"I'm so angry with my mother!"

"Obviously, my mother, I'm so young... How did you become an aunt?" Yang Xiaoman was crazy about buying cosmetics in an online shopping mall, and when she was just walking, she was hurt by a high school girl, and she was obviously much younger than her, but the little girl didn't have long eyes, and she called her aunt when she came up.

"Oops..."

"Okay!" Xu Mang sat at the head of the bed, glanced at Yang Xiaoman's tablet, and said with a frightened expression: "You... Your shopping cart is... That's more than a million, and you're not going to empty your shopping cart today, are you?"

"How?"

"I'm upset and want to go shopping to vent?" Yang Xiaoman glanced at Xu Mang, and said angrily: "Isn't my old lady beautiful?" You tell me the truth, is your skin as tight as before, and is her appearance as cute and moving as before?"

it!

This is complete madness!

Xu Mang was speechless for a moment, he couldn't imagine that an aunt would hurt so much, kicking a Xiao Man who was standing at the peak of his appearance to the bottom, completely hurting his self-esteem, and it was also... Xiaoman has always been a beautiful girl, but one day the beautiful girl became an old aunt.

Hey, hey, hey...

What's going on here?

Why is there a hint of joy in my heart?

"What are you laughing at?" Yang Xiaoman said angrily: "Say it quickly, old lady, am I the same as before?"

"Hmm!"

"Actually, don't care so much about what others think of you, just think it's beautiful. Xu Mang said with a serious face: "The good-looking skins are the same, but the interesting souls are one in a thousand, Xiaoman, you are the best!"

However, in the face of Xu Mang's chicken soup, Yang Xiaoman said with disdain: "If someone says that you are not handsome at all, and you are uglier than the too white cat that is written, what will you do?"

"Fart!"

"Although I, Xu Mang, have admitted that he is the second handsome man in the world, I can't give up the position of the first handsome because of my recognition. Xu Mang said angrily: "Don't take this kind of analogy in the future, my handsomeness is a dream that you can't touch in your life." ”

You...

I'm so angry, old lady!

Angry to the extreme, Yang Xiaoman went up and bit Xu Mang's shoulder, of course he didn't dare to use force, if he bit blood, he wouldn't feel good in his heart, but he had to bite out his teeth to make this big idiot have a long memory.

"Oops!"

"Oops, oops!"

"It hurts, it hurts... I'll go... Is it necessary?" Xu Mang said innocently: "You are the most beautiful in my heart... Why care about other people's opinions, saying that you have too many things in your shopping cart... Why don't I, husband, clean it up for you?"

Yang Xiaoman was slightly stunned, and looked at Xu Mang with wide eyes, this guy usually picks to death, this time he actually offered to help him clean up the shopping cart, there must be fraud here!

"How do you clean it up?" asked Yang Xiaoman.

"Stupid!"

"Just choose batch deletion directly. Xu Mang smiled and said, "Look... Clean up your shopping cart without spending a penny, husband, am I smart? Are you shocked? Don't kneel, don't kneel... If you really want to kneel, you can kowtow by the way. ”

Yang Xiaoman: (* ̄〈 ̄)

Be at the end of one's forbearance

This bastard is getting more and more excessive!

"Mother, I want your dog's life today!"

"Look at the punch!"

( ̄ ε(# ̄)☆╰╮o( ̄dish ̄///)

...

Life is like a book, don't rush to the end to see if it's worth reading, just savor it, you will happen to it or not to skip to the last page, because on each page you leave your own painful memories.

"Shhh

"Damn... The waist is gone. Xu Mang collapsed on the bed, trying to get up, but found that his back pain was to the limit, and when he exerted himself, it was as if the jack had pressed himself firmly on the bed, unable to move.

"Wife?"

"Wife?"

"Old witch?"

moment

The bedroom door was opened, and Yang Xiaoman stood at the door, glaring at Xu Mang angrily, and scolded, "What did you just call me?"

“...”

"Wife!" Xu Mang said embarrassedly and politely: "Anyway, help me tell the second grandfather, just say that my waist was twisted last night, and I will go to school in a few days, I will recuperate at home for a few days, and by the way, I will call my mother-in-law, and say that his son-in-law wants to eat fried kidney flowers." ”

Yang Xiaoman's face flushed, and she said angrily: "This little thing always informs my mother to come over... She's usually quite busy, so what... You want to eat stir-fried kidney flowers, don't you? I pass by the hotel when I get home from work, and ask the chef to make you a plate, what else do you want to eat?"

"No more. ”

"Exercise more in the future, always flash to the waist..."

Long

Xu Mang relied on his strong willpower, put on his clothes and pants, washed up briefly, and silently leaned against the wall to his study.

