"Huh, crystal structure diagram?" Marjoli, a professor of biology at the Carolingian Institutet of Medicine, is sensitive to words like G protein-coupled receptors. Pen @ fun @ pavilion wWw. ｂｉｑUｇE。 ｉｎｆｏ

The most professors at the Carolingian Institute of Medicine do is read the literature, especially those of scholars who are eligible for the Nobel Prize.

For them, the Nobel Prize is both an advantage and a burden.

The advantage is that Carolingian Institutet has received a lot of funding, as well as the attention of high-end scholars from abroad, and the burden is brought by the constant reading of literature.

For example, if Yang Rui wants to read literature, he basically focuses on G protein-coupled receptors, PCR, genes, genetics and other fields, in short, he reads what he needs, and other fields are usually limited to understanding, at most read a few S and know it.

Professors at the Carolingian School of Medicine can't read the literature like this, they have to read S-level papers to the end, whether they are in their own field or not, they have to read it, especially scholars who are likely to win the Nobel Prize, and fields that are likely to be awarded the Nobel Prize.

A person's time is limited, and the time of a scholar is even more so.

Nowadays, there are three or five laboratories in the more popular fields, and the professors of the Carolingian Institute of Medicine spend most of their time reading literature that is not related to their own research, and the investment in research itself can be imagined.

For Marjoelli, he is starting to get tired of being a professor at the Carolingian Institutet, but the foundation laid over the years is still there.

When he heard the words "G protein-coupled receptor" and "crystal structure diagram", he was the first to wake up and hurriedly went to the laboratory.

To be honest, if it weren't for Yang Rui, he wouldn't believe it.

As a professor of biology at the Carolinsian Institutet of Medicine, Marjoelli's most basic ability is to judge an academic direction, how long it will take to see the light of day, and how long to see the results.

Of course, such a judgment is certainly inaccurate, but there is also a certain range.

Yang Rui's ion channel laboratory has just completed a clear composition of the G protein-coupled receptor -- a few months is just a few months for Wang's scientific research results -- and Marjoli believes that the basic time to obtain the crystal structure map should also be more than three years, not more than two years.

This judgment is not a joke, and whether a lab should spend tens of millions of dollars to join such a competition is often based on this judgment:

It is expected that the crystal structure of the G protein-coupled receptor will be revealed in the next two to five years, and depending on the capabilities of our laboratory, we may be able to complete the project in the next two to four years, and we can consider joining the competition.

The crystal structure of the G protein-coupled receptor was completed in a few months by the Ion Channel Laboratory of Peking University, which means that other laboratories around the world involved in this project have all suffered a great loss.

At the same time, it also means that the resources of the whole society have been greatly saved.

However, Marjoli is not concerned about the savings, he can't help but be nervous when he thinks about the lab that is working on related projects.

The others reacted a little slower, but they all opened their eyes one after another, and hurriedly asked, "You made a clear crystal structure diagram so quickly?"

"We actually completed the study a few months ago, but it took a long time to repeat the experiment. Yang Rui said as he let everyone into the laboratory.

In fact, a few months to do repeated experiments is not much at all, and some verification experiments are laborious to do, and some of them take several years.

However, Yang Rui's words fell on the ears of those who cared, but they were as terrifying as thunder.

I started repeating the trial a few months ago, when did it come to fruition?

Dare to feel that in recent months, many laboratories around the world have been working in vain?

Marjoli felt cruel when he thought about it.

However, the world of scientific research is so cruel, those who feel cruel have died in the vast competition, and those who survive can only grit their teeth and persevere.

"I'll see what you've done. Marjoli offered to ask.

Yang Rui smiled and said, "What you see now is the result of repeated experiments, and in addition, our paper has also been written." ”

The paper is an experimental record after collation and sublimation, which is naturally the most suitable for reading.

Marjoelli didn't say much, but took it and quickly read it.

Behind him, Lancerot, also from the Katherine Medical School, also took a thick paper and read it quietly.

This kind of paper is very time-consuming to read, and generally speaking, Marjoli is used to skipping it.

But this time, he was a little reluctant.

This is a royal scientific research project.

The papers of the king-level scientific research projects are wasteful if you don't take a closer look.

Yang Rui was not in a hurry, beckoned someone to make tea for them, and sat on the side.

After a few cups of tea, Ma Qiaoli finally raised his head and said, "Director Yang, can we talk to the researcher of the specific operation?"

"Of course. "Yang Rui responds to all requests.

Today he came to show off his skills, but he hesitated when he stood up and shouted, "Gu Qiang, how did you remember over there?"

