Capital

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.

An accident two months ago left an indelible shadow on the area, and although there were no casualties, it caused irreparable economic damage, and although Huaguo is already a recognized world leader in CRISPR-Cas9 gene editing, the technology still has serious flaws.

How to make up for this deficiency has become the task to be completed by the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, although CRISPR-Cas9 gene editing technology has quickly become the hottest technology in life science due to its simplicity, efficiency and diversity.

In particular, gene therapy for human diseases is hailed as one of the most potentially transformative innovations in modern human medicine, but behind the success is often the accumulation of failures, as evidenced by the accident two months ago.

A certain department,

Silence has always shrouded in this one office, and a dozen or so top researchers in the industry are struggling to upgrade their CRISPR-Cas9 gene editing technology, and a whole month has passed, and nothing has been gained.

For the study of the repeated sequences of short palindromes at regular intervals, many of the people present were elite-level figures, but how to upgrade was difficult for everyone, including many doctors.

Initially

Everyone's goal is great, to establish a surpassing CRISPR system, but with continuous in-depth research, it is gradually found that the cruelty of reality has exceeded everyone's imagination, and the CRISPR system cannot be surpassed at this stage, only on the basis of the original fine optimization.

However, the CRISPR system has developed from the nineties to the present, and has been upgraded by countless biological scientists, to the extent that it can no longer be optimized. The CRISPR system has entered a bottleneck period, and if you want to break through... Unless there is a completely new theory.

Just like physics, the span from classical physics to modern physics is hundreds of years, and modern physics to new physics is still an unknown quantity, while biology has just undergone a huge revolution, and when the next revolution will start is as unknown as physics.

"Ugh..."

"It's so hard!" a doctor in the office sighed, his words full of helplessness: "The whole world knows that the main challenge in the standard CRISPR–Cas9 system is to reduce the probability of off-target, but who can do it? It is equivalent to borrowing the shell of the CRISPR–Cas9 system, and the contents of it will change. ”

"Then what are you going to do?" the middle-aged man sitting next to him with a sad face smiled bitterly: "If this problem is not solved, we may be greatly reduced, after all, this matter has left too much shadow." ”

Time

Helpless emotions surged into the hearts of everyone present, this problem is not a sporadic difficulty, unless there is a genius like Xu Mang, don't think about success.

Xu Mang?

Many people thought of what happened just a few days ago, about artificial intelligence that predicts the three-dimensional structure of proteins from amino acid sequences, and said that if Professor Xu Mang was asked to develop a similar AI, it could simulate the modification of target sites.

"Huh?"

"What do you think... If Professor Xu suddenly designed a gene-editing AI one day, would there be a world-class biological revolution?" the doctor said curiously, "I think it could... At present, in terms of protein structure, it has caused a huge response. ”

"Difficult!"

"It's hard!"

"I think the CRISPR system is already the most perfect existence, and it cannot be surpassed in a short period of time. The middle-aged man smiled bitterly: "Don't have this kind of thought... After all, Professor Xu Mang is engaged in physics, and occasionally plays a role in other fields, but gene editing... I don't think it's possible!"

Just as everyone was discussing this matter, Academician Zhong walked in and said to everyone present: "Ahem... For a moment, I'm here to announce two things. ”

Words fall,

The office fell into silence, and everyone looked at Academician Zhong standing at the door with a hint of doubt in their eyes.

"First of all, I won the right to use the artificial intelligence 'Xu Man System' that predicts the three-dimensional structure of proteins from amino acid sequences. Professor Zhong said: "In the near future, systematic hunting will be carried out, and in the future, everyone can use this technology to study the structure of proteins." ”

"Second... Professor Xu has accepted my request to help us achieve a new level in the field of gene editing. Professor Zhong said, "But... I hope that you will not start to relax because of the addition of Professor Xu Mang, and you will still have to keep doing your best. ”

“？？？”

“？？？”

“？？？”

He... Is he really coming?

Hearing Academician Zhong's words, many people were surprised and were infinitely surprised, but then there were doubts, not questions about Xu Mang, but questions about their own strength.

It's pretty miserable to say, I have to take a physicist exam to save the day, which... Did this creature learn in vain?

"To motivate you guys, uh... Your entire team will pit against Professor Xu to see who can take the lead in the innovation in the field of gene editing. Academician Zhong smiled: "He has only one person, but you have more than a dozen, there should be no problem, right?"

No problem?

That's not a small problem!

If it was before, everyone was full of confidence, how could one person fight against a team of more than ten people, but now... I'm sorry, I can really fight against it! And not only against a team, not long ago, Xu Mang single-handedly suppressed nine American AI teams.