"Ahh

"I'm going to die... This is just the beginning!" Xu Mang thought of the miserable life of fifty years in the future, and instantly felt a trace of despair, his life was ruined like this, and he was a little unwilling to think about it.

That's it...

Solve the problem at hand first.

Turn on your computer,

Xu Mang flipped through the detailed information about the CRISPR system, not to mention the database of the Institute of Biochemistry and Cell Biology of the Academy of Sciences, which is really easy to use, but after reading it for a long time, I didn't find any useful content.

forthwith

Xu takes a problem-based approach, such as asking for greater precision, starting with precision, where the CRISPR–Cas9 system cuts DNA duplexes at specific sites in the genome, and then relies on the cell's own repair system to repair the damage and perform gene editing.

But...

This repair system, which may insert or delete DNA bases where the genome is severed, is not entirely reliable.

"Huh?"

"Is there a problem?" Xu Mang looked at the data, tilting his head and falling into contemplation, in the process it seems that researchers cannot control the results of gene editing, and there may be differences between cells.

On this issue,

Xu Mang searched for relevant information, and then found that biologists added templates to guide genome editing in the process, but there were still some unsolvable problems.

By inserting a specific DNA sequence into the genome, the DNA repair system in many cells prefers to insert or delete a single or a few bases, which is particularly unreliable because there is no way to replace a DNA fragment with the target sequence.

What to do?

That's the problem, but what to do next?

At this time, Xu Mang's mind was blank, except for the paste, all kinds of eating, drinking and fun, and there was not even a single punctuation mark about breaking through the existing CRISPR system.

I...

Probably not!

"Hello?"

"Chen Xi?" Xu Mang received a call from Chen Xi and asked with a confused face, "Are you going to break up again?"

“...”

"Brother Xu Mang... Do you wish I and Tianmei broke up, right?And then you can stand on the side and watch the show?" Tatsuki said speechlessly, "I'll just say hello, are you free tonight?"

"Yes, yes!" Xu Mang nodded, but soon his smile turned into a trace of sorrow, and he said helplessly: "How did you pass that level of Sister Xiaoman?"

“...”

"Why don't you forget it?" Chen Xi said helplessly: "Sister Xiaoman knows that if I take you to take a bath, I will be scolded to death by her." ”

"Ugh..."

"This woman is too violent. Xu Mang sighed and said indifferently: "No, I won't go... It just so happens that I don't have much time, I just promised to help someone solve a problem, and now my mind is blank, this problem is too difficult..."

Suddenly,

There was silence on the other end of the phone.

"Brother Xu?"

"Have you heard of Ollie?" Tatsuki asked cautiously, "Quite positive." ”

Xu Mang: ???

What's that?

Oreo cookies?

Under Chen Xi's guidance, Xu Mang saw the legendary Ollie, but after reading it, he was still confused.

Maybe...

I have completely detached myself from society, and my own world is full of scientific research.

...

A few days later,

Department of Biology Building, Fuda University,

Because of the arrival of a person, breaking the harmonious atmosphere here, Professor Xu Mang... He's back!

"it!"

"Professor Xu, he seems to be in a molecular biology lab, I don't know what he's doing... Don't... Is he ready to develop a new AI technology?" A biology student said to his friend in horror, "That's amazing!"

“...”

"Don't you say... It is possible that miracles will be created again. Another student standing next to him said, "It's a pity... This time, I only arranged three postdoctoral fellows in molecular biology to follow Professor Xu to conduct research, but unfortunately... What a pity!"

meanwhile

In the molecular biology laboratory,

The three young postdocs stood in front of Xu Mang with respectful faces, although the three of them had a high prestige among the students, but when facing Xu Mang, they seemed to return to the time when they were studying, and the feeling of following the instructor to do experiments for the first time.

Nervous!

Particularly nervous!

Xu Mang is much younger than them, but age is of little use here, Xu Mang is the youngest Nobel Prize winner in natural sciences in history, directly breaking the record held by Lawrence Prague in 1915, when Laurence Prague was only twenty-five years old, and Xu Mang was more than three years younger than him.

"Anyway..."

"Do you know what you're studying this time?" asked Xu Mang curiously.

"Breaking through the existing framework of gene editing. A postdoc surnamed Chen said, "Professor Xu... The three of us are okay in this area. ”

Xu Mang was stunned for a moment, and said with a smile: "That's good, then it's up to you to play, this is a problem we need to solve, I printed a few copies, you guys will take a look at it yourself, if you have any ideas, the four of us can discuss it." ”

moment

The three young postdocs got the information, opened it and looked at it, and in just a dozen seconds, the three of them were completely confused.

This...

Solve the problem of replacing a DNA fragment with a target sequence?

Are you sure you can do it?

Impossible!

......