More than 30 kinds of compounds in animal experiments were synthesized by Yang Rui step by step. Pen @ fun @ pavilion wWw. ｂｉｑUｇE。 ｉｎｆｏ

Naturally, Yang Rui is also clear about the outcome of these compounds.

In the final analysis, Yang Rui only needs one or two compounds in the end, no more than four, and the rest of the compounds will be eliminated.

If you want to speed things up, the best thing to do is to get the compounds that should be phased out sooner.

The reason why the screening of active substances is getting slower is naturally because the remaining compounds are becoming safer, and those that are obviously unsafe, such as those with acute toxicity, have been brushed out in several initial tests.

But in the next tests, those unsafe compounds will eventually be eliminated, and it is only a matter of time.

The problem is that Yang Rui doesn't want to wait that long.

Some tests will not be carried out until much later, and some will not even be needed in the 80s, but will only be needed in the 90s.

However, as a developer of new drugs, considering the situation in ten years, it is simply too normal, and after ten years, new drugs may not be on the market, and even drugs that are on the market may be withdrawn.

For example, a large number of drugs withdrawn in the 90s are metabolized by mixed functional oxidase, which is no problem in itself, but patients often do not take one drug, but will use a variety of drugs, and the result is that these drugs metabolized by mixed functional oxidase are very likely to cross-react, and such a consequence is either not tested in animal experiments, or it is also the last test.

Because drug cross-reactivity is not the focus of animal experiments.

However, from the perspective of the success of a drug, drug cross-reactivity cannot run away.

Similarly, there are genotoxicity issues, metabolite issues, pharmacokinetic profiles, and even whether raw materials are readily available and whether the synthesis cost is reasonable and low.

These are issues that ordinary people do not consider, but they are the ones that pharmaceutical companies must consider. For example, in 10 years' cold medicine, products ******** as raw materials will not be considered, and some raw materials that need to be closely monitored have such problems.

Think about it, you can also understand, if you buy a box of cold medicine to check your ID card, but also limit the quantity, its sales can be imagined, in Europe and the United States, it is equivalent to turning over-the-counter drugs into prescription drugs, in order to several times the sales difference, pharmaceutical companies can not be cautious.

All in all, all the work of pharmaceutical companies is done with prudence.

Whether a drug can become a clinical candidate after animal testing means whether it costs $20 million to $200 million and waits four or five years for clinical research for pharmaceutical companies.

Such an amount of money and time is enough for two countries to engage in a localized low-intensity war, and how can pharmaceutical companies be careless.

What Yang Rui needs to do is to eliminate the compounds that are destined to be eliminated as soon as possible, so that he can focus his time and energy on a few compounds, and then make detailed tests and analyses.

In the end, if these few compounds can meet the requirements of clinical candidates, even if Yang Rui can't personally promote them to market, there will be pharmaceutical companies actively doing it.

The only trouble is that such an elimination work requires Yang Rui to spend more time participating, rather than the other way around.

Naturally, this will take some valuable time.

However, Yang Rui also felt that he needed such an experience, and that ferrenone was what he wanted to do, not the medicine that Sinovel needed, but one day, if Sinovel Labs wanted to develop and grow, it still needed to make its own medicines.

Yang Rui occupied two cubicles in the main laboratory and began the design of animal experiments.

Wei Zhenxue and Wang Xiaoyun are still responsible for the part of animal experiments, and Yang Rui only makes requirements, looks at the results of the experiment, and does not directly participate.

After all, animal experimentation is not a good thing after all, and even with the 3R principle, some experiments can still be uncomfortable.

As a graduate student in the Department of Biology, Yang Rui has more than 100 rat lives under his command, but this does not mean that he likes this work.

On the other hand, Yang Rui does not need to do these things by feeding the compounds, observing and measuring the results, and finally killing the animals.

Yang Rui is busy enough with design experiments.

In order to pass the FDA or possibly the drug regulatory agencies of European countries, Yang Rui must first make a detailed record of the experiment, including the preface and follow-up questions, that is, how to think, how to do it, and what the results are.

More specifically, it is why we think this way, why we do it, what we use it to do, and the meaning of the results we make.

This complex process can protect the public to the greatest extent and restrict the progress of scientific research to the greatest extent.

However, although Yang Rui was busy enough, his progress still caught Wei Zhenxue and Wang Xiaoyun off guard.

In just two days, the two of them couldn't bear it, and when Yang Rui checked, he found that they hadn't even completed a third of the task.

"The reaction time of the guinea pig is not up to us. Wang Xiaoyun explained helplessly, she was still busy writing the experimental report in her hand, and they had more things to write than Yang Rui.

Wei Zhenxue was so tired that he couldn't turn his head, so he only said: "I haven't slept for a day and a night, boss, add an assistant." ”

Yang Rui, who worked 110 hours a day, was also startled when he saw Wei Zhenxue like this, and asked Wang Xiaoyun: "You really haven't slept for a day and a night?"

"I slept yesterday, and Lao Tu helped me a little. Wang Xiaoyun was a little embarrassed.

"Where's Grace?"

Wang Xiaoyun hesitated for a moment and said, "She said that she didn't accept your order." ”

"Why?"

"Messy life, that's probably what it means. Wang Xiaoyun said: "Grace is continuing to follow the regular steps little by little. ”

Yang Rui groaned and asked, "What about you, do you think my experimental design is correct?"

"We've screened out a compound, and judging from the results, the experimental design works. Wang Xiaoyun doesn't need to praise Yang Rui, what she said is very true.

Yang Rui bowed his head slightly and said, "Then continue with the current state...... Isn't it okay not to add people?"

"You must add people, at least people stop the equipment, so that we can speed up the screening. ”

This sentence moved Yang Rui, the instruments in the laboratory are limited, but it is still feasible to use them at different times.

"I'll help you find two more people. Yang Rui is reluctant to increase the staff of the laboratory too quickly, the cost paid is on the one hand, the limited resources are on the other, and the busyness of the laboratories in Sinovel Labs is also second to none.

After some blending, the number of compounds decreases rapidly.

If this method is not used, these three compounds may take hundreds of hours of experimenters and tens of thousands of dollars before they are eliminated.

Within a few days, the number of alternative compounds dropped to a staggering 8, and Grace couldn't help but come to learn from it.

……