"Director Yang, what's the situation on our side?" Pang Jiancheng asked Yang Rui with a smile, thinking to himself: The acting skills are quite good, Peking University is really a hidden dragon and a crouching tiger. Pen × fun × Pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

No one thought that there would be new research results, and Pang Jiancheng naturally couldn't think of it, just because it was all arranged by Yang Rui, he started to praise him.

On the contrary, a few foreigners, listening to the "three-dimensional structure" mentioned by the translator, whispered.

Yang Rui hesitated for a moment, coughed twice, and said, "There seems to be good news coming out of our laboratory, everyone wait for a while." ”

After speaking, Yang Rui followed the student back to the laboratory and directly asked for the photos taken.

Gu Qiang and a group of others gathered in front of the electron microscope, with different expressions.

"I wanted to be idle, so I took a few shots, but I made them with the leftover materials from the second phase of the repeated experiment, so I don't know if it will interfere with the results of the experiment. Gu Qiang was a little proud and a little worried to explain to Yang Rui.

The boss of the laboratory has all the power in the laboratory, and the results made by the people under him must also be approved by the boss.

Otherwise, when encountering the worst person in charge of the laboratory, refusing to admit the experimental results of his subordinates, or even reprimanding them as fraud, his subordinates can only swallow tears in their stomachs - going to other laboratories to do repeated experiments is easier said than done, otherwise, Yang Rui would not have mobilized everyone that day to do the second phase of repeated experiments with a large number of experiments and resources, it was still the situation of one laboratory, and it was even more difficult to change laboratories.

Not only that, but researchers who leave the laboratory of a bigwig-level scholar will encounter many other problems, and even if they prove their previous opinions, it will not affect the bigwigs - the results you have made this time do not prove that you did not cheat this time, nor can it prove that you did not cheat last time.

Galileo's experiment in which two balls fell at the same time is still suspected of falsification, and the correct theory does not mean that the experiment is correct.

On the contrary, there are more scholars who have ruined their reputations and left the scientific community.

Therefore, no matter what Gu Qiang has done, his first and best choice will always be recognized by Yang Rui, and then see how much credit Yang Rui can give him.

After the streptomycin incident, the value of the academic community to the specific executor has become quite clear.

"Spread out a little bit and do your own thing. Xu Zhengping expelled all the people around him before Yang Rui started to officially watch the film.

Before the paper is officially published, the photograph of the electron microscope is first-hand evidence and first-hand information, and it is absolutely not for anyone else to see.

Biologists have always complained about the Nobel Prize for Watson and Crick to share the double helix structure of DNA, and one of the reasons is that they suspected that they had peeked at Rosalind Franklin's X-ray crystal diffraction pattern - of course, they must have seen it, but the question is whether it was a peek or not, because Ms. Franklin's early death has made the argument irrefutable.

However, the crux of the matter is actually a photograph.

However, what kind of picture is the X-ray crystal diffraction of DNA taken by Rosa Linde? White flowers on a black background, two crossed black reflective strips, the kind that no one wants to look at on the street.

Watson later wrote a book, saying that he was stunned and his heart pounded when he looked at it, because only the spiral structure would appear in the photograph as two crossed black reflective strips.

Whatever the photo Gu Qiang makes, it should not be made public in the lab until the paper is published.

Only Xu Zhengping needed to remind him, and all the researchers came to their senses and returned to their positions one by one, leaving only Gu Qiang looking at Yang Rui nervously.

Yang Rui nodded to Gu Qiang, then took out the photo and read it carefully.

Compared with others, Yang Rui has always had an advantage in reading images.

He doesn't read the specific image of the photograph, only to see if the image conforms to the theory of three-dimensional structure, which is what all those who look at the image need to do. Why do you want to learn about the eight forms of fractures in school, and the chapters are used to check if there are corresponding elements on the image, if there is, it proves that it is a fracture, and if not, it proves that there is not.

However, scholars in the 80s knew little about the three-dimensional structure of G protein-coupled receptors, which gave Yang Rui a comparative advantage.

He only looked at it for a while, then put the image back in the bag, and then looked at Gu Qiang with a scrutinizing gaze.

"Director Yang......" Gu Qiang was a little weak and shouted.

"Did you take a record of the experiment?"

"I did. Gu Qiang hurriedly took it out, this is a good habit, and it is also the place where the ion channel laboratory is stronger than other laboratories, even if it is a casual experiment, you must make experimental records, and you must remember while doing it.

