It is not only Grace who is following the progress of research in Sinovel Labs, but also JieliZeneca, as well as pharmaceutical companies from Japan and Norway. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

After discovering that the number of candidate compounds in Sinovel Laboratories was rapidly declining, several companies inquired about the situation.

The 8 alternative compounds are considered an important node, if the rapid decline is due to technical reasons such as safety, it means that the compound is likely to fail animal testing, but if it is the opposite, it means that the compound has a lot of room for selection.

The abundance of choice means that the cost can be significantly reduced.

Yang Rui made more than 30 kinds of compounds in one go, and the synthetic circuits he adopted were naturally strange, and some of them were unimaginable with normal thinking.

However, most of the more than 30 compounds use expensive raw materials or catalysts.

It's not that expensive raw materials or catalysts can't be used in drugs, it's about profit.

These companies focus on coenzyme Q10 catalyst formulations for profit, and deferiprone for profit.

Moreover, compared to the catalyst formulation of coenzyme Q10, the grade of deferiprone is much higher.

A new drug, for a super large company like Pfizer, is also a few core items every year, and for ordinary medium and large pharmaceutical companies, it often represents a fraction of the company's assets.

In short, if a pharmaceutical company can produce a new drug, it will be ranked among the world's pharmaceutical companies.

Don't look at the tens of thousands or more pharmaceutical companies in the world, 99% of which are generic drug companies.

Generic drug companies are not necessarily weak, but original drug companies must be strong, whether it is strong strength, strong laboratory, or strong spirit, they are all strong, because the strong strength and laboratory and spirit brought by a new drug may be converted into money in the future.

Dozens of new drugs that appear every year in the world, half plus half, half plus half, and more than half, all belong to multinational pharmaceutical companies.

The rest belong to small and medium-sized pharmaceutical companies, and there may not be one in a year.

It's a risky business.

However, there are still people who are involved in it.

JieliZeneca is a multinational pharmaceutical company with annual sales exceeding 10 billion US dollars, but the number of new drugs they can add each year is also limited, usually hovering around three.

Deferiprone may not be a bombshell, but who knows?

Many drugs have only been developed after they have been marketed, and then they have become billions of billions of bombs.

Therefore, people who originally stared at the coenzyme Q10 catalyst inevitably focused on ferriprone which was very well tested in animal experiments.

However, Yang Rui did not agree to the visit of companies such as Jielikang, let alone the visit of Japanese and Norwegian companies.

He didn't even let Grace know the details of his experiment, only the briefing came out of the small cubicle and appeared in front of the others in the morning report.

So, over the next two days, Yang Rui removed a compound again, and then ended his independent work in the laboratory.

The remaining 7 compounds are not too risky, in fact, they all have the potential to be used as finished drugs for deferiprone products, and several of them are appearing as generic drugs, so naturally there are no major safety concerns.

Yang Rui just needs to follow the steps and let them finish the animal experiments.

And the closer it gets to completion, the more curious companies like Zeliceca become.

At this stage, they are really just curious.

However, this curiosity also makes them itch.

On the third day after Yang Rui screened out the last seven compounds, Frankie directly led a group of people to Peking University.

The so-called monk can't run away from the temple, and when people find Peking University, Yang Rui really can't run away.

Not only can't you run away, but you can't keep a low profile at all.

A group of foreigners have arrived at the school, and everyone must pay attention.

When Yang Rui received a call to pick up people outside, Dean Liu also ran out.

"Oh, so many international friends come to visit our school, why don't you say Yang Rui, what is it for this time?" Dean Liu said as if complaining, his eyes lit up like a monkey.

"For the deferiprone research of Sinovel Labs. Yang Rui explained in one sentence.

Dean Liu naturally knew about this, and said with an "oh" sound: "It's all for this medicine, didn't you say that it doesn't make money?"

"It won't make money in the short term, but it won't necessarily be in the long run. Yang Rui then said: "No matter how you say it, it is an original drug, and there are many benefits to having a patent for an original drug." ”

"In other words, you smell a fishy shark again?" Dean Liu nodded understandingly.

Yang Rui smiled: "It's not that serious, it's the animal experiment stage, and they can't make money even if they take it." ”

Every year, thousands of drugs pass animal experiments, and only a few are valuable.

"What are you doing then?" Dean Liu's attitude changed rapidly.

"I still smell fishy, but I haven't seen the meat, so I guess I won't rob it too fiercely. ”

Yang Rui turned around and took Dean Liu with him to entertain representatives of foreign companies who came from afar.

There was also the director of the canteen, who asked along the way: "Do you want to open a private room, what shall we give them to eat?"

"Just eat the papers. Yang Rui replied neatly, and when he arrived at the place, he really fed a group of people a bunch of documents.

Arnold and the others were so happy that they hurriedly looked through it, and Grace was the first to grab it in her hand and said, "It's too thin." ”

"When you go back to the lab, I'll give you a thickened version. Yang Rui smiled and reassured, no matter how you say it, you take the initiative to work for nothing, and you should be given some privileges.

Grace seemed to be quite satisfied, but the change in her expression was very weak, and she just looked at the information.

Arnold was beside him, comparing the completion of various aspects of animal experiments.

Clinical candidates have some hallmark characteristics, and the more these features have, the more necessary it is to conduct clinical trials.

Jielizen, a multinational company that often does mergers and acquisitions, has its own methods, and by scoring these characteristics, he can judge the approximate value of a compound.

Frankie quietly calculated for Arnold on the side, and said: "It is effective in animal models, no genotoxicity, no acute and chronic toxicity, and the basic 15 points can be obtained." ”

"The target of action has been clinically verified, and the iron chelator is very simple, so it's worth 3 points. There is a competitive advantage, but can it be better than deferoxamine?"

"It's 2 points, a total of 5 points. ”

"That's 20 points, and in terms of raw materials and costs, these compounds are different...... I'll take a look, and I can basically get five points. Twenty-five minutes?" Arnold took a breath.

Jielizen's calculation formula is simple and complex, but it has never been based on 60 points, as far as the oral calculation formula they use now, it can reach 30 points, which is a rare high score, and the company will generally contact and try to acquire.

Frankie looked down at the document and said, "7 backup compounds, at least 10 points, right?"

"Hmm...... Their animal experiments have not yet been completed, and I don't think I need to count the backup compounds first, who knows how many will pass in the end. "Alexander-Arnold doesn't want to give a 35-point score.

Frankie said indifferently: "Because it is a rare disease drug, there is a 7-year drug monopoly period, do you want to add points to this?"

Arnold hesitated for a moment and said, "Even so, rare diseases mean low sales, and the monopoly is to make up for the lack of sales...... Count it as a 3. ”

Although it was only a private estimate, he was embarrassed to be too unfair.

Frankie said, "That's 28 points?"

"Hmm......" Arnold looked at the row below that hadn't been counted, a little tooth sore.