The tour process that Yang Rui prepared for Jielikang and other companies was very short, but it was enough for them to understand the work of the laboratory. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

This is also a very important point, the experimental data of third-rate laboratories are not credible, just like the articles of many unknown scholars in unknown universities are rarely cited, and the main reason is the credibility problem. Scholars read these articles more to provide an idea, and when they really need data, they will still do it themselves before they can rest assured.

The data from ferriprone in the Huarui lab is very good, so Yang Rui let them know about the Huarui lab first.

As for the specific data and so on, there is no need to release it.

What everyone else sees is a simple collection of data.

But this collection of data is enough for the representatives of each company to ponder for a long time.

At the end of the visit, Yang Rui took Grace, Wei Zhenxue, Wang Xiaoyun and other people from the drug team to send the representatives of various companies out of the door in a friendly manner.

Watching a car start and then slowly leave, Grace let out a rare laugh.

Wei Zhenxue looked at Grace's smile inexplicably and asked, "You also like to watch car exhaust?"

Wang Xiaoyun habitually helped Wei Zhenxue translate.

Grace frowned incomprehensibly: "Also?"

Wei Zhenxue understood the words, smiled "oh", and said: "I don't mean that I like to watch car exhaust, I don't like to watch car exhaust, but Bao Xi likes it, have you heard the story of the princes of the beacon opera......?"

"Old Wei. Yang Rui was dumbfounded when he heard this, and sighed: "How are you really annoying." ”

Wang Xiaoyun was also stupid, and stopped translating after realizing it, and said: "Old Wei, fortunately you don't know English, otherwise, you would have been able to smoke in the afternoon." ”

"What do you mean?" Wei Zhenxue didn't understand.

"Cremate your cigarettes. Wang Xiaoyun's voice was fierce.

Wei Zhenxue was not affected at all, and said with a smile: "Impossible." According to the rules of our hometown, people must stop for seven days when they die, and if I die today, you will burn me today? You are too bad, but fortunately it is not my daughter-in-law. ”

Wang Xiaoyun said angrily: "I'm a bad person, you don't want to ask why you died?"

"There's no need, we're not afraid of death, don't study chemistry if you're afraid of death, don't you say?" Wei Zhenxue made a resolute expression, with the facial features on the big face, like a puppet army's death squad.

Grace looked at the two of them who were talking quickly blankly, and asked Yang Rui in surprise, "They were talking to me just now, right?"

"Yes. ”

"Why didn't you say it halfway through?"

"Hmm......" Yang Rui didn't know how to explain the story of a funny and angry normal person.

"Did I do something wrong?" Grace felt that Yang Rui's expression was very familiar, so she said: "I often make people angry, it doesn't matter, you just tell me what went wrong." ”

"It's not your problem. Yang Rui didn't bother to explain, and said directly: "You just watched Jielikang's people leave and laughed, why?"

"I'm wondering how they're going to get it back after they've assessed the prospect of going ferrite. Grace smiled softly again.

"The profit of deferiprone will not be too high, after all, there is deferoxamine. ”

"For drugs that have just been tested on animals, the most important thing is how much they can pass clinical trials. After Grace finished speaking, she added, "I hope you can choose a suitable company to sell it, rather than choosing the highest price." ”

"Huh?"

"While the companies with the highest offers may be the most interested, that doesn't mean they have the best ability to execute. Grace said: "A suitable company may only need two or three years to complete the clinical trial of deferiprone , and an unsuitable company may take seven or eight years to ......."

"I got it, I would choose the most suitable business, even if it wasn't profitable. Yang Rui was righteous.

"How can it not be profitable. Grace glanced at him and said, "I am the only one in your team as a medicinal chemist, and I don't need a salary, and the total development time is no more than three months, even if you add your theoretical research time, it doesn't cost much, and you will become a monopoly." ”

"That's not bad either. Yang Rui laughed.

……

The next day.

Van Lunding made a similar exclamation: "The Chinese are really going to get rich." ”

Arnold also said with a calm face: "54 points is indeed a score to get rich." ”

What they do is clinical candidate evaluation, which is to evaluate that a drug has a good chance of passing a clinical trial.

Only drugs with a high probability of passing will they enter clinical candidates, and then they will have the opportunity to conduct clinical trials.

Contrary to the intuition of ordinary people, those drugs that may be very effective in treating diseases do not have a strong advantage in the evaluation of clinical candidates, for the simple reason that there are many good drugs, and you have to be able to pass the review to make money.

Any drug that gets a high score in the evaluation of a clinical candidate means that it has a lot of promise, and companies like ZereZeneca and Pfizer like to buy drugs after the animal testing stage.

They will spend tens of millions of dollars to buy a drug, and then spend two or three times the price for clinical trials, and once it is successfully passed, they can earn back all the previous efforts in one go.

It is also for this reason that three-quarters of the original drugs developed in countries around the world each year are developed on the targets of existing drugs.

Such an original drug, although it is also original, is not very original, but it is very safe.

They are cash cows that are able to make profits safely.

The more extreme example is the antidepressant SSRIS, which the FDA has approved for no less than seven products, each of which has generated more than $1 billion in sales.

In any pharmaceutical company, the "blockbuster" is so important that it is difficult to find it, in contrast, it is much easier to make an original drug with the target of SSRIS as the target.

Deferiprone is different, because the last seven active substances left by Yang Rui have a good effect, and their scores are very high, which greatly increases the chance of deferiprone passing clinical trials.

As long as it can pass clinical trials and be officially launched, how to sell it is another matter.

According to JieliZeneca's evaluation model, usually compounds with more than 30 points can be included in the list of clinical candidates, and more than 40 points are basically ranked in the forefront, there is no major problem, and clinical trials will definitely be conducted.

As for drugs with more than 50 points, there are not necessarily a few per year.

Arnold also calculated and calculated before he determined that deferiprone reached the standard of 54 points.

"This guy has too many patents. Arnold didn't know whether to admire or be annoyed.

Big Pharma doesn't mind looting small companies by squatting patents if there is an opportunity.

For a drug with annual sales that may be hundreds of millions, and itself is worth more than one billion or even tens of billions, big pharmaceutical companies can do everything.

Frankie personally checked the patent and said: "Yang Rui is still fighting a lawsuit for PCR, and he must be very concerned about the patent issue." ”

"In one go, I registered patents for intermediates, preparation methods, products, crystals, amorphous forms, and compositions!" Arnold gritted his teeth, "He is too insecure to give people a sense of trust." ”

Frankie pondered the issue of "trust" for a long time.

……