Chapter 49 Systematic Biology
The codons corresponding to different amino acids are another level of selective expression, which is related to their own properties and also related to the emergence of the pattern of combination, but this is based on the intrinsic nature of the matrix, the isoelectric point, the pH value, etc. are the variables, and their proportions are intrinsic
The efficiency at different levels makes the overall coupling, such as the lifespan of red blood cells is limited, but it has multiple levels of distribution function coupling, such as the number of neonates, distribution
The synthesis of nucleotides of DNA, RNA is associated with amino acids: alanine, one-carbon units, aspartic acid, glutamine
Transformed into PRPSCs rich in β-folds, the water solubility deteriorates, and it is easy to aggregate and form starchy fibers that precipitate in brain tissue, causing damage. Writing, Fun, and Pavilion www.biquge.info This is a change at multiple levels by changing the probability of a change of a certain nature, and finally expressing the nature of the essence at a certain level
The binding group is a structural pattern, and catalysis is the guide to the selective expression of the matrix, which is variable, and this is also based on the basic principle. This kind of layered coupling or overlapping is a high-dimensional structure, and the projection of different levels is a certain selective expression
Loops are selective expressions of networks, and their connections are probabilistic, but the combination of probabilities makes its intrinsic a cyclic path that we can understand. The network is a large probability library, and its expression not only includes the generation of order, but also the expression of some order problems, which is actually a kind of accumulation, like a way to save the order. Reversible reactions and irreversible reactions must exist at the same time, and they have a certain distribution, which requires a certain irreversible reaction as the direction of guidance, which is the emergence of patterns. Moreover, irreversible reactions also have corresponding irreversible reactions in the opposite direction, which is a hierarchical coupling, such as
Transport allows the same substance to be coupled to other levels, such as lactate from the muscle through the blood to the liver to synthesize glucose and transport it back to the muscle, which is a coupling that requires constant replenishment
Systematic homeostasis is required, that is, the concentration of some substances, such as blood glucose, is maintained, which is an intrinsic of the network and can be synthesized by various pathways (with high probability)
The transfer of electrons leads to the generation of energy, which is coupled so that the potential energy of the cycle is released
The basic structure of the disease can be diffused into a matrix, causal-correlated
The final effect of orthogonal experiments is the eigenvalue, which we pass by its range or other proportions
Knowledge graphs, connections of different subjects (relatively independent), can be decomposed into operations of different sublayers (change probability)
Essential amino acids are the connection between an individual and the outside world, which is a coupling that requires transport to couple. At the same time, there is a potential difference, which has a limit, but the combination of different amino acids can play a complementary role, that is, collocation
Origin of Life: Formation of Fundamental Molecules (Miller's Discharge Experiment) – Specific Chemical Reaction Coupling (Formation of Dynamic Networks of Multiple Reactive Pathways),
History, that is, the portrayal of the present, is a selective expression of the Internet. Essentially, this is an iterative process, the Bayesian network.
The basic knowledge is the collapse path, i.e., the eigen, of selective expression. According to the combination of the networks diffused by the intrinsics, the process of deriving new eigens is a Bayesian network
Proteins are the basis, and the probability of infinite combinations of their first-order sequences can collapse into second-order modules (e.g., A-helix, B-fold, etc.) and three-dimensional spatial structures (relatively stable arrangement of groups), as well as a variety of interactions. Different levels have their different eigenvalues, and the protein interaction network is a surviving structure of various hierarchical combinations, and it is still changing, and its essence is the coupling of distribution functions
DNA, RNA is a structure like a probability network, so it can regulate the expression of proteins, which is also a hierarchical coupling
Enzyme is a high-level concept, which is a kind of guided probability collapse, the increase of free energy is the increase of probability, and then the decrease is a more certain path
The various metabolisms are certain combinatorial patterns, and there are also certain common pathways TAC
The existence of an enzyme itself is a transitional state, which is a guide that makes the way the probability collapses after combination follow a certain pattern
At equilibrium, the positive and negative reaction velocities are equal, so there is an equilibrium constant k, which is the ratio of the power product of the concentration, which is a high-dimensional level.
Equilibrium concentrations are the characteristics of multi-level demand achievement, such as blood glucose concentrations, which are the result of statistics, like the thermodynamic Boltzmann distribution
At the DNA level, there is more emphasis on the information carried by the sequence, and gene expression and protein synthesis are coupled networks: genes are intrinsic emergences of 3 billion base pairs – elements are genes or non-coding regions intrinsic emergences – and c/g enrichment is intrinsic emergence of elements
The smaller the granularity of the division, the greater the degree of coupling
Regulation: The key enzyme is the central node, which determines the overall essence, i.e., direction and speed; the number and activity of enzymes are regulated by genes and RNA expression (genes are internal, and the environment is externally modified); allosteric regulation of enzymes is the regulation of the network, so that enzymes are regulated by multiple regulatory pathways; and multiple paths are regulated simultaneously
Its big has no inside, and its small has no outside. Its structure is coupled, i.e., there is a high-dimensional topology between the levels.
To grasp the whole, it is necessary to sacrifice the details. Just as the Tao is a wave function, it can only be grasped as a whole (write a functional formula), but the specific observation is a partial collapse, and the grasp at this time is incomplete.
The assumption that elements such as yin and yang, the five elements, and so on are the basic units of the network, have been piled up into a high-dimensional structure, that is, the network, according to the traversal at different levels. The low-dimensional structure of the network, the operation of the sequence, is quantized, that is, relatively fixed. Yin and Yang are essentially concepts that arise relatively
Nature is the framework of a network, and our interpretation is a selective expression, i.e., the observation and collapse of the wave function
The commonality of the network is regarded as a common divisor.
The Five Elements Shengke is a kind of sequence processing, what monarchs and ministers are envoys, and the relationship between the punishment and the harm is the matching of the sequence (the ideal situation is complementary, and the similarity is suboptimal, and it is mismatched again)
The construction of the system: the overall relatively stable intrinsic and the local comparative change of the status quo (a kind of contrast, division)
The essence of motion: multi-level coupling, i.e., the operation of matrix eigens is chaotic
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