Van Lunding watched as truckloads of rats were transported into the Sinovel lab, his face cloudy. Pen @ fun @ pavilion wWw. ｂｉｑUｇE。 ｉｎｆｏ

Animal experiments, for the development of a new drug, can be called a great progress.

For example, products such as coenzyme Q10, if they are not directly extracted from animal tissues, and they enter the market at a high price of health care products, so there is no possibility of commercialization at all.

This is also because the efficacy of coenzyme Q10 is not significant enough, if it can really treat heart disease, rather than a small auxiliary effect, pharmaceutical companies in various countries have already spent hundreds of millions of dollars to try to synthesize it.

Although the synthesis of organic molecules is difficult, it is just a doctoral student's graduation thesis.

Of course, there are some PhDs who can't complete their graduation thesis anyway, so that they can't graduate for five or six years.

In any case, entering animal testing means that a large number of chemical molecules have been synthesized, and if they are sold now, they can already make a lot of money.

Fan Lunding thought of the bonus that Yang Rui might get, or the bonus that Yang Rui lost, and he was in a trance.

"This Chinese, he doesn't know what he is doing!" Van Lunding thought to himself, if he had the ability to synthesize more than 30 compounds a year, he would have earned a million a year, and he didn't want to nest in a third-world university.

Yang Rui has synthesized so many compounds in less than two months, even if there is theoretical research -- this is what makes Van Lun Ding tooth acid even more, when did Yang Rui do the theoretical research? Fan Lunding now knows that Yang Rui has completed the semi-synthesis of coenzyme Q10, the study of potassium ion channels, and the invention of PCR in less than a year before, and then wrote a book on genomics......

Fan Lunding couldn't imagine where Yang Rui's time for theoretical research came from.

Although many scholars have famous periods of high fertility, such as the famous miracle year, the Latin word is used to refer to Newton's 1666, when Newton left Cambridge to escape the plague and returned to his hometown, and in this year, to be precise, from 1665 to mid-1667, Newton constructed calculus, established the law of gravitation, and completed the experiment of decomposing visible light into monochromatic light, which is equivalent to reshaping the three fields of mathematics, mechanics and optics.

The miracle year of the English language belongs to Einstein's 1905, the year in which Einstein created the special theory of relativity, published two papers in succession, "On the Electrodynamics of a Moving Body" and "Is the Inertia of an Object Related to the Mass It Contains", and in the same year, three other heavyweight papers brought Brownian motion and quantum theory to a new realm, any of which was Nobel Prize-level.

Compared with Newton's miracle year and Einstein's miracle year, Yang Rui's 1983, or 1983 to 1984, is nothing to praise, although PCR is strong, after all, it is not at the level of calculus or quantum theory, and gravitation and special relativity are immortal works, more than an order of magnitude above PCR.

However, these things are also more than an order of magnitude surpass for Van Lunding.

Standing with Van Lundin, watching the rat-carrying cars go in and out were also Frankie and Arnold.

When the two heard Fan Lunding's words, they smiled at each other, thinking to themselves, of course Yang Rui knew what he was doing.

Franky's ass was already crooked, and he was too lazy to say it, Arnold felt that Van Lunding still had use value, and comforted: "No matter what Yang Rui thinks, we just have achieved our goal." ”

Fan Lunding smiled bitterly: "I thought that by making 20 kinds of active substances, I would be able to drag down the Sinovel experiment......"

If a small biological company can make 20 kinds of targeted active substances in three years, it is all lucky.

Time is also a very large cost for a biological company, which also implies the problem of success rate, simply put, the cost of the results made in 3 years must be more than three times the results made in a year.

If Yang Rui uses three years to make 20 kinds of active substances, the materials and manpower consumed during this period will naturally be needed to do experiments every day for three years.

However, it has now taken him two months to make 20 active substances, and it doesn't take much material to achieve his goal.

Arnold originally hoped that Yang Rui would sell the catalyst formula of coenzyme Q10 because of the increasing scientific research budget, but the result was the opposite, Yang Rui could have lowered the scientific research budget, and his plan was almost bankrupt.

