Eight o'clock in the evening. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

Dean Liu hurried over on a bicycle and showed the instructor at the police station his work card and letter of introduction.

Also with Li Zhangzhen,

The instructor of the police station suddenly realized: "I said that you look familiar, you are Yang Rui, I heard that you want to win the award?"

"Nothing. "The nominations haven't come out, so Yang Rui naturally won't admit it.

"I'm sure I'm not mistaken, it's an award. The instructor patted his head: "Look at my dog memory, I can't remember where the is buried." ”

Yang Rui looked at him speechlessly, and said in his heart: You bury the things you bury and eat by yourself, so don't dig them out for a treat.

The aunt of the neighborhood committee was still a little unconvinced, stared at Dean Liu's work card for a long time, and said, "It's just such a young man, is it from your Peking University?"

Dean Liu smiled: "Yang Rui is a student at our Peking University, and he must be young." ”

"At such a young age, you are going to let go out and talk to foreigners? The aunt of the neighborhood committee said, and then said: "Let's talk about things, why don't you find a better place to talk about things with foreigners? It's not easy to talk about, and the cowhide is blowing all over the sky, what's the use? We in China, we just let you make it upside down, so that foreigners can hear it, hey, it's all bragging......

The aunt chattered, and Dean Liu could only stretch his neck to listen, otherwise what should he do?

After sticking for half an hour, Yang Rui and the others could be considered to have escaped.

A few foreigners were quite excited, and they all thought it was a rare life experience, such as the joy of looking down on piranhas after just swimming in the Amazon River, watching TV interviews with drug dealers after just passing through the slums of Mexico City, and just boarding a plane to gaze at the statue of the leader after graffiti in Pyongyang.

However, there is no way to continue the negotiation, in fact, there is no need to carry out, the conditions of the previous negotiations are also informative, and in the end, who is willing to sign the contract, who can agree to Yang Rui's conditions, or if they want to bargain, they all have to be determined later, and even the CEOs and even the board of directors of each company will decide. After such a VAM agreement is negotiated, the minimum situation is to pay $1 million and get nothing, or it may pay $20 million or more to get more than one active substance to pass the phase I clinical trial, and of course, it may also cost tens of millions or even $100 million to get a drug that passes the phase II clinical trial.

If it is 1 million US dollars, several people present can naturally decide, but everyone is not rushing to lose, since the amount involved in signing the contract may be hundreds of millions, then it must be approved by someone with such authority, and naturally it is not possible to decide on the spot.

Of course, although there was no decision on the spot, and not even a paper agreement was signed, everyone present was very happy.

In addition to one more experience, Yang Rui's performance also strengthened their confidence in deferione.

Indeed, deferiprone is not a bombshell, let alone a big killer like penicillin, but, God, how many people in the entire pharmaceutical industry have thought that they can sign a new penicillin?

It's like architects dream of building the world's first building, and everyone can take this as their lifelong goal, who can sign a contract every time they do a design, and that's the kind of requirement?

In the same way, everyone knows that the annual sales of blockbusters are more than 1 billion US dollars, and one of them can make a lot of money, and make money playing Porsche and hitting Ferrari every day, but when signing a contract, you can't just look at the bombshell.

Lobster is delicious, but you can't just eat it.

In this era when the whole industry can only give birth to double-digit new drugs every year, there are lobsters to catch in the hand, there are steaks can not be let go, even if the left hand grasps the lobster, the right hand grasps the steak, and the steamed bun is also to step on it, otherwise, who knows if the lobster and steak are finished, whether it will be interrupted, or, what if the FDA suddenly buries the lobster and steak with a brain pump? This kind of thing happened not once or twice, otherwise, Wall Street would not have paid so much attention to the drug reserve capacity of pharmaceutical companies.

Because of this, in this industry, the most original drug companies do are new drugs with the same target, for example, in order to treat chronic myeloid leukemia, biologists have found that the molecular target BCR-ABL may have a therapeutic effect, so the laboratory of the pharmaceutical company conducts high-throughput screening on this, makes thirty or fifty active substances, and starts animal experimental clinical trials step by step, and finally, imatinib appears, and seems to have achieved the expected goal, so, has this target completed the task?

Of course it can't be, this just shows that the molecular target BCR-ABL is indeed as effective as biologists say, so more pharmaceutical companies will get involved in this field, so dasatinib and nilotinib were born, and the relationship between these drugs is like the relationship between Yang Rui's last seven remaining compounds.

If all the seven compounds made by Yang Rui finally pass the clinical trial, then theoretically, seven drugs for deferiprone can be produced.

In fact, it is often the case that pharmaceutical companies have two or three compounds or even more compounds that have passed clinical trials, which is not a bad thing, for pharmaceutical companies, on the one hand, they can choose the best compounds to make drugs, on the other hand, they can also wait for the patent protection period to expire, they can register a generic drug by themselves, or even during the patent protection period, they can register multiple drugs by themselves, so as to occupy the market and raise the threshold.

