Yu Yucheng's "review well" is not a lie, as soon as the words fell, he took out "Biochemistry" and read it seriously. Liu Jian also ended watching and concentrated on his "Cell Biology". -- Because the exam is imminent.

The so-called "exam" is not the final of the Biology Olympiad two months later, but the final exam of the Olympiad training class.

The final exam may seem commonplace, but for most intensive students, it is no less important than the National Olympiad finals. Because many of the propositioners of the final examination are teachers from Jinling University, Soochow University, and Liangjiang Normal University, their existence is to inspect the quality of students on behalf of the school. As long as you can get into their eyes, it will be easy to get the escort qualification. For those students who have no hope of winning the first place in the national competition and have relatively mediocre results in other subjects, it is already very satisfying to be able to go to second-rate famous schools such as Jinling, Soochow and Liangjiang Normal School. Even if you are sure of winning the first prize in the national competition, it is an excellent choice to hold a guaranteed place in your hand and then ride a donkey to find a horse. Therefore, everyone attaches great importance to it and tries their best to show their strength in the exam.

Although when they were separated, Teacher Huang Tongyuan asked herself to take the first place every time to live up to her five times and three times, but Jiang Shuiyuan did not demand this first too much. The reason is that in addition to the fact that there are too many masters, and you may not be able to get it, you also want to try to get rid of utilitarianism, can you find a little fun in learning?

On Friday afternoon, the day before the end of the intensive training class, the final exam was held as scheduled in a small classroom at Rokuchao Middle School.

Compared with the more or less flustered of others, the water source of the river seems to be as calm as water. After getting the test paper, he roughly flipped through it from beginning to end, and the questions were not too difficult, most of them were from those reference books, and only a few questions were out of range. Guess you have to use your brain or try your luck. It doesn't matter, the key is that there is a 50-point additional question in addition to the normal test paper with a full score of 100 points, and the question is very simple:

"If possible, what direction of research do you want to do, what is the goal, and what are the possible ways to achieve it?"

To be honest, his impression of biology is still limited to the reference books he has read in the past and the content that everyone has discussed in the past few days, and he is far from rising to the realm of long-term doubt and independent exploration. There are no ideas that are eager to be put into practice. If you really want to put a bunch of instruments and materials in front of you, you will have a feeling that a dog has bitten the king - there is nowhere to eat!

While Jiang Shuiyuan was doing the test papers, he was thinking about what kind of research he would do if the conditions permitted? It was not until a certain moment that his eyes inadvertently swept over the bracelet on his left wrist that was neither gold nor jade, nor wood nor stone, and he had a plan in his heart. After finishing the previous test papers and spending nearly twenty minutes to clear his mind, he picked up a pen and wrote his question on the blank A4 paper:

"Development of a Portable DNA Damage Detector".

He then went on to write: "DNA damage accumulates with age, affecting chromosomal replication, transcription, and other DNA metabolism events, leading to genomic instability and cellular dysfunction." In general. DNA damage has a number of potentially harmful effects: cell death, loss of cell function, permanent arrest of cell proliferation (aging), and genetic mutations. The latter is mainly associated with cancer, and all these damaging effects are related to the aging process. This view is also supported by cellular studies from human focal progeria and studies in mouse models of DNA damage repair deficiencies. It is of great significance to develop a portable DNA damage detector to monitor the accumulation of DNA damage in real time by comparing it with the early DNA structure sequence, which is of great significance for intervening in cell aging and preventing the occurrence of cancer. ”

The theoretical support is very strong, and the reasons are high-sounding. But Jiang Shuiyuan knew that if he wanted to develop such a DNA damage detector, even if it was several times or dozens of times larger than his own bracelet. There are also huge technical challenges. Because before that, he wanted to find out what the origin of this bracelet given by Shuibei Niangniang was, and he had specially learned about the working principle, development level, and operation method of the current DNA sequencer.

According to the information found on the Internet and in the library, the second-generation DNA sequencer that is now more mainstream is stupid and stupid, and the speed and efficiency are outrageously slow, even so. The selling price still ranges from 100,000 yuan to hundreds of thousands of yuan. As for the third-generation DNA sequencer, which covers high-throughput sequencing technology and can automatically pot, injection, data collection and analysis, the efficiency has been improved, but the total electrophoresis time of each sample is still more than 2.5 hours, and the weight is two or three hundred catties. What's even more impressive is its price. At least, it will cost millions of yuan! It is by no means something that ordinary people can afford.

