Chapter 31: Preliminary Discussion of Disease Models
Establish the various symptoms of the disease as a mapping, and the different symptoms correspond to a disease as a set, in which a certain weight is given to the symptoms, that is, probability. Pen Fun Pavilion wWw. biquge。 The focus of info is to understand the relationships between symptoms and construct new subsets that make matrix operations possible. It can be logically calculated, and the relationship can be determined by the Venn diagram, which is multi-dimensional. And an individual can have different diseases at the same time, so that a variety of symptoms appear, this is mixed with other syndromes, Chinese medicine requires us to divide the priority, but I think this is a simplification of calculation, I tend to build a topological space, decompose various symptoms into a matrix, and substitute various indicators into the construction space when diagnosing, and the space is the disease
The study of primary and secondary disorders is helpful in relationship building, because the calculation of symptoms should not be easy, and it makes sense to determine the priority. At the same time, the hidden Markov model has reference value
Multi-level effects of sodium intake, cell membrane proteins, receptor proteins, cardiopulmonary function, neurotransmitter production, intestinal microbiota
Urea nitrogen is filtered in this part of the renal body of the kidneys and excreted into the urine, and if the kidneys' excretion function deteriorates, the concentration of urea nitrogen in the blood increases. Therefore, urea nitrogen has become an important indicator to understand whether the kidney is functioning properly. I don't really appreciate this kind of thinking, and I tend to take a comprehensive index, which is to couple the spin coupling between the molecular level, the cellular level, the organ level, the system level, and the layer
Genetically inherited predisposition to cancer, local persistent bacterial infection and immune activation and prolonged exposure to alcohol stimulation, local abnormal hyperplasia, resection of residual organs
Establish some symptoms of a typical disease, and some strange diseases may be a variant without typical symptoms
The combination of chemical component separation and simple active ingredient screening can explain part of the pharmacodynamic material basis and mechanism of TCM compound to a certain extent,--- TCM compound has the characteristics of multi-component and multi-target synergistic overall effect
When you have a heart problem———— left arm will be sore, numb, and painful.
When you have liver problems———— calves tend to cramp when you sleep at night.
When there is a problem with the kidneys——— the voice will not come out, and it will be hoarse.
Migraines ——— when there is a problem with the spleen and stomach.
Brain partitioning—the connection between internal organs and body divisions
The use of some human-derived factors, peptides and other drugs should not be simple intravenous or intramuscular injection or oral or topical or intraperitoneal injection, but should be in line with the metabolism at the cellular level, and the use of prodrugs is a bit interesting
Both adaptive and traumatic changes are fundamental pathological changes in the occurrence of the disease. Adaptations are: atrophy, hypertrophy, hyperplasia, metaplasia
The ruler of the prescription is also a complex system, how to construct the connection?
The relationship between gold, wood, water, fire and earth migrates to the central law of DNA-RNA-protein, which has symbiosis (translation and transcription), phase restraint (inhibition, such as chemical equilibrium), shengji antigram (equilibrium shift), and intergenerational similarity (chromosomes), forming cycles
DNA-RNA-protein premise: addition and subtraction can be arbitrarily offset on the timeline
(↑) (↓) (=) represents each individual in a matrix,
(↑↓) (↑↓) (↑↓)
(↓) (↑)?
Any single digit is equal to 0 of the sum of the two digits before and after. 809 times and 0 separated by the sum of two digits. 309 times the difference
From the substantive study of "syndrome", to explore concise indicators or data to express and identify the diagnosis of various syndromes, it is necessary to construct a group of indicators to map to a disease
The fuzzy set is quantized, and one or the other, which means that the matrix that each indicator can be decomposed into has some molecular differences
Correlation = (Same - Opposite) / (Same + Opposite)
Open = (opposite) / (same + opposite)
Closed = (Same) / (Same + Opposite)
Various human test indicators cannot be fixed at a point, but a region, and fuzzy math is the operation of the region
Stem cells offer the possibility of high differentiation potential and can be considered as new energy in the system
If you want to stop it, cut it off
Even though the change is still the same
Bayes formula, a proportion, conditional interchange, decomposition, complementarity
The distribution function is a probability density function, a higher-order probability
Organ culture is not a simple imitation, printing is not advisable, we should look for its most fundamental structure, so that it can develop into a complete organ, that is, to build scaffolds, the focus is to provide the possibility of various connections, and various cohesin proteins such as qualitative acid in the extracellular matrix can be used as glia as scaffolds
Ultrasound provides a frequency of vibration that conforms to the intermediate level and helps to stimulate cell regeneration
Focus is the means, and the visual imaging is guaranteed
Two-dimensional variables need to be studied as a whole, and the boundaries of the variables are calculated in two-dimensional space
Definitions cannot be calculated as criteria for distinction.
