Arnold and Frankie lowered their heads to discuss, and employees from other companies also went around in a corner, discussing and calculating in whispers. Pen "Fun" Pavilion www.biquge.info

After Grace finished reading the things in her hand, she looked up and saw that several people were talking in the corner, and she couldn't help pouting, and said, "You are all doing clinical candidate evaluations, there is not much difference between the evaluations of each family, why not read it out loud, save some time, and let everyone devote their energy to real research." ”

Everyone is a pharmaceutical company, and they know what they are doing with each other, but there is still a big difference between having a fig leaf and not having one, as if your neighbor has a child, whether it is your neighbor's or your own, you don't have to say it - "Congratulations, the child is really yours" does not make the neighbor feel happy.

It's a pity that Grace is not a good neighbor, she doesn't care if the others are still looking at each other, and says to herself: "The results of the animal experiment on ferrite are very good, everyone can see it, what's the use of your secret calculations, can Sinovel not know what he has made?"

"The results are really good, but the side effects are also huge, and we were just talking about the side effects. "Arnold lied and came out of his mouth.

Grace snorted and said, "Just some gastrointestinal reactions, joint pain, minor drug allergies, liver dysfunction, zinc deficiency, weight gain, dry skin, rashes, agranulocytosis and neutropenia...... What's so big about it that compared to the dangers faced by people with thalassemia, these are simple questions. ”

Yang Rui glared when he heard this, and reluctantly added: "These adverse reactions are relatively mild and reversible, and they are related to the dose and individual sensitivity, among which the most serious complication is agranulocytosis, but the probability of occurrence is very low, and it is temporary." ”

"That said, but do the FDA and other agencies think so? There are so many problems with animal experimentation, and it takes a while to get into clinical trials. "So far, no company has proposed a purchase or purchase, but at this stage, Arnold and others have consciously lowered their expectations for deferiprone

Buying and selling in the pharmaceutical field is very expensive, very expensive, and it is not easy to reduce any of them, and Arnold himself is a professional in charge of negotiations in the company, and he does not let go of a word.

Grace scoffed at Arnold's words and said, "Deferiprone can be used orally, and this alone makes it a great improvement over deferoxamine, and the FDA will figure it out, if they still play golf......"

Or the VIP box of the Yankees, the same effect. The man sitting on the right side said a word, followed by a sentence: "Our Americans' favorite is always baseball, always baseball!"

"Because your rugby is so boring. "Frankie uses the word football, in England, football is football, and in the United States, it is rugby, and any Englishman who is unhappy with an American, or any American who is unhappy with a British, can use football to provoke and try everything.

The man on the right really felt the provocation, sneered, and said, "If I'm bored, I'll find a woman instead of a sissy." ”

"You're Raymond of the Greenstone Corner Company, right?" Yang Rui didn't want a few foreigners to quarrel in the conference room of Peking University, so he stood in the middle and interrupted them.

"I'm Raymond, and you have a good memory. "Raymond has broad shoulders and a strong voice.

"Greenstone Corner is also an original pharmaceutical company, I remember for sure. Yang Rui smiled and nodded. Compared to the well-known super pharmaceutical companies such as Pfizer, Greenstone Point is only a medium-sized original drug company, but despite this, it has annual sales of more than $2 billion, and it is also a behemoth in other industries.

Yang Rui looked at both sides and said with a smile: "Everyone is here to learn about the animal experiments of ferrite ketone." Let's talk about animal testing today. More on that later. ”

"Animal testing is perfect, what is there to talk about. Grace clasped her hands to her chest, looked at a group of men proudly, and almost said the evaluation of "local chickens and dogs".

"You have pretty good numbers, but we don't have all the numbers. The Norwegian, who was sitting on the far right, looked up and spoke, but his eyes were fixed on Grace.

Grace's Nordic ancestry is very eye-catching, and it is extremely in line with the Norwegian aesthetic, they say no, but in fact, they also prefer this kind of Scandinavian and British and American style mix and match of fashionable girls.