Reducing the volume and weight of millions of instruments by nearly 100 times, increasing the efficiency by dozens of times, and reducing the price to a range that normal people can accept, just thinking about it makes me feel a lot of pressure. What's more, if you want to realize the portability of DNA damage detection, in addition to DNA sequencing, it also involves massive data comparison, which must be processed by workstations!

It is precisely because of the endless emergence of various problems that Jiang Shuiyuan tried his best to fill the gaps, and only barely drew a circle two or three minutes before the end of the exam. As for whether this circle looks like melon seeds or is full of loopholes in the eyes of the marking teacher, then he can't care about it.

This is one of the few times since Jiang Shuiyuan got the bracelet to fill up the exam time, and only after handing in the paper did he find that he was tired and dizzy. He was about to go out for a walk and take a rest, when he heard He Dayi, who had just walked into the classroom, say loudly: "Don't be in a hurry to leave, there is still a situation form to fill out, and it is not too late for you to go to play after filling it out!"

"What watch?" someone asked.

There were a few chuckles from the corner: "What else can it be? Of course, it's a table of escort students!"

He Dayi did not answer positively: "You will know when you get it." ”

Taking advantage of the interval between the announcements, Shi Yang flashed over and asked with a winkled eyebrow: "Jiang Shuiyuan, how did you answer the last additional question? Could it be to study modern and contemporary literature?"

"How is that possible! This is a biology exam, and my brain hole is not as big as you think. ”

"What's that?"

"DNA damage. What about you?"

Shi Yang's eyebrows suddenly danced: "Of course, I am doing taxonomic research, especially plant taxonomy, that is where my dream lies." If all things were possible, I wanted to create a handheld plant identifier for the general public and biology enthusiasts. As we all know, the Flora of China, edited by the Department of Biology of Jingshi University and the Institute of Botany of the Chinese Academy of Sciences, is currently the world's largest and most abundant botanical taxonomic work, which records the scientific names, morphological characteristics, ecological environment, geographical distribution and other information of 301 families, 3408 genera and 31142 species of plants in China. In order to compile this book, it took more than 300 scientists across the country 50 years of work, and ordinary people want to read it and recognize all the plants around them, which is tantamount to ascending to the sky. - Not to mention ordinary people, sometimes even plant taxonomists themselves are frightened!"

Jiang Shuiyuan smiled: "So they came up with a Flacourtiaceae?"

It is considered one of the most difficult families to identify due to its lack of obvious boundaries, few common features between genera and genera, and no stable identification traits. In the identification process, the genus is often identified first. Because of this, the family is often considered to be a loose family composed of heterogeneous families. That's why plant taxonomists often joke and say: if you feel in doubt, put it in the family Aeaeaceae.

Shi Yang also laughed: "Not only that, but there are also many plant classifications that subvert the three views in daily life, such as the star fruit we often see, which actually belongs to the sorrel family. Another example is that plum and plum blossoms are not one, and the relationship is very far away, one belongs to the subclass Magnolia, Camphoridae, Wax Plum family, Wax plum genus, and the other belongs to Rosaceae, Rosaceae, Plum family, and apricot. The same goes for turnips and carrots. It's doubtful about the science of plant taxonomy!"

Jiang Shuiyuan nodded: "Radishes are of the cruciferous order, cruciferous family, and radish genus, while carrots are of the order Apiformes, Apiaceae, and carrots, and the relationship between the two is very far away, and they are indeed not a family!"

Shi Yang said: "But the general public doesn't know! My idea is to make full use of today's advanced technologies such as DNA extraction, pattern recognition, and chip technology, with the Flora of China as the basic support, integrating traditional morphological classification, current cell taxonomy, and chemical taxonomy. In the process of walking, traveling, traveling and exploring, the public and biology enthusiasts can identify the surrounding plant species anytime and anywhere, so as to improve the attention and awareness of the whole society to the animals and plants around them. At the same time, the research team of plant taxonomy has been expanded in disguise, so as to avoid the complete extinction of many plants before they have been classified, studied and recognized by biologists in today's urbanization, industrialization and modernization. ”

Jiang Shuiyuan couldn't help but praise: "Good idea!" (To be continued.) )