Chapter 464 Benzodiaze
The compound codenamed C01A is in the form of a white crystalline powder, insoluble in water, soluble in organic solvents such as acetone.
According to Lao Yan's report and Shen Qi's identification, the two can be sure that the main component of C01A is benzoazaziz.
"Benzozozazines, old smoke, there is really yours. Shen Qi said.
The more well-known benzoazepam drugs on the market include diazepam, oxazepam, etc., which mainly play several roles: sedative, anxiolytic, and hypnotic.
That is, tranquilizers and sleeping pills, which are prescription drugs and have a certain degree of addiction.
In particular, diazepam, which was newly included in the list of carcinogens by the World Health Organization, has changed from a prescription drug to a banned drug.
"C01A does have value, but not the kind of value I was expecting. But anyway, this is also the result of your hard work in the past few months, put together a complete experiment report, and show me again. Shen Qi didn't know how to evaluate Lao Yan, and arranged for Lao Yan to study drugs for anemia, and as a result, he made a suspected product of sleeping pills + tranquilizers.
It can't be said that Lao Yan's academic level is not good, he didn't know what to think about designing a synthetic route, and finally got C01A with a total yield of 22%, which is also a reflection of a high level.
Later, Lao Tu next door gave Shen Qi an inspection report, which was about the analysis of the properties of Shen Qi's self-made Le Luo Xianfen ADME.
Lao Tu has done a lot of experiments on monkeys and mice in the past few months, and the experimental data show that the skeleton structure of Shen Qi's self-made Leluosine is benzothiophene, the protein binding rate is greater than 95%, there is no CYP involved in metabolism, the half-life is 1.15 days, and the metabolite is glucuronide.
Lao Tu's conclusion is that Shen Qi's self-made Leluo Xianfen can play a certain role in regulating estrogen in animals. However, it will take time to verify whether it can be equated with the American version of Le Luoxenfine.
To validate a drug, in vivo experiments are necessary, animal experiments are the first step, and the key is clinical trials, after all, drugs are ultimately used to treat humans.
Shen Qi and their center have no conditions or qualifications to do clinical trials, so Lao Tu gave the above conclusion.
Shen Qi never thought of taking this test product and entrusting a qualified institution to do clinical trials, he just practiced his hands and accumulated pharmaceutical experience and data.
From theoretical research to laboratory preparation, to animal experiments, clinical trials, to obtaining approval from relevant departments and marketing sales, it is not so easy to launch a new drug.
Shen Qi, Lao Yan and Lao Tu, they can only do animal experiments at present, develop some chemical experiments in small batches in the laboratory, and accumulate experimental data on animals.
At five o'clock in the afternoon, Shen Qi shouted Lao Yan, set off, and went on a blind date.
When he came downstairs, Lao Yan consciously sat in the driver's seat of Shen Qi's Mercedes-Benz SUV, and went out to eat with the leader, so he couldn't let the leader drive.
Lao Yan drove to the gate of the courtyard, waited with Shen Qi for a while, and saw two women coming out of the courtyard building.
One is pregnant with her belly up, and the other girl is supporting the pregnant woman.
"Dr. Ou is your wife, who is the short-haired one next to you?" asked Lao Yan.
"Xiao Lian, my wife's best friend. Shen Qi got out of the car, opened the back door, helped Ou Ye to the back row, he also went to the back row, and let Xiao Lian sit in the co-pilot seat.
Shen Qi introduced everyone to know: "Yan Jun, a chemical engineer in our center. This beauty is Xiao Lian, an assistant researcher at the Academy. By the way, Xiaolian, what's your full name?"
Xiao Lian: "My full name is Lian Zilu. ”
"Lotus seed dew?" Lao Yan wanted to laugh when he heard it.
You old smoke, you have to laugh when you meet, is lotus dew funny? Shen Qi said: "Very sweet name, people are like their names, Xiaolian is a sweet girl." Let's go, Lao Yan drives, go. ”
The place to dine is a tranquil place for chatting.
The old smoke is one meter seventy-five, not high, not white, and does not have a prosperous beauty. His fingers are yellow, which is caused by long-term smoking.
Xiaolian is 1.58 meters, slightly chubby, a little white, Lao Yan didn't give her an amazing feeling, just an ordinary science and engineering man.
Shen Qi knocked on the side and pointed out euphemistically that Cinderella marrying Prince Charming, or a working boy marrying Bai Fumei, these stories are all artistic treatments that are higher than reality.
In reality, most marriages are a good match, and the life experience, social status, and family background of both husband and wife are roughly the same, so that the marriage can be stable for a long time.
The matchmaker has done his part, Shen Qi feels that he has done his best, whether there is fate or not, Lao Yan and Xiaolian can grasp it yourself.
"We had a very pleasant chat today, so let's do it, Yan Gong, you can take a taxi later, send Xiaolian back, and you can also carry out the second half of the activity to deepen your understanding. Ou Ye and I withdrew first, and I have already bought it, so I wish you all a good time. Shen Qi and his wife left the scene early, leaving room for Lao Yan and Xiaolian to be alone.
Back at the academician's villa, Ou Ye said: "In fact, every girl has a dream of Prince Charming. ”
Shen Qi: "But history tells us that princes basically marry the daughters of aristocratic families. ”
Ouye: "Can you not be so realistic?"
"Ordinary girls and princes are not necessarily happy. Shen Qi said.
"Yan Jun has no characteristics. As soon as Ou Ye went home, he vetoed the old cigarette that Shen Qi had ceremoniously launched.
"Whether there are characteristics or not, you don't count if you say it, Xiaolian only counts if you say it. I think they're a good fit, and I see people better than you. Okay, you go to rest early, I'll check the information and go to sleep. Shen Qi helped Ou Ye up to the second floor and entered the bedroom.
"Are you planning a math overhaul?" asked Oye.
"The project has already been established. Shen Qi said.
Ou Ye was very interested and said, "Who is in the project team?"
"I, Li Zhenqiang, are just the two of us at the moment. ”
"Li Zhenqiang's major is algebraic geometry, who does number theory?"
Shen Qi patted his chest: "Your husband and me." ”
"What about you?" Ou Ye pinched Shen Qi's ears and asked more and more curiously: "How far have you reached the number theory section?"
Shen Qi said modestly: "I haven't started to do it yet, because my level is limited, and I have encountered a lot of difficulties in the initial advancement of the number theory section. After you have a baby, I will ask Dr. Ou, an expert in number theory, about related questions, but now, Dr. Ou's main task is to raise a baby. ”
"Good. Ou Ye touched Shen Qi's head, and then touched her belly, in front of her, in her womb, her husband, and children were her most important family.
Mathematics is another spiritual sustenance for Ouye, but there will always be a period in a woman's life when she can't concentrate all her energy on the cause she loves.
A few days later, Lao Yan handed Shen Qi a chemical experiment report, which specifically elaborated on the molecular design, synthesis route design, product and yield of each step, crystal preparation and other experimental processes of C01A.
This is a chemistry paper, Lao Yan is a chemistry major, he knows some knowledge of medicinal chemistry, but it is not the same thing as a pharmacologist and a medical scientist.
The way of writing medical papers is very different from Lao Yan's chemical papers, medical papers do not write about the specific process of drug preparation, and pharmacologists and medical scientists pay more attention to the research results in professional fields such as drug resistance monitoring, clinical research, pharmacokinetics and BE.
So what is the specific use of C01A and whether it has scientific research value, this needs to be judged by Shen Qi.