Experiment records are useless in most cases, but when you make a discovery, especially a world-class discovery, your only regret is that the experiment is not detailed enough!

"If I had ...... It's good", which is often said by people who have not been systematically trained.

The purpose of systematic training is to prepare researchers and seize every hard-won opportunity, after all, there is a limit to the number of times a person can step on dog shit in a lifetime, except for Gu Qiang.

Yang Rui glanced at Gu Qiang again, read the experiment record, and said, "There is no problem for the time being, but I still have to see the repeated experiment." ”

"Of course. After Gu Qiang finished speaking, he said in a low voice: "In this case, will the three-dimensional structure be made?"

Yang Rui hesitated for a moment and said, "Basically." ”

"Yay!" Gu Qiang shouted in a low voice.

"I still have to perfect the rest of the parts, and then draw the three-dimensional structure, but that's basically it, the rest is rough work. Yang Rui also said with some emotion.

The most important and primary need for the third phase of experiments, that is, the three-dimensional structure of G protein-coupled receptors, is to find the activation mode of fine extracellular ligands and G protein-coupled receptors.

To put it simply, the G protein-coupled receptor is a protein, although it is invisible to the human eye, but at the molecular level, it is a very large existence. It's like a molecular edifice, with people and cars coming in and out all the time.

These people or cars coming in and out are extracellular ligands.

For example, how does the human sense of smell come about?

The outside air contains all kinds of molecules, which enter the human nose, and some of the molecules that can be distinguished by humans will come into contact with a certain G protein-coupled receptor in the human body, and this molecule is a pedestrian who enters the G protein-coupled receptor building.

Pedestrians enter the building, and the building sends a signal to the brain, and the brain searches for information to tell humans what you just smelled.

To delineate the three-dimensional structure of the G protein-coupled receptor, it is necessary to describe the appearance of this edifice, and the most difficult thing is not the outline - the outline of the huge G protein-coupled receptor is still easy to make, the most difficult, the main and important part is to see how it accepts pedestrians and vehicles.

Specifically, it is to look at the position and shape of various openings in the G protein-coupled receptor molecule.

In other words, what humans want to know is where the elevator of this G protein-coupled receptor edifice is, where the garage door is, where the front entrance, side doors and back doors are, and whether there are flyovers and rooftops.

Scanning G protein-coupled receptors with an instrument is like scanning a building with a laser, they don't really see everything in the building, but rely on various feedback to get answers.

It's like shining a laser light on the door of a building, and if the door is closed, the laser will give a reflection and get the wrong answer that there is no door here.

The scanning of G protein-coupled receptors is a bit more complicated, because the protein is moving, and it only when it relates to the extracellular ligand that it exhibits the necessary three-dimensional structure, otherwise it is a closed protein.

To put it mildly, G protein-coupled receptors are often exchanged with the outside world, but it is very difficult to catch that moment of image.

Historically, it took about 4 years for Kobe Carr to explode in character and capture the scene he needed - the moment when an extracellular ligand touched a G protein-coupled receptor.

Gu Qiang spent about four months doing relevant research.

Shit luck triumphed over hard work, which has happened countless times in history, and it won't be the last.

It's just that for Yang Rui, this time is too coincidental.

"You go ahead and repeat the experiments, writing down all the records you can think of. "It's impossible for Yang Rui to give up this achievement, and the next time he takes the photo he wants, the devil knows which century it will be.

However, Yang Rui must not allow these achievements to be exposed to the Swedes unprepared.

The temptation of the Nobel Prize is something that no scholar can resist.

"Who can take over the repeated experiment?" Yang Rui asked in a loud voice.

Several researchers looked at each other, and finally Su Xiankai stood up.

Yang Rui nodded and said, "Now distinguish the second phase of the experiment from the third stage of the experiment, the electron microscope is not allowed to move, Tian Bing, you will assist Gu Qiang to make records." ”

It is normal to complete the records before repeating the lab.

After a little fuss in the laboratory, Yang Rui glanced at the electron microscope again, and although he was a little hesitant, he walked out.

"Ladies and gentlemen, we have just completed a new round of repeat experiments to prove that we have obtained the crystal structure map of the N-terminal ligand domain of the G protein-coupled receptor binding complex to the ligand. Yang Rui used an announcer tone to face a group of Swedes who were spicy and stuck out their tongues.

……