36 Molecular diseases are diseases whose pathogenesis is intrinsic to the molecular level, and the abnormalities caused by gene expression problems (mutations in various structures and expression levels and expression sequences), such as structure and synthesis amounts, are essentially matching problems. Pen~fun~Pavilion www.biquge.info such as sickle cell anemia is caused by the β globin sixth codon from normal glutamic acid GAG to hydrophobic valine GTG, the formation of HBS leads to a decrease in solubility, different levels of matching make the kinetic properties of the network is in the normal range; the appearance of the disease is low probability, but after the appearance we can look for its posterior probability (for individuals), that is, to find possible pathways; at different stages of development, the combination of proteins is different, and they regularly replace each other, and their synthesis presents a strict process of growth and decline; synthesis and degradation rate, the structure should be matched as a whole; metabolic pathways are the intrinsic characteristics of the network, the result of its collapse can be seen as different energy levels

37 Fortune-telling is the path of the collapse of the probability network, and the resonance caused by similarity makes it possible to infer the network by a certain eigen

38 Different drugs can diffuse into different networks, and the results of their calculations in the body are various manifestations: body structure and metabolic processes (different systems);

39 The inheritance of immunity is the expression of genes, and gene rearrangement is the variation of sequence matching, which is the way out of epigenetics, and the use of immune mechanisms to normalize gene expression to treat genetic diseases; When the expression pathway is mismatched, re-energizing the whole may be able to restore the body to a meaningful low-energy state, the interaction of antigens and antibodies is multi-pathway, and different sites selectively express genes at different sites, the probability of developing a specific gene carrier is different, which is an intrinsic (e.g., people with HLA-DR4 have a 6-fold higher risk of developing rheumatoid arthritis than normal people), histocompatibility, that is, the coupling of the network expression of cells, which is a high-level matching, in which the sequence matching of antigens and antibodies is intrinsic, the coupling of variable and fixed regions, and the expression pattern of broken genes, which extends to the combination level of different genesFor example, 200 million humans have diabetes, xx people have xx symptoms such as andigia, the network can be differentiated into different stages of development, and the probability network constructed at the level of the group is used to express the problem at the individual level, first ascending and then decreasing;

40 Intelligent structures: the hierarchical network of neural networks, and the genetic collapse of biological evolution, are all based on 1/0 matching

41 gene mutation or expression of gene mutation is the premise of the tumor, any tissue can produce malignant tumor (or related to stem cells, constantly screened in iteration), which is the probability collapse of the network; chromosomal variation is the expression of the gene itself, the constant relationship between a chromosomal aberration and a specific tumor (the collapse of probability), is the result is not the cause; the relationship between the detection gene and cancer is the overall and intrinsic relationship, and its correlation is high, which is the embodiment of the median value theorem and the fixed point principle; the quantum nature of the gene, its linear arrangement on the chromosome, and then further refinement, each gene can be divided into a certain coding region and non-coding regionGenes that can cause malignant transformation of host cells indicate that the role of the central node is the key to the formation of probabilistic network pathways; changes in the function or expression of proteins that regulate cell growth can be self-activated into oncogenes and induce tumor phenotypes in susceptible cells, the essence of which is the multiple expression of probability, and the network formed by it determines the tumor phenotype, location and degree according to the position of the distribution function; gene activation is a sudden change in probability such as (base substitution, deletion, insertion; gene activation, gene fusion; gene amplification); mutation is continuous, and selection is interrupted, like urinationAbnormal expression is the initiation of higher-level network mechanisms, such as Shinya Yamanaka's stem cell transduction, multi-level that is, multi-probability combination pathway, tumor occurrence is the process of development, is the coupling of multiple functions, and there is also competition between different factions within the tumor, that is, high heterogeneity, and there is also a certain chromosome competition within the cell, and the number of chromosomes in the same tumor fluctuates greatly. The origin of the tumor is from the same progenitor cell, which is the winner of the mutation, that is, it meets certain intrinsic characteristics, and there is no 100% correspondence, only a certain range of probability correspondence, such as 95% of patients with chronic myeloid leukemia (CML) are pH positive. The synergistic effect of multiple cancer-related genes has to go through multiple stages of evolution, in which different stages involve the activation and inactivation of different cancer-related genes. This is the result of the final expression of the network, the start and end points are determined, the path is uncertain, and only after the collapse can the specific path be known, what can be determined is the connection of the start and end points

