On this day,

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.

Academician Zhong was very dissatisfied with the progress of the molecular biology department, but there was no news from Xu Mang's side, which made him a little desperate for a while, seeing that the Chinese New Year was coming soon, but why was his heart so bad.

"Ugh..."

"It's about to be the New Year... Is it going to drag on for a year?" Academician Zhong originally thought that finding Xu Mang could quickly solve the breakthrough problem in the field of gene editing, but the fact was the opposite, and he seemed to be in a dilemma.

The time of talking to Xu Mang on the phone should have been ten days ago, and the kind of weak voice at that time, I'm afraid... I'm tormented enough by this question.

Then

Academician Chu, an expert in bioinformatics, came to Academician Zhong's office, saw his helpless expression, and couldn't help but smile bitterly: "I said old Zhong... You've been sad for almost three months, it's almost enough, and now that the Chinese New Year is coming, can you change your expression?"

"Ugh..."

"I want to change it too, but how?" Academician Zhong sighed: "The progress of the molecular biology department is almost zero, and Xu Mang's situation is not very optimistic, I am afraid that it will be postponed indefinitely, and the research funding for the coming year will be greatly reduced, at least in the field of gene editing, it will be reduced by about 20%. ”

"That's right. ”

"It's too big... Some objected. Lao Chu sat opposite Academician Zhong and said silently: "But you are much better than Xu Mang, the collider project has been stuck, because of this project problem, Xu Mang even resigned as a professor, his difficulties are much more serious than yours." ”

Hearing Lao Chu's words, Academician Zhong smiled bitterly: "Yes... Not the level of difficulty of a concept. ”

"Anyway..."

"Have you been in contact with Xu Mang?" Lao Chu asked curiously, "Or... You call now and ask, I have a very strong hunch that Xu Mang may have completed a breakthrough in the field of gene editing, when did you power up with Xu Mang before?"

"Ten days ago. ”

"Ten days ago?" Lao Chu showed a hint of bitterness on his face: "There are no ten days to be worse, you ask now... It might give you an unexpected result, right... Hands-free!"

Academician Zhong: ???

What's the situation?

Why is Lao Chu weird today.

No way

Academician Zhong made a phone call to Xu Mang, and soon the call was connected.

"Hello?"

"Academician Zhong?" Xu Mang's voice came out, with a hint of playfulness in his words, and said, "It's about to be the New Year... I'll give you a New Year's greeting in advance, and I won't go... The distance between the magic capital and the capital is not ordinarily far. ”

“...”

“...”

The two are helpless, it seems... After all, the Chinese New Year is coming soon, and it's not good to block others at this time, which is a bit unkind.

Academician Zhong was very hesitant, and wanted to ask about the progress several times, but he still swallowed it back, seeing that the New Year was coming, can't he give others a more reassuring New Year? I still gave up on the intention of asking.

But

Xu Mang brought it up.

"Academician Zhong called me, did you want to ask about the progress?" Xu Mang said with a smile: "I've almost finished it... A rudimentary AI system has been figured out, and it is being tested at this stage, and it is estimated that... It's broken. ”

“？？？”

“？？？”

Do...

Got it out?

That's too unexpected, isn't it?

Academician Zhong and Academician Chu looked confused, glanced at each other, and each other had shocked expressions on their faces, as well as a little incredulity.

"In my concept, I bypassed the problem of replacing the DNA fragment with the target sequence, directly cut one DNA strand, and then the reverse enzyme was guided by the RNA strand to perform gene editing at the cut. Xu Mang said solemnly: "Although it is still a CRISPR-Cas9 system, I have modified Cas9. ”

Bypass?

This... That's a good idea!

Academician Zhong hurriedly said, "Can you be more specific?"

"Yes!"

"First one strand of DNA is cut off and the target sequence Y is inserted, then the original sequence is cut off, another strand of DNA that has not been edited is cut, and finally the CRISPR system repairs the strand of DNA that has been cut. ”

"This way the enzyme doesn't need to cut the DNA double-strand, so researchers don't have to rely on a cellular DNA repair system that they can't control to gene-edit the severed DNA strands." Xu Mang paused for a moment and said seriously: "It means that with the help of a new editing system, genetic diseases related to gene mutations can be developed." ”

Time

The two academicians were completely silent, and what Xu Mang said could not be done at all on the existing gene editing tools.

"That's right!"

"I thought of another solution the day before yesterday. Xu Mang smiled: "Its accuracy is comparable to my editing tool system, which can directly achieve base substitution without cutting the double strands of DNA through chemical methods, such as replacing T with A and G with C." ”

"The CRISPR–Cas9 gene editing system can't do this, but...", Xu Mang sighed, "This method can't solve the problem of multi-base, such as the translated black idiot symptoms, which are caused by the misinsertion of 4 DNA bases in the HEXA gene." ”

This...

It's simply,

Too tough, right?