Grace ignored his gaze and said, "You don't need all the data, the current results are enough for you to evaluate." ”

Arnold coughed vigorously, reluctant to talk about the assessment again.

Representatives of other companies were also silent, looking down at the experimental instructions that Yang Rui gave them, and quietly making their own assessments.

There was a sudden silence in the conference room.

Grace snorted dissatisfiedly, sat down next to Yang Rui, and said boredly: "You should give me the enhanced version of the information now." ”

"There's no way I'm going to take that stuff out of the lab. Yang Rui said: "I'll show you when I go back." ”

"Looking at their appearance, you can't analyze them for an hour or two. After Grace finished speaking, she added, "You should find a good salesman, otherwise, your ferrenone will not sell for a good price." ”

"How do you know I'm going to sell ferrite ketoxone? I can do clinical trials myself. ”

"Are you ready for $200 million?" Grace looked at Yang Rui like a fool.

$200 million in 1984 is not a small number, at least equivalent to $400 million 30 years later, and in fact, by 30 years later, pharmaceutical companies are often making more than $700 million in financial provisions for a new drug. It's not that you have to spend so much money, but if you don't have that much money, the risk of shutting down because of money will be greatly increased, and investors will lose confidence.

Yang Rui does not have $700 million, nor can he take out $200 million, so if he wants to go public, he can only do it through large companies.

Yang Rui laughed twice, and said something that he didn't believe: "We can go public in other countries first." ”

"It's just spending more money. Americans will not reduce the number and cost of your clinical trials just because your drug is marketed in other countries, and neither will Europe, only drugs that have passed the FDA will be able to enter the European and Asian markets through various agreements. Grace focused on explaining to Yang Rui that she didn't want a good drug to fail to go on the market because of Yang Rui.

Yang Rui sighed, this is the power of American fathers, if you don't follow his standards, you will have to spend more money, which is more terrible than the death penalty.

There is a head-killing business in the world, and there is no money-losing business.

But from another point of view, although the bloated and corrupt FDA is inefficient, the safety of drugs that have passed the FDA is indeed commendable, and the FDA is still much more reliable than the drug regulatory bureaus of third world countries.

"If Jielikang makes an offer, don't make it less than $20 million. Grace said: "After completing animal experiments, deferiprone should be able to sell at this price." ”

Yang Ruihan laughed and didn't talk about the price.

Grace thought he didn't want to sell it, and said, "You sell it to big pharma companies so that you can get this drug on the market as soon as possible, so that patients suffering from thalassemia can get life-sustaining drugs." If you wish, I would suggest that you set up a non-profit charitable foundation, and of course, you can continue to invest in the research of the laboratory. ”

"When the time comes, you have to leave. Yang Rui asked.

Grace nodded as a matter of course and said, "Although I plan to stay in China for five years, the progress of deferiprone is beyond the expected schedule, so I have no reason to stay, and the time saved is ready to be used for the promotion of deferiprone and in addition, I am also ready to raise some funds to support thalassemia patients who cannot afford the cost of treatment." ”

"Very ideal. ”

"Thank you. After graduating with a Ph.D., she turned down a number of high-paying jobs, traveled to Africa and other places, doing research on genetic diseases that few pharmaceutical companies pay attention to, and finally established a research direction on metal chelators, which is difficult to make money.

If you want to find a reasonable analysis, Grace may have too much "white guilt", working in Africa, helping poor African families, alleviating the pain of African children due to genetic diseases, and making Grace's mood easier.

Yang Rui did not comment on this, and waited for the representatives of Jielikang and other companies to look at the documents and read almost it, and said: "The animal experiments of Huarui laboratory on ferriprone are nearing the end, and we welcome all companies to send representatives to the company to understand the specific situation, each company is limited to two people, and those who are interested can fill in the application later." ”

"Give me an application. ”

"We want it too. ”

"It's all done. Arnold laughed twice and said, "Jielicang is not afraid of competition. ”

Yang Rui nodded and asked people to send an application to everyone.

Arnold whispered to Frankie, "Check the patents they have filed." ”

……