42 Genealogical analysis is to preliminarily determine the probability of individual disease through the population level; diagnosis is to find the intrinsic characteristics, look for connections, similarities, imprints, and find the matching of sequences (DNA sequences, gene expression sequences, etc.) through hybridization;p the explosive growth of CR makes the information diffusion become a network and can be observed; the network formed by large-scale observation of gene chips can be differentiated into different matrices according to different criteria, and its intrinsic significance has certain biological significance; antisense oligonucleotide technology uses the principle of complementary pairing to silence or increase expressionThe coexistence of sense strand and antisense strand RNA inhibits gene expression more than 10 times more efficiently than single sense strand or antisense strand RNA. Antisense technology blocks the expression of some specific genes to achieve the purpose of inhibiting the expression of harmful genes. Whether the synonym is enhanced or not, different collocations can make the overall intrinsic of the network within a certain normal range

43 All treatments are to make the body return to a certain period, to make up for the deficit, to achieve the balance of the network, and to use genetic algorithm to find treatment: different programs have different adaptability, to find the optimal combination solution. The higher the fitness, the greater the probability of formation, and finally there must be a certain path; combined with immune algorithm, matching, different degrees of matching; gene therapy, the use of recombinant DNA technology, the introduction of a certain sequence (normal gene or complementary sequence), so as to have a certain impact on the gene expression network, can make the body's network return to the state of normal people: replace or compensate for the function of defective genes, or inhibit the overexpression of genes, the modification or replacement of gene structure and the enhancement or inhibition of gene expression, a certain network expression is a combination, we need to find a relatively simple eigen, such as the combination of several genes, which is the way of epigenetics

44 The convergence of network algorithms is hierarchical clustering, which imitates the behavior of nature and looks for the pattern of complex networks; the connection between Turing machine and biological behavior is essentially the iteration of probability, and at the same time uses its convergence nature to cluster; fitness is probability, and its behavior is probabilistic, but the result can be determined, and the optimal solution can be found with a relatively large probability; coding is the mathematical language transformation of the problem, which is a kind of dimensionality reduction, which enables the computation to be carried out; different parameters are different characteristics of the network; and search is based on the matching of various criteria

45 At the level of systems, each discipline is a genealogy and selective expression, while systems science describes the social relations of the whole: based on interactions, statistics are used to grasp the whole

46 Complex synthetic biology of a single cell = different behaviors of cell population behavior, and the risk of recurrence of individual chromosomal and polygenic diseases is a precursor probability with population morbidity

47 Bayes' theorem is a simple ratio of inverse probability, which is based on the operation at the group level, which conforms to the Matthew effect of the network (highly clustered, sparsely distributed), so that the specific distribution is polarized and closer to reality (there are many of them, and there are none);

48 detection methods; Direct measurement (enzyme activity, binding of specific substances such as antibodies), indirect measurement (culture of bacteria)

49 The various genetic diseases themselves are distributed at different levels, and familial clustering is the embodiment of the high-throughput central node nature of the network, such as mono/polygenic genetic diseases. Chromosomal disorders, on the other hand, are sparsely distributed and associated with herdity

50 The incidence rate is high, the harm is great, the early treatment can achieve better curative effect, indicating that its effect is cumulative, this process is related to the development of the disease, it is the non-central node of the network, the substitution is high, and the compensation of the network can be used to form an individual with a normal phenotype