There are many uncertainties in the early stages of the disease, which is the reverse argument, based on the assumption that the disease is an entity, and I tend to think that it is the conditional expression of the etiology. The two sets of etiology and symptoms are coupled in the human body, i.e., they are causal to each other, so that each variable develops in a different direction
To make a diagnosis, it is necessary to rule out the possibility of other diseases, and reverse thinking may lead to the true root cause
When an unexpected result occurs during the operation, consider establishing a complex space
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Grading, molecular clocks, speculating germline occurrence with molecular sequences and structures, such as RNA, DNA, etc
First-order: sequence alignment, exploring homology, and comparing the phylogenetic relationships
Second order: structure, energy minimization, can be --- RNA, DNA--- protein, RNA, --- RNA from DNA. matrix
Calculate with statistics
The hidden Markov model predicts infinite possibilities and the convergence distribution of its quantum energy levels, and builds a framework based on probability
The function and its expression level are coupled and expressed in differential equations. Expressed in a bit matrix?
Transcription, splicing, small RNA molecules, translation, epigenetics, protein structure/function, development, evolution, disease, and other multi-level coupling
The common denominator of the structure may be the various probabilities and distributions, such as the proportion of primitives in the secondary structure, the proportion and distribution of the secondary in the tertiary structure, and the spatiotemporal expression of various genes, which are also proportions and probabilities and distributions. It is important to regulate the formation of loops
Migration of omics
Ecological niche, energy level distribution
There are also different levels of matching, similar nature, different lengths, and the idea of modularity is also important
SimilarityImpliesSimilarityInFunction(and/orstructure)) is used to guess function (sequencesimilarityimpliessimilarityinfunction(and/orstructure)) but there is also spatial structural homology, and it seems that convolution-probability similarity can be used to predict structure and function (path selection)
Sequencing can take advantage of different biases to bind to viral sequencing
In addition to logically deducible first-order relations, complications are either higher-order relationships or first-order relationships that we have not figured out. Atrial fibrillation with thrombosis, edema, right ventricular failure, less intimal infection, and more lung infection (kinetic analysis, comprehensive statistical analysis)
01234, Sodium-Potassium-Calcium-Pro-Potassium, Internal and External Pumps
Explanation: Ventricular myocardial action potentials are divided into five phases, namely phase 0 (except the polar phase) and stages 1, 2, 3, and 4 (repolar phase), phase 0 sodium influx, stage 1 potassium efflux, stage 2 calcium influx (and potassium efflux), stage 3 potassium efflux, and stage 4 recovery by NA+_k+ pump activity. (alternate, sodium, potassium, calcium; effect continuous, chemical and physical; self-regulating system for stability)
The competitive inhibition of enzymes is more like a group transformation of a network
Endogenous histamine, gastrin, and acetocholine, H+-K+-ATPase pump intracellular H+ out of the cell
Receptors and transport pumps form a network to optimize drug action
Pilocarpine, physostigmine, mannitol and timolol in the treatment of glaucoma have different mechanisms of action and the same pharmacological effects. An example of a network, the same disease, different treatment, different disease, which requires the determination of the node and path relationship of the network
One, cholinergic drug pilocarpine: M receptor stimulant directly stimulates M receptors on the pupil sphincter to make the pupil narrow;
2. Physostigmine: It is a cholinesterase inhibitor, which inhibits cholinesterase activity, accumulates ethylcholine, acts on the M receptor on the pupillary sphincter, and also causes miosis.
These two drugs reduce intraocular pressure by narrowing the pupils, pulling the iris toward the center, thinning the roots, and enlarging the anterior chamber angle space, allowing aqueous humor to return smoothly.
