Macalet frowned, this question was undoubtedly questioning his answer, and the study and expression of genes were indeed full of randomness, and he was not easy to answer this question.

"These are two problems, the adaptability and stability of the mouse do not have much to do with it, it may have something to do with his own expression. I think this student should go back and make up for the class, do you have anything else you would like to ask about genetic engineering?"

After Macallet's words were spoken, a discussion immediately began.

Including Zhang Shulan also frowned, this is obviously quibbling, gene expression is the cause of fitness, and adaptability is the result of gene expression.

This macalet obviously couldn't catch Bai Ye's question, but he couldn't explain the problem, so there was no way to explain why SHR used istar mice instead of other types of mice such as SD or KM.

Or rather...... He is not engaged in research in this area at all, but nonsense and fabricated answers.

Thinking of this, Zhang Shulan looked at the young Bai Ye with interest.

I saw Bai Ye say lightly: "Can I think that the priority of SHR may not be able to withstand the examination of the market, or can we try to use other mice for research, and try gene grafting to get a new type of mature essential hypertension mice?"

When Macalet heard this, he immediately said with a straight face: "Any experiment needs results and data to prove, SHR can persist in being widely recognized internationally for several years, it has the meaning of his existence, any doubt needs data and experiments to support, if not, your words are just a meaningless argument." ”

With that, Macalet got up and left.

This meeting broke up unhappily, and Bai Ye undoubtedly smashed the field of Longka's new SHR product release.

But Bai Ye has gained a lot, and he feels that he has found a direction, that is, to start with SHR mice, to study KM mice, and maybe find a mechanism for gene expression.

Since SHR has lost 100% of its antihypertensive genes after so many generations of development, while KM mice do, it means that there is something in KM to control the gene expression of KM mice.

Dong Cunguang looked at Bai Ye and gave a thumbs up.

"You're awesome!"

Bai Ye smiled, he didn't want to raise the bar, he just wanted to get some knowledge.

The two got up and were about to leave, when Zhang Shulan stepped forward.

Bai Ye was a little surprised, he had listened to Zhang Shulan's lectures, which were very simple and did not contain a bit of academic exaggeration.

"Professor Zhang?"

Zhang Shulan smiled: "You are very good, you are doing genetic engineering, what's your name?"

Bai Ye shook his head: "I'm a medical student, my name is Bai Ye." ”

Zhang Shulan's eyes lit up: "BPFH score that Bai Ye?"

Bai Ye didn't expect him to be so famous: "Yes." ”

When Zhang Shulan heard this, she immediately raised her eyebrows and smiled: "You are Bai Ye, the proud protégé that Liu Lao praised all day long!"

Bai Ye was stunned, a little confused, what is the situation?

Zhang Shulan smiled and said: "Isn't your mentor Academician Liu Boli Liu? I praise you all day long, and I can't wait to talk about you and say how good you are! When I heard what you said today, I also believed it. A good lad indeed!"

Bai Ye scratched his head in embarrassment and said thank you, only then did he remember that the teacher was also an academician of the Chinese Academy of Sciences, and he probably knew Professor Zhang.

Zhang Shulan said at this time: "Actually, the idea you put forward is very good, our research on mice has been stuck in the latest foreign reports, has been learning, never questioned, your idea is worth trying, this is my phone, if you don't understand anything, you come to the Chinese Academy of Sciences to find me." ”

Saying that, Zhang Shulan read a series of phone calls to Bai Ye and left with a smile.

Bai Ye looked at Zhang Shulan's departing figure, suddenly remembered something, and hurriedly said, "Teacher Zhang...... Don't tell my mentor I'm studying rats again......"

Zhang Shulan was stunned when she heard this, and almost broke her feet, and then laughed and walked away.

Bai Ye sighed, hey...... I'm going to be scolded again for not doing my job.

And Dong Cunguang's face was flushed and he pulled Bai Ye with a little excitement: "Zhang ...... Sheet...... Professor Zhang even left you a phone number!"

Bai Ye snorted: "Yes, you heard it too, didn't you remember it?" I'll go back to you, do you know Teacher Zhang?"

Dong Cunguang said with a shy face: "She is my idol, and many of her thoughts have a great influence on me. I have always hoped for the doctoral examination of Mr. Zhang's ......"

Bai Ye sighed: "Then you won't say hello?"

Dong Cunguang said embarrassedly: "I'm too nervous to speak, I'm afraid that if I stutter and leave a bad impression on Teacher Zhang." ”

Bai Ye: "......"

At this meeting, Bai Ye felt that the 1,000 yuan was not spent in vain, so he had a few meals, stayed in a high-end hotel for two days, got acquainted with an international master, met a domestic celebrity, and came up with a research idea.

Overall, Bai Ye gave himself a full score.

Back in the laboratory, Bai Ye began to study according to the original train of thought.

Check the information, especially for some basic disciplines such as anatomy and physiology of mice, fortunately, it is a law that can be used in a hundred ways, and the progress is still very fast.

One morning at the end of July, Bai Ye couldn't believe it, could he have found it like this?

However, it is a bit too bizarre.

Why do you say that this is just an ordinary base on the double helix structure of mouse DNA, guanine?

Can this thing affect the expression of genes to achieve a special variation in transcription?

Bai Ye couldn't believe it, and in order to confirm, he directly found the drug that he had done the experiment on and wanted to experiment.

Three days later, Bai Ye finally completed the verification and got a conclusion!

Under special circumstances, there is a certain chance that this guanine may cause RNA to be mutated, which will lead to mutation in the expression of genes during translation!

This is the expression of the adaptation of mice to certain special environments.

Of course, this does not mean that all gene expression is related to the guanine of mice, but that the existence of this purine will affect the stability of the gene structure of mice and achieve variation in some special circumstances.

Bai Ye quietly looked at the slowly laboratory in front of him and took a deep breath.

This should be the main reason for the failure of the Keao experiment, when the mouse was stimulated by that drug, the guanine was mutated, resulting in changes in the transcription and translation process of DNA molecular structure, which inhibited the reproduction of tumor cells.

In the final analysis, the reason is this guanine!

Decades of unsolved mysteries finally have a reason, thinking of this, Bai Ye is a burst of emotion, if the mouse experiment failed, it would not be used as a phase I clinical trial, and those patients would not have died.

Bai Ye sighed, maybe science is developing in dialectics, maybe one day Newton's laws will be overturned?

Bai Ye smiled, wrote down an answer in his notebook, sorted out the data, and put it in his bag.