With the previous foundation, Bai Ye is now very comfortable with the genes of mice.

The study of the genetic stability of KM mice must find a starting point, and Bai Ye found the drugs made in those failed experiments after querying countless materials, maybe these will be an opportunity.

It's just that those drugs are really not easy to find, and Bai Ye spent a lot of effort to find the data of those failed experiments.

The next step is to stimulate under various experiments, hoping to find the mutated RNA sequence, and transcription and translation may be the cause of the change.

However, there was almost no progress in the next research, Bai Ye basically couldn't find the point of mutation, and these genes were very stable.

Shouldn't it be studied in the state of genes?

Is it impossible to study a gene sequence alone and study it in mice?

At lunchtime, Dong Cunguang found Bai Ye.

"There's an academic meeting at the Hyatt Regency tomorrow, and I suggest you check it out. ”

Bai Ye was thinking about mice when he was eating and sleeping at this time, and when he heard Dong Cunguang's words, he raised his eyes and asked, "What is the meeting about?"

Dong Cunguang mixed rice: "It was a conference held by Longka Company to promote SHR and its model mice, and invited many experts, as well as the staff of the European gene bank, I think I can go and listen to it." ”

The experiment had come to a standstill, and Bai Ye still felt the need to listen to it, hoping to gain something.

The next morning, the two went to the Hyatt Regency Hotel, paid 2,000 yuan, and got two passes to participate in the conference.

The lecture was held in a large conference hall, and Bai Ye and the others chose a good place in order to hear clearly.

On the first day of the conference, the keynote speaker was a domestic leader in the field of genetic engineering: Ph.D. supervisor of medical bioengineering: Zhang Shulan, who graduated from Johns Hopkins University with a bachelor's degree and a master's degree, had the opportunity to stay in school, and resolutely returned to China and entered the Chinese Academy of Sciences to work in the field of bioengineering.

Zhang Shulan is good at gene splicing technology, today the main content of the talk is how to use molecular genetics as the theoretical basis, with the modern methods of molecular biology and microbiology as a means, to achieve genes from different sources according to the pre-designed blueprint, and then build hybrid DNA molecules, and then introduce them into living cells, change the original genetic characteristics of organisms, and obtain new varieties.

This is the development of genetic engineering by using modern means to break reproductive isolation and realize genetic engineering.

Zhang Shulan spoke very seriously, especially for those basic theories and the excavation of new ideas.

Zhang Shulan spoke very basically, and did not have too much advanced cutting-edge knowledge, but this kind of conference is not a professional academic conference, but a marketing of her own products in the name of an academic conference.

But Bai Ye's harvest is also very large, and in two days, these experts and professors systematically sorted out the knowledge, which further consolidated Bai Ye's genetics, which was not solid and solid.

On the third and last day of the conference, it seemed that several influential celebrities in the world had come to the venue.

"Let us give a round of applause to Dr. Macalet from the European Genetic Analysis Library, who has decades of experience in mouse genetic analysis and has unique insights into mouse research......"

Dong Cunguang whispered to Bai Ye: "Macalet is one of the main expert members who conducted SHR research at the beginning, and his analysis of the SHR gene is very good, and he has basically completely analyzed it......"

Bai Ye nodded: "Then he didn't propose the idea of improving SHR?"

Dong Cunguang sneered: "When the mind is shrouded in gold coins, knowledge begins to be biased. ”

And what Macalet is best at research is to prove the advantages of SHR, he believes that SHR mice are the product of God because of hundreds of generations of culture, of course, the most important thing is that he has done experiments many times when the gene fragment of SHR hypertension is implanted into other mice, and it is difficult for those mice to show the general stable hypertension performance of SHR. Of course, I want to be skeptical. ”

"But...... Gene mutations are indefinite, including gene grafting, and the resulting mice will produce different results according to individual differences, so they are not suitable for mass production and experiments. ”

Macalet has to say that he is very professional and has made a lot of efforts in the field of SHR's continuous development and innovation.

"Biological evolution is the most perfect genetic engineering, he can get the most suitable genes to change their biological attributes, SHR after hundreds of generations of research, we summarize every shortcoming, expect to change from the perspective of genetic engineering, of course, this is a process, just like bioengineering is a development discipline, we can only change if we continue to recognize new things. ”

…………

Finally, Makalette asked, "Do you have any questions?"

Everyone smiled and shook their heads, but at this time, Bai Ye got up: "I want to ask, why are the mice selected by the first generation istar mouse, and not KM mice or guinea pigs?"

Everyone turned their heads to look at Bai Ye one after another, some were surprised, some were curious, some were dismissive, but some were thinking about this question.

Macalet was stunned for a moment, and looked at the person who asked the question with interest, he had a meeting in Kyoto more than once, but the person who raised this question was the first one: "This is an interesting question, in fact, I have also used other mice, but the effect is not as good as istar, in general, the homologous genes of these mice are the same, and even many mice are obtained by hybrid genes." But here comes the issue of gene stability and recessive gene expression. ”

Bai Ye's eyes suddenly lit up, this was the first time he had heard about the question of genetic stability.

Macalet continued, "KM mice are known to be the most genetically stable, and the genetic structure is not easy to mutate, and obtaining mice with similar hypertension may require more energy and cycle to culture, and do not necessarily get this 100% hypertension. ”

"But in the course of the experiment, the istar mouse found that his genes were stable and his recessive gene expression was very good...... I think it might be the reason. ”

Bai Ye kept digesting this Macalet words in his mind, and suddenly there was an idea in his mind: "istar mice and km mice are both very stable mice, and KM mice are also inbred mice, it stands to reason that after countless generations of reproduction, there should be recessive gene expression, but why can't they find it? Could it be because of adaptability?"

Bai Ye asked: "The gene sequences of istar mice and KM are not much different, isn't the gene expression you said contradictory? If you really say that, I would like to ask, is the adaptability and survival ability of mice related to the selective expression of genes?"

As soon as Bai Ye's words fell, the scene was in an uproar.