"I'm done. Gu Qiang replied in a low voice.

"Then come here, Su Xiankai, Fan Zhenlong...... Come here, too. Yang Rui singled out the names of several people.

"I see the name of researcher Gu Qiang in the paper. Ma Qiaoli was accustomed to nature, and directly began to trace the completion of the experiment, and asked: "Researcher Gu Qiang, is it convenient to introduce the experimental process?"

Gu Qiang said obediently: "I formed the complex in the presence of detergents, we named this complex ARGS complex, and after testing, I found that it can effectively couple in the phospholipid bilayer......

"Wait, detergent is a must, why do you want to create complexes in the presence of detergent?" Marjoelli questioned in his first sentence.

Gu Qiang looked at Yang Rui, didn't get an answer, shrugged his shoulders, and said: "Because to ensure the purity of G protein, it is necessary to have a detergent, and we want a pure complex, which can only be carried out under the condition of the presence of detergent." ”

"Even if the conjugation efficiency is greatly reduced?"

"Of course. Gu Qiang also studied this issue at the beginning.

However, Marjoli had read much more literature than Gu Qiang, and immediately asked: "Haven't you considered another way, such as not using detergents, but using physical or other means to ensure the purity of G protein, and I see that many laboratories are trying to do this." How do you make a judgment?"

Gu Qiang opened his mouth, but he didn't know how to answer.

He had never actually thought about it.

The experimental plan given to him by Yang Rui was to synthesize it in the presence of detergents, and Gu Qiang's theoretical system was weak, so he did not consider bypassing this point.

Of course, it was also his experiment that was done too quickly and quickly broke through this difficulty.

However, Marjoli's question is also typical, Gu Qiang thought for a moment, and said honestly: "This is my task at that time. ”

"You mean, did Mr. Yang Rui arrange your plan?"

"Yes. ”

Marjoley's gaze naturally turned to Yang Rui and asked, "Mr. Yang Rui, what did you think about it at that time?"

"I didn't think about it. ”

"Huh?"

"I arranged for others to try other options. Yang Rui said calmly: "Our investment in G protein-coupled receptors is still relatively large. ”

Marjoelli immediately understood, and said, "How many of you groups are trying?"

"Of course. Su Xiankai and Fan Zhenlong were both in different groups at the time. Yang Rui replied in the most concise way.

That's how it is.

As the person in charge of the laboratory, Yang Rui proposed a plan to arrange different researchers to do verification, which is the most basic laboratory operation plan.

This is like Yang Rui leading a march, when he encounters a fork in the road, he can certainly decide on the line based on experience and theory, but he can also send people to explore directly.

Gu Qiang was lucky to find the right direction, that's all.

In a few simple words, Marjoli knew it.

He asked Gu Qiang a few more questions, and slowly turned the topic to Yang Rui.

Academic achievements are attributed to IQ and distributed according to IQ, and the hard work itself is worthless.

Yang Rui asked and answered, and soon established a corresponding image in the hearts of everyone.

As the problem deepened, some scholars began to lose track of the conversation between Marjoli and Yang Rui, and most began to focus their thoughts on the project itself.

"The Ion Channel Laboratory of Peking University has resolved the crystal structure of G protein-coupled receptors. ”

"Yang Rui's research is advancing so fast. ”

"Unbelievable. ”

The whispered discussion of a few people gradually turned into a discussion of a group of people.

It's so alarming that everyone's questions are stacked.

Marjoelli, however, didn't care what others thought, and asked questions on his own. From his point of view, understanding Yang Rui now has become a necessary homework.

The G protein-coupled receptor represented by Wang Qi was broken through by Yang Rui in a row, and as long as Ma Qiaoli thought of the sensation that this news could cause, he had to be careful and careful.

However, as he spoke, the scene in the backyard suddenly appeared in Marjooli's mind.

"Mr. Yang Rui, I remember, we seem to have talked about the three-dimensional structure before? Is it the three-dimensional structure of G protein-coupled receptors? Are you involved in it?"

The scholars present seemed to have been reminded, and their expressions when they looked at Yang Rui were not right.

Think about it, if the repeated experiment of crystal structure started a few months ago, it means that the main project ended a few months ago, and for such a long time, it is impossible for the Ion Channel Laboratory of Peking University to only do repeated experiments and not do new research.

So, the new research ......

Could the new research be the three-dimensional structure of G protein-coupled receptors?

A group of biologists looked up at the tall Yang Rui, and inexplicably had a sense of looking up.