The reform of the Qingshan Pharmaceutical Factory has added a number of departments, coupled with a bunch of relatives and friends who were taken away by Tian Xuelin before, the entire pharmaceutical factory seems to be facing reconstruction, and there are several more ministers and directors in an instant, and there are a lot more positions such as supervisors and team leaders at the bottom.

Naturally, a radish has a pit, and now there are many pits, so who is the radish?

At the suggestion of Fang Jifan, Liu Feng referred to Mo Yimin's opinions and decided to adopt a multi-management approach, on the one hand, to recruit talents from the society, mainly to other pharmaceutical factories, and to dig into the wall; on the other hand, to widely face the bottom of the staff, adopt a competition system, if there are really talents, Liu Feng will not hesitate to reward.

For a time, the reform of Tsingshan Pharmaceutical Factory caused an uproar in the factory, which was even more exciting than the news of Liu Feng's acquisition of the pharmaceutical factory.

"Have you heard, the new boss has invested more than 100 million yuan, and our pharmaceutical factory doesn't have to go out of business!"

"yes, that's good news, at least we don't have to change jobs!"

"Not only that, the new official has taken office three times, our new boss is going to move seriously this time, and several departments have been added in one go, and our opportunity has come!"

……

All in all, it's a joy for all!

The employees of the pharmaceutical factory saw the hope and were all overjoyed; the government departments did not have to worry about the bankruptcy of the pharmaceutical factory, let alone trouble Liu Feng

If you want to say that the only one who is not particularly happy, it is only Liu Feng.

Moreover, recently, this kid has always been sad.

In addition to the painful matter of spending money like running water, the cycle of new drug research and development is the biggest culprit that causes him to be so worried.

"Boss, are you kidding, a new drug is on the market in a year?" Wang Qingshan, the head of the R&D Department, looked at Liu Feng like he was mentally retarded, and he didn't know why, he always felt that he was on a thief ship: This pharmaceutical factory eats jujube pills!

"What, what's the problem? Don't worry, the problem of money is definitely not a problem!"

Liu Feng patted his chest and said unashamedly.

Minister Wang was about to cry, and his face was longer than a horse's face: "Boss, don't you know, if it's a generic drug, it's okay to say, although the time is a little tight to market a new drug a year, but as long as the manpower is sufficient, it is not impossible to work overtime, but if you really develop a new drug completely, don't say one year, it is ten years, which is short!"

Do you know how much time it took to get the company that ranks first in R&D strength in China, and anlotinib, a new anti-cancer drug that they recently launched?"

"How much time?"

"12 years!"

"How much?"

"12 years!"

Liu Feng was dumbfounded. What the hell, it took so long!

In the past 12 years, how many things has he been able to research! It is still a large company with the largest research strength in China, how can the level be so lo! Liu Feng pursed his lips disdainfully.

He thought that it would only take a few years at most to research a new drug, but if he was able to open himself, he would be able to get it in a few months at most, 12 years! Are you kidding?

Liu Feng looked at Wang Qingshan with a face full of contempt.

"Why is it taking so long!"

Liu Feng's expression, in the eyes of Minister Wang, was even more desperate.

This boss also came to do R&D, just like this, what kind of R&D! I don't know anything, if it weren't for the fact that you have published several papers in Nature Magazine, and the size is also a corner, Lao Tzu would have slapped him in the face and said goodbye and left!

"Boss, 12 years is already a good level! If it is placed abroad, a new anti-cancer drug like anlotinib will definitely not be on the market for 15 or 20 years.

The research and development of drugs is different from other chemicals, as long as the final product is made, drug research and development should not only make the product out, but also involve the safety of the human body.

Therefore, the study of a new drug mainly involves four stages.

The first stage is the research project, which is to study the disease clearly, and then find the appropriate ingredients, that is, the main components that play a role in the disease, and search for cutting-edge papers, medical journals or their own experiments, which generally takes three months to many years.

Unless that kind of luck is particularly good, and you find a relevant research paper after a search, and people have not taken a fancy to and started to study this substance, and then you can directly study this main ingredient according to the map, otherwise, two or three years will only be less!

This is the first stage.

The second phase takes even more time.

The main purpose of the second stage is to develop the drug.

It involves the analysis and study of the composition and structure of this component, the design and opening up of the industrial synthesis route of this substance, the systematic analysis of this raw material and the impurities involved, and then based on this raw material, add other excipients, make a preparation, and carry out systematic verification of the preparation, etc., which takes at least 2~5 years!

The third stage is to conduct bioequivalence experiments on this drug, which generally takes 1 to 2 years, and after that, there is a fourth stage, which is also a more time-consuming stage, that is, clinical research, which can be as short as about a year or as long as several years!

If there is a problem in any of these stages, the research and development of new drugs will come to a standstill or even face the result of re-engineering, even if the fourth stage is passed, there is still a period of production and distribution time to open sales before the market; therefore, a new drug research and development results, can be completed in about 5 years, it is definitely very fast, and now the daily life is that new drugs from research to listing, generally in 10~15 years, or even more than 20 years.

So, boss, a new drug is on the market a year, are you sure you're not kidding?"

"Eh, is it?" Looking at Wang Qingshan's mentally retarded expression, Liu Feng was embarrassed.

We seem a little ignorant!

From Wang Qingshan's statement, Liu Feng found that his golden finger did not seem to be omnipotent, at least, in the field of new drug research and development, he could not completely rely on cheating.

In Liu Feng's view, at least more than half of the four steps mentioned by Wang Qingshan are artificially set up research barriers, and their purpose is also to ensure the safety of drugs.

In this regard, Liu Feng naturally expressed his understanding, it seems that he is thinking too simply.

Before, he thought that it would be enough to directly synthesize a certain compound and then manufacture it into a drug and go directly to the market, but where did he think that there were so many twists and turns involved, and it is no wonder that the anlotinib researched by Tianzheng Daqing Company is claimed to have spent billions of R&D funds, and it seems that it is not an exaggeration.

Liu Feng thought secretly in his heart.

It's just that in this way, his small assets of hundreds of millions seem to be completely insufficient!

From Wang Qingshan's description, Liu Feng found that he could open up some places in the first and second stages, such as discovering which compounds would be effective for which diseases, the industrial synthesis route of compounds, and analyzing what impurities and other things could only save half of the time at most.

It seems that the idea of making a lot of money with drugs is really a long way to go!