Arnold wiped his face and said, "They are now going to do animal experiments on more than 30 compounds at the same time, which will also increase the immediate cost, you stare at them first, see the results and then decide what to do, don't be discouraged." ”

"Grace joined Sinovel Labs, and they do animal experiments, and there is a high probability that they will get results. Van Lunding retreated.

"You have to continue to play your part and strengthen the guidance, for example, try to raise their standards, animal testing is also very expensive, and the results will only be seen sooner. Alexander-Arnold kept cheering Van Lunding on.

Frankie said casually: "Yang Rui is a young man in the pharmaceutical field, but it's not like you just listen to what you say, don't raise the standard too outrageously, lest he return you." ”

Fan Lunding nodded silently and said, "There is no need to improve it in particular, I will directly translate the FDA's requirements to him, such a team will not be able to pass the test no matter what." ”

The FDA has been evaluated by the industry as too strict in terms of standards, and the same drugs that can be marketed in Europe often cannot be marketed in the United States.

By the 21st century, this polarization has become so severe that there are more than 200 new drugs for patients in Europe than in the United States, so much so that bringing good European drugs back to the United States has become a business.

Anyone who can buy the rights to operate a European drug in the United States and then pass it through the FDA's animal experiments and phase III clinical trials often means hundreds of millions of dollars in revenue.

Therefore, it is a high requirement to follow the requirements of the US FDA during the development stage.

Half of all drugs will be disqualified from the market – and Europeans won't want a failed product under the FDA standards, they want a successful product that can pass their own standards.

Van Lunding received clear instructions from Arnold and did not look at the pigs in the cage, and immediately returned to copy the rules.

On the other side, a large number of mice and rats were locked up in a compound not far away.

Yang Rui's Huarui laboratory already had a large amount of vacant land, and in order to avoid being repossessed by the government, courtyards were built one after another.

The yard where mice and rats are kept has also been designed for a long time, and it is also an indispensable configuration for laboratory animals in biological laboratories.

Yang Rui even designed the location where the gorillas would be held in advance.

However, now it is only mice and rats that can be used.

The mouse is more cute, it is bred from the small house mouse, as the smallest of the mammals, the mouse is the most thoroughly studied, but also the most convenient for primary experiments.

The rat is the white mouse, and it comes in many varieties, including the Chinese brown mouse, which is the common house mouse, which is relatively less cute.

But whether cute or not, these mice and rats have to contribute to the development of human medicine and biology.

In detail, this is a cruel act, but the reality is so cruel.

Animal experiments for the sake of cosmetics are the most vulnerable to criticism from society, especially animal organizations, so that many people initiate activities to not use cosmetics or "be cruel", but even if a girl who loves beauty can refuse to use a beautiful white rabbit as a nail polish for a safety test, or a pink pig as a skin test, she can refuse to use a pink pig to do a skin test, and she can't refuse to use a pink pig to do a skin test, and she can't refuse to save herself.

The only thing that can be done is to ensure the necessity of using experimental animals, and to ensure the living environment of experimental animals.

Grace carefully checked each cage, labeled each cage, carefully fed a small amount of water to the mice and rats, and asked about various indicators in simple English.

Wei Zhenxue graduated from the Department of Chemistry, had never done animal experiments before, and was a little afraid of mice, so he looked at it from a distance and said cool words: "If my wife is so good to me, I am willing to be a guinea pig." ”

"Write these down sentences, wait a few days, and we'll look at them again. Wang Xiaoyun laughed twice and stepped forward to help.

Wei Zhenxue looked at the meticulous work status of the two ladies, and said a rare good word: "Old Tu **** luck, if you marry a wife, you have to marry this kind of good wife and mother." ”

The corners of Tu Xian's mouth twitched twice, he shrunk his neck, patted Wei Zhenxue's shoulder with deep feeling, and said, "If a woman from the biology department is good to you, you have to think about her deeper purpose. ”

……