51 Genetic probability is quantized, with each generation equivalent to 1/2, which is the basis (the most intrinsic path), followed by the selective expression of probability, i.e., Bayesian. Because the mating of each generation is a correction of probability. The whole situation should be considered, and although the pre-probability is a hypothesis, it would be better if it was based on a certain network

52. Organ transplantation is used as a solution for various congenital metabolic defects, and autologous organs are modified to a certain extent and then transplanted back. Preliminary consideration of blood, bone marrow tissue, immune cells. It may be possible to strongly stimulate gene expression in organs in vitro, regardless of the pharmacokinetic and pharmacodynamic effects of the drug

53 Gene substitution is the ultimate solution, but we need to solve the problem of precise cutting and bonding, followed by the ontological diffusion of genes, like the exchange of plasmids in bacteria, and the use of red blood cells as drug carriers

54 Transduction of a specific sequence – the expression of a specific protein, which relates to the central law

55 Gene therapy is at the genetic level, which is a direct intrinsic and may be combined with the cellular level to form a probability network

56 different cells are expressed at the population level, looking for certain intrinsic features to identify specific target cells, such as tumor cells. A certain gene is transduced to a specific cell according to certain conditions, so as to improve the sensitivity to the drug. This is essentially an operation on the different dimensions of recognition, making it possible to exhibit changes in probability:1 Correcting the genetic mutation of tumor cells, reducing their growth rate, and inducing tumor regression. 2. Introduce enzyme drug precursors (pro-drugs) to form tumor-specific sensitivity. 3. The target gene is introduced to enhance the immunogenicity of the tumor, so that it can be recognized by the body's immune system. Using the role of the external system, the inside should be combined with the outside, and the comprehensive effect

57 Searching for intrinsic genes, or using network equivalence, efficient introduction, excluding changes in the resistance of the cell itself, i.e., the immune system, efficient expression of genes, achieving controllable regulation, using the body's own balance, and searching for target cells is also a kind of intrinsic

58 The establishment of the overall structure is like the relationship between the stone and the church, accumulating details, constantly traversing, and finally ascending; the establishment of a high-dimensional structure, that is, the panorama, uses the holographic characteristics of information to deduce the unknown through the known; the law is the collapse path of the relationship network constructed from infinite combinations, that is, the intrinsic, and the understanding of the whole is a specific and meaningful combination; the high-dimensional probability network constructed according to experience can be integrated into the original system for meaningful structures, and what is stimulated is a whole pattern, and each simple position can be diffused into a network with a certain effect; the expert system can reformulate the problem and constantly abstract it, from qualitative to quantitative, so that the network collapses to a mathematical operation, finds the eigen, and then spreads back into a network of high-dimensional structures, that is, the answer to the problem, which is also a eigen: find the panorama and then focus on the details of a particular combination, which is the collapse of the wave function. According to the classification of basic principles, this is the result of the minimization of energy with a certain knowledge structure, and the Tao gives birth to one, one life, two to two, three to all things

59 Genealogy analysis and gene chip gene expression similarity (find the distribution function), the use of linkage analysis, the use of linkage analysis, the body of different relatively independent processes of the expression and pathway intrinsism, the higher level of the body is the relative pathway competition and balance formed by the network; allele is a relative relationship, can be regarded as intrinsic, the upper level of the same gene is different loci, which is related to the combination of genes; cross-inheritance is the characteristics of the quantum gene combination network; gene pleiotropy (one-to-many) and genetic heterogeneity (many-to-one) are in different directions; the proportion of patients of different sexes is related to companion inheritance and limited inheritanceThe probability of the expression of a certain trait is increased, which is a kind of convergence; both dominant and recessive genes should be expressed to a certain extent, which is a probabilistic behavior, and the trait is the final intrinsic result; penetrance and expressiveness are both probabilistic expressions, which are affected by the environment and the expression of other genes

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