Hearing Xu Mang's introduction, the two bigwigs of the Academy of Sciences were so shocked that they couldn't speak, and sat in place with a stunned expression.

"Anyway..."

"I see the new system as flexible, simple, and capable of multiple gene editing functions. "A system composed of a combination of enzymes, including the modified Cas9 enzyme, can alter, delete a single base or insert a small DNA sequence without damaging the DNA duplex. ”

Academician Zhong took a deep breath and asked cautiously, "Xu Mang... How long will it take?"

"Before the Chinese New Year. ”

"Give me another five days, and when I finish the test, I'll give it to you..."Xu Mang smiled: "I got an AI, you can use AI to conduct simulation tests, modify them according to the test results, and then go to the laboratory for the final test." ”

"Anyway, it's about reducing your workload, after all, the future is an era of artificial intelligence. Xu Mang said helplessly: "Academician Zhong... This is the result of my best efforts, and if I am still not satisfied with this result, sorry... There's really nothing I can do about it. ”

Dissatisfied?

Are you kidding!

This is clearly more than expected!

What Xu is saying is more advanced than any modified CRISPR–Cas9 system, because it does not rely on the cell's own repair system for gene editing.

"No!"

"Professor Xu... If it all came true, I swear... Your new system is sure to be the world's most advanced gene editing tool. Academician Zhong said seriously: "I'm not joking, this is beyond any imagination. ”

Xu Mang opened his mouth and whispered, "Academician Zhong... I have a request, can you tighten the constraints in the field of gene editing in the future? There are some worries, fears that the human beings of the future may not be human in the true sense of the word. ”

"I know what you're worried about. ”

"Indeed, in this regard... Our binding force is not enough, including a very serious mistake that occurred not long ago. Academician Zhong's tone was a little serious: "Recently, I will propose relevant measures and implement them all within a year." ”

"Oh..."

"That's fine. Xu Mang said: "I'll hang up first." ”

moment

call drops,

However, the excitement was still wrapped around the hearts of Academician Zhong and Academician Chu, and they couldn't imagine what they had just heard, and they couldn't imagine that Xu Mang had really done something that the world had not done in this field, and he had broken through the dilemma in the field of gene editing.

"Old Clock..."

"What should I do?" Academician Chu smiled bitterly: "Such a genius is actually engaged in physics... Are you angry?"

"Ugh..."

"There is still a huge gap between our researchers and the world's top level. Academician Zhong said helplessly: "It's a pity... There is only one Xu Mang in this world, and I really hope that there will be more cameras, so I can't imagine what will happen in the future. ”

"One Xu Mang is enough... He's pretty much omnipotent. Academician Chu smiled: "If you have difficulties, find Xu Mang, this sentence is not wrong!"

...

meanwhile

A villa far away in the magic capital,

Xu Mang was sitting on the sofa, accompanying Xiaoman to watch a boring TV series, speaking of which this TV series is very... It is quite thought-provoking, it reflects the education problems of modern families for their children, and also reflects the helplessness of children when facing learning pressure.

"Husband?"

"You say... Will our children be stupid in the future?" Yang Xiaoman frowned and asked with a serious face: "You are a big scientist, I am a big entrepreneur, and as a result, our children... The grades are always at the bottom of the whole grade, who will go to the parent-teacher conference in the future?"

Xu Mang: (°ー°〃)

That's right!

In case it's very naughty, who will go to this parent's meeting?

"I'm not going!"

"I won't go if I am killed..."Xu Mang shook his head and said with a serious face: "I'm a big scientist, and I also want to be embarrassed, anyway... I won't go to say anything. ”

Yang Xiaoman is so angry, in fact, she doesn't want to be embarrassed, but she has to go to one for two people, what can I do?

At last

Under the succumb to force, Xu Mang became the first choice for a parent-teacher conference.

"Actually..."

"You don't have to be at the bottom of the test, but you may also be the first in the positive. Xu Mang gently took Xiao Man into his arms, leaned into her ear and said, "Let me ask you a question, the problem of the absorption section of plane light waves by binding electrons in a certain potential field. ”

"May I ask if the electrons are bound to the basis by the potential below..."

didn't wait for Xu Mang to finish speaking,

Yang Xiaoman glared at him viciously, and said angrily: "Get out!

"Hey, hey..."

"No, right?" Xu Mang said with a smile: "The problem has been found, that is, you are too stupid and have dragged down my smart and powerful genes." ”

Yang Xiaoman: (* ̄〈 ̄)

After a family education, Xu Mang hugged Xiaoman, with a little grievance on his face.

However, it can be determined that

Xu Yang and Xu Man are already invincible in terms of fighting.

...

On this day,

The second phase of the Xuman system was completed, but the real data from the laboratory was missing.

"Hello?"

"Academician Zhong. ”

"It's done, but... I'd like to ask you to lead the whole team and help me verify the correctness of the AI simulation!"

There is a problem with this Internet café, which is written...... When the mouse fails, the pointer moves to the game client on its own...... Don't???

(End of chapter)