It can well be imagined

Less is more, no... It's not right to fight one against a hundred... It should be a husband and a husband, and ten thousand people should not be opened, this is Professor Xu Mang.

"Academician Zhong... You're kidding. The doctor said: "All kinds of deeds tell us that none of the people who competed with Professor Xu Mang ended well, and I estimate that we can't, this is not a confrontation of magnitude at all." ”

"Lost before you started?" Academician Zhong said helplessly: "Cheer up, we can't rely on Professor Xu Mang alone, what if he fails?"

Words fall,

Academician Zhong left, and on the way to his office, he met a colleague, Academician Chu, an expert in bioinformatics.

"Old Bell?"

"I heard that you went to Fuda?" Lao Chu asked curiously, "I remember you went yesterday, right? I met you here this morning, and I don't think I'll be back overnight, right?"

Academician Zhong smiled bitterly: "Yes... It's not about solving the matter two months ago, I hope to summarize the relevant experience based on a previous mistake, and then strive to make a breakthrough in this field, but the breakthrough is so simple. ”

"So..."

"You found Professor Xu Mang?" Lao Chu smiled: "How is the situation?

"Yes. ”

"At the same time, I also got the right to use the 'Xu Man System'. Academician Zhong said: "By the way, Lao Chu... What do you think is the probability that Xu Mang will break through the existing framework in the field of gene editing?"

"I don't know. ”

"Don't ask me that question. Lao Chu said bitterly: "His business... I'm not going to say anything. ”

“...”

Academician Zhong said helplessly: "Is it necessary to be so cautious? Can it or not, in terms of probability, it is only 50 percent, and it is so difficult to give an accurate explanation?"

"It's not difficult!"

"But if the other party is Xu Mang, it will be difficult... You should know what I mean. Lao Chu said seriously: "Don't look at him as a physics, but he knows everything, and he is proficient in everything, which is completely unreasonable." ”

Academician Zhong smiled: "Tell your department to assist the molecular biology department in making a breakthrough in the field of gene editing." ”

"Good!"

"Are you planning to have a competition with Xu Mang?" asked Lao Chu.

"Almost!"

"I want to see how far the researchers in our department are from Professor Xu Mang. Academician Zhong said: "Professor Xu Mang's main job is physics, and they graduated from biology, don't you want to know how much the gap between the two is?"

Lao Chu opened his mouth, and an unspeakable voice was stuck in his throat.

Let's be honest...

Not at all!

...

Magic City,

Yang Xiaoman and Xu Mang were walking hand in hand, in fact, Xu Mang didn't want to come out, this cold day... And the cold in the south is not the same as the cold in the north, the north belongs to the physical attack, while the south belongs to the magic attack, with moisture... If you don't get it in your old age, you will get rheumatic bone disease.

"Ugh..."

"Wife?"

"Aren't you cold at all?" Xu Mang asked cautiously: "I'm almost freezing, take care of the heating at home and don't blow it, what kind of walk do you come out for, if I catch a cold... Do you know how much our country has lost? The progress of a large research project has been put on hold, and time is money!"

Yang Xiaoman: (# ̄~ ̄#)

Take a walk after dinner and increase the emotions between each other, why is there so much nonsense?

I'm!

"Will you die if you walk for a while?" Yang Xiaoman said angrily: "Aren't you researching gene editing? Can you edit your own genes first? I'm too lazy to die..."

After being educated by Xiaoman, Xu Mang was a lot more honest, silently accompanying her and carrying out cold wind activities.

Then

A couple who looked like young high school couples walked up to them.

"Auntie?"

"Auntie, wait a minute!" Suddenly, the girl rushed to Yang Xiaoman and asked curiously, "Auntie... You look good in this dress, does it feel warm to wear?"

Pander to...

Aunt?

When Yang Xiaoman heard the little girl call herself an aunt, her brain suddenly short-circuited, and she looked at her with a confused expression.

"Uh..."

"It looks quite warm, I'm going to buy one for my mom too!" The little girl carefully studied Xiao Man's coat, and didn't seem to notice how terrifying the expression of the owner of the dress was at this time.

I...

Aunt?

Buy one for Mom?

Yang Xiaoman has completely collapsed, as if he has lost his nerves and can't feel breathing, and even the air is suffocated...

suddenly

Xu Mang hugged Yang Xiaoman, and shouted at the little couple with a nervous face: "Run! Run! It's still too late to run, otherwise you will be transformed... You're going to be sunk!"

......