3. Dehydration drug mannitol: by rapidly increasing plasma osmolality, promoting the transfer of interstitial fluid water to plasma and producing dehydration, reducing intraocular pressure in glaucoma patients.
Four, β receptor blocking drug timolol can reduce aqueous humor production and treat glaucoma without adverse reactions such as pupil constriction and concomitant spasticity.
Analgesia, sedation, repression, a common pathway of the network
Tension is a ratio that illustrates a range of proportions to normal values
Medication, such as playing the piano, must have a certain rhythm. The first is necessity, a specific expression at a specific time, i.e., determining 123456. Then there are the subsequent changes, which should conform to certain laws. Then there is the density, the right place has the right expression, and the overall effect should be comprehensively considered, and then some adjustments should be made in this high-dimensional network. This is based on interaction, multi-level synthesis
Nutritional anesthesia, the concept of coupling
The potential difference is all dynamics, the interaction can be regarded as a function of the node group, and the unity of opposites is the coupling of its various properties, the construction of the central node and the secondary module, the coupling of multiple variables, the more certain path, the coordination of proportions, and the dynamical system of the network
Liu Wansu's cold and cool faction is fiery and talks about "the six qi are all cremated" and "the five ambitions are all able to make fire"
Fire is the redundancy of information produced by the combination
Zhu Zhenheng (Zhu Danxi) Yang Yang School Raising Yin Theory "Phase Fire Theory" "Yang is often more than enough, Yin is often insufficient"
Zhang Congzheng attacked the evil faction and said that "if the evil goes, it will be safe", and the evil will be punished
Emphasis on the breaking of symmetry
Li Gao's theory of mending the soil and making up the soil "internal injury to the spleen and stomach, all diseases are born"
Grab the center node to pry the whole
The operation of the air engine seems to be used to describe the movement of the network, rising, descending, converging, and dispersing
Yin and Yang are quantized, and Yin and Yang are the embodiment of the principle of uncertainty, such as the continuous repetition of chemical equilibrium
The regulation of the network is not about throwing weights at the scale, but about the overall application of the relationship between the nodes, such as the activation and inhibition of enzymes
Protein structure is ultimately to take into account the existence of symmetry and is a deeper mathematical geometry
The reciprocating cycle of interactions
Yin and yang, virtual reality, cold and heat, etc. can be regarded as logical sequences, and their 1 and 0 ultimately constitute a Turing machine, which can be regarded as high-dimensional
Transmission of the central node
The similarity of the node group, the similarity of the properties
Hypothetical and real heterozygosity is the cause of distribution
The essence of disease treatment lies in network regulation, and reverse treatment and treatment are all adjustment methods, and reverse treatment is biased towards the symptoms of the disease that are consistent with the essence of the disease, that is, the variables are at the same level
The construction of the network is based on dynamic equilibrium, and its basic units are loops: sensory and motor feedback. At the level of the body are the nervous and immune and humoral regulatory systems
The hierarchical coupling of the probabilistic network enables the global properties to be expressed as eigenlevels with high probability
The overall correspondence of the concept of substrata is similar to that of various omics. Further consideration should be given to the order of the combination and the equivalence of information about its probability
The order of the loops completes the coupling
If there is an inside, there must be an outside, and the network structure is reversed according to the eigenvalues
Disease is an expression of the network, just like normal
Dialectics is the division of the hierarchy of the network, and the criteria are: yin and yang, cold and heat, the surface and the inside, the virtual and the real, the parts of the meridians, and the treatment method is the cycle of the speed network returning to normal
Determine the general base, as if building a network of European geometry in the medical system: the disruption of the balance of smooth muscle, vascular permeability, etc
Formula: such as the surface pattern = muscle surface pattern + lung system pattern, yang deficiency = qi deficiency + deficiency cold, yin deficiency = blood deficiency + deficiency heat. Health Differentials = Initial Stage + Epithermia, Qi Differentials = Phase II + Heat, Camp Syndromes = Phase III + Fainting, Blood Differentiation Certificates = Late Stage + Blood Movement + Wind. Diphtheria syndrome differentiation wind-heat epidemic virus pattern = wind-heat + punctate pseudo-membrane, yin deficiency and dry heat = hissing + strip-like pseudo-membrane, epidemic poison attack on the throat = hissing + obstruction. It should be a probabilistic network
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