense to copy carbamazepine, but this is an auxiliary software after all, and it can't be predicted 100% accurately. I feel that the next step of double nitronitation is scientific research value, try it, the experiment is a continuous attempt, maybe the blind cat will bump into the dead mouse, hit the luck. Shen Qi insisted on doing double nitroation and began to prepare raw materials.

The boss is so stubborn, and Lao Yan has no choice, so he can only do the preparatory work before the experiment with Shen Qi.

Preparations took place throughout the day, and the raw materials had to be reformulated and synthesized.

The next day, the experiment began, codenamed C01B.

Shen Qi and Lao Yan went into battle together, and trifluoroacetamide protection was specially introduced to isolate nitrogen atoms, preventing the formation of double-substituted cationic intermediates by dispersing the electron cloud density on nitrogen.

This protection allows the nitrification reaction to take place further, and at the same time, Shen Qi added nitrotrifluoromethanesulfonic acid, a strong nitrifying agent, which is specially designed to overcome the slow nitrification of benzoazazine derivatives.

At this time, two days have passed, Shen Qi and Lao Yan are on shifts, and at least one person is on duty at any time in the laboratory.

Finally, the dinitrogenated compounds were condensed with glyoxal, sodium bisulfite to obtain quinoxaline, and the target product was obtained by deprotection.

The target product is a pale blue crystal, crystal clear, beautiful with magical colors.

Shen Qi and Lao Yan were fascinated by its dreamy appearance, and the hard work of the past few days was not in vain.

"That's the beauty of chemistry, a bunch of toxic raw materials, and finally an incredibly beautiful product. "The old smoke was tightly covered from the toes to the top of his head, and there was hardly an inch of bare skin on his body.

Shen Qi, who was also heavily armed, observed the target product intently, and said: "Just looking at the appearance, C01B is more than one grade higher than C01A, this thing is not used for medicinal purposes, and it can be sold for a lot of money when it is sold as jewelry." ”

Both Shen Qi and Lao Yan know that for chemical products, appearance is important, and efficacy is more important, that is, the intrinsic nature of chemical products.

Through nuclear magnetic resonance, molecular weight determination and other chemical methods, Shen Qi and Lao Yan determined the molecular formula, molecular weight and molecular structure diagram of C01B.

"Therefore, its name is 4-oxo-5-phenyl-1,3,4,6-tetrahydro-6,10-methylene-2H-1,4-benzoazazoxane, which is the closest commercial drug to C01B in the database?"

The match given by Sybyl is: carbamazepine tablets.

"It shouldn't be, why is it carbamazepine tablets again? This database hasn't been updated?" Lao Yan felt that the computer was fooling them.

"Check out the latest papers on organic chemistry and medicinal chemistry. Shen Qi suggested that he needed to know the approximate pharmacological properties of C01B, otherwise it would be very blind to do animal experiments without a target.

After consulting a large number of literatures and consulting two senior professors from the Institute of Chemical Sciences and the Department of Medicine, Shen Qi came up with a speculation that the main role of C01B should be to regulate the dopamine secretion in the nucleus accumbens region of the limbic dopamine system in the midbrain, which is the basic mechanism of nicotine addiction.

Shen Qi laughed: "Chemistry is an interesting subject, and the C01B obtained after double nitrosylation of C01A made by Lao Yan, theoretically speaking, should be a chemical test to restrain smoking addiction." Who will be spared by the heavens, you smoker, crookedly whipping up a brand new smoking cessation compound!"

"?" Lao Yan was shocked, he would have to pay it back sooner or later?

Shen Qi's wording is very rigorous, he has been saying that C01B is a chemical test product, which theoretically has the effect of quitting smoking, and does not say that it is a drug.

The C01B obtained in the preliminary stage of the laboratory can only be regarded as a chemical test product, which can only be called a chemical commodity after being verified to be safe and effective through various property tests, and finally produced commercially.

The drugs and chemical products on the market are all chemical commodities, which means that they have been widely recognized by people and are willing to pay for them.

The development of a new non-generic commercial drug requires a lot of hard work from many scientists, and after a long period of experimental research and process verification, it can be marketed and marketed for the benefit of mankind.

Shen Qi has three guns, one of which is mainly responsible for raising animals and dissecting animals, and the only people who are really engaged in innovative research are Shen Qi and Lao Yan.

Shen Qi said: "This C01B, I think there is potential for commercialization, as far as I know, the cessation rate of that kind of smoking cessation gum is only 20%, nicotine acetylcholine receptor agonist smoking cessation drugs have a higher success rate of smoking cessation, but smokers use this drug, smoking is quit, but they have a certain addiction dependence on smoking cessation drugs." ”

"It's very difficult to quit smoking, what are the things that people who can't do if they can quit smoking?"

"Addicted to smoking again?" Shen Qi smiled.

"I'm out smoking, I'm out smoking. "It's a habitual action for the old cigarette to touch the cigarette case, but the cigarette is not on the body, and it is locked in a locker outside the laboratory.

Shen Qi and Lao Yan came outside the laboratory together and took off their masks and protective goggles.

Lao Yan found that Shen Qi was looking at him with a mysterious smile, he shivered, and felt a chill and fear: "Boss, I can't quit this addiction, don't use me as a human experiment!"

Shen Qi patted Lao Yan's shoulder: "Making a new commercial drug is quite a hard and long job, if you can't make full use of external resources, you can't make a commercial smoking cessation drug with you, me, and Lao Tu." As for clinical trials, how could I possibly do it on you? The last person I want to provoke is a chemist. If I test you today, you might poison me tomorrow. ”

"Chemists have to obey the law, too, don't they? Lao Yan said, and asked, "What should I do next?"

Shen Qi said: "There are more than one billion smokers in the world, and more than half of them have the desire to quit smoking. ”

"Then you have to recruit a few assistants with me, even in the initial stage of the laboratory, I am stretched alone, and you are very busy, it is impossible to squat in the laboratory all day. Lao Yan made a request.

"You send out a few articles first, there are no scientific research results, why should I ask for people?" Shen Qi said, and then asked with concern: "What happened to you and Xiaolian?"

Lao Yan talked about the matter: "If you don't add experimenters to me, I can only stay in the laboratory, how can I have time to pick up girls?"

"Yo, it's all soaked, it's okay to keep up the good work. The experimenter is not so fast to arrive, you take it first, experiment during the day, and pick up girls at night, this rhythm is very good. ”

Shen Qi and Lao Yan came to the third floor, Shen Qi pointed to a vacant small room and said: "From today onwards, this is a smoking room, you go and buy a cigarette butt recycling equipment with ventilation function, which is the kind of equipment in the airport smoking room, and find financial reimbursement after you buy it." But I still hope that you can quit smoking. ”

"Good, good, long live understanding. Lao Yan was overjoyed, found a paper cup to catch some water, squatted in the empty house and smoked.

Shen Qi came to the café and sat down to drink coffee.

There are not many people in the café, which shows that the staff of the center are very busy.

Shen Qi saw Witten, Zhou Yu'an, and Xiao Junlong sitting and chatting together at a certain table, with happy expressions.

Picking up the coffee cup, Shen Qi walked to the table and sat down: "It seems that the N-S equation project has made significant progress?"

"It's not that fast. Zhou Yu'an shook his head.

"Then you're smiling so happily?" asked Shen Qi.