Because the pharmaceutical industry is inherently profitable, even if it earns less, there are twenty or thirty percent of the benefits, and the benefits of new drugs with the same target are that the risk is lower and the funds are returned faster, so they have become the first choice of most pharmaceutical companies.

Deferiprone began to be taken seriously, not only because of its status as a rare drug, which made its expected sales low, but also because of its status as a pure original drug, which made it risky and slow to return funds.

The former is a situation that is relatively difficult to change, but the latter has now been changed by Yang Rui.

The seven active substances that have passed animal experiments have reduced the risk of passing clinical trials, and Yang Rui is willing to sign a VAM agreement, which further reduces the risk.

Original drug companies are not afraid of high costs, they are more afraid of risks.

As long as the risk is low, 60 million or 100 million, I don't feel anything about them.

Now the cost of new drug development is rising, 200 million 300 million is very common, that is still done in the case of a very expensive bottom cost, Yang Rui's gambling agreement, in fact, is very in line with the expectations of pharmaceutical companies.

However, the gentlemen of the pharmaceutical company were happy, but Dean Liu was not happy.

He handed over his bike to a Zeliconia employee, got into Zelicon's car, and asked them about the negotiations.

Yang Rui told him selectively, and before he could talk about the price of the second phase of the clinical trial, Dean Liu let out a long sigh:

"I remember you asked us before, do we want to do ferrione? Dean Liu asked regretfully.

Yang Rui nodded: "If you refuse, I will cooperate with Sinovel Laboratory." ”

"That is, if we had said yes then, we would have been able to recover tens of millions of dollars by now?"

"Not necessarily, if I sign this agreement, I may not get a dime, but it is possible to recover tens of millions. "The VAM agreement is not mandatory, if Peking University has a patent for deferiprone , the most likely way to sign is a milestone direct authorization, so that there is a chance to recover 20 or 30 million, or 40 or 50 million.

Dean Liu selectively ignored the part of "I can't get a dime", looked at Yang Rui with straight eyes, and said: "We missed the PCR, and we also missed the ferrite, Yang Rui, you can't stuff all the good things into Huarui." ”

Yang Rui shrugged his shoulders and said, "I've asked you about both things, and you don't want me to send Huarui." ”

"You ought to persuade us more. ”

"No matter how good I say, the funding is real, and it is the funding that persuades you, right?" Yang Rui said: "PCR cost more than one million dollars at the beginning, and it was even higher to go to ferrite, and now it is said that it cost millions of dollars, that is good luck, if you are unlucky, two or three hundred million dollars, and it will be spent, and Peking University can't get so much funding, and I blow it all over the sky, and the project still has to be yellow." ”

When he did PCR, Yang Rui asked with fake feelings, if Peking University really wanted it, he would rather drop out than give it. However, the situation of deferiprone is different, if Peking University is really willing to take this risk, Yang Rui is willing to take out deferiketone. Because the risk is real, Yang Rui is not sure how long it will take to make it before doing it, and he is not sure what the results and costs will be. Maybe in the end, it will really take a year or two, tens of millions of dollars, and it is possible.

If Peking University can invest in full, it will naturally provide more and more professional experts in the pharmaceutical industry, and Yang Rui will not only save time to do other things, because the prestige and honor that come from going to ferrite are also a lot.

Of course, now that things have been made, it is useless for Dean Liu to say anything.

Dean Liu himself knew this, shook his head, and said, "No, if you have a new project, you have to give us a good explanation." ”

"That's for sure. Yang Rui said a word in a real way, and then asked: "You can afford the projects that require a lot of funds?"

"It depends on how much. Speaking of funding, Dean Liu was still a little weak, turned his head and said, "Let's talk about ferrite ketone first." ”

"Didn't you just say that?"

"You just talked about the negotiations, the causes and consequences, and you didn't talk about the specific research. ”

"Ah...... How long does that have to be said?"

"Don't worry, let's go back and talk slowly. Dean Liu patted the back of the driver's seat in front of him as he spoke, and said, "Go to Peking University." ”

"Now?" Yang Rui looked at his watch, and it was past 8 o'clock in the evening.

Dean Liu said unequivocally: "Go, Academician Cai, they are all waiting." In the field of new drug research, we have just started in China. ”

As he spoke, Dean Liu swept Yang Rui up and down with his eyes.

Yang Rui was swept away and asked, "Everyone can't wait in the office, when I call you, you'll all get off work." ”

"It's off. Everyone is gathered at Academician Cai's house, sister-in-law is cooking, let's hurry up, and we can mix some soup. Dean Liu said and urged the driver.